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子宫内膜癌术中冷冻切片病理检查的诊断准确性及其影响因素

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中华妇幼临床医学杂志（电子版） 2016年第1期12卷 40-46页

作者：王利丽王心吴楠尚丽新顾玉婵赵谦谦北京军区总医院妇产科 100010 大连医科大学辽宁116044

目的探讨子宫内膜癌(EC)术中冷冻切片病理检查的诊断准确性及其影响因素。方法选择2006年1月至2014年12月,北京军区总医院妇产科诊治的170例EC患者为研究对象。以术后石蜡包埋切片病理检查结果为诊断金标准,比较所有EC患者术中冷冻切片... 详细信息

目的探讨子宫内膜癌(EC)术中冷冻切片病理检查的诊断准确性及其影响因素。方法选择2006年1月至2014年12月,北京军区总医院妇产科诊治的170例EC患者为研究对象。以术后石蜡包埋切片病理检查结果为诊断金标准,比较所有EC患者术中冷冻切片病理检查在诊断肿瘤细胞级别、组织学类型、肌层浸润深度及宫颈累及方面的敏感度和特异度差异,及影响术中冷冻切片病理检查粗符合率的临床因素。本研究遵循的程序符合北京军区总医院人体试验委员会制定的伦理学标准,得到该委员会批准,并与患者签署临床研究知情同意书。结果 1在肿瘤细胞级别的诊断上,术中冷冻切片病理检查诊断低分化的敏感度(87.5%)分别较诊断高分化、中分化的敏感度(74.7%、56.1%)高,且差异有统计学意义(χ2=4.28、23.97,P=0.028、0.000);诊断低分化的特异度(98.4%)较诊断高分化的特异度(75.4%)高,且差异有统计学意义(χ2=22.65,P=0.000)。2在肿瘤组织学类型的诊断上,术中冷冻切片病理检查诊断为Ⅰ型的敏感度(88.5%)较诊断为Ⅱ型的敏感度(33.3%)高,诊断为Ⅰ型的特异度(45.5%)较诊断为Ⅱ型的特异度(88.8%)低,且差异均有统计学意义(χ2=63.99、43.03,P=0.000、0.000)。3在诊断肿瘤肌层浸润深度上,术中冷冻切片病理检查诊断深肌层浸润的敏感度(95.0%)较诊断浅肌层浸润的敏感度(86.5%)高,且差异有统计学意义(χ2=4.61,P=0.032);诊断深肌层浸润的特异度(99.2%)与浅肌层浸润的特异度(95.5%)比较,差异则无统计学意义(χ2=1.52,P=0.218)。4在诊断宫颈累及方面,术中冷冻切片病理检查诊断宫颈累及的敏感度(20.0%)较诊断无宫颈累及的敏感度(100.0%)低,诊断宫颈累及的特异度(100.0%)较无宫颈累及的特异度(20.0%)高,且差异均有统计学意义(χ2=133.33、133.33,P=0.000、0.000)。5研究的10项临床因素中,肥胖、组织学类型为Ⅰ型及低分化EC患者术中冷冻切片病理检查在诊断肿瘤细胞级别方面的粗符合率(81.9%、72.4%、91.7%)较无肥胖、组织学类型为Ⅱ型及高/中分化EC患者(63.8%、0、65.6%)高,且差异均有统计学意义(P<0.05);有阴道异常出血或排液、肥胖、有高血压和(或)糖尿病及宫腔深度≥8mm的EC患者术中冷冻切片病理检查在诊断肌层浸润深度上准确性较高,但在诊断肌层浸润深度方面的粗符合率(91.4%、94.5%、93.4%、95.2%)较无阴道异常出血或排液、无肥胖、无高血压和(或)糖尿病及宫腔深度<8 mm的EC患者(28.6%、78.3%、84.3%、86.0%)高,且差异均有统计学意义(P<0.05)。结论术中冷冻切片病理检查在诊断肌层浸润深度上准确性较高,但在EC肿瘤细胞级别、组织学类型、宫颈累及的诊断上有一定局限性。EC患者在术中的手术范围不能完全依据冷冻切片病理检查结果进行判断。

关键词：子宫内膜肿瘤冷冻切片石蜡包埋活组织检查女性

Phenotype Analysis and Fine Mapping of the Male Sterile Mutant ms10 in Rice (Oryza sativa L.)

