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Prediction of cell-cell communication patierns of dorsal root ganglion cells:single-cell RNA sequencing data analysis

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Neural Regeneration Research 2024年第6期19卷 1367-1374页

作者： Yanna lian Cheng wu li liu xiangyao li National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology Ministry of Education Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina International Institutes of Medicine the Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwuZhejiang ProvinceChina Zhejiang University-University of Edinburgh Institute Zhejiang University School of MedicineZhejiang UniversityHainingZhejiang ProvinceChina Biomedical Sciences College of Medicine and Veterinary MedicineThe University of EdinburghEdinburghUK Core Facilities of the School of Medicine Zhejiang UniversityHangzhouZhejiang ProvinceChina

Dorsal root ganglion neurons transmit peripheral somatic information to the central nervous system,and dorsal root ganglion neuron excitability affects pain *** root ganglion stimulation is a new approach for managing pain *** of the cell-cell communication among dorsal root ganglion cells may help in the development of new pain and itch management ***,we used the single-cell RNA-sequencing(scRNA-seq)database to investigate intercellular communication networks among dorsal root ganglion *** collected scRNA-seq data from six samples from three studies,yielding data on a total of 17,766 *** on genetic profiles,we identified satellite glial cells,Schwann cells,neurons,vascular endothelial cells,immune cells,fibroblasts,and vascular smooth muscle *** analysis revealed that eight types of dorsal root ganglion neurons mediated proprioceptive,itch,touch,mechanical,heat,and cold ***,we predicted several distinct forms of intercellular communication among dorsal root ganglion cells,including cell-cell contact,secreted signals,extracellular matrix,and neurotransmitter-mediated *** data mining predicted that Mrgpra3-positive neurons robustly express the genes encoding the adenosine Adora2b(A2B)receptor and glial cell line-derived neurotrophic factor family receptor alpha 1(GFRα-1).Our immunohistochemistry results confirmed the coexpression of the A2B receptor and GFRα-*** injection of the A2B receptor antagonist PSB-603 effectively prevented histamine-induced scratching behaviour in a dose-dependent *** results demonstrate the involvement of the A2B receptor in the modulation of itch ***,our findings provide insight into dorsal root ganglion cell-cell communication patterns and *** results should contribute to the development of new strategies for the regulation of dorsal root ganglion excitability.

关键词： cell-cell communications CellChat dorsal root ganglion scRNA-Seq database

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Future Changes in Various Cold Surges over China in CMIP6 Projections

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Advances in Atmospheric Sciences 2024年第9期41卷 1751-1768页

作者： li MA Zhigang WEI Xianru li Shuting wu Key Laboratory of Environmental Change and Natural Disasters of Chinese Ministry of Education Beijing Normal UniversityBeijing 100875China State Key Laboratory of Earth Surface Processes and Resource Ecology(ESPRE) Beijing Normal UniversityBeijing 100875China Academy of Disaster Reduction and Emergency Management Ministry of Emergency Management and Ministry of EducationBeijing 100875China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China

Cold surges(CSs)often occur in the mid-latitude regions of the Northern Hemisphere and have enormous effects on socioeconomic *** report that the occurrences of CSs and persistent CSs(PCSs)have rebounded since the 1990s,but the trends related to the frequencies of strong CSs(SCSs)and extreme CSs(ECSs)changed from increasing to decreasing after *** highest-ranked model ensemble approach was used to project the occurrences of various CSs under the SSP1-2.6,SSP2-4.5,and SSP5-8.5 *** frequencies of the total CSs show overall decreasing ***,under the SSP1-2.6 scenario,slight increasing trends are noted for SCSs and ECSs in *** circulations that are characterized by an anomalous anticyclonic circulation with a significantly positive 500-hPa geopotential height(Z500)anomaly at high latitudes along with significant negative anomalies in China were favorable for cold air intrusions into *** addition,the frequencies of all CS types under the SPP5-8.5 scenario greatly decreased in the long term(2071-2100),a finding which is thought to be related to negative SST anomalies in the central and western North Pacific,differences in sea level pressure(SLP)between high-and mid-latitude regions,and a weaker East Asian *** terms of ECSs,the decreasing trends observed during the historical period were maintained until 2024 under the SSP1-2.6 *** to the SSP1-2.6 scenario,the Z500 pattern showed a trend of strengthened ridges over the Ural region and northern East Asia and weakened troughs over Siberia(60°-90°E)under the SSP2-4.5 and SSP5-8.5 scenarios,contributing to the shift to increasing trends of ECSs after 2014.

