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Does high altitude increase risks of the elderly patients with coronary artery disease？

Journal of Geriatric Cardiology 2009年第3期6卷 137-141页

作者： Tian-Yi wu zhong-yan Zhan Qin-Li wu Suo-Lung Baomu yu-Ling Jie Min Sun State Key Laboratory of High Altitude Medicine High Altitude Medical Research Institute Qinghai 810012 China Emergency Center of Qinghai-Tibet Railway Golmud 816000 China Qinghai- Tibet Railroad Company Xining 810016 China

Objective To assess the effect of altitude hypoxia on the elderly patients with coronary artery disease （CAD）. Methods Three subject groups were surveyed during their train trip on the highest railroad the Qinghai-Tibet Railway： 22 elderly individuals with documented CAD, 20 healthy elderly controls, and 20 healthy young controls, all of whom from Beijing near the sea level （76 m）, Survey questions addressed clinical features of their healthy conditions and aspects of their coronary disease. The baseline study was performed at Xining at an altitude of 2261m, and then during acute exposure to altitudes of 2808 m, 4768m, 5072 m and 4257 m by train for 24 hours. Resting pulse rate, blood pressure, oxygen saturation, electrocardiograph （ECG）, and cardiac work estimated by the heart rateblood pressure double product were obtained five times in each subject at different altitudes. Results On arrival to altitudes between 4768 m and 5072 m, the older passengers, especially those with preexisting coronary disease, had higher HR, higher BP, and lower SaO2, as well as more frequent abnormalities on ECG, as compared to the younger healthy subjects. As compared with the healthy elderly controls, incomplete right bundle branch block, left ventricular hypertrophy, and ST segment depression were more frequently seen in the elderly coronary patients （P〈0.01）. Cardiac work in group 1 was increased by 13% 12 hours after arrival to altitudes between 2808 m and 5072 m. Oxygen saturation decreased significantly with the altitude increasing by train ascent but improved after inhalation of oxygen. Most of the older subjects tolerated their sojourn at high altitude well except one who developed angina repeatedly with a significant ST segment depression. Conclusions Coronary events and ECG signs of myocardial ischemia are rare in elderly individuals with CAD who travel from sea level to moderate altitudes of 1500m to 2800 m. Patients with CAD who are well compensated at sea level generally t

关键词： coronary artery disease elderly high altitude hypoxia angina

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Expression and purification of bioactive high-purity human midkine in Escherichia coli

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第2期10卷 79-86页

作者： zhong-hui ZHANG Li-juan DU Di XIANG Shun-ying ZHU Ming-yuan wu Hui-li LU yan yu Wei HAN Laboratory of Regenoromics School of Pharmacy College of Life Science and Biotechnology Shanghai Municipality Key Laboratory of Veterinary Biotechnology School of Agriculture and Biology Shanghai Jiao Tong University Shanghai 200240 China

Midkine is a heparin-binding growth factor, which plays important roles in the regulation of cell growth and differentiation. The non-tagged recombinant human midkine （rhMK） is therefore required to facilitate its functional studies of this important growth factor. In the present work, rhMK was expressed in Escherichia coli （E. coli） BL21 （DE3）. The expression of midkine was efficiently induced by isopropyl-13-D-thiogalactopyranoside （IPTG）. After sonication, midkine was recovered in an insoluble form, and was dissolved in guanidine hydrochloride buffer. renaturation of the denatured protein was carried out in the defined protein refolding buffer, and the refolded protein was purified using S-Sepharose ion-exchange chromatography. The final preparation of the rhMK was greater than 98% pure as measured by sodium dodecylsulfate-polyacrylamid gel electrophoresis （SDS-PAGE） and reverse phase high performance liquid chromatography （RP-HPLC）. The purified rhMK enhanced the proliferation of NIH3T3 cells.

