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Hormone-based pharmacotherapy for metabolic dysfunction-associated fatty liver disease

Medical Review 2024年第2期4卷 158-168页

作者： Zara Siu wa Chui Yaqian Xue Aimin Xu State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong Kong SARChina Department of Medicine The University of Hong KongHong Kong SARChina School of Biomedical Sciences The University of Hong KongHong Kong SARChina State Key Laboratory of Pharmaceutical Biotechnology The University of Hong Kong999077Hong Kong SARChina Department of Medicine The University of Hong Kong999077Hong Kong SARChina Department of Pharmacology and Pharmacy The University of Hong Kong999077Hong Kong SARChina

metabolic dysfunction-associated fatty liver disease(MAFLD)has reached epidemic proportions globally in parallel to the rising prevalence of *** its significant burden,there is no approved pharmacotherapy specifically tailored for this *** potential drug candidates for MAFLD have encountered setbacks in clinical trials,due to safety concerns or/and insufficient therapeutic ***,several investigational drugs that mimic the actions of endogenous metabolic hormones,including thyroid hormone receptorβ(THRβ)agonists,fibroblast growth factor 21(FgF21)analogues,and glucagon-like peptide-1 receptor agonists(gLP-1RAs),showed promising therapeutic efficacy and excellent safety *** them,resmetirom,a liver-targeted THRβ-selective agonist,has met the primary outcomes in alleviation of metabolic dysfunction-associated steatohepatitis(MASH),the advanced form of MAFLD,and liver fibrosis in phase-3 clinical *** hormone-based pharmacotherapies not only exhibit varied degrees of therapeutic efficacy in mitigating hepatic steatosis,inflammation and fibrosis,but also improve metabolic ***,these three hormonal agonists/analogues act in a complementary manner to exert their pharmacological effects,suggesting their combined therapies may yield synergistic therapeutic *** in-depth studies on the intricate interplay among these metabolic hormones are imperative for the development of more efficacious combination therapies,enabling precision management of MAFLD and its associated comorbidities.

关键词： metabolic hormones metabolic dysfunctionassociated steatohepatitis(MASH) liver fibrosis biopharmaceutical development clinical trials

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SELECTIVE COPPER REMOVAL FROM CUPRIFEROUS gOLD CONCENTRATE

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中国有色金属学会会刊：英文版 1995年第1期5卷 36-41页

作者： Deng Tong(Institute of Chemical metallurgy, Academia Sinica, Beijing 100080) Muir David(School of MPS , Murdoch University, wa 6150, Australia) ACAD SINICA INST CHEM METBEIJING 100080PEOPLES R CHINA MURDOCH UNIV SCH MATH & PHYS SCIMURDOCHWA 6150AUSTRALIA

ＳＥＬＥＣＴＩＶＥＣＯＰＰＥＲＲＥＭＯＶＡＬＦＲＯＭＣＵＰＲＩＦＥＲＯＵＳＧＯＬＤＣＯＮＣＥＮＴＲＡＴＥＤｅｎｇ；Ｔｏｎｇ（ＩｎｓｔｉｔｕｔｅｏｆＣｈｅｍｉｃａｌＭｅｔａｌｌｕｒｇｙ，ＡｃａｄｅｍｉａＳｉｎｉｃａ，Ｂ... 详细信息

ＳＥＬＥＣＴＩＶＥＣＯＰＰＥＲＲＥＭＯＶＡＬＦＲＯＭＣＵＰＲＩＦＥＲＯＵＳＧＯＬＤＣＯＮＣＥＮＴＲＡＴＥＤｅｎｇ；Ｔｏｎｇ（ＩｎｓｔｉｔｕｔｅｏｆＣｈｅｍｉｃａｌＭｅｔａｌｌｕｒｇｙ，ＡｃａｄｅｍｉａＳｉｎｉｃａ，Ｂｅｉｊｉｎｇ１０００８０）Ｍｕｉｒ...