关键词： cold surge “highest-ranked”model ensemble anticyclonic circulation geopotential height China

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Dynamic response of water-rich tunnel subjected to plane P wave considering excavation induced damage zone

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Underground Space 2024年第2期15卷 113-130页

作者： Gongliang xiang Ming Tao Rui Zhao Huatao Zhao Muhammad Burhan Memon Chengqing wu School of Resources and Safety Engineering Central South UniversityChangsha 410083China School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China School of Civil and Environmental Engineering University of Technology SydneyNSW 2007Australia

The stability analysis of a deep buried tunnel subjected to dynamic disturbance is an important *** this study,the transient response has been obtained by establishing a water-rich tunnel model considering excavation damage zone(EDZ).Based on Biot’s two-phase dynamic theory and wave function expansion method,the analytical solution of dynamic response around the water-rich tunnel containing EDZ subjected to P wave is ***,Fourier transform and Duhamel’s integral technique is introduced to calculate the transient response,and the equivalent blasting curve is adopted to input excitation *** dimensionless parameters thickness N and shear modulus ratio lare defined to characterize the degree of damage in the surrounding rock,investigating the influencing factors,such as the parameters and the incident source *** results indicate that the dynamic stress concentration factor(DSCF)gradually decreases as the dimensionless parameters ***,it is observed that the DSCF is more sensitive to changes in the thickness parameter ***,the influence of the waveform parameters has been taken into account in the analysis of transient response,and the stress state and transfer process in each time stage of the EDZ are *** study establishes a theoretical foundation for comprehending the mechanical behavior and support design considerations associated with a deep-buried water-rich tunnel containing EDZ.

关键词： Water-rich tunnel Two-phase dynamic theory Wave scattering Transient response Dynamic stress concentration

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Numerical Study on Local Flow and Heat Transfer Characteristics of Supercritical CO_(2) in PCHE with Sinusoidal Channels

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Journal of Thermal Science 2024年第1期33卷 41-55页

作者： WENZhexi LV Yigao li Qing wu Jinglin School of Energy Science and Engineering Central South UniversityChangsha 410083China

Local heat transfer and flow characteristics,which is crucial to the overall performance of supercritical CO_(2) recuperators,is rarely examined in details in reported *** this paper,the local heat transfer and flow characteristics of supercritical CO_(2) in sinusoidal channel printed circuit heat exchangers are numerically investigated under the working conditions of *** on the simplified physical model constituted by10 pitches,the variations of Re,heat flux,Nu,secondary flow and other relevant parameters along the flow direction are analyzed *** is further made between the high and low temperature recuperators(HTR and LTR).It's observed that the local heat transfer and flow characteristics vary greatly from the inlet to the outlet,especially in the *** of 127.5% and 61.7% can be observed on the cold side of the LTR for Re and heat transfer coefficient h, *** indicate that the temperature difference and heat transfer coefficient h should not be regarded as constant and the distribution of h should be carefully considered in the design of the *** complicated interactions among the varying thermophysical properties,buoyancy and the periodically changed centrifugal force are believed to be the key that shapes the flow ***,the changes of the wavy angle θ are found to have greater influence than the changes of mass flow rate in reshaping the flow field when θ>25°.Though gravity direction strongly affects the local heat transfer and flow characteristics,it's also found that the effects on the overall thermal-hydraulic performance are relatively *** the installation direction that yields a_y=g should better be avoided for the sinusoidal channel printed circuit heat exchanger.

关键词： printed circuit heat exchanger supercritical CO_(2) sinusoidal channel heat transfer recuperator

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A Bus Planning Algorithm for FPC Design in Complex Scenarios

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Chinese Journal of Electronics 2024年第2期33卷 346-352页

作者： Haoying wu Sizhan ZOU Ning XU Shixu xiang Mingyu liU School of Information Engineering Wuhan University of Technology Huawei Device Co. Ltd.

Flexible printed circuit(FPC) design in complex scenarios has a list of pin concentration areas, which lead to extremely congested intersection regions while connecting the pins. Currently, it is challenging to explore the routability and to find topologically non-crossing and routable paths manually for the nets timely. The existing bus planning methods cannot offer optimal solutions concerning the special resource distribution of the FPC design. To investigate an effective way to shorten the routing time of FPC and achieve enhanced performance, a bus planning algorithm is proposed to tackle complex area connection problems. On the basis of the pin location information, the routing space is partitioned and generally represented as an undirected graph, and the topological non-crossing relationship between different regions is obtained using the dynamic pin sequence. Considering the routability and electrical constraints, a heuristic algorithm is proposed to search the optimal location of the crossing point on the region boundary. Experimental results on industrial cases show that the proposed algorithm realize better performance in terms of count and routability in comparison with numerous selected state-of-the-art router and methods.