关键词： Exnression. Purification. Human midkine. Escherichia coli

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Trivalent Ni oxidation controlled through regulating lithium content to minimize perovskite interfacial recombination

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Rare Metals 2022年第1期41卷 96-105页

作者： Jin-Jin Zhao Xiao Su Zhou Mi Ying Zhang yan-Jun Hu Hua-Jun Guo Yi-Nan Jiao yu-Xia Zhang yan Shi Wei-zhong Hao Jing-Wei wu Yi Wang Cun-Fa Gao Guo-zhong Cao School of Materials Science and Engineering School of Mechanical EngineeringShijiazhuang Tiedao UniversityShijiazhuang 050043China School of Materials Science and Engineering Hebei Key Laboratory of Material Near Net Forming TechnologyHebei University of Science and TechnologyShijiazhuang 050018China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Materials Science and Engineering University of WashingtonSeattleWA 98195-2120USA

Organic–inorganic hybrid perovskite solar cells,one of the most promising photovoltaic devices,have made great progress in their efficiency and preparation *** this study,uniform,highly conductive Li_(n)NiO_(x)(0≤n≤1;0ping,controlled interfacial oxidation was induced by Ni^(3+).The Li_(0.32)NiO_(x)inhibited charge recombination,reduced the defect density,and enhanced the photocurrent density.A maximum power conversion efficiency of 20.44%was obtained by Li_(0.32)NiO_(x).Further,in the long-term,in-air stabilities of unencapsulated Li_(n)-NiO_(x) perovskite solar cells were demonstrated.

关键词： Lithium ions Ni^(3+) Oxidized defect Photocurrent Perovskite solar cells

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Room-temperature ferromagnetism and piezoelectricity in metalfree 2D semiconductor crystalline carbon nitride

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Nano Research 2024年第6期17卷 5670-5679页

作者： Yong Wang Dingyi yang Wei Xu Yongjie Xu yu Zhang Zixuan Cheng Yizhang wu Xuetao Gan Wei zhong yan Liu Genquan Han yue Hao Wide Bandgap Semiconductor Technology Disciplines State Key Laboratory School of MicroelectronicsAcademy of Advanced Interdisciplinary ResearchXidian UniversityXi’an 710071China Emerging Device and Chip Laboratory Hangzhou Institute of TechnologyXidian UniversityHangzhou 311200China INRS Centre for Energy Materials and Telecommunications1650 Boul.Lionel BouletVarennesQC J3X 1P7Canada National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures and Jiangsu Provincial Key Laboratory for NanotechnologyNanjing UniversityNanjing 210093China School of Education Jiangsu Open UniversityNanjing 210036China Department of Physics Shaanxi University of Science and TechnologyXi’an 710021China Department of Applied Physical Sciences The University of North Carolina at Chapel HillChapel HillNC 27514USA Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi'an 710129 China

Two-dimensional(2D)materials that combine ferromagnetic,semiconductor,and piezoelectric properties hold significant potential for both fundamental research and spin electronic ***,the majority of reported 2D ferromagnetic-semiconductor-piezoelectric materials rely on d-electron systems,which limits their practical applications due to a Curie temperature lower than room temperature(RT).Here,we report a high-crystallinity carbon nitride(CCN)material based on sp-electrons using a chemical vapor deposition *** exhibits a band gap of 1.8 eV and has been confirmed to possess substantial in-plane and out-of-plane ***,we acquired clear evidences of ferromagnetic behavior at room *** structural characterizations combined with theoretical calculations reveal that incorporating structural oxygen into the highly ordered heptazine structure causes partial substitution of nitrogen sites,which is primarily responsible for generating room-temperature ferromagnetism and *** a result,the strain in wrinkles can effectively modulate the domain behavior and piezoelectric potential at room *** addition of RT ferromagnetic-semiconductor-piezoelectric material based on sp-electrons to the family of two-dimensional materials opens up numerous possibilities for novel applications in fundamental research and spin electronic devices.

关键词： crystallinity carbon nitride room-temperature ferromagnetism piezoelectricity magnetic force microscopy density functional theory(DFT)calculations

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Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3298-3312页

作者： Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian yang Ya-ping Wang Li-Bin Pan Hang yu Chi-yu He Hai-Bin Luo Zhen-Xiong Zhao Xin-Bo Zhou yu-Li Wang Jie Fu Pei Han yu-Hui Dong Gang Wang Song Li yan Wang Jian-Dong Jiang wu zhong State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China Beijing Institute of Pharmacology and Toxicology Beijing 100000China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China School of Pharmaceutical Sciences Hainan UniversityHainan 570228China National Engineering Research Center for the Emergence Drugs Beijing 100000China

Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota.

