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A Deepfake Detection Algorithm Based on Fourier Transform of Biological Signal

Computers, Materials & Continua 2024年第6期79卷 5295-5312页

作者： Yin Ni Wu Zeng Peng xia.guang Stanley Yang Ruochen Tan School of Electrical and Electronic Engineering Wuhan Polytechnic UniversityWuhan430023China School of Mathematics and Computer Science Wuhan Polytechnic UniversityWuhan430048China Paul g.Allen School of Computer Science and Engineering University ofWashingtonSeattleWA98195USA School of Computer Science and Engineering University of CaliforniaSanDiegoCA92093USA

Deepfake-generated fake faces,commonly utilized in identity-related activities such as political propaganda,celebrity impersonations,evidence forgery,and familiar fraud,pose new societal *** current deepfake generators strive for high realism in visual effects,they do not replicate biometric signals indicative of cardiac *** this gap,many researchers have developed detection methods focusing on biometric *** methods utilize classification networks to analyze both temporal and spectral domain features of the remote photoplethysmography(rPPg)signal,resulting in high detection ***,in the spectral analysis,existing approaches often only consider the power spectral density and neglect the amplitude spectrum—both crucial for assessing cardiac *** introduce a novel method that extracts rPPg signals from multiple regions of interest through remote photoplethysmography and processes them using Fast Fourier Transform(FFT).The resultant time-frequency domain signal samples are organized into matrices to create Matrix Visualization Heatmaps(MVHM),which are then utilized to train an image classification ***,we explored various combinations of time-frequency domain representations of rPPg signals and the impact of attention *** experimental results show that our algorithm achieves a remarkable detection accuracy of 99.22%in identifying fake videos,significantly outperforming mainstream algorithms and demonstrating the effectiveness of Fourier Transform and attention mechanisms in detecting fake faces.

关键词： Deepfake detector remote photoplethysmography fast fourier transform spatial attention mechanism

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The Epstein-Barr virus-miRNA-BART6-5p regulates TgF-β/SMAD4 pathway to induce glycolysis and enhance proliferation and metastasis of gastric cancer cells

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Oncology Research 2024年第5期32卷 999-1009页

作者： XUHUI ZHAO xiaOMIN HUANg CHUNYAN DANg xia wa.g YUjiaO QI HONgLINg LI The First Clinical Medical College Gansu University of Traditional Chinese MedicineLanzhou730000China Department of Oncology Gansu People’s HospitalLanzhou730000China The Clinical Medical College Ningxia Medical UniversityNingxia750004China

Background:EBV-miR-BARTs exhibit significant relevance in epithelial tumors,particularly in EBVassociated gastric and nasopharyngeal ***,their specific mechanisms in the initiation and progression of gastric cancer remain insufficiently *** and Methods:Initially,EBV-miRNA-BART6-5p and its target gene SMAD4 expression were assessed in EBV-associated gastric cancer tissues and cell *** transfection induced overexpression of EBV-miRNA-BART6-5p in AgS and MKN-45,and downregulation in EBVpositive cells(SUN-719).The subsequent evaluation aimed to observe their impact on gastric cancer cell proliferation,migration,and glycolytic processes,with the TgF-β/SMAD4 signaling pathway value clarified using a TgF-β***:EBV-miRNA-BART6-5p exhibits pronounced upregulation in EBV-associated gastric cancer tissues and EBV-positive cells,while its target gene SMAD4 demonstrates downregulated *** of it can promote the proliferation and migration of gastric cancer ***,We found EBV-miRNA-BART6-5p promotes glycolysis of gastric cancer *** of the TgF-β/SMAD4 signaling pathway resulted in suppressed proliferation and migration of gastric cancer cells,concomitant with a diminished glycolytic ***:In this study,we found that EBV-miRNA-BART6-5p can target SMAD4,effectively increasing glycolysis in gastric cancer cells by regulating the TgF-β/SMAD4 signaling pathway,thereby enhancing the proliferation and metastasis of gastric cancer *** findings may offer new insights into the metabolic aspects of gastric cancer.

