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Imaging tumor hypoxia:Blood-borne delivery of imaging agents is fundamentally different in hypoxia subtypes

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Journal of Innovative Optical Health Sciences 2014年第2期7卷 12-17页

作者： peter Vaupel Armulf Mayer Department of Radioncology and Radiotherapy University Medical Center 55131 MainzGermany

Dedicated to the memory of Professor Briton Chance on the ccasion of his 100th birthday(July24 th,2013),and remembering mary erciting discussions on the orygenation of breast cancer,ontumor hyporia in general and imaging of the orygenation status of malignant *** tissue subvolumes are a hallmark feat ure of solid malignant tumors,relevant for cancertherapy and patient outcome because they increase both the intrinsic aggressiveness of tumor cells and their resist ance to several commonly used anticancer *** mech-anisms leading to hypoxia are diverse,may coexist within the same tumor and are commonlygrouped according to the duration of their *** hypoxia is mainly caused by difusionlimitations resulting from enlarged intercapilary distances and adverse difusion geometriesand--to a lsser extent--by hypoxemia,compromised perfusion or long-lasting microregionalfow ***,acute hypoxia preferentilly results from transient disruptions in *** each of these features of the tumor microenvironment can contribute to a criticalreduction of oxy gen availability,the delivery of imaging agents(as well as nutrients and anti-cancer agents)may be compromised or remain unaffected,Thus,a critial appraisal of the ffectsof the various mechanisms leading to hypoxia with regard to the blood-bome delivery of imagingagents is necessary to judge their ability to correctly represent the hypoxic phenotype of solidmalignancies.

关键词： Delivery of imaging agents tumor hypoxia hypoxia subty pes,chronic hypoxia acutehypoxia.

Phytochrome-regulated Gene Expression

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Journal of Integrative Plant Biology 2007年第1期49卷 11-20页

作者： peter H. Quail Department of Plant and Microbial Biology University of Cafifomia Berkeley CA 94720 USA U.S. Department of Agriculture/Agriculture Research Service-Plant Gene Expression Center 800 Buchanan Street Albany CA 94710 LISA

Identification of all genes involved in the phytochrome （phy）-medieted responses of plants to their light environment is an important goal in providing an overall understanding of light-regulated growth end development. This article highlights end integrates the central findings of two recent comprehensive studies in Arabidopsis that have identified the genome-wide set of phy-reguleted genes that respond rapidly to red-light signals upon first exposure of dark-grown seedlings, and have tested the functional relevance to normal seedling photomorphogenesis of an Initial subset of these genes. The data：（a） reveal considerable complexity in the channeling of the light signals through the different phy-femily members （phyA to phyE） to responsive genes; （b） identify a diversity of transcription-factor-encoding genes as major early, if not primary, targets of phy signaling, end, therefore, as potentially important regulators in the transcriptional-network hierarchy; and （c） identify auxin-related genes as the dominant class among rapidly-regulated, hormone-related genes. However, reverse-genetic functional profiling of a selected subset of these genes reveals that only a limited fraction are necessary for optimal phy-induced seedling deetioletion.

关键词： expression profiling phytochrome signaling transcriptional networks microarrays reverse genetics functional profiling transcription factors auxin-related genes

Reactivation of the insulin-like growth factor-Ⅱsignaling pathway in human hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第11期14卷 1690-1698页

作者： Kai Breuhahn peter Schirmacher Institute of Pathology University Hospital of HeidelbergHeidelberg 69120Germany

Constitutive activation of the insulin-like growth factor (IGF)-signaling axis is frequently observed in human hepatocellular carcinoma(HCC).Especially the over- expression of the fetal growth factor IGF-Ⅱ,IGF-Ⅰ receptor(IGF-IR),and cytoplasmic downstream effectors such as insulin-receptor substrates(IRS)contribute to proliferation,anti-apoptosis,and invasive behavior. This review focuses on the relevant alterations in this signaling pathway and independent in vivo models that support the central role IGF-Ⅱsignaling during HCC development and *** this pathway has become the center of interest as a target for potential anti-cancer therapy in many types of malignancies,various experimental strategies have been developed,including neutralizing antibodies and selective receptor kinase inhibitors,with respect to the specific and efficient reduction of oncogenic IGF-Ⅱ/IGF-IR-signaling.