关键词： Depression Morinda oficinalis oligosaccharides Gut microbiota Tryptophan hydroxylase 5-Hydroxytryptophan decarboxylase 5-Hydroxytryptophan Serotonin Drug metabolism

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First-Principles Study of the Structural, Electronic and Optical Properties ofHexagonal LiIO_(3)

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Chinese Physics Letters 2013年第6期30卷 174-177页

作者： YAO Gang CHEN yu AN Xin-You JIANG zhong-Qian CAO Lin-Hong wu Wei-Dong ZHAO yan State Key Laboratory Cultivation Base for Nonmetal Composites and Functional Materials School of Materials Science and EngineeringSouthwest University of Science and TechnologyMianyang 621010 Science and Technology on Plasma Physics Laboratory Research Center of Laser FusionCAEPMianyang 621900 College of Science Inner Mongolia University of TechnologyHohhot 010051

The structural parameters,electronic structure,chemical bonding and optical properties of hexagonal LiIO_(3) are investigated in the framework of density functional *** calculated lattice parameters are in agreement with the previous experimental *** band structure,density of states,and Mulliken charge population are obtained,and indicate that hexagonal LiIO_(3) has an indirect band gap of 2.81 ***,the optical properties are also calculated and analyzed in *** is shown that hexagonal LiIO_(3) is a promising dielectric material.

关键词： material. hexagonal (3)

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Vibration test and numerical analysis of loess slope site under high-speed train loading condition

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yantu Lixue/Rock and Soil Mechanics 2020年 41卷 333-344页

作者： Zheng, Hai-zhong yan, wu-Jian Shi, yu-Cheng Wang, ping Xu, Shi-yang Tian, Wen-Tong Key Laboratory of Loess Earthquake Engineering Lanzhou Institute of Seismology CEA Lanzhou 730000 China Geotechnical Disaster Prevention Engineering Technology Research Center of Gansu Province Lanzhou 730000 China

In order to study the site effect of loess stepped slope under the train loading condition, the field test was carried out on the stepped slope of a specific embankment section of Tongwei-Qin'an line which belongs to Baoji-Lanzhou special passenger line. Based on the time and frequency domain analysis of the measured vibration signals, the site effect of loess stepped slope and the train speed impacts on the site vibration are studied. Based on the Hilbert-Huang transform, the vibration of train, track and the movement state of the train are analyzed. Based on the field investigation, three different types of slope models are established by using finite element software, and the dynamic response of different types of slope site under the train load is analyzed. The results show that the peak acceleration tends to attenuate with the increase of the distance from the track center, but there is an obvious vibration rebound at the fourth terrace. The vibration frequency of each test point is mainly concentrated in 5-90 Hz, and the spectrum characteristics of each test point are obviously different. With the increase of distance from the track center, the main vibration frequency moves from high frequency to low frequency. The peak acceleration and vibration acceleration levels at each terrace are not only controlled by train speed, but also affected by topographic and geomorphological characteristics. The acceleration nephograms of three different slopes at the same time are different. Besides, the difference between vibration acceleration peak value and displacement peak value at three slopes in the horizontal direction is very large, but the difference in the vertical direction is small. © 2020, Science Press. All right reserved.

关键词： Hilbert-Huang transform

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Restrictive Cardiomyopathy Resulting from a Troponin Ⅰ Type 3 Mutation in a Chinese Family

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Chinese Medical Sciences Journal 2016年第1期31卷 1-7页

作者： yan-ping ruan Chao-xia Lu Xiao-yi Zhao Rui-juan Liang Hui Lian Michael Routledge Wei wu Xue Zhang zhong-jie Fan Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China McKusick-Zhang Center for Genetic Medicine Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100005 China Leeds Institute of Cardiovascular & Metabolic Medicine University of Leeds Leeds LS2 9JZ UK

