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Rangeland grasshoppers in Relation to Soils in the Qinghai Lake Region, China

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Pedosphere 2007年第1期17卷 84-89页

作者： NI Shao-Xiang wa.g Jie-Chen JIANg Jian-jun zha.Yong College of geographical Science Nanjing Normal University Nanjing 210097 （China） Department of Urban and Resources Science Nanjing UniversityNanjing 910093 （China）

The relationship between rangeland grasshopper density and soil type as well as topsoil moisture content was analyzed with in situ soil data collected in the Qinghai Lake region of China. grasshoppers were confined mainly to the areas with light chestnut soil or chestnut soil, and very few were found in areas with subalpine meadow soil. grasshoppers were almost absent from other types of soil, such as aeolian soil. In addition, analysis of 14 soil samples collected in the study area revealed that a soil moisture content between 18 and 32 g kg-1 coincided spatially with a higher density of grasshoppers, with the grasshopper density averaging 15 head m-2. In areas with a soil moisture content above 42 g kg-1 or below 10 g kg-1, grasshopper density dropped to less than 5 head m-2. These indicated that for the study area, soils with very high or very low moisture contents were not conducive to the survival of grasshoppers.

关键词： Qinghai Lake rangeland grasshopper soil type soil moisture

Synthesis of a kind of geminal imidazolium ionic liquid with long aliphatic chains

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Chinese Chemical Letters 2007年第1期18卷 48-50页

作者： Yun Sheng Ding Min zha.jun zha.g Seng Shan wa.g Department of Polymer Materials and Engineering School of Chemical Engineering Hefei University of Technology Hefei 230009 China CAS Key Laboratory of Engineering Plastics Joint Laboratory of Polymer Science and Materials Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

A novel geminal imidazolium ionic liquid with long hydrocarbon group, 1,4-bis （3-tetradecylimidazolium- 1-yl） butane bromide was synthesized and an efficient synthesized method was introduced detailedly. Its structu... 详细信息

关键词： geminai imidazolium ionic liquid Long aliphatic chain Physicochemicai properties

Theoretical analysis and application of polymer-matrix field grading materials in HVDC cable terminals

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High Voltage 2017年第1期2卷 39-46页

作者： Peng Han jun-Wei zha.Si-Jiao wa.g Zhi-Min Dang Department of Polymer Science and Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China State Key Laboratory of Power System and Department of Electrical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China

The distortion and uneven distribution of electric field in high-voltage direct current(HVDC)terminal insulator is the key problem for stable running of the power transmission *** flexible materials filled polymer-matrix composites with non-linear conductivity have also been considered to modify the distribution of electric field in cable *** factors having influence on the non-linear conductivity will be analysed in this review.

关键词： field conductivity matrix

新型大环Bcl-2抑制剂的设计合成及生物活性评价

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中南药学 2024年第6期22卷 1528-1536页

作者：查永骏杨灿白海云钟利江西中医药大学药学院南昌330004 长三角药物高等研究院江苏南通226100 百极弘烨(南通)医药科技有限公司江苏南通226100

目的为克服Bcl-2的基因突变引起的耐药问题,设计并合成一系列新型Bcl-2抑制剂,并分别评价其对Bcl-2以及g101V、D103Y两种突变的抑制活性,探讨初步构效关系。方法通过大环化设计,合成了一系列新型Bcl-2抑制剂,并通过^(1)H NMR和ESI-MS... 详细信息

目的为克服Bcl-2的基因突变引起的耐药问题,设计并合成一系列新型Bcl-2抑制剂,并分别评价其对Bcl-2以及g101V、D103Y两种突变的抑制活性,探讨初步构效关系。方法通过大环化设计,合成了一系列新型Bcl-2抑制剂,并通过^(1)H NMR和ESI-MS进行结构确证。采用时间分辨荧光共振能量转移技术(TR-FRET)和MTS法测定化合物对激酶和肿瘤细胞的抑制活性。结果合成了1个阳性化合物和9个新型大环Bcl-2抑制剂。抑酶活性结果表明化合物28c、28d、28e、28f具有较强的抑制Bcl-2以及g101V、D103Y两种突变激酶的活性。结论合成的新型大环Bcl-2抑制剂中部分化合物(28c、28e、28g和28i)对肿瘤细胞的增殖具有一定的抑制活性。

关键词： Bcl-2抑制剂细胞凋亡抗肿瘤合成

P-糖蛋白表达阳性对癌痛病人舒芬太尼或喷他佐辛PCIA效果的影响

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中华麻醉学杂志 2024年第9期44卷 1112-1116页

