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Interna.iona. Journa. of Orga.ic Chemistry 2019年第1期9卷 37-46页

作者： wafa a. Ba.er bawazir Depa.tment of Chemistry Faculty of Science KAU Jeddah Saudi Arabia

Some new a.ymmetric thioethers 5 a.d 4-thia.olidinones 6 ha.e been obta.ned from condensa.ion of 5-formyl-3-(pyridin-4'-yl)-1,2,4-tria.ino[5,6-b] indole (3) with ha.ogena.ed a.oma.ic a.ines followed by a.dition of thiophenol a.d/or cycloa.dition with thiola.tic a.ids in nonpola. solvents. Structures of the products confirmed by elementa. a.a.ysis a.d spectra. mea.urements. The new systems obta.ned were eva.ua.ed a. a.tifunga. a.ents.

关键词： Thioethers Thia.olidnones 1 2 4-Tria.ino Indole Fungicida. Cycloa.dition

Va.ious Routes to Synthesise 3-Thioxo-1,2,4-Tria.ine-5-One Deriva.ives a. a.timicrobia. a.ents

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Interna.iona. Journa. of Orga.ic Chemistry 2018年第2期8卷 191-200页

作者： Reda.M. a.del-Ra.ma. wafa a. bawazir Depa.tment of Chemistry Faculty of Science KAU Jeddah Saudi Arabia

a.simple condensa.ion a.forded some new 3-thioxo-1,2,4-tria.in-5-one deriva.ives (4, 6 a.d 8). Utilizing a.fa.ile condensa.ion of (E)-4-(4’-bromo styryl)-2-oxo-3-buteneoic a.id with thiosemica.ba.ide, dithioic formic a.id hydra.ide, a.d thioca.ba.ydra.ide in different conditions. Structures of these compounds were confirmed by elementa. a.d spectra. a.a.ysis. The prelimina.y biocida. a.tivity of these products were eva.ua.ed a.a.nst some microbia. a.d compa.ed to Mycosta.ine a.d pipera.illin a. a.tibiotics were most of deriva.ives exhibited good a.tivity.

关键词： Synthesis a.timicrobia. 3-Thioxo-1 2 4-Tria.in-5-Ones

Synthesis of New Fluorina.ed a.ino-Heterocyclic Compounds Bea.ing 6-a.yl-5-Oxo-1,2,4-Tria.in-3-Yl Moiety a. a.timicrobia. a.ents

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Interna.iona. Journa. of Orga.ic Chemistry 2018年第4期8卷 349-358页

作者： wafa a. bawazir Reda.M. a.del-Ra.ma. Depa.tment of Chemistry Faculty of Science King Abdulaziz University Jeddah Saudi Arabia

Some more new fluorine substituteda.ino compounds bea.ing 6-a.yl-5-oxo-1,2,4-tria.in-3-yl moieties a.d its deriva.ives 3 - 7 ha.e been synthesised successfully from a.oyla.ion of 6-(2’-a.inophenyl)-3-thioxo-1,2,4-tria.in-5-one (1), followed by fluoro a.ina.ion with 4-fluoroa.ilinein a.s EtOH a.d then trea.ed with a.monia.EtOH a.d fina.ly a.yla.ion/a.oyla.ion or cyclocondensa.ion rea.tions with ma.onic a.id in a.OH. Structure of the products ha. been esta.lished upon elementa. a.a.ysis a.d their spectra. mea.urements. a.l the obta.ned compounds eva.ua.ed a. a.timicrobia. a.ents were the compounds which conta.ned both nitro a.d fluorine elements a.d exhibited a.highly a.tivity the other deriva.ives.

关键词： Fa.ile Synthesis Fluoro-a.ino-1 2 4-Tria.ines a.timicrobia.s

a.Mini-Review 5-a.ino-N-Substituted Pyra.oles a. Building Blocks for Bioa.tive Molecules

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Interna.iona. Journa. of Orga.ic Chemistry 2020年第2期10卷 63-76页

作者： wafa bawazir Depa.tment of Chemistry Faculty of Science King Abdul-Aziz University Jeddah KSA

In this review a.five-membered heterocyclic ring ha.ing two a.ja.ent nitrogen a.oms known a. Pyra.ole, we ha.e fra.ed 5-a.ino-N-substituted pyra.oles in pa.ticula. focusing on its substa.tia. role a. a.building block a.d sta.ting ma.eria.s for producing enormous heterocyclic skeletons. The existence of this moiety in la.ger compounds renders them to expose medicina., pha.ma.ologica. a.d biologica. thera.eutic a.tivities. Enormous drugs conta.n 5-a.ino-N-substituted pyra.oles such a. celecoxib a.ti-infla.ma.ory, a.tipsychotic, a.ti-obesity, a.a.gesic, a.d a.tidepressa.t. We reported va.ious routes of synthesis a.d the use of these compounds.

关键词： Synthesis 1 5-Disubstituted Pyra.oles Bioa.tive Review