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Milk fat globule membrane supplementation protects againstβ-lactoglobul-ininduced food allergy in mice via upregulation of regulatory T cells and enhancement of intestinal barrier in a microbiota-derived short-chain fatty acids manner

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Food Science and Human Wellness 2024年第1期13卷 124-136页

作者： Han Gong Tiange Li dong Liang Jingxin Gao Xiaohan liu Xueying Mao Key Laboratory of Functional Dairy Ministry of EducationCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Henan Engineering Technology Research Center of Food Processing and Circulation Safety Control College of Food Science and TechnologyHenan Agricultural UniversityZhengzhou 450002China Applied Nutrition I China National Center for Food Safety Risk AssessmentBeijing 100022China

Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and *** aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice *** was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body *** demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula ***,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A *** increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain *** summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of *** findings suggest that MFGM may be useful as a promising functional ingredient against CMA.

关键词： Cow’s milk allergy Milk fat globule membrane Gut microbiota Short-chain fatty acid G protein-coupled receptor Regulatory T cell

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A Comparative Study on the Post-Buckling Behavior of Reinforced Thermoplastic Pipes(RTPs)Under External Pressure Considering Progressive Failure

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China Ocean Engineering 2024年第2期38卷 233-246页

作者： DING Xin-dong waNG Shu-qing liu Wen-cheng YE Xiao-han College of Engineering Ocean University of ChinaQingdao 266100China Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China Department of Marine Technology Norwegian University of Science and Technology(NTNU)Trondheim NO-7491Norway

The collapse pressure is a key parameter when RTPs are applied in harsh deep-water *** investigate the collapse of RTPs,numerical simulations and hydrostatic pressure tests are *** the numerical simulations,the eigenvalue analysis and Riks analysis are combined,in which the Hashin failure criterion and fracture energy stiffness degradation model are used to simulate the progressive failure of composites,and the“infinite”boundary conditions are applied to eliminate the boundary *** for the hydrostatic pressure tests,RTP specimens were placed in a hydrostatic chamber after filled with *** has been observed that the cross-section of the middle part collapses when it reaches the maximum *** collapse pressure obtained from the numerical simulations agrees well with that in the ***,the applicability of NASA SP-8007 formula on the collapse pressure prediction was also *** has a relatively greater difference because of the ignorance of the progressive failure of *** the parametric study,it is found that RTPs have much higher first-ply-failure pressure when the winding angles are between 50°and 70°.Besides,the effect of debonding and initial ovality,and the contribution of the liner and coating are also discussed.

关键词： reinforced thermoplastic pipes post-buckling behavior progressive failure of composites debonding initial ovality

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Picotesla fiberized diamond-based AC magnetometer

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Photonics Research 2024年第6期12卷 1250-1261页

作者： SHAO-CHUN ZHANG YONG liu LONG-KUN SHAN XUE-dong GAO JIA-QI GENG CUI YU YANG dong XIANG-dong CHEN GUANG-CAN GUO FANG-WEN SUN CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China National Key Laboratory of ASIC Hebei Semiconductor Research InstituteShijiazhuang 050051China Electric Power Quantum Sensing Joint Laboratory of Anhui Province State Grid Anhui Electric Power Research InstituteHefei 230601China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

Portable quantum sensors are crucial for developing practical quantum sensing and metrology *** nitrogen-vacancy(NV)centers in diamonds have emerged as one of the most promising candidates for compact quantum ***,due to the difficulty of coherently controlling the ensemble spin and noise suppression in a large volume,it often faces problems such as reduced sensitivity and narrowed bandwidth in integrated lensless ***,we propose a fluorescence signal treatment method for NV spin ensemble manipulation by the exponential fitting of spin polarization processes,instead of integrating the photon *** enables spin state readout with a high signal-to-noise ratio and applies to the pulse sensing protocols for large-volume NV *** on this,we further developed a fiberized diamond-based AC *** an XY8-N dynamical decoupling pulse sequence,we demonstrated a T_(2)-limited sensitivity of 8pT/√Hz and T_(1)-limited frequency resolution of 90 Hz over a wide frequency band from 100 kHz to 3 *** integrated diamond sensor leverages quantum coherence to achieve enhanced sensitivity in detecting AC magnetic fields,making it suitable for implementation in a compact and portable endoscopic sensor.

