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微射出成型导光板的微结构分析

纳米技术与精密工程 2006年第2期4卷 111-114页

作者：沈永康吴伟裕洪荣宏龙华科技大学机械工程系

探讨了楔型导光板在微射出成型时的波峰落后现象,並以湿蚀刻制程将导光板扩散点制作于模板上,于微射出成型后将扩散点与导光板一体成型制作出来,用单一参数法探讨了制造工艺参数与导光板平面度及复制性的关系．结果表明,波峰落后现象是... 详细信息

探讨了楔型导光板在微射出成型时的波峰落后现象,並以湿蚀刻制程将导光板扩散点制作于模板上,于微射出成型后将扩散点与导光板一体成型制作出来,用单一参数法探讨了制造工艺参数与导光板平面度及复制性的关系．结果表明,波峰落后现象是由于射出速度太慢、剪切热影响小使温度分布低、黏度升高、流动阻力大以及流动速度慢所造成的．影响平面度的最重要的制造工艺参数为模具温度,低模具温度时有较佳的平面度．模温为影响复制性的最重要的因素．

关键词：导光板微结构平面度复制性粗糙度微射出成型

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5-羟色胺受体及其在疼痛调控中的研究进展

第二军医大学学报 2016年第12期37卷 1517-1523页

作者：孔二亮吴飞翔俞卫锋第二军医大学东方肝胆外科医院麻醉科上海200438

5-羟色胺(5-hydroxytryptamine,5-HT)受体广泛分布于中枢和外周神经系统,参与机体多种生理功能的调控。5-HT及其类似物通过与不同亚型、不同部位的5-HT受体结合,对疼痛信号产生抑制或易化作用。在中枢神经系统,下行的5-HT能神经元能够... 详细信息

5-羟色胺(5-hydroxytryptamine,5-HT)受体广泛分布于中枢和外周神经系统,参与机体多种生理功能的调控。5-HT及其类似物通过与不同亚型、不同部位的5-HT受体结合,对疼痛信号产生抑制或易化作用。在中枢神经系统,下行的5-HT能神经元能够激活抑制性中间神经元而发挥镇痛作用,且镇痛作用的强弱与5-HT能神经元的受体类型和分布密度有关。在外周,5-HT受体能够参与疼痛信号的传导,与痛觉过敏密切相关。本文主要综述了中枢和外周不同亚型5-HT受体在不同部位对疼痛信号的调控作用,为急慢性疼痛治疗与康复的基础理论研究和作用靶点选择提供参考。

关键词： 5-羟色胺 5-羟色胺受体疼痛脊髓

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策勒河流域地貌形态及其对生态格局的影响

干旱区研究 2011年第2期28卷 355-362页

作者：吴玉伟杨发相花婷中国科学院新疆生态与地理研究所新疆乌鲁木齐830011 中国科学院研究生院北京100049 中国科学院寒区旱区环境与工程研究所甘肃兰州730000

策勒河发源于昆仑山中段北坡,自南向北流入塔里木盆地,流域为干旱区典型的山地-绿洲-荒漠格局。利用GIS软件对策勒河流域的数字高程模型数据进行处理,并结合其他资料进行综合分析。结果表明:1 500～3 500 m的中海拔地区地貌形态类型多样... 详细信息

策勒河发源于昆仑山中段北坡,自南向北流入塔里木盆地,流域为干旱区典型的山地-绿洲-荒漠格局。利用GIS软件对策勒河流域的数字高程模型数据进行处理,并结合其他资料进行综合分析。结果表明:1 500～3 500 m的中海拔地区地貌形态类型多样,面积占总流域面积的58.05%;地形坡度≤15°的平缓、微缓、缓坡地区占70.31%;流域内东北和东两个坡向的面积占优势,分别占流域总面积的15.40%和14.19%;流域切割深度最小值为0 m,最大值281 m,大于20 m的区域占流域面积的28.68%;流域内切割密度最小值为0,最大为7.81 km/km2,大于1 km/km2的区域占流域面积的42.74%。该流域生态格局的特点表现在山地从高到低植被的分带变化上,利用ArcGIS平台对植被类型图进行归类处理,并与高程数据叠加分析得到策勒河流域生态格局的垂直带谱。研究结果丰富了地貌及生态地貌学研究的内容,为流域环境保护、生态恢复与水土保持提供参考。

关键词：地貌形态数字高程模型生态格局策勒河流域新疆

二氧化硅对成纤维细胞和肺上皮细胞的DNA损伤作用

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中国职业医学 2002年第3期29卷 29-31页

作者：余晨曾昭玉吴巍巍浙江大学医学院劳动卫生与环境卫生研究所尘肺研究室浙江杭州310031

目的　研究小剂量二氧化硅 (SiO2 )粉尘对中国仓鼠肺成纤维细胞 (CHL)和貂肺上皮细胞 (CCL 6 4)的DNA损伤作用。方法　采用彗星试验 ,按SiO2 粉尘不同的作用浓度 (终浓度 0、7 5、15、30、6 0、12 0mg/L)和时间分组 ( 1h、2h)来观察DNA... 详细信息

