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Surveillance of drug resistance tuberculosis based on reference laboratory data in Ethiopia

Infectious Diseases of Poverty 2019年第3期8卷 107-107页

作者： Getu Diriba Abebaw Kebede Habteyes Hailu Tola Ayinalem Alemu Mengistu Tadesse Epherem Tesfaye Zemedu Mehamed Abiyot Meaza Bazezew Yenew Hilina Molalign Biniyam Dagne waganeh sinshaw Misikir Amare Shewki Moga Yeshiwork Abebaw Getachew Sied Ethiopian Public Health Institute Addis AbabaEthiopia

Background:Both passive and active surveillance of drug resistance have an important role in tuberculosis(TB)control *** data are important to estimate the magnitude of drug resistance TB,to know the trend of the disease,assess the performance of the program,and to forecast diagnosis and treatment ***,this study aimed to determine the prevalence and the proportion of drug resistant tuberculosis in Ethiopia based on passively collected ***:A cross-sectional study was conducted at the National Tuberculosis Reference Laboratory and seven Regional TB laboratories in Ethiopia on a retrospective data collected from July 2017 to June,*** were collected by standardized checklist from TB culture laboratory registration *** of recovery rate,contamination rate,and prevalence of drug resistance TB were determined by Statistical Package for Social Science(SPSS)version ***:Of 10134 TB suspected individuals included into this analysis,1183(11.7%)were culture *** overall contamination proportion was 53%and nontuberculous mycobacteria proportion was 0.98%.First-line drug susceptibility test was performed for 329 M ycobacterium tuberculosis complex isolates,and the proportion of resistance was 5.7 and 6.3%for isoniazid and rifampicin *** proportion of multidrug-resistant tuberculosis(MDR-TB)was 4.3%in new patients,while 6.7%in previously treated ***,there was no category for 0.6%patients,and the overall proportion of MDR-TB was 11.6%.Conclusions:The result of this study indicated that MDR-TB is a serious public health problem in ***,strengthen prevention and control program is vital to halt the burden of drug resistant TB in the country.

关键词： Tuberculosis Multidrug-resistant tuberculosis Rifampicin resistance Isoniazid resistance

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