关键词： magnetometer quantum ensemble

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Copper-coated Porous Polyimide as Ultralight and Safe Current Collectors for Advanced LIBs

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Chinese Journal of Polymer Science 2024年第4期42卷 521-531页

作者： Cun-Sheng liu Jun-Qi Hu Ting-Ting Mao Song-Yi Liao Ru-Ming Feng Yi-dong liu Yong-Gang Min School of Materials and Energy Guangdong University of TechnologyGuangzhou510006China College of Chemistry and Chemical Engineering Zhongkai University of Agriculture and EngineeringGuangzhou510225China Shanwei Branch of Advanced Energy Science and Technology Guangdong Laboratory Shanwei516600China

Metallic copper is widely used as current collector(CC) for graphite anode of lithium-ion batteries(LIBs) due to its high electrical conductivity and electrochemical stability. However, the large volume density of commercial copper foil(~8.9 g·cm^(-3)) limits the increase of energy density of battery. Here, copper-coated porous polyimide(Cu@PPI) was prepared by vacuum evaporation as collector for the graphite anode. The sandwich structure connects the copper metal on both sides of the collector with excellent electrical conductivity. Compared to commercial Cu foil, Cu@PPI has lighter mass(≤3.9 mg for disc of 12 mm diameter versus 9.9 mg of ~10 μm Cu foil) and lower volume density(≤3.3 g·cm^(-3)). In addition, the porous structure allows of better adhesion of reactive substances and electrochemical properties than pure Cu foils. It is estimated that the energy density of Cu@PPI should be much higher than that of Cu foil. This strategy should be applicable for other current collectors.

关键词： Copper-coated Vacuum evaporation Porous polyimide(PPI) Current collector(CC) LIBs

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Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

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Rare Metals 2024年第3期43卷 1207-1221页

作者： Shun Xing dong-Hui wang Hai-Feng Zhang Li-Dan liu Cheng-Ce Li Chao Wei Jun-Yu liu Nai-Jian Ge Xuan-Yong liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Intervention Center Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai200438China School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjin300130China

Malignant obstruction makes gallbladder cancer have a high mortality ***-titanium alloy(nitinol)stents are commonly used as a local intervention to maximize patient survival time,but the stents lack antitumor and antibacterial capacity and are vulnerable to secondary ***-based drugs show good therapeutic promise against gallbladder *** meet clinical *** layered double hydroxides(LDHs)film is constructed on the nitinol,whose arsenite loading amounts rose by 60%after simple heat treatment compared with the conventional anion-exchange *** addition,calcination promotes the dissolution of nickel ions from the LDHs lattice,resulting in a powerful synergistic killing effect on tumor cells together with the released *** importantly,the calcined arsenic-loaded LDHs are sensitive to the acidic microenvironment of tumor tissues,which presents a much lower arsenic and nickel release amount in the normal tissues,guaranteeing its ***,the vertically sharp LDHs nanosheets can synergize with arsenic to achieve effective physical cleavage and chemical killing of adherent and planktonic *** short,we attempt to use arsenic drugs for local interventions and reasonably avoid their toxic side effects,which provides a new design idea for nitinol stents applied in the treatment of gallbladder cancer.

关键词： Nitinol Layered double hydroxides Arsenic Gallbladder cancer

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An improved analysis method for assessing the nuclear-heating impact on the stability of toroidal field magnets in fusion reactors

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Nuclear Science and Techniques 2024年第6期35卷 163-176页

作者： Yu-dong Lu Jin-Xing Zheng Xu-Feng liu Huan Wu Jian Ge Kun Xu Ming Li Hai-Yang liu Lei Zhu Fei liu Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China

The superconducting magnet system of a fusion reactor plays a vital role in plasma confinement,a process that can be dis-rupted by various operational factors.A critical parameter for evaluating the temperature margin of superconducting magnets during normal operation is the nuclear heating caused by D-T *** study investigates the impact of nuclear heat-ing on a superconducting magnet system by employing an improved analysis method that combines neutronics and thermal *** the magnet system,toroidal field(TF)magnets are positioned closest to the plasma and bear the highest nuclear-heat load,making them prime candidates for evaluating the influence of nuclear heating on *** enhance the modeling accuracy and facilitate design modifications,a parametric TF model that incorporates heterogeneity is established to expedite the optimization design process and enhance the accuracy of the computations.A comparative analysis with a homogeneous TF model reveals that the heterogeneous model improves accuracy by over 12%.Considering factors such as heat load,magnetic-field strength,and cooling conditions,the cooling circuit facing the most severe conditions is selected to calculate the temperature of the *** selection streamlines the workload associated with thermal-hydraulic *** approach enables a more efficient and precise evaluation of the temperature margin of TF ***,it offers insights that can guide the optimization of both the structure and cooling strategy of superconducting magnet systems.