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Phyton-International Journal of Experimental Botany 2021年第3期90卷 803-813页

作者： Gang Wei Hongxia Yang Jingwen wu Zixian Xiong nan Wang College of Agronomy and Biotechnology Rice Research InstituteSouthwest UniversityChongqing400715China

There is a positive correlation between fertility and yield,and the decrease of fertility is bound to a greatly reduced crop *** sterile mutants can be used in hybrid ***,rice male sterility has an important value in research and application,and the study of related mutants is also very *** mutant ms10(male sterile 10)reported in this study was induced by ethyl methane sulfonate(EMS)in the indica maintainer line Xinong *** was no significant difference between the ms10 and wild type in the vegetative growth ***,in the reproductive growth stage,ms10 showed that the plant became shorter,the anther became smaller and the color became lighter,and finally showed the phenotype of male sterility in comparison to the wild type.I2-KI staining showed that the pollen was malformed and only a little was *** electron microscopy observation showed that the exine waxy layer of the ms10 anther decreased,suggesting that the protective effect on pollen was *** may be one of the reasons leading to the phenotype of male ***,the pollen showed shrinkage and collapsed,and the structure of germinating pore cover *** may be the result of *** analysis showed that the male sterility phenotype of the mutant was controlled by a single recessive nuclear ***10 was mapped between the molecular markers IND37 and IND51 on chromosome 4,with a physical distance of 178.6 *** results lay the foundation for further studies on MS10.

关键词： Gene mapping male sterility rice(Oryza sativa L.)

Experimental Study on the Characteristics of CO_2 Hydrate Formation in Porous Media below Freezing Point

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China Petroleum Processing & Petrochemical Technology 2015年第3期17卷 32-38页

作者： Zhang Xuemin Li Jinping wu Qingbai Wang Chunlong nan Junhu Western China Energy & Environment Research Center Lanzhou University of Technology Cold and Arid Regions Environmental Engineering Research Institute Chinese Academy of Sciences

Porous medium has an obvious effect on the formation of carbon dioxide hydrate. In order to study the characteristics of CO2 hydrate formation in porous medium below the freezing point, the experiment of CO2 hydrate formation was conducted in a high-pressure 1.8-L cell in the presence of porous media with a particle size of 380 μm, 500 μm and 700 μm, respectively. The test results showed that the porous medium had an important influence on the process of CO2 hydrate formation below the freezing point. Compared with porous media with a particle size of 500 μm and 700 μm, respectively, the average hydrate formation rate and gas storage capacity of carbon dioxide hydrate in the porous medium with a particle size of 380 μm attained 0.016 14 mol/h and 65.094 L/L, respectively. The results also indicated that, within a certain range of particle sizes, the smaller the particle size of porous medium was, the larger the average hydrate formation rate and the gas storage capacity of CO2 hydrate during the process of hydrate formation would be.

关键词： CO2 hydrate formation rate porous media formation characteristics gas storage capacity

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遥感影像管理分发研究

测绘与空间地理信息 2013年第1期36卷 82-83页

作者：王宏伟武赫男李德军孙晓锐袁昱纬吴婧文空军航空大学吉林长春130022

近年来,遥感影像获取技术的不断革新,影像分辨率不断提高,其数据量呈现几何级数增长。面对海量的遥感影像数据,如何将其加以有效的管理分发,成为实际应用中迫切需要解决的问题。本文介绍了目前国内外遥感影像管理系统的研究现状,整理分... 详细信息

近年来,遥感影像获取技术的不断革新,影像分辨率不断提高,其数据量呈现几何级数增长。面对海量的遥感影像数据,如何将其加以有效的管理分发,成为实际应用中迫切需要解决的问题。本文介绍了目前国内外遥感影像管理系统的研究现状,整理分析了各种研究成果,最后文章给出了作者自己的见解。

