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Long term outcomes of saphaneous vein graft intervention in elderly patients with prior coronary artery bypass graft

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Journal of Geriatric Cardiology 2014年第1期11卷 26-31页

作者： Ji-Hong WANG Wei LIU Xin DU Chang-Sheng MA Xue-si wu Department of Cardiology Beijing An-Zhen Hospital Capital Medical University Beijing 100029 China Department of Cardiology Beijing Ji-Shui-Tan Hospital the 4th Clinical College of Peking University Health Science Center Beo'ing 100035 China

Objectives To investigate the procedure characteristics and long term follow-up ofpercutaneous coronary intervention （PCI） for sa phaneous vein graft （SVG） lesions in the elderly patients. Methods From December 2005 to December 201 l, 84 graft lesions were treated percumneously. Seventeen were located at proximal anastomosis, 48 were located at SVG body, 19 were located at distal anastomosis. Pri mary endpoint was defined as major adverse cardiovascular events （MACE, composite of cardiac death, target vessel revascularization, acute myocardial infarction）. Results The graft age was 6.7 i 4.0 years. Most anastomosis lesions （80.0%） presented within one year post coro-nary artery bypass grafting （CABG）. Proximal anastomosis lesion had the lowest successful rate for PCI compared with graft body and distal anastomosis lesions （70.6% vs. 91.7%, 79.0%, P 〈 0.05）. The distal embolic protection device was used in 19.1% of patients, most frequently used in body graft PCI （29.2%, P 〈 0.01）. The diameter of the stent was smallest in distal anastomosis group （2.9 ±0.4 mm, P 〈 0.05）. The highest post dilatation pressure was required in the proximal anastomosis （17.8 ± 2.7 atm, P 〈 0.05）. The patients were followed up for 24.3 ±16.9 months. MACE occurred in 18.57% of patients. Incidence of MACE was highest among proximal anastomosis PCI （47.1% vs. body graft PCI 16.7%, distal anastomosis PCI 21.1%; P 〈 0.05）. Old myocardial infarction was the predictive factor for the poor clinical outcomes （P〈 0.04）. Conclusions PCI of SVG lesions is feasible with lower success rate. PCI of ostial graft anastomosis lesions had the lowest procedure success rate and highest MACE rate compared with graft body and distal anastomosis lesions. Old myocardial infarction was a predictive factor of poor outcomes.

关键词： Graft Anastomosis Percutaneous coronary intervention Coronary artery bypass grafting

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CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma

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Cancer Biology & Medicine 2020年第2期17卷 357-370页

作者： Ting Li si wu Lei Jia Wenfeng Cao Yuan Yao Gang Zhao Hui Li Department of Gastrointestinal Cancer Biology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Key Laboratory of Cancer Immunology and Biotherapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Pathology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China

Objective:The E3 ligase,CRL4,plays diverse roles in different cellular processes,such as DNA damage,transcriptional regulation,cell cycle progression,and cell *** previous study showed that CUL4A and CUL4B had a strong association with tobacco smoking risk in lung squamous cell carcinoma(SCC)and small cell lung carcinoma(SCLC).This study aimed to define the potential mechanism underlying the roles of CUL4A and CUL4B in the development of SCC and ***:We determined the role of CUL4A and CUL4B in the cell cycle and apoptosis of SCC and SCLC,and identified the key apoptosis-related gene involved in the oncogenic activity of CUL4B by Western blot,immunohistochemical staining,flow cytometry,and enzyme inhibition ***:We found that depletion of CUL4A and CUL4B reduced the proliferation of SCC and SCLC ***4Aknockdown but not CUL4Bknockdown arrested cells in Gl phase while upregulating P21 and cU L4Bknockdown promoted cell apoptosis through upregulation o f ***,CUL4B decreased FO X03A expression by activating the ERK signaling pathway and mediating FOXO3A degradation via the ubiquitin-proteasome ***:These results identified the function of E3 ligase CRL4 in regulating SCC and SCLC cell proliferation,which provides a potential strategy for cancer therapy by targeting FOXO3A and the E3 ligase,CRL4.