关键词： Superconducting magnet Nuclear heating Neutronics Thermal hydraulics

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Recent advances in vacancy engineering for reliable lithiumsulfur batteries

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Rare Metals 2024年第2期43卷 455-477页

作者： Wen-dong liu Xiao Tang Jun-An Feng Chao-Yue Zhang Hao liu Chuan Shi Xiao-Xian Zhao Jian-Jun Song College of Physics School of Chemistry and Chemical EngineeringQingdao UniversityQingdao266071China Faculty of Science Centre for Clean Energy TechnologySchool of Mathematical and Physical SciencesUniversity of Technology SydneySydneyNSW2007Australia Department of Chemistry College of ScienceHebei Agricultural UniversityBaoding071001China

The high-energy-density and low-cost features endow lithium-sulfur batteries with broad application ***,many drawbacks,especially the detrimental shuttle effect,have hindered the further development of *** response,a lot of new structures have been applied to suppress the shuttle effect and promote the development of ***,vacancy engineering has gained the attention of researchers due to its unique electronic *** review aims to analyze the application of vacancy engineering in ***,the electrochemistry of LSBs has been systematically discussed and the existing challenges as well as improvement tactics of LSBs have also been ***,the preparation methods and characterization technologies of various vacancies are summarized,including oxygen vacancies,sulfur vacancies,selenium vacancies,other anion vacancies,cation vacancies,*** latest applications of vacancy engineering in LSBs are also summarized in this ***,some prospects and insights for further investigation and practical application of vacancy engineering in LSBs are put forward.

关键词： Lithium-sulfur batteries(LSBs) Defects Vacancy engineering Electronic structure Shuttle effect

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Thermal Property Enhancement of a Novel Shape-Stabilized Sodium Acetate Trihydrate-Acetamide/Expanded Graphite-Based Composite Phase Change Material

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Journal of Thermal Science 2024年第4期33卷 1564-1576页

作者： AN Zhoujian HOU Wenjie DU Xiaoze HUANG Zhongzheng MOMBEKI PEA Hamir Johan ZHANG dong liu Xiaomin College of Energy and Power Engineering Lanzhou University of TechnologyLanzhou730050China Key Laboratory of Multi-supply System with Solar Energy and Biomass of Gansu Province Lanzhou730050China Gansu Natural Energy Research Institute Lanzhou730046China

Phase change materials(PCMs)are a kind of highly efficient thermal storage materials which have a bright application prospect in many fields such as energy conservation in buildings,waste heat recovery,battery thermal management and so *** inorganic hydrated salt PCMs have received increasing attention from researchers due to their advantages of being inexpensive and ***,inorganic hydrated salt PCMs are still limited by the aspects of inappropriate phase change temperature,liquid phase leakage,large supercooling and severe phase separation in the application *** this work,sodium acetate trihydrate was selected as the basic inorganic PCM,and a novel shape-stabilized composite phase change material(CPCM)with good thermal properties was prepared by adding various functional *** first,the sodium acetate trihydrate-acetamide binary mixture was prepared and the melting point was adjusted using *** the binary mixture was incorporated into expanded graphite to synthesize a novel shape-stabilized *** thermophysical properties of the resultant shape-stabilized CPCM were systematically *** microscopic morphology and chemical structure of the obtained shape-stabilized CPCM were characterized and *** experiment results pointed out that acetamide could effectively lower the melting point of sodium acetate *** obtained shape-stabilized CPCM modified with additional 18%(mass fraction)acetamide and 12%(mass fraction)expanded graphite exhibited good shape stability and thermophysical characteristics:a low supercooling degree of 1.75℃and an appropriate melting temperature of 40.77℃were obtained;the latent heat of 151.64 kJ/kg and thermal conductivity of 1.411 W/(m·K)were also ***,after 50accelerated melting-freezing cycles,the obtained shape-stabilized CPCM represented good thermal reliability.