Objective To identify the pathogenic variant responsible for restrictive cardiomyopathy （RCM） in aChinese *** Next generation sequencing was used for detecting the mutation and results verified bysequencing. We used restriction enzyme digestion to test the mutation in the family members and 200 unrelatednormal subjects without any cardiac inherited diseases when the mutation was *** Five individuals died from cardiac diseases, two of whom suffered from sudden cardiacdeath. Two individuals have suffered from chronic cardiac disorders. Mutation analysis revealed a novelmissense mutation in exon 7 of troponin I type 3 （TNNI3）, resulting in substitution of serine （S） withproline （P） at amino acid position 150, which cosegregated with the disease in the family, which is predictedto be probably damaging using PolyPhen-2. The mutation was not detected in the 200 unrelated subjectswe *** Using next generation sequencing, which has very recently been shown to be successfulin identifying novel causative mutations of rare Mendelian disorders, we found a novel mutation of TNNI3 in aChinese family with RCM.

关键词： restrictive cardiomyopathy autosomal dominant troponin I

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A non-surgical suturing strategy for rapid cardiac hemostasis

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Nano Research 2023年第1期16卷 810-821页

作者： yuan Gao Jun Zhang Nan Cheng zhong Liu yuan-Bin wu Qian-Qian Zhou Chen-yan Li Miao yu Seeram Ramakrishna Rong Wang yun-Ze Long Collaborative Innovation Center for Nanomaterials&Devices College of PhysicsQingdao UniversityQingdao 266071China Department of Adult Cardiac Surgery the Sixth Medical Center of PLA General HospitalBeijing 100084China Institute of Health Service and Transfusion Medicine Beijing 100850China Center for Nanofibers&Nanotechnology Department of Mechanical EngineeringNational University of SingaporeSingapore 117574Singapore State Key Laboratory of Bio-Fibers&Eco-Textiles Qingdao 266071China

As the central organ of the human body,once the heart is damaged,it will cause devastating damage to the circulation system of the whole body,often leading to rapid ***,the only treatment option to stop bleeding in penetrating cardiac injuries is surgical suturing,which is extremely complex and *** addition,it is difficult to implement this kind of treatment in battlefields with poor medical ***,there is an urgent need to develop an effective cardiac hemostasis *** this work,we propose a two-step hemostasis strategy that can effectively stop bleeding for penetrating heart *** is,cardiac hemostatic plug(CHP)is made from the nanocomposite(polylactic acid/gelatin/absorbable hemostatic particles,PLA/GEL/AHP)with high biosafety,excellent hemostatic performance,and degradability which is used to block cardiac bleeding,and then wound surface is sealed by in-situ electrospun medical glue fibers(N-octyl-2-cyanoacrylate,interfacial toughness:221±23 J·m−2),thus completing cardiac hemostasis(porcine heart with 1 cm diameter penetrating wound).The hemostasis process is simple and quick(ping various functional particles,and the PLA/GEL/AHP composite nanofiber membrane prepared by this method is also a promising hemostatic material.

关键词： heart cardiac hemostasis nanocomposite solution blow spinning electrospinning

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利用铝型材厂废渣研制的刚玉磨介的晶相结构和性能表征

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硅酸盐通报 2006年第6期25卷 26-29页

作者：吴任平于岩阮玉忠福州大学材料学院福州350002

采用铝型材厂废渣为主要原料,通过添加少量粘土,滑石及碳酸钡复合助烧剂研制刚玉耐磨瓷。主要探讨不同烧结温度对产品各项性能指标的影响。采用XRD和SEM等主要测试手段探讨其晶相结构和显微结构。结果表明最佳烧结温度为1410℃时,试样... 详细信息

采用铝型材厂废渣为主要原料,通过添加少量粘土,滑石及碳酸钡复合助烧剂研制刚玉耐磨瓷。主要探讨不同烧结温度对产品各项性能指标的影响。采用XRD和SEM等主要测试手段探讨其晶相结构和显微结构。结果表明最佳烧结温度为1410℃时,试样的主要晶相有5种,刚玉为主晶相,含量约75%,各项性能指标均达到或超过市售常规产品。

关键词：铝型材厂废渣刚玉晶相性能

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