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Smith normal forms of incidence matrices

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Science China Mathematics 2013年第7期56卷 1359-1371页

作者： SIN peter Department of Mathematics University of Florida

A brief introduction is given to the topic of Smith normal forms of incidence matrices. A general discussion of techniques is illustrated by some classical examples. Some recent advances are described and the limits o... 详细信息

关键词： Smith normal form incidence matrix adjacency matrix

Cockroach as the Earliest Eusocial Animal

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Acta Geologica Sinica(English Edition) 2010年第4期84卷 793-808页

作者： peter VRSANSKY Geological Institute Slovak Academy of SciencesBratislavaSlovakia Russian Academy of Sciences MoscowRussia

A completely preserved cockroach Socialaperlucida gen. et sp. nov. （Blattida： Socialidae faro. nov.） is described from the Mesozoic （Albian Early Cretaceous） amber of Archingeay in France. It is categorized within the new family Socialidae, originating from the Mesozoic cockroach family Liberiblattinidae, and representing the sister group to the most basal known eutermite families. Numerous direct and indirect morphological evidence （such as a unique narrow body and pronotum with reduced coloration, legs without carination and with numerous sensillar pitts （forelegs） as adaptations to life in nests analogical to the living termitophillous species; enlarged head, long palps for communication, a general venation modified in a direction towards termites （subcosta and radial vein [R] approximated, R branches approximated, simplified, cross-veins reduced）, and possibly also the development of the breaking forewing sutura for detaching wings after marriage flight）, suggest its eusocial mode of life. Thus, the first eusociality originated within cockroaches, prior to giving birth to termites; termites and Cryptocercus are not directly related. The group of eusocial cockroaches makes termite morphotaxon polyphyletic, but also in this case, the erection of a new order for mastotermites （including Cratomastotermitidae） and/or the inclusion of eusocial, morphological cockroaches within termites appears counterproductive, thus an example of such a general exception to the taxonomical procedure is provided.

关键词： fossil insect Mesozoic amber Blattida eusociality termite origin polyphyletic taxon new family

Possibilities for Healthcare Computing

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Journal of Computer Science & Technology 2011年第4期26卷 625-631页

作者： peter Szolovits Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology

Advances in computing technology promise to aid in achieving the goals of healthcare. We review how such changes can support each of the goals of healthcare as identified by the U.S. Institute of Medicine： safety, effectiveness, patient-centricity, timeliness, efficiency, and equitability. We also describe current foci of computing technology research aimed at realizing the ambitious goals for health information technology that have been set by the American Recovery and Reinvestment Act of 2009 and the Health Reform Act of 2010. Finally, we mention efforts to build health information technologies to support improved healthcare delivery in developing countries.

关键词： healthcare computing United States national plans meaningful use criteria substitutable applications medical natural language processing mobile health telehealth

Comorbidity in cirrhosis

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World Journal of Gastroenterology 2014年第23期20卷 7223-7230页

作者： peter Jepsen Department of Hepatology and Gastroenterology Aarhus University HospitalDK-8000 Aarhus CDenmark Department of Clinical Epidemiology Aarhus University HospitalDK-8000 Aarhus CDenmark

Cirrhosis patients’comorbidities are their other diseases than *** are neither causes nor consequences of cirrhosis,but they can increase mortality and are therefore clinically *** are also an important source of confounding in epidemiologic *** scoring systems have been developed as tools to measure the cirrhosis patient’s total burden of comorbidity,and they are useful in the clinic and for epidemiologic *** recently developed CirCom score is the only comorbidity scoring system developed specifically for cirrhosis patients,and it may be preferred over the older,generic,and more complex Charlson comorbidity *** of individual comorbid diseases can provide insight into the interactions between cirrhosis and other diseases and thus into the pathophysiology of *** article reviews the literature on comorbidity in cirrhosis.

关键词： Liver cirrhosis Comorbidity Prognosis Epidemiology

Open Science and Data Science

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Data Intelligence 2021年第1期3卷 95-105页

作者： peter Wittenburg Max Planck Computing and Data Facility Gießenbachstraße 285748 GarchingGermany

Data Science(DS)as defined by Jim Gray is an emerging paradigm in all research areas to help finding non-obvious patterns of relevance in large distributed data collections.“Open Science by Design”(OSD),i.e.,making artefacts such as data,metadata,models,and algorithms available and re-usable to peers and beyond as early as possible,is a pre-requisite for a flourishing DS ***,a few major aspects can be identified hampering a fast transition:(1)The classical“Open Science by Publication”(OSP)is not sufficient any longer since it serves different functions,leads to non-acceptable delays and is associated with high curation *** data lab practices towards OSD requires more fundamental changes than OSP.(2)The classical publication-oriented models for metrics,mainly informed by citations,will not work anymore since the roles of contributors are more difficult to assess and will often change,i.e.,other ways for assigning incentives and recognition need to be found.(3)The huge investments in developing DS skills and capacities by some global companies and strong countries is leading to imbalances and fears by different stakeholders hampering the acceptance of Open Science(OS).(4)Finally,OSD will depend on the availability of a global infrastructure fostering an integrated and interoperable data domain-“one data-domain”as George Strawn calls it-which is still not visible due to differences about the technological key *** therefore is a need for DS,but it will take much more time to implement it than we may have expected.