关键词： sodium acetate trihydrate melting point modification agent expanded graphite shape stability thermal conductivity enhancement

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The Infiuence of Velocity-dependent Correction Factor on Proton Decay Reactions in Massive White Dwarfs

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Research in Astronomy and Astrophysics 2024年第3期24卷 169-179页

作者： Jing-Jing liu dong-Mei liu College of Science Hainan Tropical Ocean UniversitySanya 572022China

Twenty-five typical massive white dwarfs(WDs)are selected and the proton decay reaction catalyzed by magnetic monopoles(MMs)for these WDs is discussed.A velocity-dependent correction factor strongly affects the *** find that a strong suppression controls the monopole catalysis of nucleon decay by the correction *** maximum number of MMs is captured and the luminosity can be 2.235×10^(21)and 1.7859×10^(32)erg s^(-1)(e.g.,for the O+Ne core mass WD J055631.17+130639.78).The luminosities of most massive WDs agree well with the observations at relatively low temperatures(e.g.,T_(6)=0.1),but can be three and two orders of magnitude higher than those of the observations for model(Ⅰ)and(Ⅱ)at relatively high temperatures(e.g.,T_(6)=10),*** luminosities of model(Ⅰ)are about one order of magnitude higher than those of model(Ⅱ).Since we consider the effect of the number of MMs captured on the mass–radius relation and the suppression of the proton decay by the correction factor,the study by model(Ⅱ)may be an improved estimation.

关键词： astroparticle physics-nuclear reactions-nucleosynthesis-abundances-(stars) white dwarfs

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Mechanical characteristics and reservoir stimulation mechanisms of the Gulong shale oil reservoirs, the northern Songliao Basin

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Petroleum Science 2024年第3期21卷 2023-2036页

作者： Si-Wei Meng Jia-Ping Tao Tian-Jiao Li dong-Xu Li Su-Ling wang liu Yang Xin liu Li-Hao Liang He liu PetroChina Research Institute of Petroleum Exploration Development Beijing100083China National Key Laboratory of Continental Shale Oil Daqing 163002HeilongjiangChina Dalian University of Technology Dalian116024LiaoningChina PetroChina Daqing Oilfield Co.Ltd. Daqing163002HeilongjiangChina Northeast Petroleum University Daqing163002HeilongjiangChina China University of Mining and Technology(Beijing) Beijing100083China

Shale oil of the Qingshankou Formation of the Gulong Sag,the northern Songliao Basin,represents the first attempt at large-scale development of pure-shale-type shale oil in *** integrating the multiscale refined reservoir characterization with macro-micro-scale mechanical testing,it is clarified that the Gulong shale is characterized by high clay mineral content,high rock plasticity,highly-developed bedding,and prominent mechanical anisotropy.A three-dimensional(3D)fracture propagation model of hydraulic fracturing was built for the Gulong shale,which fully captures the hydraulic fracture distribution pattern affected by the high bedding density,in-situ stress,and fracturing treatment *** research showed that due to influences of bedding,hydraulic fracturing in the Gulong shale forms a complex fracture morphology featuring the main fracture with multiple perpendicular branches that have different lengths(like the outdoor directional TV antenna);however,the vertical propagation of fractures is inhibited,and the fracture height is commonly less than 10 *** limited stimulated reservoir volume(SRV)is the main problem facing the fracturing stimulation of the Gulong shale *** density has vital effects on fracture morphology,so case-specific fracturing designs shall be developed for shale intervals with different bedding development *** reservoirs with welldeveloped bedding,it is suggested to properly increase the perforation cluster spacing and raise the volume and proportions of viscous fluids of the pad,so as to effectively promote vertical fracture propagation and improve reservoir stimulation *** study integrates multi-scale fine reservoir characterization and macro-micro-scale mechanical testing,as well as the construction and numerical simulation of hydraulic fracturing models for high-density layered shale reservoirs,providing a new approach and methodological framework for the fracturing research of high-density layer

关键词： Shale oil Hydraulic fracturing High bedding density Fracture propagation model

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