检索结果-南通市图书馆

Large-Scale Multi-Objective Optimization Algorithm Based on Weighted Overlapping Grouping of Decision Variables

Computer Modeling in Engineering & Sciences 2024年第7期140卷 363-383页

作者： Liang Chen Jingbo Zhang linjie wu Xingjuan Cai Yubin Xu Shanxi Key Laboratory of Big Data Analysis and Parallel Computing Taiyuan University of Science and TechnologyTaiyuan030024China School of State Key Laboratory of Novel Software Technology Nanjing UniversityNanjing210008China

The large-scale multi-objective optimization algorithm(LSMOA),based on the grouping of decision variables,is an advanced method for handling high-dimensional decision ***,in practical problems,the interaction among decision variables is intricate,leading to large group sizes and suboptimal optimization effects;hence a large-scale multi-objective optimization algorithm based on weighted overlapping grouping of decision variables(MOEAWOD)is proposed in this ***,the decision variables are perturbed and categorized into convergence and diversity variables;subsequently,the convergence variables are subdivided into groups based on the interactions among different decision *** the size of a group surpasses the set threshold,that group undergoes a process of weighting and overlapping ***,the interaction strength is evaluated based on the interaction frequency and number of objectives among various decision *** decision variable with the highest interaction in the group is identified and disregarded,and the remaining variables are then reclassified into ***,the decision variable with the strongest interaction is added to each *** minimizes the interactivity between different groups and maximizes the interactivity of decision variables within groups,which contributed to the optimized direction of convergence and diversity exploration with different *** was subjected to testing on 18 benchmark large-scale optimization problems,and the experimental results demonstrate the effectiveness of our *** with the other algorithms,our method is still at an advantage.

关键词： Decision variable grouping large-scale multi-objective optimization algorithms weighted overlapping grouping direction-guided evolution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeting the organelle for radiosensitization in cancer radiotherapy

引用

Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 52-71页

作者： Xiaoyan Sun linjie wu Lina Du Wenhong Xu Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Afliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China

Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-energy ionizing radiation to destroy cancer cells. However, this method has several limitations, including low radiation energy deposition, severe damage to surrounding normal cells, and high tumor resistance to radiation. Among various radiotherapy methods, boron neutron capture therapy (BNCT) has emerged as a principal approach to improve the therapeutic ratio of malignancies and reduce lethality to surrounding normal tissue, but it remains deficient in terms of insufficient boron accumulation as well as short retention time, which limits the curative effect. Recently, a series of radiosensitizers that can selectively accumulate in specific organelles of cancer cells have been developed to precisely target radiotherapy, thereby reducing side effects of normal tissue damage, overcoming radioresistance, and improving radiosensitivity. In this review, we mainly focus on the field of nanomedicine-based cancer radiotherapy and discuss the organelle-targeted radiosensitizers, specifically including nucleus, mitochondria, endoplasmic reticulum and lysosomes. Furthermore, the organelle-targeted boron carriers used in BNCT are particularly presented. Through demonstrating recent developments in organelle-targeted radiosensitization, we hope to provide insight into the design of organelle-targeted radiosensitizers for clinical cancer treatment.

关键词： Cancer radiotherapy Organelle-target Radiosensitization Boron neutron capture therapy Nanomedicines

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phylogenetic analysis of Fulgoroidea based on the morphological characters of the forewing base structure(Hemiptera:Auchenorrhyncha)

引用

Entomotaxonomia 2022年第2期44卷 103-113页

作者： Xiaoyun ZHAO linjie wu Daozheng QIN College of Plant Protection Northwest A&F UniversityYanglingShaanxi 712100China

The forewing base structure of a representative species from 13 families of Fulgoroidea were *** show that these families differ mainly from the characters of various sclerites,the presence or absence of humeral plate,proximal and distal median plate,and the method of connection between each *** phylogenetic relationships based on forewing structure support the monophyly of *** and Flatidae were recovered as sister *** is the most primitive family in Fulgoroidea.

关键词： planthopper phylogeny morphology monophyletic group

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

工作场所噪声测量标准的研究进展

引用

工业卫生与职业病 2024年第5期50卷 464-469页

作者：刘海英李扬武林杰李金哲沈彤张美辨安徽医科大学公共卫生学院中国疾病预防控制中心职业卫生与中毒控制所

该文采用系统性综述的方法，从工作分析、测量策略及个体测量要求、评价指标、仪器校准与不确定性分析等6个方面入手，对比分析了12个国家或标准化组织的噪声暴露测量标准或技术规范。结果表明有7个国家要求在测量前识别职业噪声的类型... 详细信息