关键词： copper selective leaching cupriferous gold concentate

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内蒙古草业产业化经营现状和发展思路

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中国草地学报 2008年第1期30卷 102-107页

作者：高娃内蒙古草原勘察设计院内蒙古呼和浩特010051

通过对内蒙古草业产业化经营状况及国内外产业化经营的分析,探讨了内蒙古草业产业化经营的基本思路,确立内蒙古草业产业化经营的发展方向为:在草原生态保护建设和合理利用的基础上,围绕把全区建设成为国家重要绿色草业产品基地的目标,... 详细信息

通过对内蒙古草业产业化经营状况及国内外产业化经营的分析,探讨了内蒙古草业产业化经营的基本思路,确立内蒙古草业产业化经营的发展方向为:在草原生态保护建设和合理利用的基础上,围绕把全区建设成为国家重要绿色草业产品基地的目标,适应国内外市场需要,加大基地建设力度,做大做强龙头企业。按照区域化布局、专业化生产、一体化经营、企业化管理、社会化服务的思路,以科技为支撑,提高农牧民组织化程度,创新经营组织方式,建立健全利益连结经营机制,促进草业快速发展。

关键词：草业产业化经营现状思路

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苯乙烯吡唑类化合物的合成及体外抗增殖活性

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精细化工中间体 2017年第5期47卷 25-27,60页

作者：陈南张美慧王斓徐莉英夏明钰董金华沈阳药科大学基于靶点的药物设计与研究教育部重点实验室辽宁沈阳110016 沈阳药科大学药物化学实验中心辽宁沈阳110016 沈阳药科大学生命科学与生物制药学院辽宁沈阳110016

以3,4-二甲氧基苯甲醛为原料,经羟醛缩合、环合、烷基化、亲核取代等反应合成5个未见文献报道的苯乙烯吡唑类化合物,结构均经核磁共振氢谱和质谱确证,以MTT法考察目标化合物对4种肿瘤细胞的增殖抑制作用。其中化合物5b^5e对肿瘤细胞HT2... 详细信息

以3,4-二甲氧基苯甲醛为原料,经羟醛缩合、环合、烷基化、亲核取代等反应合成5个未见文献报道的苯乙烯吡唑类化合物,结构均经核磁共振氢谱和质谱确证,以MTT法考察目标化合物对4种肿瘤细胞的增殖抑制作用。其中化合物5b^5e对肿瘤细胞HT29的增殖抑制作用强于先导化合物姜黄素。化合物5a和5d抑制A375细胞增殖的IC_(50)值与姜黄素相当。

关键词：苯乙烯吡唑类化合物抗增殖合成

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碳酸氢钠注射液的质量研究

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中国医药导报 2009年第18期6卷 52-54页

作者：王志远吉林省德惠市疾病预防控制中心吉林德惠130300

目的:验证新生产的碳酸氢钠注射液是否符合质量标准、达到上市销售要求。方法:按照碳酸氢钠注射液的质量标注,进行一系列的质量研究。结果:碳酸氢钠注射液的各项指标均达到要求。结论:新生产的碳酸氢钠注射液符合质量标准,允许上市销售。

关键词：碳酸氢钠注射液质量标准研究

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Probiotic metabolites from Bacillus coagulans ganedenBC30^(TM) support maturation of antigen-presenting cells in vitro

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World Journal of gastroenterology 2012年第16期18卷 1875-1883页

作者： Kathleen F Benson Kimberlee A Redman Steve g Carter David Keller Sean Farmer John R Endres gitte S Jensen NIS Labs 1437 EsplanadeKlamath FallsOR 97601United States ganeden Biotech 5915 Landerbrook DriveMayfield HeightsOH 44124United States AIBMR Life Sciences 4117 S MeridianPuyallupWA 98373United States

AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune ***:ganeden Bacillus coagulans 30(gBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(met) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of met was subjected to size exclusion centrifugation,generating three fractions:met and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear *** maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow ***:Treatment of PBMC with met supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell *** biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite *** were also seen for the dendritic cell maturation markers CD80 and *** CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright *** co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell *** selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory ***:The data show that a primary mechanism of action of gBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making.

