检索结果-南通市图书馆

Acta Biochimica et Biophysica Sinica 2004年第12期36卷 845-850页

作者： Hou, Wei-Hong wagn, tian-yun Yuan, Bao-Mei Chai, Yu-Rong Jia, Yan-Long tian, Fang Wang, Jian-Min Xue, Le-Xun Laboratory for Cell Biology Zhengzhou UniversityZhengzhou 450052 China

Human canstatin, a 24 kD fragment of the α2 chain of type IV collagen, has been proved to be one of the most effective inhibitors of angiogenesis and tumor growth. To investigatein vivoantiangiogenesis activity andin vitroeffects on endothelial cell proliferation of recombinant mouse canstatin, the cDNA of mouse canstatin was introduced into an expression vector pQE40 to construct a prokaryotic expression vector pQE-mCan. The recombinant mouse canstatin efficiently expressed inE. coliM15 after IPTG induction was monitored by SDS-PAGE and by Western blotting with an anti-hexahistidine tag antibody. The expressed mouse canstatin, mainly as inclusion bodies, accounted for approximately 35% of the total bacterial proteins. The inclusion bodies were washed, lysed and purified by the nickel affinity chromatography to a purity of approximately 93%. The refolded mouse canstatin was tested on the chicken embryo chorioallantoic membranes (CAM), and a large number of newly formed blood vessels were significantly regressed. In addition, recombinant mouse canstatin potently inhibited endothelial cell proliferation with no inhibition on non-endothelial cells. Taken together, these findings demonstrate that the recombinant mouse canstatin effectively inhibited angiogenesis of the chicken embryo in a dose-dependent manner and specially suppressed in vitro the proliferation of human umbilical vein endothelial cells.

关键词： mouse canstatin angiogenesis inhibitor prokaryotic expression

Adversarial attacks and defenses for digital communication signals identification

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第3期10卷 756-764页

作者： Qiao tian Sicheng Zhang Shiwen Mao yun Lin College of Computer Science and Technology Harbin Engineering UniversityHarbin150001China College of Information and Communication Engineering Harbin Engineering UniversityHarbin150000China Department of Electrical and Computer Engineering Auburn UniversityAuburnAL36849USA

As modern communication technology advances apace,the digital communication signals identification plays an important role in cognitive radio networks,the communication monitoring and management *** has become a promising solution to this problem due to its powerful modeling capability,which has become a consensus in academia and ***,because of the data-dependence and inexplicability of AI models and the openness of electromagnetic space,the physical layer digital communication signals identification model is threatened by adversarial *** examples pose a common threat to AI models,where well-designed and slight perturbations added to input data can cause wrong ***,the security of AI models for the digital communication signals identification is the premise of its efficient and credible *** this paper,we first launch adversarial attacks on the end-to-end AI model for automatic modulation classifi-cation,and then we explain and present three defense mechanisms based on the adversarial *** we present more detailed adversarial indicators to evaluate attack and defense ***,a demonstration verification system is developed to show that the adversarial attack is a real threat to the digital communication signals identification model,which should be paid more attention in future research.

关键词： Digital communication signals identification AI model Adversarial attacks Adversarial defenses Adversarial indicators

Degradation-adaptive neural network for jointly single image dehazing and desnowing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第2期18卷 247-249页

作者： Erkang CHEN Sixiang CHEN tian YE yun LIU School of Ocean Information Engineering Jimei UniversityXiamen 361021 China College of Artificial Intelligence Southwest UniversityChongqing 400715 China

1 Introduction In harsh winter scenes,the captured images often suffer from hazeand snowdegradationssimultaneously,which significantly affect the performance of high-level computer vision ***,most existing dehazing methods[1-4]and desnowing methods[5-7]are specialized to address only one type of weather-related degradation,and they struggle to effectively handle multiple types of degradations.

关键词： neural handle computer

Macrophage polarization disorder in the endometrial immune microenvironment may contribute to recurrent implantation failure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

REPRODUCTIVE AND DEVELOPMENTAL MEDICINE 2024年第3期8卷 162-168页

作者： Liu, yun Tan, Xian-Ming He, tian-tian Sun Yat sen Univ Affiliated Hosp 7 Dept Obstet & Gynecol Shenzhen 518000 Peoples R China Sun Yat sen Univ Sch Med Shenzhen Campus Shenzhen 518000 Peoples R China Sun Yat sen Univ Affiliated Hosp 3 Dept Obstet Guangzhou 510000 Peoples R China