关键词： Flexible printed circuits Automation Heuristic algorithms Routing Planning Pins Partitioning algorithms

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英国农业旅游发展的基本特征与经验启示

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社会科学家 2005年第6期20卷 115-117页

作者：吴相利江南大学商学院江苏无锡214122

文章从英国农业旅游兴起发展的市场、社会经济、文化基础、旅游景点经营者动机等背景条件入手分析了英国农业旅游业兴起与发展的天时、地利、人和的条件,总结归纳了其农业旅游业发展中的一些基本特征,并指出其发展中的一些对我们有益的... 详细信息

文章从英国农业旅游兴起发展的市场、社会经济、文化基础、旅游景点经营者动机等背景条件入手分析了英国农业旅游业兴起与发展的天时、地利、人和的条件,总结归纳了其农业旅游业发展中的一些基本特征,并指出其发展中的一些对我们有益的启示。

关键词：英国农业旅游景点发展特征经验

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Solid-state NMR studies of proteins in condensed phases

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Magnetic Resonance Letters 2024年第3期4卷 1-10页

作者： Jiani xiang Xialian wu Angelo L.Chu Junxia Lu Key Laboratory of Industrial Fermentation(Ministry of Education) School of Life and Health SciencesHubei University of TechnologyWuhan430068China Interdisciplinary Institute of NMR and Molecular Sciences School of Chemistry and Chemical EngineeringThe State Key Laboratory of Refractories and MetallurgyWuhan University of Science and TechnologyWuhan430081China Thomas Jefferson High School for Science and Technology 6560 Braddock RdAlexandriaVA22312USA

Some proteins perform their biological functions by changing their material states through liquid-liquid phase *** phase separation,the protein condenses into a concentrated liquid phase and sometimes into a gel phase,changing its dynamic properties and intermolecular interactions,thereby regulating cellular *** the biological significance of this phenomenon has been widely recognized by researchers,there is still a lack of a comprehensive understanding of the structural and dynamic properties of the protein in the condensed *** this phase,molecules usually contain domains with varied dynamic properties and undergo intermediate *** angle spinning(MAS)solid-state NMR(SSNMR)experiments are very powerful in studying rigid protein polymers such as *** incorporation of solution-like experiments into SSNMR and the development of J-coupling based MAS SSNMR techniques extend its ability to study partially mobile segments of proteins in a condensed liquid or gel phase which are not visible by solution NMR or dipolar-coupling based ***,it has been applied in studying protein condensation and has provided very important information that is hard to obtain by other techniques.

关键词： Magic angle spinning(MAS)solid-state NMR(SSNMR) Protein condenses J-coupling based MAS SSNMR liquid-liquid phase separation

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Investigation on cavitating turbulent flow for the twisted NACA66 hydrofoil using a PANS model with helicity modification

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Journal of Hydrodynamics 2024年第2期36卷 219-231页

作者： Chen Geng Zhao-hui Qian Ke-xin Zheng Wei-xiang Ye Xian-wu Luo State Key Laboratory of Hydroscience cand Engineering Deparment of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China

In the present paper,the unsteady cavitating turbulent flow over the twisted NACA66 hydrofoil is investigated based on an modified shear stress transfer k-ωpartially averaged Navier-Stokes(MSST PANS)model,i.e.,new MSST PANS(NMSST PANS)model,where the production term of kinetic energy in the turbulence model is modified with *** with the experimental data,cavitation evolution and its characteristic frequency are satisfactorily predicted by the proposed NMSST PANS *** is revealed that the interaction among the main flow,the reentrant jets,and sheet cavitation causes the formation of the primary shedding cavity near the mid-span and the secondary shedding cavity at each side of the twisted hydrofoil,and further induces the remarkable pressure gradient around shedding *** with the development of the primary and the secondary shedding cavities,the great pressure gradient associated with large cavity volume variation promotes the vortical flow generation and the spatial deformation of vortex structure during cavitation evolution,and results in the primary and the secondary U-type ***,dynamic mode decomposition(DMD)analysis is utilized to confirm the interaction among the main flow,the main reentrant jet and two side reentrant jets,and *** results indicate that the proposed NMSST PANS model is suitable to simulate the complicated cavitating turbulent flow for various engineering applications.