关键词： Squamous cell lung cancer small cell lung cancer CUL4A CUL4B P21 FOXO3A

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Automatic Video Segmentation Based on Information Centroid and Optimized SaliencyCut

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Journal of Computer Science & Technology 2020年第3期35卷 564-575页

作者： Hui-si wu Meng-Shu Liu Lu-Lu Yin Ping Li Zhen-Kun Wen Hon-Cheng Wong College of Computer Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Computing The Hong Kong Polytechnic UniversityHong Kong 999077China Faculty of Information Technology Macao University of Science and TechnologyMacao 999078China

We propose an automatic video segmentation method based on an optimized SaliencyCut equipped with information centroid(IC)detection according to level balance principle in physical *** the existing methods,the image information of another dimension is provided by the IC to enhance the video segmentation ***,our IC is implemented based on the information-level balance principle in the image,and denoted as the information pivot by aggregating all the image information to a *** effectively enhance the saliency value of the target object and suppress the background area,we also combine the color and the coordinate information of the image in calculating the local IC and the global IC in the *** saliency maps for all frames in the video are calculated based on the detected *** applying IC smoothing to enhance the optimized saliency detection,we can further correct the unsatisfied saliency maps,where sharp variations of colors or motions may exist in complex ***,we obtain the segmentation results based on IC-based saliency maps and optimized *** method is evaluated on the DAVIS dataset,consisting of different kinds of challenging *** with the state-of-the-art methods are also conducted to evaluate our *** visual results and statistical comparisons demonstrate its advantages and robustness for automatic video segmentation.

关键词： automatic video segmentation information centroid saliency detection optimized SaliencyCut

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基于全基因组重测序技术筛查通道侗族原发性高血压易感基因

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中华高血压杂志（中英文） 2024年第2期32卷 153-163页

作者：周太梅杨华江兴林杨通平杭远欣吴斯王海英湖南医药学院公共卫生与检验医学院湖南怀化418000 首都医科大学附属北京天坛医院药剂科

目的采用Illumina二代测序技术结合DNA pooling策略和生物信息学分析,在全基因组水平上初步筛查通道侗族人群原发性高血压的易感基因。方法以100例通道侗族原发性高血压患者及100名健康对照人群为研究对象,提取其外周血DNA并分别制备... 详细信息

目的采用Illumina二代测序技术结合DNA pooling策略和生物信息学分析,在全基因组水平上初步筛查通道侗族人群原发性高血压的易感基因。方法以100例通道侗族原发性高血压患者及100名健康对照人群为研究对象,提取其外周血DNA并分别制备两组的DNA pooling,构建文库并采用二代测序技术进行测序。使用比对软件BWA将测序数据与参考基因组进行比对,得到的BAM比对结果文件采用GATK软件对单核苷酸多态性(SNP)和插入缺失(InDel)进行检测,采用CNVnator检测拷贝数变异(CNV),Breakdancer检测结构变异(SV),使用ANNOVAR和内部软件AnnoDB对变异结果进行注释及影响预测。针对原发性高血压组和对照组编码区共有SNP进行Fisher精确检验,筛选出P<0.05的SNP位点,采用在线平台DAVID和KOBAS对筛选出来的差异表达基因进行基因本体(GO)功能注释和京都基因和基因组百科全书(KEGG)通路富集分析,采用STRING数据库的蛋白质相互作用分析平台和Cytoscape软件进行关键基因筛选及相互作用网络图的构建。结果对照组与EH组分别检测到4 311 896和4 554 994个SNP位点,InDel位点总数分别为772 269和870 230个,CNV总数分别为8 027和7 052个,SV总数分别为5 534和8 072个。对照组与高血压组编码区共有的SNP为21 861个。在Cytoscape软件的cytoNCA模块下基于介数中心性(BC)算法进行网络拓扑结构分析以筛选关键基因时,发现两组编码区的差异基因丝氨酸/苏氨酸蛋白激酶1(AKT1)、表皮生长因子受体(EGFR)、血管紧张素转换酶(ACE)、整合素β_(1)亚单位(ITGB1)、基质金属蛋白酶9(MMP9)、低密度脂蛋白受体(LDLR)等BC值更高,在整个网络图中与其他基因之间的通路联系更密集,流经的信息量更多。结论通过DNA pooling与二代测序技术相结合,筛查出一批可能与通道侗族人群EH发生、发展相关的易感基因。通道侗族原发性高血压的发病机制可能主要涉及AKT1、EGFR、ACE介导的信号传导通路。

关键词：原发性高血压全基因组重测序 DNA pooling 通道侗族

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面向类脑计算的低电压忆阻器研究进展

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物理学报 2024年第20期73卷 131-155页

作者：贡以纯明建宇吴思齐仪明东解令海黄维凌海峰南京邮电大学材料科学与工程学院有机电子与信息显示国家重点实验室南京210023

忆阻器是非易失性存储器和神经形态计算的优秀候选者.电压调制作为其关键性能策略,是获得纳瓦超低功耗、飞焦超低能耗工作的基础,有助于打破功耗墙、突破后摩尔时代算力瓶颈.然而基于高密度集成忆阻器阵列的类脑计算架构还需重点考虑开... 详细信息