Objective:To investigate the role and mechanisms by which macrophages (M Phi) contribute to the immune environment of the endometrium in cases of recurrent implantation failure (RIF).Methods:Endometrial transcriptome data from women with and without RIF (control group) were collected. The CIBERSORT software was used to determine the abundance of immune cells within the endometrial tissue based on expression profiles. Weighted gene co-expression network analysis was used to identify crucial regulatory genes and ***:Application of CIBERSORT confirmed significant infiltration of macrophages in the RIF group. SOX6, TTC21A, KLHL31, NFIA, TNNT1, TPM1, CPVL, FUS, PEX5, and SLC43A3 were all closely correlated with M2 and M0 macrophages. Metascape and DisNor analyses revealed that these genes contribute to the regulation of macrophage polarization via the Wnt signaling ***:This study identified dysregulation of macrophage polarization within the immune microenvironment of the endometrium in patients with RIF. A comprehensive analysis was conducted to investigate the potential mechanisms underlying this disorder. Dysregulation of macrophage polarization in the endometrium of patients with RIF is strongly associated with the Wnt signaling pathway.

关键词： Macrophage Polarization disorder Immune microenvironment Recurrent implantation failure Assisted reproductive technology EXPRESSION ACTIVATION

Failure mechanism and infrared radiation characteristic of hard siltstone induced by stratification effect

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2024年第3期21卷 1058-1074页

作者： CHENG yun SONG Zhanping XU Zhiwei YANG Tengtian tian Xiaoxu School of Civil Engineering Yancheng Institute of TechnologyYancheng 224051China School of Civil Engineering Xi'an University of Architecture and TechnologyXi'an 710055China Shaanxi Key Laboratory of Geotechnical and Underground Space Engineering Xi'an 710055China China Railway Construction Bridge Engineering Bureau Group Co. Ltd.Tianjin 300300China

The deformation in sedimentary rock induced by train loads has potential threat to the safe operation of tunnels. This study investigated the influence of stratification structure on the infrared radiation and temporal damage mechanism of hard siltstone. The uniaxial compression tests, coupled with acoustic emission(AE) and infrared radiation temperature(IRT) were conducted on siltstones with different stratification effects. The results revealed that the stratigraphic structure significantly affects the stress-strain response and strength degradation characteristics. The mechanical parameters exhibit anisotropy characteristics, and the stratification effect exhibits a negative correlation with the cracking stress and peak stress. The failure modes caused by the stratification effect show remarkable anisotropic features, including splitting failure(Ⅰ: 0°-22.50°, Ⅱ: 90°), composite failure(45°), and shearing failure(67.50°). The AE temporal sequences demonstrate a stepwise response characteristic to the loading stress level. The AE intensity indicates that the stress sensitivity of shearing failure and composite failure is generally greater than that of splitting failure. The IRT field has spatiotemporal migration and progressive dissimilation with stress loading and its dissimilation degree increases under higher stress levels. The stronger the stratification effect, the greater the dissimilation degree of the IRT field. The abnormal characteristic points of average infrared radiation temperature(AIRT) variance at local stress drop and peak stress can be used as early and late precursors to identify fracture instability. Theoretical analysis shows that the competitive relationship between compaction strengthening and fracturing damage intensifies the dissimilation of the infrared thermal field for an increasing stress level. The present study provides a theoretical reference for disaster warnings in hard sedimentary rock mass.

关键词： Hard siltstone Failure mechanism Stratification effect Infrared radiation characteristic Temporal-damage mechanism Dissimilation

维普期刊数据库

Hepatic cystic lesions mimicking liver abscess on imaging: A report oftwo cases

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 86-89页

作者： yun-Wen Jiang Yong-Hong Yu tian-An Jiang Shu-Yuan tian Department of Ultrasound Medicine Tongde Hospital of Zhejiang ProvinceHangzhou 310012China Department of Ultrasound Medicine the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Hepatic cystic lesions include congenital dysplasia,inflammatory cystic lesions,neoplastic cystic lesions and parasitic cystic *** different treatment modalities can be chosen for these lesions,differential diagnosis is particularly important[1].Clinical features or imaging findings of cystic lesions of the liver are typical;for instance,liver abscess often shows thick-walled enhancement on contrast-enhanced CT.