关键词： Cavitating turbulent flow partially averaged Navier-Stokes(PANS)model hydrofoil numerical simulation

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Efficacy and safety of Qingfei Huatan formula in the treatment of acute exacerbation of chronic obstructive pulmonary disease:A multi-centre,randomised,double-blind,placebo-controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 561-569页

作者： Hui-zhi Zhu Cheng-yi li liang-ji liu Jia-bing Tong Zhi-hui Lan Shu-guang Tian Qiao li xiang-li Tong Ji-feng wu Zhen-gang Zhu Su-yun li Jian-sheng li Department of Respiratory Medicine the First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230031Anhui ProvinceChina Graduate School Anhui University of Traditional Chinese MedicineHefei 230012Anhui ProvinceChina Department of Respiratory Medicine Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330006Jiangxi ProvinceChina Department of Respiratory Diseases the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina Department of Pulmonary Diseases Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Traditional Chinese MedicineFuyang 236600Anhui ProvinceChina Department of Respiratory and Critical Care Medicine Jiangxi Province Hospital of Integrated Chinese and Western MedicineNanchang 330002Jiangxi ProvinceChina Department of Respiratory Medicine the First Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province Zhengzhou 450046Henan ProvinceChina

Background Chronic obstructive pulmonary disease(COPD),a common respiratory disease,can be effectively treated by traditional Chinese medicine(TCM).Qingfei Huatan,a TCM formula,has been reported to effectively alleviate the clinical symptoms of COPD ***,there is a lack of multi-centre,randomised,double-blind,controlled clinical trials documenting the clinical efficacy and safety of this formula in the treatment of acute exacerbation of COPD(AECOPD).Objective This study evaluated the efficacy and safety of Qingfei Huatan formula in the treatment of AECOPD,thereby providing high-quality clinical ***,setting,participants and interventions A total of 276 patients with AECOPD were included in this multi-centre,randomised,double-blind,placebo-controlled trial and were randomised into treatment and control groups at a ratio of 1:*** in the treatment and control groups took Qingfei Huatan granules or simulated Qingfei Huatan granules twice a day,for 14 days,in addition to Western medicine *** patients were followed up for 3 *** outcome measures The primary outcome was time taken to symptom *** secondary outcomes included duration of antibiotic use,clinical symptom and sign score,TCM syndrome score,dyspnoea score,and quality of life(QOL)***,the safety of the formula was assessed through routine urine and stool tests,electrocardiograms,liver and kidney function tests,and the observation of adverse events throughout the *** The time taken for effective stabilisation(Plisation(Plinical symptom and sign score decreased in both groups,particularly in the treatment group(P<0.01).On days 9,12 and 14 of treatment,the TCM syndrome scores of both groups were reduced(P<0.01),with more significant reductions in the treatm

关键词： Acute exacerbation of chronic obstructive pulmonary disease Clinical trial Syndrome of phlegm-heat congesting lung Qingfei Huatan formula Traditional Chinese medicine

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World’s first implementation of close-fit pipe jacking of twin tunnels for construction of subway station--Innovation in equipment and construction technology

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Frontiers of Engineering Management 2024年第2期11卷 369-376页

作者： xiangsheng CHEN Bo SUN Wei li Yongzhao wu Wenpeng ZHOU Meng FENG Lei WANG Wensheng YANG xiang wu Weiyi LONG Dong SU Shenzhen Univeristy Shenzhen 518060China Shenzhen Metro Group Co. Ltd.Shenzhen 518031China Shenzhen Municipal Design&Research Co. Ltd.Shenzhen 518000China Sinohydro Bureau 11 Co. Ltd.Zhengzhou 450001China China Railway Engineering Equipment Group Co. LTD.Zhengzhou 450000China Shenzhen University Shenzhen 518060China

1 Project overview The Shasan station of Phase II of Shenzhen’s urban rail transit line 12 is situated in Bao’an District,*** comprises a two-level underground island platform station,measuring 212 m in length,and 22.6 m in width,with an overburden thickness of about 7.0 ***.1 illustrates the presence of a large underground reinforced concrete stormwater culvert,measuring 11.5 m by 3.6 m,traversing the station’s center.

关键词： Subway station close-fit pipe jacking of twin tunnels modular rectangular pipe jacking machine Structural Transformation equipment construction

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