关键词： EBV TgF-β/SMAD4 glycolysis gastric cancer

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嗜热链球菌937胞外多糖生物合成途径及表型分析

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食品与发酵工业 2024年第12期50卷 101-108页

作者：夏亚灵徐欣徐心怡瓦云超顾瑞霞扬州大学食品科学与工程学院江苏扬州225000 江苏省乳品生物技术与安全控制重点实验室江苏扬州225000

嗜热链球菌在生长过程中产生的胞外多糖能够改善发酵乳制品质地,还具有多种生理生化功能。为探究组氨酸、异亮氨酸和谷氨酸对嗜热链球菌937胞外多糖的调控机制,该研究通过全基因组测序,分析了菌株胞外多糖合成途径,随后探究了3种氨基酸... 详细信息

嗜热链球菌在生长过程中产生的胞外多糖能够改善发酵乳制品质地,还具有多种生理生化功能。为探究组氨酸、异亮氨酸和谷氨酸对嗜热链球菌937胞外多糖的调控机制,该研究通过全基因组测序,分析了菌株胞外多糖合成途径,随后探究了3种氨基酸浓度提升对菌株生长、胞外多糖产量和性质以及epsABCD转录水平的影响。结果发现,该菌具有转运葡萄糖、蔗糖等特异性PTS转运系统和乳糖渗透酶;具有合成UDP-葡萄糖、UDP-半乳糖和dTDP-鼠李糖的潜力;染色体上存在由18个编码基因组成的eps基因簇。当3种氨基酸浓度提升至15 mmol/L时,菌株胞外多糖产量提升1.5倍、分子质量提升1.2倍、单糖组成摩尔比发生变化并且epsABCD转录水平均显著上调(P<0.05)。3种氨基酸通过调控epsABCD的表达,提升了胞外多糖产量并调节了化学性质,该研究结果在基因水平上为嗜热链球菌胞外多糖生物合成提供了更好的解释。

关键词：嗜热链球菌胞外多糖 eps基因簇氨基酸转录调控机制

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Ureteral double J stent displaced into vena cava and management with laparoscopy: A case report and review of the literature

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World Journal of Clinical Cases 2018年第16期6卷 1160-1163页

作者： xia-wa Mao gang Xu jia-Quan xiao Hui-Feng Wu Department of Urology the Second Affiliated Hospital of Zhejiang University School of Medicine

We reported displacement of a ureteral double J stent into the vena cava and laparoscopic management in a 69-year-old patient with a history of ureteral stent placement. Preoperative computed tomography and plain X-rays showed malpositioning of the double J stent and displacement into the inferior vena cava. The characteristics of stent misplacement precluded endovascular procedures and explorative laparoscopic surgery was performed. The intra-and postoperative periods were uneventful. Postoperative imaging demonstrated that the new double J stent was in the right position. The patient was discharged 7 d after the operation and was symptom free at the 4-mo followup.

关键词： Double J stent Displacement Inferior vena cava Laparoscopy

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Machine learning and tectonic setting determination:Bridging the gap between Earth scientists and data scientists

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geoscience Frontiers 2024年第1期15卷 339-353页

作者： Pratchaya Takaew jianhong Cecilia xia Luc S.Doucet Department of Spatial Sciences School of Earth and Planetary SciencesCurtin University6845 PerthWAAustralia Earth Dynamics Research group School of Earth and Planetary SciencesCurtin University6845 PerthWAAustralia State Key Laboratory of geological Processes and Mineral Resources China University of GeosciencesWuhanHubei 430074China

Technological progress and the rapid increase in geochemical data often create bottlenecks in many studies,because current methods are designed using limited number of data and cannot handle large *** geoscience,tectonic discrimination illustrates this issue,using geochemical analyses to define tectonic settings when most of the geological record is missing,which is the case for most of the older portion of the Earth’s *** are the primary target for tectonic discrimination because they are volcanic rocks found within all tectonic settings,and their chemical compositions can be an effective way to understand tectonics-related mantle ***,the classical geochemical discriminant methods have limitations as they are based on a limited number of 2 or 3-dimensional diagrams and need successive and subjective steps that often offers non-unique ***,weathering,erosion,and orogenic processes can modify the chemical composition of basalts and eliminate or obscure other complementary geotectonic *** address those limitations,supervised machine learning techniques(a part of artificial intelligence)are being utilized more often as a tool to analyze multidimensional datasets and statistically process data to tackle big data *** contribution starts by reviewing the current state of tectonic discrimination methods using supervised machine *** learning,especially Convolutional Neural Network(CNN)is the most accurate ***,it requires a large dataset and considerable processing time,and the gain of accuracy can be at the expense of ***,this study designed guidelines for data pre-processing,tectonic setting classification and objectively evaluating the model *** also identify research gaps and propose potential directions for the application of supervised machine learning to tectonic discrimination research,aimed at closing the divide between earth scientists and data scie

关键词： Machine learning Artificial intelligence geochemistry Igneous petrology Basalts Tectonic settings

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搜索服务响应时间异常诊断

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计算机研究与发展 2024年第6期61卷 1573-1584页

作者：夏思博马明华金鹏翔崔丽月张圣林金娃孙永谦裴丹南开大学软件学院天津300457 先进计算与关键软件(信创)海河实验室天津300450 清华大学计算机科学与技术系北京100084