关键词：遥感影像影像管理影像金字塔

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有机酯类润滑油基础油的性能与应用

化工时刊 2016年第7期30卷 26-31页

作者：彭显才费逸伟吴楠姚婷杨宏伟卞森空军勤务学院学员一大队江苏徐州221000 空军勤务学院航空油料物资系江苏徐州221000

介绍了有机酯的分类和工业合成方法、结构性能特点及其应用,重点分析了有机酯结构与性能的相关性和优缺点。由于有机酯具有良好的粘温性、低温性及氧化安定性等性能,因此广泛用于工业润滑油基础油,尤其是在航空涡轮发动机方面应用甚广。

关键词：有机酯合成方法结构性能相关性应用

Probing the intrinsic optical quality of CVD grown MoS2

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nano Research 2017年第5期10卷 1608-1617页

作者： Amina Zafar Haiyan nan Zainab Zafar Zhangting wu Jie Jiang Yumeng You Zhenhua Ni Department of Physics and Key Laboratory of MEMS of the Ministry of Education Southeast University Nanjing 211189 China Ordered Matter Science Research Center Southeast University Nanjing 211189 China

Optical emission efficiency of two-dimensional layered transition metal dichalcogenides （TMDs） is one of the most important parameters affecting their optoelectronic performance. The optimization of the growth parameters by chemical vapor deposition （CVD） to achieve optoelectronic-grade quality TMDs is, therefore, highly desirable. Here, we present a systematic photoluminescence （PL） spectroscopic approach to assess the intrinsic optical and crystalline quality of CVD grown MoS2 （CVD MoS2）. We propose the use of the intensity ratio between the PL measured in air and vacuum as an effective way to monitor the intrinsic optical quality of CVD MoS2. Low-temperature PL measurements are also used to evaluate the structural defects in MoS2, via defect-associated bound exciton emission, which well correlates with the field-effect carrier mobility of MoS2 grown at different temperatures. This work therefore provides a sensitive, noninvasive method to characterize the optical properties of TMDs, allowing the tuning of the growth parameters for the development of optoelectronic devices.

关键词： transition metaldichalcogenides MoS2 chemical vapor deposition photoluminescence defect mobility

Experimental Study on the Axial Compression Performance of Bamboo Scrimber Columns Embedded with Steel Reinforcing Bars

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Structural Durability & Health Monitoring 2024年第6期18卷 805-833页

作者： Xueyan Lin Mingtao wu Guodong Li nan Guo Lidan Mei College of Civil Engineering and Transportation Northeast Forestry UniversityHarbin150000China Department of Building Engineering College of Civil EngineeringTongji UniversityShanghai200092China College of Transportation and Civil Engineering Fujian Agriculture and Forestry UniversityFuzhou350002China

In this paper,a new type of bamboo scrimber column embedded with steel bars(rebars)was proposed,and the compression performance was improved by pre-embedding rebars during the preparation of the *** effects of the slenderness ratio and the reinforcement ratio on the axial compression performance of reinforced bamboo scrimber columns were studied by axial compression tests on 28 *** results showed that the increase in the slenderness ratio had a significant negative effect on the axial compression performance of the *** the slenderness ratio increased from 19.63 to 51.96,the failure mode changed from strength failure to buckling failure,and the maximum bearing capacity decreased by 43.03%.The axial compression performance of the reinforced bamboo scrimber columns did not significantly improve at a slenderness ratio of 19.63,but the opposite was true at slenderness ratios of 36.95 and *** the reinforcement ratio increased from 0%to 4.52%,the bearing capacity of those with a slenderness ratio of 51.96 increased by up to 16.99%,and the stiffness and ductility were also ***,based on existing specifications,two modification parameters,the overall elastic modulus Ec and the combined strength fcc,were introduced to establish a calculation method for the bearing capacity of the reinforced bamboo scrimber *** calculation results were compared with the test results,and the results showed that the proposed calculation models can more accurately predict the bearing capacity.