关键词： Mononuclear phagocytes Dendritic cell maturation Co-stimulatory molecules Antigen-presentation Probiotics metabolites

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广西南宁地区5岁以下儿童细菌性脑膜炎的流行病学监测

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中华流行病学杂志 2004年第5期25卷 391-395页

作者：董柏青唐振柱林玫李翠云谭冬梅梁大斌廖和壮刘先知权怡方锦嵩吴兴华秦卫文 Kilgore PE Kennedy wa 徐志一 ClemensJD 广西壮族自治区疾病预防控制中心南宁530021 广西壮族自治区妇幼保健院 International Vaccine Institute Republic of Korea UCLA Center for Vaccine Research TorranceCAUSA

目的分析南宁地区5岁以下儿童细菌性脑膜炎的发病率、流行特征、病原谱、后遗症等的特点。方法采取以监测区域所有医院、卫生院及村卫生室为监测单位,以人口为基数的流行病学监测方法,以符合筛选标准的病例作为研究病例;采集脑脊液(C... 详细信息

目的分析南宁地区5岁以下儿童细菌性脑膜炎的发病率、流行特征、病原谱、后遗症等的特点。方法采取以监测区域所有医院、卫生院及村卫生室为监测单位,以人口为基数的流行病学监测方法,以符合筛选标准的病例作为研究病例;采集脑脊液(CSF)和血液标本,按照统一规程进行病原学分离和临床诊断。结果在26个月的监测期内,在5岁以下儿童中共收集到符合筛检标准的研究病例1272例,其中临床诊断病例265例,临床诊断病例年均发病率为86.36/10万,病原确诊细菌性脑膜炎病例38例,年均发病率为12.38/10万。确诊病例的病原谱以葡萄球菌为主,次为大肠埃希菌和肺炎双球菌(Sp);年龄分布以1月龄以下年龄组为最高,次为1～12月龄组,1～24月龄组是Sp和流感嗜血杆菌(Hi)所致脑膜炎的高发年龄组;并发症和后遗症发生率分别为13.16％和0.00％,病死率18.42％。实验室分别从1193份血培养标本和1211份CSF培养标本中分离出40株Hi和23株Sp等致病菌,但均未分离到脑膜炎奈瑟菌(Nm)。结论首次证实广西存在Hi所致脑膜炎,年均发病率为0.98/10万,处于较低发病水平;确诊细菌性脑膜炎年均发病率12.38/10万,是当前危及儿童健康的重要问题;确诊细菌性脑膜炎的病原谱以葡萄球菌为主。

关键词：广西南宁地区 5岁以下儿童细菌性脑膜炎流行病学疾病监测

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Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder

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World Journal of Psychiatry 2024年第1期14卷 159-178页

作者： Renee J Dufault Katherine M Adler David O Carpenter Steven g gilbert Raquel A Crider College of graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States Department of Health Sciences University of New HavenWest HavenCT 06516United States Institute for Health and the Environment School of Public HealthState University of New YorkAlbanyNY 12222United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Department of Statistics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

BACKgROUND Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations,creating conditions for the neurodevelopmental disorders known as autism and attention deficit/hyperactivity disorder(ADHD).Children with these disorders have difficulty metabolizing and excreting heavy metals from their bloodstream,and the severity of their symptoms correlates with the heavy metal levels measured in their *** may play a key role in helping parents reduce their ultra-processed food and dietary heavy metal intake by providing access to effective nutritional epigenetics *** To test the efficacy of nutritional epigenetics instruction in reducing parental ultra-processed food *** The study utilized a semi-randomized test and control group pretest-posttest pilot study design with participants recruited from parents having a learning-disabled child with autism or ***-two parents who met the inclusion criteria were randomly selected to serve in the test(n=11)or control(n=11)*** test group participated in the six-week online nutritional epigenetics tutorial,while the control group did *** efficacy of the nutritional epigenetics instruction was determined by measuring changes in parent diet and attitude using data derived from an online diet survey administered to the participants during the pre and post intervention *** intake scores were derived for both ultra-processed and whole/organic *** sample t-tests were conducted to determine any differences in mean diet scores within each *** There was a significant difference in the diet scores of the test group between the pre-and post-intervention *** parents in the test group significantly reduced their intake of ultra-processed foods with a preintervention diet score of 70(mean=5.385,SD=2.534)and a post-intervention diet score of 113(mean=8.692,SD=1.750)and the

关键词： Epigenomics Parenteral nutrition Autism Attention deficit/hyperactivity disorder Ultra-processed foods Heavy metals

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Determinants of Maternal Mortality at the Community University Hospital of Bangui: Central African Republic

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Open Journal of Obstetrics and gynecology 2023年第9期13卷 1478-1486页