较低的网络服务响应时间对提升用户体验至关重要.以搜索引擎这一典型的网络服务场景为例,服务提供商应确保网络服务(搜索)响应时间在1 s以内.在实践中,服务响应时间会受到用户浏览器、运营商、页面加载方式等诸多服务属性的影响.为了进... 详细信息

较低的网络服务响应时间对提升用户体验至关重要.以搜索引擎这一典型的网络服务场景为例,服务提供商应确保网络服务(搜索)响应时间在1 s以内.在实践中,服务响应时间会受到用户浏览器、运营商、页面加载方式等诸多服务属性的影响.为了进行针对性的优化,服务提供商需要找出使服务响应时间过长的规则,即一些属性的组合.然而现有研究工作遇到了3方面挑战:1)搜索日志数据量大;2)搜索日志数据分布不平衡;3)要求泛化度高的规则.因此设计了Miner(multi-dimensional extraction of rules),一种新型服务响应时间异常诊断框架.Miner使用自步采样机制应对第1个挑战和第2个挑战.针对第3个挑战,Miner使用Corels算法挖掘出泛化率高且召回率高的规则.使用2家国内顶级搜索引擎服务提供商的响应时间日志数据评估了Miner性能,结果显示Miner的泛化率和召回率均高于现有方法,并证明了Miner挖掘出的规则可被运维人员采纳并做针对性的优化.

关键词：网络服务质量自步采样搜索引擎搜索响应时间数据挖掘

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基于VOSviewer软件对烧伤患者功能康复研究热点的可视化分析

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中国疗养医学 2024年第3期33卷 1-6页

作者：独焕张红霞张凤娃甘肃中医药大学护理学院甘肃兰州730000 甘肃省人民医院烧伤科二病区/整形外科甘肃兰州730000

目的了解烧伤患者功能康复领域的研究热点及发展趋势,为今后研究提供参考。方法检索自建库起至2023年3月中国知网(CNKI)和Web of Science(WOS)数据库中关于烧伤功能康复的相关文献,应用VOSviewer软件对获取相关研究的发文量、发文国家... 详细信息

目的了解烧伤患者功能康复领域的研究热点及发展趋势,为今后研究提供参考。方法检索自建库起至2023年3月中国知网(CNKI)和Web of Science(WOS)数据库中关于烧伤功能康复的相关文献,应用VOSviewer软件对获取相关研究的发文量、发文国家与机构、作者、载文期刊以及关键词进行可视化分析。结果共纳入878篇文献,涉及47个国家和2583位作者。文献年发文量总体呈上升趋势。美国是发文量最多的国家;加拿大圣地儿童医院是发文量最多的机构。英文文献发文量最多的作者是Schneider,主要作者形成4个团队,团队规模较大且紧密;中文文献发表过1次相关文献的作者占绝大多数,主要作者形成4个团队,团队规模小且联系不足。《Burns》《中国临床康复》是本领域载文量较多的期刊。近年来关注度最高的关键词为生活质量、管理、早期康复训练、关节活动度、康复效果、虚拟现实。结论烧伤功能康复领域相关研究呈上升趋势,美国在该领域处于领先地位,不同国家之间、不同作者团队之间的合作交流有待加强。目前实施早期康复训练,改善肢体功能,提高患者生活质量是该领域的研究热点;关节活动度为该领域热点结局指标;多学科、多领域共同协作模式是该领域最新研究趋势。

关键词：烧伤功能康复文献计量学分析可视化分析

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基于Web of Science和CNKI糖尿病足研究文献的可视化分析

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中国疗养医学 2024年第1期33卷 6-11页

作者：张红霞张凤娃独焕甘肃中医药大学护理学院甘肃兰州730000 甘肃省人民医院烧伤科二病区整形外科甘肃兰州730000

目的运用文献计量学的方法分析中、英文数据库中糖尿病足的研究现状,探究其当前热点研究和今后研究方向。方法分别采用Web of Science(WOS)和中国知网(CNKI)数据库进行中、英文文献的检索,检索日期自建库至2023年3月20日,纳入糖尿病足... 详细信息