关键词： Hepatocellular carcinoma Insulin-like growth factor-Ⅱ Insulin-like growth factor-Ⅰ receptor Insulin receptor substrate House models Therapy

The importance of different forms of prevention in travel medicine

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 74-77页

作者： peter Felkai SOS Hungary Medical Service Szentendrei ut 301 BudapestHungaryH-1039

The Asia-Pacific region is becoming an increasingly popular destination for holidaymakers and business *** the seductive tourist attractions and the growing financial importance of the region,infectious diseases have unfortunately repeatedly caused major epidemics in the *** area includes various geographical situations from high mountains to the subtropical and monsoon forests,dry deserts and *** travel medicine specialist’s task is to decrease the various risk of travel to the *** diseases,extreme temperatures and marine hazards could be almost entirely prevented by primary prevention forms of travel medicine such as vaccination,chemoprophylaxis and pretravel *** are some high-risk groups(e.g.,elderly people,backpackers,families with children,adventure travelers) among the growing number of ***,the increased numbers of such travelers result in a rising incidence of travelrelated illnesses and *** those groups,primary prevention sometimes is not enough. The pretravel medical check up,specialists’ consultations and treatment,as forms of secondary prevention,are also essential in travel *** who suffer from serious illnesses or who have accidents must often be repatriated."State-of-the-art repatriation",as a special form of tertiary prevention of travel medicine will play an important role in the future and is direcdy related to effective travel insurance,which could help in providing good medical care to the patients even far from their *** levels,methods and importance of prevention in travel medicine are discussed in this article.

关键词： Travel medicine Preventive medicine Graduate education Medical assistance Pretravel advice Travel-related illness Prexisting disease Emporiatrics

Advanced approaches to high precision MEMS metrology based on interferometric,confocal,and tactile techniques

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Optoelectronics Letters 2008年第2期4卷 143-146页

作者： peter Lehmann Mahr GmbH 37073 Goettingen Germany

Geometrical features of micro-systems can be determined by either tactile or optical profiling techniques, which show different non-linear transfer characteristics. This has to be considered especially, if the instruments operate close to their physical limitations. Depending on the specific measuring task either point-wise or areal optical measurement may be advantageous. Hence, examples for both approaches are discussed. Furthermore, systematic effects, which are related to the measuring principle have to be taken into account, e.g. if sharp edges or slopes are present on the measuring object. As it is shown, for white-light interferometry these difficulties can be solved by a two-wavelength technique.

关键词：精密度 MEMS 计量方法干涉测量触摸技术

ABP1： Finally Docking

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Molecular Plant 2015年第3期8卷 356-358页

作者： peter Grones Institute of Science and Technology (IST) Austria 3400 Klosterneuburg Austria Department of Plant Systems Biology VIB and Department of PlantBiotechnology and Bioinformatics Ghent University 9052 Gent Belgium Mendel Centre for Plant Genomics and Proteomics Masaryk University (CEITEC MU) 62500 Brno Czech Republic

Auxin, one of the plant hormones, is a key regulator of plant growth and development. At the cellular level, it controls different processes, such as cell expansion, division, and differentiation that are reflected by its regulatory role in a plethora of developmental mechanisms. An important feature of the auxin action is its differential distribution within tissues mediated by the polar auxin transport machinery, which can be dynamically regulated in response to internal and external stimuli. Receptors at the cell surface or cell interior are needed to sense and interpret fluctuations in the auxin distribution.

关键词： @@

What can we learn from negative results in clinical trials for proliferative vitreoretinopathy?

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1413-1415页

作者： peter Wiedemann Medical Faculty Leipzig UniversityLeipzig 04103Germany

INTRODUCTION Since the beginning of vitreoretinal surgery proliferative vitreoretinopathy(PVR)has been a constant *** is the major cause for surgical failure after primary rhegmatogenous retinal detachment(RRD)resulti... 详细信息

关键词： proliferative surgery clinical

Two uncommon manifestations of leptospirosis:Sweet's syndrome and central nervous system vasculitis

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Asian Pacific Journal of Tropical Medicine 2011年第1期4卷 83-84页

作者： peter George Department of Medicine Yenepoya Medical CollegeMangaloreS India

To leptospirosis is the commonest spirocheatal infection in the tropical and temperate countries of Indian sub-continent and Africa and the most common zoonosis *** protean manifestation of this infectious disease is a challenge for practising clinicians across the world. In poor developing countries,at most clinical suspicion it is essential in the diagnosis of this *** this report,we are able to document two uncommon manifestations of leptospirosis, namely Sweet’s syndrome and central nervous system vasculitis.

关键词： Leptospirosis Sweet’s syndrome Central nervous system vasculitis

Memoirs of a Survivor: Masuji Ibuse's Black Rain

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外国文学研究 2005年第2期27卷 128-132页

作者： peter Messent professor of modern American literature at the University of Nottingham in England

This paper examines the motif of survival in Masuji Ibuse’s Hiroshima novel Black Rain (1969). It explores narrative technique, figurative language, voice and t one, and the gap between thought and feeling, to show h... 详细信息

关键词：日本广岛原子弹小说叙事技巧《暴雨》 Masuji Ibuse