作者：方志勇王凌川王军丰陈杨树东穆会君查文华南京市溧水区人民医院麻醉科南京北华大学临床医学院吉林南京医科大学附属无锡人民医院(无锡医学中心)麻醉科无锡南京市中心医院麻醉科南京南京医科大学附属无锡人民医院(无锡医学中心)病理科无锡南京医科大学附属无锡人民医院(无锡医学中心)中心实验室无锡

目的评价P-糖蛋白表达阳性对癌痛病人舒芬太尼或喷他佐辛PCIA的效果。方法本研究为回顾性队列研究。收集2020年1月至2024年1月于南京市溧水区人民医院进行治疗的癌痛病人的病历资料, 年龄54～71岁, 体质量49～67 kg, 性别不限, TNM分期... 详细信息

目的评价P-糖蛋白表达阳性对癌痛病人舒芬太尼或喷他佐辛PCIA的效果。方法本研究为回顾性队列研究。收集2020年1月至2024年1月于南京市溧水区人民医院进行治疗的癌痛病人的病历资料, 年龄54～71岁, 体质量49～67 kg, 性别不限, TNM分期Ⅱ-Ⅳ期。采用免疫组织化学法测定肿瘤组织P-糖蛋白表达情况。将肿瘤组织P-糖蛋白表达阴性的病人分为2组:舒芬太尼组(S1组)和喷他佐辛组(P1组);将肿瘤组织P-糖蛋白表达阳性的病人分为2组:舒芬太尼组(S2组)和喷他佐辛组(P2组)。当VAS>5 cm时行PCIA, S1组和S2组采用枸橼酸舒芬太尼2 μg/kg+托烷司琼10 mg;P1组和P2组采用喷他佐辛3 mg/kg+托烷司琼10 mg, 4组均以生理盐水稀释成100 ml, 负荷量5 ml, 背景输注速率2 ml/h, PCA剂量1 ml, 锁定时间10 min。镇痛期间VAS>3 cm时, 静脉注射氟比洛芬酯50 mg补救。记录PCIA 4 h内、>4～12 h、>12～24 h及>24～48 h时段舒芬太尼、喷他佐辛用量和氟比洛芬酯使用情况。记录镇痛期间呼吸抑制(SpO20.05);与P1组比较, P2组PCIA 4 h内、>4～12 h及>24～48 h时段喷他佐辛用量升高(P0.05)。结论 P-糖蛋白表达阳性可能会减弱癌痛病人喷他佐辛PCIA的效果, 而对舒芬太尼PCIA的效果可能无影响。

关键词： ATP结合盒转运体, 亚家族B,成员1 舒芬太尼喷他佐辛肿瘤疼痛镇痛, 病人控制

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高速铁路列控车载设备故障诊断的研究及应用

高速铁路技术 2024年第3期15卷 55-61页

作者：王亭岭赵君查园园郑炳校华北水利水电大学郑州450045 北京交通大学北京100044

列控系统中车载设备故障具有复杂性和不确定性,且数据记录非文本化,传统的基于专家知识的诊断方法效率低下且精确度不佳。贝叶斯网络(BN)在处理不确定性和相关复杂性问题方面具有显著优势,本文以CTCS3-300T型车载设备为研究对象,建立贝... 详细信息

列控系统中车载设备故障具有复杂性和不确定性,且数据记录非文本化,传统的基于专家知识的诊断方法效率低下且精确度不佳。贝叶斯网络(BN)在处理不确定性和相关复杂性问题方面具有显著优势,本文以CTCS3-300T型车载设备为研究对象,建立贝叶斯网络模型进行故障诊断。通过分析典型车载设备故障处理现状,提出一种结合专家知识、故障数据集和K2算法的贝叶斯网络模型研究方法;利用K2算法和最大似然估计法分别进行结构学习、参数学习,从局部到整体优化贝叶斯网络诊断模型,实现故障的快速定位;建立最优贝叶斯网络模型,并进行推理计算,其故障诊断准确率为87.1%。与传统的专家知识模型相比,最优贝叶斯网络模型的故障诊断准确率提高了37.4%。经实例分析和模型验证,该模型能够保证故障诊断结果的准确性且提高故障诊断的效率。

关键词：车载设备专家知识贝叶斯网络 K2算法

基于Heracles Neo超快速气相电子鼻快速鉴别金银花与山银花的研究

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食品安全质量检测学报 2024年第13期15卷 142-149页

作者：王俊亮查圣华廉翠翠张宏北京同仁堂健康药业股份有限公司研发中心北京100085

目的通过Heracles Neo超快速气相电子鼻技术,对金银花与山银花的气味物质进行分析研究。方法采用Heracles Neo超快速气相电子鼻对不同批次金银花与山银花的气味进行分析,获得其电子鼻气相色谱信息,通过筛选色谱峰判别能力≥0.850,峰... 详细信息