该文采用系统性综述的方法，从工作分析、测量策略及个体测量要求、评价指标、仪器校准与不确定性分析等6个方面入手，对比分析了12个国家或标准化组织的噪声暴露测量标准或技术规范。结果表明有7个国家要求在测量前识别职业噪声的类型，4个国家在工作分析时定义了相似暴露组；10个国家对个体噪声测量仪麦克风的摆放位置提出了明确要求；是连续噪声的主要评估指标，多数国家采用LpeakC计权或A计权来评价脉冲噪声水平；除了测量前的声学校准，澳大利亚等4个国家还要求测量结束后的校准，并规定校准偏差。

关键词：噪声工作场所测量标准噪声类型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Membrane fusion reverse micelle platforms as potential oral nanocarriers for efficient internalization of free hydrophilic peptides

引用

Nano Research 2023年第7期16卷 9768-9780页

作者： Mengting Lin linjie wu Yiying Lu Xiaoyan Bao Haiqing Zhong Qi Dai Qiyao Yang Yiyi Xia Xin Tan Yaxin Qin Ruolin Jiang Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Pharmacy Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China The Second Affiliated Hospital College of MedicineZhejiang UniversityHangzhou 310058China

Orally administered peptides or proteins are garnering increasing preference owing to their superiority in terms of patient compliance and ***,the development of oral protein formulations has stalled due to the low bioavailability of macromolecules that encounter the aggressive gastrointestinal environment and harsh mucus villi ***,we propose an ideal reverse micelle/self-emulsifying drug delivery system(RM/SEDDS)nanoplatform that is capable of improving the oral bioavailability of hydrophilic peptides by preventing enzymatic degradation and enhancing mucosal *** the passage through the mucus,the self-emulsifying drug delivery system with optimal surface properties effectively penetrates the viscoelastic mucosal barrier,followed by the exposure of the inner reverse micelle amphipathic vectors,which autonomously form continua with the lipidic cell membrane and facilitate the internalization of *** membrane-fusion mechanism inaugurates a new way for hydrophilic peptide delivery in the free form,circumventing the traditional impediments of the cellular internalization of nanocarriers and subsequent poor release of *** more importantly,reverse micelles are not spatially specific to the laden drugs,which enables their delivery for a myriad of peptide clinical *** conclusion,as an exquisitely designed nanoplatform,RM/SEDDS overcomes multiple physiological barriers and opens a new path for drug cellular entry,providing new prospects for the development of oral drug delivery systems.

关键词： oral drug delivery system reverse micelle self-emulsifying drug delivery system membrane fusion hydrophilic peptide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国内外工作场所噪声风险分级管理现况

引用

工业卫生与职业病 2024年第5期50卷 470-475页

作者：李扬曾安可武林杰刘海英刘晓旭张美辨中国疾病预防控制中心职业卫生与中毒控制所安徽医科大学

工作场所噪声风险分级管理是噪声控制的一个有效措施，该文从划分分级的噪声水平、管理措施、行动水平几个方面进行对比分析我国、新加坡、巴西、意大利和欧盟工作场所噪声风险分级相关标准或法规，结合我国相关规范性文件或标准进行阐... 详细信息

工作场所噪声风险分级管理是噪声控制的一个有效措施，该文从划分分级的噪声水平、管理措施、行动水平几个方面进行对比分析我国、新加坡、巴西、意大利和欧盟工作场所噪声风险分级相关标准或法规，结合我国相关规范性文件或标准进行阐述我国现有工作场所噪声作业分级的不足，为完善和修订我国工作场所噪声作业分级提供依据。建议我国工作场所噪声作业分级的修订可考虑参考欧盟行动水平，完善其暴露风险分级及对应噪声水平，每一级别分级遵循噪声危害控制层次来制定相应的风险管理措施。

关键词：噪声风险分级作业分级行动水平综述

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Few-layered hexagonal boron nitride nanosheets stabilized Pt NPs for oxidation promoted adsorptive desulfurization of fuel oil

引用

Green Energy & Environment 2024年第3期9卷 495-506页

作者： Peiwen wu Xin Song Linlin Chen Lianwen He Yingcheng wu Duanjian Tao Jing He Chang Deng linjie Lu Yanhong Chao Mingqing Hua Wenshuai Zhu School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang212013China College of Chemical Engineering and Environment State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum-BeijingBeijing102249China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang330022China College of Science State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum-BeijingBeijing102249China