目的　研究小剂量二氧化硅 (SiO2 )粉尘对中国仓鼠肺成纤维细胞 (CHL)和貂肺上皮细胞 (CCL 6 4)的DNA损伤作用。方法　采用彗星试验 ,按SiO2 粉尘不同的作用浓度 (终浓度 0、7 5、15、30、6 0、12 0mg/L)和时间分组 ( 1h、2h)来观察DNA损伤。以彗星尾长 (彗头末端到彗尾末端的长度 )作为DNA损伤程度的评价指标。结果　与对照组相比 ,SiO2明显增加了CHL及CCL 6 4细胞的DNA迁移距离 (P <0 0 1) ,在 7 5～ 12 0mg/L的剂量范围内 ,彗星尾长随作用剂量的增加而增加 ;一般 2h组比 1h组引起更严重的DNA损伤。结论　小剂量SiO2 粉尘确有遗传毒性 ,体外试验可致CHL细胞和CCL 6 4细胞DNA链断裂。由彗星试验的系列浓度SiO2

关键词：二氧化硅成纤维细胞肺上皮细胞 DNA损伤

Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes: accessing β-chiral sulfones bearing S-stereocentric cyclic sulfinamides

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Science China Chemistry 2025年第01期 257-263页

作者： Jiapian Huang Chenxin Wang Xu Wang Xiaoyu Zhou wei Xiao Jie wu School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies Taizhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereospecificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH2SO2Ph group plays a crucial role in the stereoselectivity control.

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Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology research 2025年第1期33卷 67-81页

作者： Xiang Li Wenke Jin Lifeng wu Huan Wang Xin Xie wei Huang B O Liu State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical Technology Chengdu University of Traditional Chinese Medicine Chengdu 611137 China. Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China.

Background:Triple-negative breast cancer (TNBC), characterized by its lack of traditional hormone receptors and HER2, presents a significant challenge in oncology due to its poor response to conventional therapies. Autophagy is an important process for maintaining cellular homeostasis, and there are currently autophagy biomarkers that play an effective role in the clinical treatment of tumors. In contrast to targeting protein activity, intervention with protein-protein interaction (PPI) can avoid unrelated crosstalk and regulate the autophagy process with minimal interference pathways.Methods:Here, we employed Naive Bayes, Decision Tree, and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC, aiming to uncover novel therapeutic targets. Meanwhile, the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay, and the interaction relationship was verified by molecular docking and CO-IP experiments after intersection. Colony formation, cellular immunofluorescence, cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tests were used to predict the clinical therapeutic effects of manipulating candidate PPI.Results:By developing three PPI classification models and analyzing over 13,000 datasets, we identified 3733 previously unknown autophagy-related PPIs. Our network analysis revealed the central role of Beclin 2 in autophagy regulation, uncovering its interactions with 39 newly identified proteins. Notably, the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1, which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay results. Subsequently, investigations showed that overexpressing Beclin 2 increased Ubiquilin 1, promoted autophagy-dependent cell death, and inhibited proliferation and metastasis in MDA-MB-231 cells.

关键词： Artificial intelligence (AI) Autophagy Beclin 2 Protein-protein interactions (PPI) Triple-negative breast cancer (TNBC) Ubiquilin 1

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： wei-Min Qin Zhongliang Li Wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan wu Zhiqin Ruan yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex promotes intestinal development as a new iron supplement

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Science China Life Sciences 2025年第1期 219-231页

作者： Yingying Feng yuying wu Jialu Wang Zhenglin Dong Qian yu Shuangshuang Xia Chunxue Liu Haihua Wang Xin wu Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of Sciences ANYOU Biotechnology Group Co.Ltd Qingdao Seawin Biotech Group Co. LTD

Iron is a crucial micronutrient, and its deficiency can have detrimental effects on the health of infants. Dietary polysaccharide-iron(Ⅲ) complexes(PICs) are promising for addressing iron deficiency due to their minimal adverse reactions and high iron absorption rate. This study aimed to investigate the effects of dietary Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex(EP-Fe) on newborns, using 3-day weaned piglets as the iron-deficiency model. Results showed that EP-Fe improved iron levels and promoted intestinal development in piglets. Transcriptome sequencing revealed that EP-Fe increased the survival of intestinal epithelial cells under hypoxia by upregulating the expression of genes that promote the development of the vascular system. Additionally, EP-Fe enhanced the mucosal barrier functions by inhibiting myosin light chain kinase(MLCK)/phosphorylated myosin light chain(p-MLC) signaling pathway to increase the expression of intestinal tight junction proteins. Furthermore, the 16S r RNA gene sequencing of gut microbiota showed that EP-Fe promoted the enrichment of Bacteroides＿fragilis and other gut microbes that can metabolize carbohydrates. In conclusion, EP-Fe is an effective iron supplement for newborns, and it can be developed as a comprehensive nutritional supplement.

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