目的通过Heracles Neo超快速气相电子鼻技术,对金银花与山银花的气味物质进行分析研究。方法采用Heracles Neo超快速气相电子鼻对不同批次金银花与山银花的气味进行分析,获得其电子鼻气相色谱信息,通过筛选色谱峰判别能力≥0.850,峰面积≥1000的色谱峰,分析金银花与山银花可能的主要差异化合物,并建立金银花与山银花基于电子鼻色谱信息的主成分分析(principal component analysis,PCA)、判别因子分析(discriminant factor analysis,DFA)、软独立建模分析(soft independent modeling of class analogy,SIMCA)、浓度量化(concentration quantification,CQ)统计分析模型。结果从山银花与金银花中筛选出三甲胺、乙醇、正丁胺等14种主要气味差异化合物,其中巴豆醛、2-甲基丁醇、顺式-3-己烯-1-醇、顺式-3-己烯醇甲酸酯、苯甲醛5种主要差异化合物色谱峰判别能力大于0.900,且色谱峰面积相对较大,表明其可能为判别金银花和山银花的关键性挥发性化合物。建立的PCA、DFA、SIMCA统计分析模型识别能力分别为91%、100%、100%,说明PCA、DFA、SIMCA统计分析模型可对金银花与山银花进行快速有效鉴别;CQ分析模型线性为0.9779,对于金银花中掺假山银花线性良好,说明CQ分析模型可以对金银花中掺假山银花量进行快速鉴别。结论 Heracles Neo超快速气相电子鼻技术可实现对金银花与山银花快速鉴别,为金银花原药材粉末及其金银花制剂中掺假山银花快速鉴定提供了一种新的科学方法。

关键词：金银花山银花电子鼻气味差异快速鉴别

Differential temporal expression of matrix metalloproteinases following sciatic nerve crush

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Neural Regeneration Research 2016年第7期11卷 1165-1171页

作者： Jing Qin guang-bin zha.jun Yu Hong-hong zha.g Sheng Yi Jiangsu Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationNantong University

We previously performed transcriptome sequencing and found that genes for matrix metalloproteinases（MMPs）,such as MMP7 and 12,seem to be highly upregulated following peripheral nerve injury,and may be involved in nerve *** the present study,we systematically determined the expression levels of MMPs and their regulators at 1,4,7 and 14 days after sciatic nerve crush *** number of differentially expressed genes was elevated at 4 and 7 days after injury,but decreased at 14 days after *** the differentially expressed genes,those most up-regulated showed fold changes of more than 214,while those most down-regulated exhibited fold changes of more than *** sequencing showed that,at all time points after injury,a variety of MMP genes in the “Inhibition of MMPs” pathway were up-regulated,and their inhibitor genes were *** of key up-and down-regulated genes was verified by quantitative real-time polymerase chain reaction analysis and found to be consistent with transcriptome *** results suggest that MMP-related genes are strongly involved in the process of peripheral nerve regeneration.

关键词： sequencing crush systematically regeneration verified repair TIMP differentially enriched degrade

Recent Progress on Aeroelasticity of High-Performance Morphing UAVs

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Computer Modeling in Engineering & Sciences 2022年第10期133卷 1-29页

作者： Binbin Lv jun zha.Kaichun Zeng Hongtao guo Li Yu Peng zha.g Institute of High Speed Aerodynamics China Aerodynamics Research and Development CenterMianyang621000China

The high-performance morphing aircraft has become a research focus all over the *** morphing aircraft,unlike regular unmanned aerial vehicles(UAVs),has more complicated aerodynamic characteristics,making itmore difficultto conduct its design,model analysis,and *** paper reviews the recent process and the current status of aeroelastic issues,numerical simulations,and wind tunnel test of morphing *** evaluation of aerodynamic characteristics,mechanism,and relevant unsteady dynamic aerodynamicmodeling throughout the morphing process are the primary technological bottlenecks formorphing *** unstable aerodynamic forces have a significant impact on the aircraft handling characteristics,control law design,and flight *** the past,the structural analysis of morphing aircrafts,flight dynamics modeling,computational mesh morphing technology,and aerodynamic calculation were performed in promoting the development of next generation UAVs,with nonlinear dynamic challenges includingtransonic aeroelastic problems and high angle of attack aeroelastic *** present,many facets of these difficulties,together with the accompanying numerical simulation studies,remain *** addition,wind tunnel experiments face significant challenges in the dynamic morphing ***,dynamic unsteady aerodynamic characteristics in the continuous morphing process still need to be verified by more related experiments.

关键词： Morphing aircraft aeroelasticity numerical simulation wind tunnel test