作者： gertrude Rose De Lima Kogboma Wongo Thibaut Boris Clavaire Songo-Kette gbekere Rodrigue Herman Doyama-Woza Siméon Matoulou-M’bala wa-Ngogbe Alida Koirokpi Sabrina Ouapou georges Trésor gamache Norbert Richard Ngbale Abdoulaye Sepou Department of gynaecology and Obstetrics Centre Hospitalier Universitaire Communautaire Bangui Central African Republic Department of gynaecology and Obstetrics Centre Hospitalier Universitaire de l’Amitié Sino Centrafricaine Bangui Central African Republic Department of Public Health Faculty of Health Sciences University of Bangui Bangui Central African Republic

Introduction: Pregnancy is a physiological condition that can sometimes end in death. The death of a woman is a constant concern for the obstetrician and is considered a major public health problem in our developing countries. Objective: To identify the determinants that contribute to maternal morbidity and mortality in the gynaecology and Obstetrics Department of the University Community Hospital. methodology: We conducted a retrospective study from 1 January 2015 to 31 December 2019 (5 years) in the obstetrics and gynaecology department of the Centre Hospitalier Universitaire Communautaire (CHUC). It focused on the determinants of maternal mortality. Our study population consisted of all women who died during the period and met the World Health Organization (WHO) definition of maternal mortality (MOMA). We used non-probability sampling with the exhaustive choice technique. Results: The study revealed that the number of deaths recorded was 98, while 17,172 live births were registered during the same period. The maternal mortality ratio was 570 per 100,000 live births. The most common age group was 20 to 24, with an average age of 26. The frequency of death among primiparous women was 37.74%, pauciparous women 28.30% and multiparous women 26.42%. direct causes were dominated by abortion complications (22.41%), followed by infections (9.30%) and haemorrhage (8.19%). Indirect causes were dominated by anaemia with a proportion of 45.16%. The majority of maternal deaths occurred in the post-partum period (34.71%). Most maternal deaths occurred after vaginal delivery, 19 cases (63.33%), while 11 deaths (36.66%) occurred after caesarean section. The occurrence of direct causes was associated with age less than or equal to 25 years, abortion complications and primiparity, with a statistically significant difference. Conclusion: At the end of this study, complications of unsafe abortion and poverty are all factors contributing to the rise in the maternal mortality rate. Emp

关键词： Maternal Mortality Determinants Community Hospital

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复配乳化剂协同作用对搅打稀奶油稳定性及搅打品质的影响

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食品与发酵工业 2023年第23期49卷 187-193页

作者：宋志鑫王文琼袁佩佩瓦云超顾瑞霞江苏省乳品生物技术与安全控制重点实验室扬州大学食品科学与工程学院江苏扬州225127

该研究固定复配乳化剂总质量分数为0.3%,使用亲水乳化剂吐温-80和亲油乳化剂单甘油酯以不同比例复配制备搅打稀奶油,从乳液界面性质及脂肪结晶性质变化的角度研究其协同作用对产品品质的影响。结果表明,当吐温-80与单甘油酯的质量比由1... 详细信息

该研究固定复配乳化剂总质量分数为0.3%,使用亲水乳化剂吐温-80和亲油乳化剂单甘油酯以不同比例复配制备搅打稀奶油,从乳液界面性质及脂肪结晶性质变化的角度研究其协同作用对产品品质的影响。结果表明,当吐温-80与单甘油酯的质量比由1∶1逐渐升至1∶4,乳液液相蛋白质浓度及表观黏度下降,结晶脂肪耐热性增强,β′晶型明显,产品打发率上升,泡沫析水率下降;当吐温-80与单甘油酯的质量比变为1∶5和1∶6时,产品中结晶脂肪β′晶型含量下降,晶体尺寸显著减小,产品打发率下降,泡沫析水率上升。因此,吐温-80与单甘油酯质量比为1∶4,符合工业生产高品质搅打稀奶油的要求,此时产品搅打时间仅需(277.3±2.5)s,打发率达(158.9±1.23)%,搅打泡沫析水率仅(1.55±0.47)%,并且兼具良好的乳液稳定性。

关键词：复配乳化剂协同作用界面性质脂肪结晶稳定性搅打品质

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