A few-layered hexagonal boron nitride nanosheets stabilized platinum nanoparticles(Pt/h-BNNS)is engineered for oxidation-promoted adsorptive desulfurization(OPADS)of fuel *** was found that the few-layered structure and the defective sites of h-BNNS not only are beneficial to the stabilization of Pt NPs but also favor the adsorption of aromatic *** employing Pt/h-BNNS with a Pt loading amount of 1.19 wt%as the active adsorbent and air as an oxidant,a 98.0%sulfur removal over dibenzothiophene(DBT)is achieved along with a total conversion of the DBT to the corresponding sulfones(DBTO_(2)).Detailed experiments show that the excellent desulfurization activity originates from the few-layered structure of h-BNNS and the high catalytic activity of Pt *** addition,the OPADS system with Pt/h-BNNS as the active adsorbent shows remarkable stability in desulfurization performance with the existence of different interferents such as olefin,and aromatic ***,the Pt/h-BNNS can be recycled 12 times without a significant decrease in desulfurization ***,a process flow diagram is proposed for deep desulfurization of fuel oil and recovery of high value-added products,which would promote the industrial application of such OPADS strategy.

关键词： Desulfurization Adsorption Catalytic oxidation Active adsorbent Dibenzothiophene

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tea Polyphenols Reducing Lipopolysaccharide-induced Inflammatory Responses in RAW264.7 Macrophages via NF-κB Pathway

引用

Chemical Research in Chinese Universities 2019年第6期35卷 1105-1110页

作者： SU Siyi LI Xiaoyu GUO Xu ZHOU Ruiming LI Manman MING Pengfei HUANG Yingying Sajid Ur RAHMAN DING Hongyan FENG Shibin LI Jinchun WANG Xichun LI Yu wu linjie College of Animal Science and Techmology Anhui Agricultural UniversityHefei 230036P.R.China

The anti-inflammatory activity of tea polyphenols(TPs)in RAW264.7 macrophages stimulated by lipopolysaccharide(LPS)was investigated in this ***264.7 macrophages were treated with different concentrations of TP(0,12.5,25,50,100,and 200μg/mL)and then stimulated by *** blank control group was set *** expression of pro-inflammatory cytokines associated with the nuclear factor-kappa B(NF-κB)signaling pathway was investigated before and after TP *** of RAW264.7 cells with TP decreased the expression of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin 1 beta(IL-1β)pro-inflammatory *** addition,TP inhibited the phosphorylation of p65 and IκB by blocking the phosphorylation and the degradation of NF-κB inhibitor *** conclusion,TP exerts anti-inflammatory effects by regulating the release of inflammatory mediators via the NF-κB signaling pathway.

关键词： Tea polyphenol Inflammatory response,RAW264.7 Nuclear factor-kappa B pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

传统诚信文化的传承创新研究

引用

首都师范大学学报(社会科学版) 2023年第5期 84-90页

作者：武林杰首都师范大学马克思主义学院

社会诚信问题是现代社会转型国家面临的共同挑战。它所引发的主体道德堕落和社会信任危机无疑严重影响整个社会精神文明的发展,从而阻碍着中国式现代化进程的顺利推进。为重构当代中国诚信观念,不仅需要建立和完善高质量的社会信用体系... 详细信息

社会诚信问题是现代社会转型国家面临的共同挑战。它所引发的主体道德堕落和社会信任危机无疑严重影响整个社会精神文明的发展,从而阻碍着中国式现代化进程的顺利推进。为重构当代中国诚信观念,不仅需要建立和完善高质量的社会信用体系,同时还应深度结合马克思主义基本原理,在破除时代性障碍的基础上,传承创新中国传统诚信文化中以“义理认同为基础,世俗教化为载体,礼法合治为保障”的价值理念,为中国社会诚信建设提供文化滋养。

关键词：传统诚信礼法合治现代传承

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

传统诚信家训的历史探究及其当代教育启示

引用

首都师范大学学报（社会科学版） 2019年第3期 143-148页

作者：武林杰首都师范大学马克思主义学院

家规族训作为中国传统道德教化的重要内容,对于传统德性文化的发展和丰富有着重要的推动作用,更是实现古代中国"德治"的一种重要媒介和基础。作为齐家教子的重要训诫,传统家训渗透于社会成员生活的方方面面,特别是在涉及诚信的生活领域... 详细信息

家规族训作为中国传统道德教化的重要内容,对于传统德性文化的发展和丰富有着重要的推动作用,更是实现古代中国"德治"的一种重要媒介和基础。作为齐家教子的重要训诫,传统家训渗透于社会成员生活的方方面面,特别是在涉及诚信的生活领域,其训诫内容更是浩瀚如烟,正是凭借这些"俗化天下"的诚信家风,才使得中国传统社会诚信风尚的形成具有了坚实的社会基础。面对当代中国失信风气逐步蔓延的社会现状,我们有必要对中国传统优良诚信家规家训进行继承和吸收,并在此基础上结合中国当代诚信教育的现状,实现对它的创造性转化和创新性发展,以促生更具成效的新时代诚信道德教育。

关键词：诚信家规蒙以养正言传身教诚信教育

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：