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Relationship between peripheral arterial disease, carotid intima-media thickness and C-reactive protein in elderly diabetic patients

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Advances in Aging Research 2013年第4期2卷 115-120页

作者： Moatassem Salah Amer Samia Ahmed Abdul-Rahman wafaa Mostafa Abd-El Gawad ibrahim Ahmad Abdel Aal Ahmad Abdel Khalek Abdel Razek Mohamed Wessam El-Huseiny Moustafa Abdel Wahab Clinical Pathology Department Faculty of Medicine Mansoura University Mansoura Egypt Geriatrics and Gerontology Department Faculty of Medicine Ain Shams University Cairo Egypt Geriatrics and Gerontology Department Faculty of Medicine Mansoura University Mansoura Egypt Radiodiagnosis Department Faculty of Medicine Mansoura University Mansoura Egypt

Purpose: To study the association between carotid intima media thickness (CIMT) and high sensitivity CRP (hs-CRP) level as markers for PAD in elderly patients with DM. Subjects: A case-control study on 90 participants aged 60 years and older divided into 60 cases (30 patients with DM alone and 30 patients with DM and comorbidities) and 30 healthy controls. All were assessed by measuring CIMT, ankle brachial index (AB), and markers for cardiovascular disease such as high-sensitivity CRP (hs-CRP), total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), and low density lipoprotein (LDL). Results: hs-CRP levels showed statistically significant difference being highest among patients with DM and comorbidities and lowest among controls (P < 0.001). Also, symptoms of PAD were significantly higher among cases than controls. ABI was able to detect PAD in many asymptomatic patients. Color changes were present in only 43.30% (n = 26) of positive PAD cases while delayed wound healing, claudication pain, rest pain, cold extremities, and trophic changes were present in 23.30% (n = 14), 16.71% (n = 10), 16.71% (n = 10), 45.00% (n = 27), and 21.7% (n = 13). Using logistic regression analysis revealed that DM, CIMT, and hs-CRP were independent predictors for PAD (OR = 4.194, 7.236, 1.003;P value = 0.044, 0.25, 0.031) after adjustment of other coronary risk factors such as sex, smoking, hypertension, TC, and TG. Conclusion: Diabetic elderly have higher prevalence of asymptomatic PAD thannon-diabetics using solely ABI. DM, CIMT, and hs-CRP are independent predictors for the occurrence of PAD. Hs-CRP levels are highest among diabetics with comorbidities.

关键词： Peripheral Arterial Disease Carotid Intima-Media Thickness Ankle Brachial Index C-Reactive Protein Elderly

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CRKL and CK2 <i>β</i>over Expression Are Independent Predictors of Patients Survival in Endometrioid Endometrial Carcinoma

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Open Journal of Obstetrics and Gynecology 2019年第4期9卷 479-493页

作者： Randa Mohamed Kaf wafaa El-Beshbishi Ahmed A. Obaya Rham Z. Ahmed Khaled Fathy Helal Mohamed SH. Ramadan Abdelwahab S. Almoregy ibrahim A. Heggy Ola A. Harb Department of Pathology Faculty of Medicine Zagazig University Zagazig Egypt Department of Clinical Oncology and Nuclear Medicine Faculty of Medicine Mansoura University Mansoura Egypt Department of Clinical Oncology and Nuclear Medicine Faculty of Medicine Zagazig University Zagazig Egypt Department of Medical Oncology Faculty of Medicine Zagazig University Zagazig Egypt Department of Gynecology & Obstetrics Faculty of Medicine Zagazig University Zagazig Egypt Department of General Surgery Faculty of Medicine Zagazig University Zagazig Egypt

Context: The prognostic significance of expression of V-Crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) and Protein kinase CK2 β in endometroid carcinoma is not fully clarified. Aim: To assess the prognostic values and clinicopathological roles of CRKL and CK2 β expression in endometroid carcinoma by correlation their expression levels with clinicopathological parameters, response to therapy, and recurrence of the tumor and patients survival. Settings: Faculty of Medicine, Zagazig University, and Mansoura University. Methods: CRKL and CK2 β expressions were evaluated in 50 paraffin blocks EC patients that were followed up for 5 years. The relationship between their level of expressions, clinicopathological criteria and prognosis of patients was analyzed. Statistical analysis used: SPSS 22.0 for windows (SPSS Inc., Chicago, IL, USA) and MedCalc windows (Software bvba 13, Ostend, Belgium). Results: High expression of CRKL and CK was positively correlated with higher grade of the tumor (p = 0.004 and 0.006 respectively), presence of L.N metastases (p = 0.009 and 0.003 respectively), presence of distant metastases (p = 0.029 and 0.003 respectively) and advanced FIGO stage (p 0.001), poor response to therapy (p = 0.046 and 0.005 respectively), higher incidence of recurrence of the tumor after therapy (p = 0.004 and 0.048 respectively), higher incidence of cancer progression p = 0.018 and 0.044 respectively), poor PFS (p = 0.008 and 0.013 respectively), and OS rates

关键词： CRKL CK2 β Endometroid Carcinoma Immunohistochemistry Prognosis

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基于投影寻踪分类法的甘蔗种质综合评价

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湖南农业大学学报（自然科学版） 2020年第2期46卷 144-149页

作者：武晋宇应雄美朱建荣赵俊刘家勇吴才文 ibrahim soliman Helal ELGAMAL 赵勇云南省农业科学院甘蔗研究所云南开远661699 云南省甘蔗遗传改良重点实验室云南开远661699

基于投影寻踪分类法对40份从法国和菲律宾引进的甘蔗种质进行综合评价。方差分析结果表明,各种质间茎径、单茎质量、蔗糖分等主要工农艺性状均存在显著差异(P<0.01),变异系数介于5.68%~51.55%,变异广泛。对各种质的株高、茎径、有效茎... 详细信息

基于投影寻踪分类法对40份从法国和菲律宾引进的甘蔗种质进行综合评价。方差分析结果表明,各种质间茎径、单茎质量、蔗糖分等主要工农艺性状均存在显著差异(P<0.01),变异系数介于5.68%~51.55%,变异广泛。对各种质的株高、茎径、有效茎、单茎质量、锤度、甘蔗蔗糖分、蔗汁蔗糖分、简纯度和纤维分等9个主要工农艺性状指标进行投影方向和投影值大小分析,结果表明:投影方向以甘蔗蔗糖分的最高,其后依次为锤度、蔗汁蔗糖分、简纯度、单茎质量和茎径等,株高和有效茎的较低;40份种质投影值大小各异,根据投影值大小,结合聚类分析将40份种质划分为5个类群,各类群投影值介于0.00~2.50,其中,第Ⅳ类群的5份种质资源(FR97–127、FR97–53、VMC95–29、VMC96–169和VMC97–30)综合性状表现优良,可供甘蔗杂交利用。综合来看,投影寻踪分类法可作为大量甘蔗种质资源评价的有效途径。

关键词：甘蔗种质资源评价投影寻踪分类法(PPC) 聚类分析

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