关键词： lesions Hepatic cystic

维普期刊数据库

Research fronts and researchers of World Journal of Psychiatry in 2023: A visualization and analysis of mapping knowledge domains

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第7期14卷 1118-1126页

作者： yun-tian Xie Yu-Jing Yang Department of Applied Psychology Changsha Normal UniversityChangsha 410100Hunan ProvinceChina

BACKGROUND In the rapidly evolving landscape of psychiatric research,2023 marked another year of significant progress globally,with the World Journal of Psychiatry(WJP)experiencing notable expansion and *** To conduct a comprehensive visualization and analysis of the articles published in the WJP throughout *** delving into these publications,the aim is to deter-mine the valuable insights that can illuminate pathways for future research endeavors in the field of *** A selection process led to the inclusion of 107 papers from the WJP published in 2023,forming the dataset for the *** advanced visualization techniques,this study mapped the knowledge domains represented in these *** The findings revealed a prevalent focus on key topics such as depression,mental health,anxiety,schizophrenia,and the impact of coronavirus disease ***,through keyword clustering,it became evident that these papers were predominantly focused on exploring mental health disorders,depression,anxiety,schizophrenia,and related *** contributions hailed authors in regions such as China,the United Kingdom,United States,and ***,the paper garnered the highest number of citations,while the American Psychiatric Association was the most cited *** It is recommended that the WJP continue in its efforts to enhance the quality of papers published in the field of ***,there is a pressing need to delve into the potential applications of digital interventions and artificial intelligence within the discipline.

关键词： World Journal of Psychiatry Psychiatry Mapping knowledge domains Visualization Analysis

The impact of broad glutamine metabolism inhibition on the tumor microenvironment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 2-4页

作者： tianhe Li yun-Ta Chuang tian-Li Wang Departments of Pathology Oncologyand Gynecology and ObstetricsThe Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21231USA

Glutamine is an importantα-amino acid that provides carbon and nitrogen sources for the biosynthesis of nucleotides,proteins,and *** also generates metabolites that fuel the tricarboxylic acid cycle and maintain intracellular redox *** cells have a heightened metabolic dependence on glutamine to support incessant tumor growth and mitigate tumor microenvironmental stresses including hypoxia,nutrient depletion.

关键词： metabolism tumor microenvironment

Development of SV2A Ligands for Epilepsy Treatment:A Review of Levetiracetam,Brivaracetam,and Padsevonil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第5期40卷 594-608页

作者： Peng-Peng Wu Bi-Rong Cao Fu-yun tian Zhao-Bing Gao Center for Neurological and Psychiatric Research and Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan528400China

Epilepsy is a common neurological disorder that is primarily treated with antiseizure medications(ASMs).Although dozens of ASMs are available in the clinic,approximately 30%of epileptic patients have medically refractory seizures;other limitations in most traditional ASMs include poor tolerability and drug-drug ***,there is an urgent need to develop alternative ***(LEV)is a first-line ASM that is well tolerated,has promising efficacy,and has little drug-drug *** it is widely accepted that LEV acts through a unique therapeutic target synaptic vesicle protein(SV)2A,the molecular basis of its action remains *** so,the next-generation SV2A ligands against epilepsy based on the structure of LEV have achieved clinical *** review highlights the research and development(R&D)process of LEV and its analogs,brivaracetam and padsevonil,to provide ideas and experience for the R&D of novel ASMs.

关键词： Levetiracetam Epilepsy Antiseizure medications Synaptic vesicle protein 2A Brivaracetam Padsevonil

Remarkably Enhanced Methane Sensing Performance at Room Temperature via Constructing a Self-Assembled Mulberry-Like ZnO/SnO_(2) Hierarchical Structure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第3期7卷 337-344页

作者： Xun Li tian Tan Wei Ji Wanling Zhou Yuwen Bao Xiaohong Xia Zhangfan Zeng yun Gao Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science&EngineeringHubei UniversityWuhan 430062China School of Artificial Intelligence Hubei UniversityWuhan 430062China

Development of metal oxide semiconductors-based methane sensors with good response and low power consumption is one of the major challenges to realize the real-time monitoring of methane *** this work,a self-assembled mulberry-like ZnO/SnO_(2)hierarchical structure is constructed by a two-step hydrothermal *** resultant sensor works at room temperature with excellent response of~56.1%to 2000 ppm CH_(4)at 55%relative *** is found that the strain induced at the ZnO/SnO_(2)interface greatly enhances the piezoelectric polarization on the ZnO surface and that the band bending results in the accumulation of chemically adsorbed O_(2)^(-)ions close to the interface,leading to significant improvement in the sensing performance of the methane gas sensor at room temperature.

关键词： heterojunction methane sensor oxygen vacancy piezoelectric polarization ZnO/SnO_(2)hierarchical structure

维普期刊数据库