关键词： Open Science by Design Open Science by Publication Data Science Data infrastructure Digital Objects FAIR

Medical therapy for spermatogenic failure

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Asian Journal of Andrology 2012年第1期14卷 57-60,176页

作者： Ranjith Ramasamy peter J Stahl peter N Schlegel Department of Urology Weill Cornell Medical College New York NY 10065 USA

Medical treatment of men with primary spermatogenic failure remains largely ineffective in contrast to those with secondary testicular failure. Treatment has been attempted with a multitude of agents ranging from hormones to nutritional supplements （antioxidants）. While some studies have demonstrated benefit to some treatments, no treatments have consistently demonstrated efficacy nor has it been possible to reliably identify patients likely to benefit. Idiopathic spermatogenic failure likely results from multiple discrete defects in sperm production that are as yet unidentified. A better understanding of these defects will yield more effective treatment options and appropriate triage of patients to specific therapeutic regimens. This review focuses on the rationale and current evidence for hormonal and antioxidant therapy in medical treatment of male infertility, spermatogenic failure in particular. Although empiric medical therapy for spermatogenic failure has been largely replaced by assisted reproductive techniques, both treatment modalities could play a role, oerhaos as combination therapy.

关键词： antioxidant hormones male infertility sperm spermatogenesis spermatogenic failure testicular failure

Accurate, automatic annotation of peptidases with hotpep-protease

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Green Chemical Engineering 2020年第2期1卷 124-130页

作者： peter Kamp Busk Department of Science and Environment Roskilde UniversityUniversitetsvej 1DK-4000RoskildeDenmark

Peptidases are essential for intracellular protein processing,signaling and homeostasis,physiological processes and for digestion of ***,peptidases are important biotechnological enzymes used in processes such as industrial food processing,leather manufacturing and the washing *** of peptidases is a crucial step in their characterization but peptidase annotation is not a trivial task due to their large sequence *** the present study short,conserved sequence profiles were generated for all peptidase families with more than four members in the comprehensive Merops peptidase *** sequence profiles were combined with the Homology to Peptide Pattern(Hotpep)method for automatic annotation of *** method is a standalone software that annotates protease sequences to Merops family and subgroup and is suitable for large-scale sequence *** to the Mammalian Degradome Database Hotpep-protease had an accuracy of 92%and a sensitivity of 96%for annotation of the human *** by commonly used methods(Blast and conserved domains)had an accuracy of 69%and a sensitivity of 78%.For fungal genomes,there were large differences between annotation with Hotpep-protease,Blast-and Hidden Markov Model-based annotation and the Merops annotation,which confirms the difficulty of large-scale peptidase *** annotation indicated that Hotpep-protease had a positive prediction rate of 0.90 compared to a positive prediction rate of 0.67 for Blast ***,Hotpep-protease is highly accurate method for fast and accurate annotation of peptidases.

关键词： Gene annotation Proteinase Proteolytic enzyme Peptidase Merops

Prediction of disease course in inflammatory bowel diseases

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World Journal of Gastroenterology 2010年第21期16卷 2589-2590页

作者： peter Laszlo Lakatos 1st Department of Medicine Semmelweis UniversityH-1083 BudapestKoranyi S 2AHungary

Clinical presentation at diagnosis and disease course of both Crohn's disease(CD) and ulcerative colitis are heterogeneous and variable over *** most patients have a relapsing course and most CD patients develop complications(*** and/or perforation),much emphasis has been placed in the recent years on the determination of important predictive *** identification of these factors may eventually lead to a more personalized,tailored *** this TOPIC HIGHLIGHT series,we provide an update on the available literature regarding important clinical,endoscopic,fecal,serological/routine laboratory and genetic *** aim is to assist clinicians in the everyday practical decisionmaking when choosing the treatment strategy for their patients suffering from inflammatory bowel diseases.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Disease course Predictive markers Clinical Serology Genetics

Spin Polaron in a Diluted Parabolic Magnetic Quantum Well

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Communications in Theoretical Physics 2010年第4期53卷 782-786页

作者： A.John peter Department of Physics Zhejiang Institute of Modern Physics Zhejiang University

Theoretical investigations of spin polaron in a quantum well in the spin doping superlattice systems Cd1-xinMnxinTe/Cd1-xMnxout Te are presented in this paper. A variational procedure within the effective mass approximation is employed in the presence of magnetic field to calculate the donor ionization energy. Spin polaronic shifts are estimated using a mean field theory. The results show that the donor binding energy （i） Increases with the reduction in well sizes （ii） Decreases with the magnetic field is increased for a given well width （ill） Increases to a maximum value at 90 A and then decreases as the size of the well increases beyond 90 A and （iv） Spin polaronic shifts to the donor binding energy not only decrease in a magnetic field but also with the well width. The results are compared with the existing available literature.

关键词： spin polaron donor binding quantum dot semimagnetic system