忆阻器是非易失性存储器和神经形态计算的优秀候选者.电压调制作为其关键性能策略,是获得纳瓦超低功耗、飞焦超低能耗工作的基础,有助于打破功耗墙、突破后摩尔时代算力瓶颈.然而基于高密度集成忆阻器阵列的类脑计算架构还需重点考虑开/关比、高速响应、保留时间和耐久性等器件稳定性参数.因此如何在低电场下实现离子/电子的高效、稳定驱动,构筑电压低于1 V的低电压、高性能忆阻器成为了当前实现类脑计算能效系统的关键问题.本文综述了近年来面向类脑计算的低电压忆阻器的研究进展.首先,探讨了低电压忆阻器的机制,包括电化学金属化机制和价态变化机制.在此基础上,系统总结了各材料体系在低电压忆阻器中的优势,涵盖了过渡金属氧化物、二维材料和有机材料等.进一步围绕材料工程、掺杂工程、界面工程提出了相应的低电压忆阻器实现策略,最后,展望了基于低电压忆阻器的类脑功能模拟及神经形态计算应用,并对现存问题和未来研究方向进行了讨论.

关键词：忆阻器低电压类脑计算

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高分立体卫星影像建设基础三维模型研究

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测绘与空间地理信息 2024年第2期47卷 91-94页

作者：李代云彭珍珠陈勇应国伟吴思自然资源部第六地形测量队四川成都610500

实景三维中国建设总体实施方案提出,截至2025年要建成覆盖地级以上城市城镇开发边界范围的基础三维模型数据。为提高实景三维中国基础三维模型数据生产效率,本文基于高分立体卫星影像精准定向精化的RPC参数构建立体模型并生成精准几何... 详细信息

实景三维中国建设总体实施方案提出,截至2025年要建成覆盖地级以上城市城镇开发边界范围的基础三维模型数据。为提高实景三维中国基础三维模型数据生产效率,本文基于高分立体卫星影像精准定向精化的RPC参数构建立体模型并生成精准几何信息的DSM、DEM、DOM成果,对全立测采集、基于DOM采集等不同技术方法获取的建筑轮廓以及立测、基于DEM/DSM获取的高程高度信息等精度差异进行了分析,并以哈尔滨市为试验区,验证了基于高分立体卫星影像大规模生产基础三维模型数据的技术路线及可行性。

关键词：实景三维中国基础三维模型数据高分立体卫星影像

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课程思政与新工科导向的“测控仪器设计”教学改革

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教育教学论坛 2024年第23期 57-60页

作者：孙广开牛海莎吴思进北京信息科技大学仪器科学与光电工程学院北京100192

在新一代信息技术和人工智能推动全球新一轮科技革命的浪潮下,仪器科学与技术作为支撑智能信息新技术应用发展的重要支柱,成为世界强国布局的科技制高点。在这一大背景下,为培养新时代创新型仪器人才,服务国家高精尖产业发展,将课程思... 详细信息

在新一代信息技术和人工智能推动全球新一轮科技革命的浪潮下,仪器科学与技术作为支撑智能信息新技术应用发展的重要支柱,成为世界强国布局的科技制高点。在这一大背景下,为培养新时代创新型仪器人才,服务国家高精尖产业发展,将课程思政与新工科理念融入测控技术与仪器课程教学活动中。通过重新设计课程教学目标、重构教学内容、创新教学方法,实现了思政元素、仪器前沿技术与专业知识的有机结合,取得了良好的教学效果。研究成果对激发学生自由探索、主动思考、敢于创新的思维活力,唤醒学生仪器报国的使命意识和责任感具有积极作用,可为其他工学类专业课程改革提供借鉴和参考。

关键词：新科技革命课程思政新工科仪器设计教学改革

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Analgesic effects and structural elucidation of two new flavone C-glycosides from Artemisa sacrorum

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Chinese Journal of Natural Medicines 2015年第10期13卷 786-790页

作者： WANG Qing-Hu HAN Na-Ren-Chao-Ke-Tu DAI Na-Yin-Tai wu Rong-Jun wu Jie-si College of Traditional Mongolian Medicine Inner Mongolia University for Nationalities

The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The Et OAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities of the isolated compounds were assessed in rats with hot plate test and paw pressure assay. Two new flavone C-glycosides, named as Sacroroside A and B(Compounds 1 and 2) were isolated from the Et OAc crude extract of the aerial parts of Artemisa sacrorum Ledeb. They showed significant analgesic effects. In conclusion, Compounds 1 and 2 are new natural products, which show significant analgesic effects in a dose-dependent manner.