关键词： Bamboo scrimber column steel bar axial compression performance theoretical model

Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer＇s disease

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nano Research 2015年第7期8卷 2400-2414页

作者： Li wu Jiasi Wang nan Gao Jinsong Ren Andong Zhao Xiaogang Qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China University of Chinese Academy of Sciences Beijing 100039 China

Metal ions are involved in Aβ aggregate deposition and neurotoxicity via various processes, including acceleration of Aβ aggregation, disruption of normal metal homeostasis, and formation of reactive oxygen species （ROS）. Although metal chelation is a promising therapeutic strategy for Alzheimer＇s disease （AD）, the widespread use of chelation therapy faces a significant problem; namely, it is difficult to differentiate toxic metals associated with Aβ plaques from those required by normal metal homeostasis. Furthermore, the multifactorial nature of AD and the current lack of an accepted unitary theory to account for AD neurodegeneration also restrict AD treatment through a single therapeutic strategy. This paper presents a novel bifunctional platform by integrating nonpharmacological and pharmacological cues into one system for AD treatment. This electrically responsive drug release platform, based on conducting polymer polypyrrole （PPy） incorporated with graphene-mesoporous silica nanohybrids （GSN） nanoreserviors, could realize on-demand controlled drug delivery with spatial and temporal control. Electrochemical stimulation can treat peripheral nerve injury （PNI） to stimulate neurite outgrowth. This novel system can also effectively inhibit Aβ aggregate formation, decrease cellular ROS, and protect cells from Aβ-related toxicity. The purpose of this research is to promote the design of noninvasive remote-controlled multifunctional systems for AD treatment.

关键词： drug deliver graphene mesoporous silica, Alzheimer's disease, amyloid β-peptides

Endoscopic stricturotomy in the treatment of anastomotic strictures in inflammatory bowel disease(IBD)and non-IBD patients

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Gastroenterology Report 2020年第2期8卷 143-150,I0002,I0003页

作者： Long-Juan Zhang nan Lan Xian-Rui wu Bo Shen Laboratory of General Surgery the First Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdongP.R.China Center for Inflammatory Bowel Disease Digestive Disease and Surgery InstituteThe Cleveland Clinic FoundationClevelandOHUSA Department of Colorectal Surgery and Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases the Sixth Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdongP.R.China

Backgrounds:Endoscopic stricturotomy(ESt)has been shown to be effective in treating inflammatory bowel disease(IBD)-associated anastomotic ***,the outcome of ESt in benign,non-IBD conditions has not been *** aim of this study was to evaluate the outcome of ESt in the management of IBD and non-IBD-associated ***:Data of all consecutive IBD and non-IBD patients with benign anastomotic strictures treated with ESt from 2009 to 2016 were *** primary outcomes were surgery-free survival and procedure-related ***:A total of 49 IBD and 15 non-IBD patients were included in this *** IBD group included 25 patients with Crohn’s disease and 24 with ulcerative colitis and ileal *** diseases in the non-IBD group included colorectal cancer(n=7),diverticulitis(n=5),large bowel prolapse(n=2),and constipation(n=1).Immediate technical success was achieved in all patients in both *** complications occurred on five occasions(4.7%per procedure)in the IBD group,while no complication occurred in the non-IBD group(P=0.20).Stricture improvement on follow-up endoscopy was found in 10(20.4%)and 5(33.3%)patients in the IBD and non-IBD groups,respectively(P=0.32).Six(12.2%)patients in the IBD group and four(26.7%)patients in the non-IBD group eventually required stricture-related surgery(P=0.23).IBD patients appeared to have a higher tendency formaintaining surgery-free after the procedure than non-IBD patients(P=0.08).Conclusions:Endoscopic stricturotomy was shown to have comparable outcomes,though non-IBD patients seem to have a higher need for subsequent surgery but a lower complication rate than IBD patients.

关键词： endoscopic stricturotomy inflammatory bowel disease anastomotic stricture