目的运用文献计量学的方法分析中、英文数据库中糖尿病足的研究现状,探究其当前热点研究和今后研究方向。方法分别采用Web of Science(WOS)和中国知网(CNKI)数据库进行中、英文文献的检索,检索日期自建库至2023年3月20日,纳入糖尿病足已发表的相关文献,采用Citespace 5.7.R2软件对纳入文献的国家、机构、作者及关键词等进行分析,绘制相应的可视化图谱。结果分别纳入6295篇和7255篇中、英文文献。结果显示,糖尿病足研究的首篇文献发表于1980年,为中文文献,是关于糖尿病足的治疗和预防的研究。中、英文文献的总发文量呈持续增长趋势,发文量最多的国家是美国,发文最多的国外机构是华盛顿大学;国内发文最多的机构是上海中医药大学附属曙光医院。国外核心作者发文量多于国内核心作者,国内外均尚未形成核心作者合作网络,合作均仅限于研究团队成员之间。关键词聚类方面,英文文献的结果显示目前的研究热点为伤口修复、伤口敷料的应用、抗菌治疗及糖尿病足健康教育,未发现糖尿病足的细胞或分子机制的聚类;中文文献的研究热点包括糖尿病足溃疡、创面愈合、影响因素,尚未形成糖尿病足相关指南的聚类。结论糖尿病足的中、英文研究相差不大,未来应关注糖尿病足的预防和开展相关循证研究、加强研究团队之间的合作,推动糖尿病足研究领域的发展。

关键词：糖尿病足研究热点文献计量学可视化分析

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Structural variations of a new fertility restorer gene,Rf20,underlie the restoration of wild abortive-type cytoplasmic male sterility in rice

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Molecular Plant 2024年第8期17卷 1272-1288页

作者： Shufeng Song Yixing Li Mudan Qiu Na Xu Bin Li Longhui Zhang Lei Li Weijun Chen Jinglei Li Tiankang wa.g Yingxin Qiu Mengmeng gong Dong Yu Hao Dong Siqi xia Yi Pan Dingyang Yuan Li Li State Key Laboratory of Hybrid Rice Hunan Hybrid Rice Research CenterHunan Academy of Agricultural SciencesChangsha 410125China College of Agronomy Hunan Agricultural UniversityChangsha 410128China College of Plant Protection Hunan Agricultural UniversityChangsha 410128China College of Tropical Crops Hainan UniversityHaikou 570228China Longping Branch College of BiologyHunan UniversityChangsha 410125China

The discovery of a wild abortive-type(wa)cytoplasmic male sterile(CMS)line and breeding its restorer line have led to the commercialization of three-line hybrid rice,contributing considerably to global food ***,the molecular mechanisms underlyingfertility abortion and the restoration of CMs-wa lines remain largely *** this study,we cloned a restorer gene,Rf2o,following a genome-wide association study analysis of the core parent lines of three-line hybrid *** found that Rf20 was present in all core parental lines,but different haplotypes and structural variants of its gene resulted in differences in Rf2o expression levels between sterileand restored ***20 could restorepollen fertility in the CMS-wa line and was found to be responsible for fertility restoration in some CMs lines under high *** addition,we found that Rf20 encodes a pentatricopeptide repeat protein that competes with wa352 for binding with *** interaction enhances Cox11's function as a scavenger of reactive oxygen species,which in turn restores ***,ourstudysuggestsanewactionmodeforpentatricopeptide repeatproteins inthe fertilityrestorationofCMs lines,providing an essential theoretical basisforbreedingrobustrestorer lines and for overcoming high temperature-induced fertility recovery of some CMS lines.

关键词： COX11 cytoplasmic male sterility rf20 wa352 wild abortion

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Cell responses and hemocompatibility of g-HA/PLA composites

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Science China(Life Sciences) 2011年第4期54卷 366-371页

作者： LI jia ZHENg Wei ZHENg YuFeng LOU xia Center for Biomedical Materials and Engineering Harbin Engineering University Harbin 150001 China School of Chemistry and Environmental Engineering Harbin University of Science and Technology Harbin 150040 China Department of Advanced Materials and Nanotechnology College of Engineering Peking University Beijing 100871 China Nanochemistry Research Institute Department of Chemical Engineering Curtin University of Technology Bentley WA 9102 Australia

The objective of this study was to investigate the hemocompatibility and cell responses to some novel poly（L-lactide）（PLA） composites containing surface modified hydroxyapatite particles for potential applications as a bone substitute material. The surface of hydroxyapatite （HA） particles was first grafted with L-lactic acid oligomers to form grafted HA （g-HA） particles. The g-HA particles were further blended with PLA to prepare g-HA/PLA composites. Our previous study has shown signifi- cant improvement in tensile properties of these materials due to the enhanced interracial adhesion between the polymer matrix and HA particles. To further investigate the potential applications of these composites in bone repair and other orthopedic sur- geries, a series of in vitro and in vivo experiments were conducted to examine the cell responses and hemocompatibility of the materials. In vitro experiments showed that the g-HA/PLA composites were well tolerated by the L-929 cells. Hemolysis of the composites was lower than that of pure PLA. Subcutaneous implantation demonstrated that the g-HA/PLA composites were more favorable than the control materials for soft tissue responses. The results suggested that the g-HA/PLA composites are promising and safe materials with potential applications in tissue engineering.

关键词： polylactide hydroxyapatite composites biocompatibility cytotoxicity

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