关键词： Artemisa sacrorum Ledeb Sacroroside A Sacroroside B Analgesic effect

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A polyamidoamine(PAMAM)derivative dendrimer with high loading capacity of TLR7/8 agonist for improved cancer immunotherapy

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Nano Research 2022年第1期15卷 510-518页

作者： Jia-si wu Jia-Xian Li Na Shu Qi-Jia Duan Qi-Song Tong Jing-Yang Zhang Yong-Cong Huang si-Yu Yang Zhi-Bin Zhao Jin-Zhi Du Institutes for Life Sciences School of MedicineSouth China University of TechnologyGuangzhou 510006China School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou 511442China National Engineering Research Center for Tissue Restoration and Reconstruction Key Laboratory of Biomedical Engineering oj Guangdong ProvinceSouth China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education Innovation Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhou 510006China

Tumor associated macrophages(TAMs)tend to exhibit tumor-promoting M2 phenotype and contribute to the development of immunosuppressive microenvironment of solid *** TAMs from M2 into tumoricidal M1 phenotype is robust for stimulating tumor immunosuppressive microenvironment(TIME).In this study,we developed a poly(amidoamine)(PAMAM)derivative dendrimer(denoted as fourth generation-N,N-diethylaminoethyl(G4-DEEA))for efficient loading of Toll-like receptor 7 and 8(TLR7/8)agonist(R848)to remodel the TIME for potent cancer immunotherapy,G4-DEEA exhibited a high loading capacity of R848 up to 35.9 wt%by taking advantage of its dendritic *** resulting formulation(designated as G4-DEEA@R848)effectively polarized M2 macrophages into M1 phenotype in vitro,and improved the maturation and activation of antigen-presenting *** the 4T1 orthotopic breast cancer model,G4-DEEA@R848 showed a stronger tumor inhibitory effect than free *** mechanistic studies suggested that G4-DEEA@R848 could significantly stimulate the TIME by repolarizing TAMs into M1 phenotype,reducing the presence of immunosuppressive myeloid cells and increasing the infiltration of tumor cytotoxic T *** study provides a simple but effective dendrimer-based strategy to improve the formulation of R848 for improved cancer immunotherapy.

关键词： poly(amidoamine)(PAMAM)dendrimer drug delivery tumor-associated macrophage macrophage repolarization cancer immunotherapy

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Identification of pollution sources in river based on particle swarm optimization

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Journal of Hydrodynamics 2021年第6期33卷 1303-1315页

作者： Guang-han Zhang Xiao-dong Liu si wu Zu-lin Hua Li Zhao Hong-qin Xue Peng Wang Key Laboratory ofIntegrated Regulation and Resource Development on Shallow Lake ofMinistry of Education College of EnvironmentHohai UniversityNanjing 210098China School of Civil Engineering Nanjing Forestry UniversityNanjing 210037China Yangtze Institute for Conservation and Development Hohai UniversityNanjing 210098China Jiangsu Environmental Industry CO. LTDNanjing 210037China

The pollution sources identification model is presented by the coupling of the river water quality model and particle swarm optimization(PSO)algorithm to estimate pollution sources from the measured/simulated contaminant concentration in the ***“twin experiment”is adopted to verify the feasibility of the identification model,and three cases are constructed to explore the results of the identification model in different *** experiment test demonstrated that the identification model is effective and efficient,while the model can accurately figure out the quantities of the pollutants and position of a single pollution source or multiple sources,with the relative error of the mean is less than 3%.Many factors are explored,including the level of random disturbance and the impact of particle population *** outcome showed that the disturbance level is less than 5%,thus the precision is preferable,and when the number of particles is three,the identification is the *** performing multiple sources,identification of multiple sets of monitoring sections respectively can obtain more accurate results with less *** this paper,the optimization method of the inverse problem is applied to the identification of river pollution sources,which can help us to identify pollution sources and provide us a scientific basis for subsequent water pollution control and prevention.

关键词： Identification model particle swarm optimization(PSO)optimization source identification surface water

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