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Reg4 regulates 5-fluorouracil sensitivity in gastric cancer through MAPK/Erk/Bim signaling pathway

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Reg4 regulates 5-fluorouracil sensitivity in gastric cancer ...

The C-Reactive Protein/Albumin Ratio Predicts Long-Term Outcomes of Patients with Operable Non-Small Cell Lung Cancer

浙江省免疫学会第十次学术大会

作者： Jiaoyue Jin Fanrong Zhang Kaiyan Chen Nan Zhang junzhou wu Lisha Ying Dan Su Cancer Research Institute Zhejiang Cancer Hospital and Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province

Aim:Reg4 is a member of the Reg multigene family,and is highly up-regulated in many gastrointestinal *** cancer cells with high Reg4 expression is resistant to 5-fluorouracil(5-FU),but the mechanism is not very *** the present study,we aimed to comfirm the role of Reg4 in GC cells once again,and further investigate the mechanism by which Reg4 regulates the 5-FU response in GC ***:Protein expression of Reg4 in gastric cancer cells was analyzed by western *** on over-expression and siRNA knockdown of Reg4 were conducted for 5-FU sensitivity and apoptosis analyses.5-FU metabolism and intracellular signaling were examined by real time PCR and western ***:Western blot showed Reg4 expression was low or null in SGC-7901,BGC-823 gastric cancer cell lines,and high in AGS,MKN28,MKN45 gastric cancer cell *** overexpression and knockdown of Reg4 demonstrated that low Reg4 expression promoted the sensitivity to 5-FU,and 5-FU-induced *** were no significant influences on the mRNA levels of thymidylate synthase,orotate phosphoribosyltransferase and dihydropyrimidine *** investigation showed enhanced Reg4 expression activated the P42/P44 phosphorylation,and regulated 5-FU sensitivity through MAPK/Erk/Bim signaling ***:The results indicate that Reg4 may play an important role in5-FU-induced cell ***,upregulation of Reg4 in response to 5-FU may represent an intrinsic mechanism of resistance to this anticancer drug.

关键词： Reg4 5-fluorouracil apoptosis gastric cancer

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The C-Reactive Protein/Albumin Ratio Predicts Long-Term Outc...

浙江省免疫学会第十次学术大会

作者： Fanrong Zhang Lisha Ying Kaiyan Chen Jiaoyue Jin Nan Zhang junzhou wu Yimin Zhang Dan Su Cancer Research Institute Zhejiang Cancer Hospital & Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province Department of Oncology The First Clinical Medical College of Wenzhou Medical University Department of Clinical Laboratory Zhejiang Cancer Hospital

Purpose:To investigate the association between C-reactive protein/albumin ratio(CAR),an inflammation-based prognostic score,and clinicopathological factors,as well as its association with long-term outcomes in patients with operable non-small cell lung cancer(NSCLC).Methods:A total of 617 operable NSCLC patients were retrospectively evaluated and the data of preoperative serum CRP and serum albumin was *** correlation between the CAR and clinicopathological factors was analyzed using the chi-square test.A Cox proportional hazards regression model was performed to evaluate the association between the CAR and ***:The CAR was significantly related to sex,smoking status,BML histology type and clinical stage(p < 0.05).The patients with characteristic of male,smoker,BMI under 18.5,squamous cell carcinoma or clinical stage Ⅲ had a high level of ***,elevated CAR indicated a worse outcome,and the patients with higher CAR had 2.02-fold risk for disease progression(95%CI 1.48-2.74,p < 0.001)and 2.61-fold risk for death(95%CI 2.02-3.37,p < 0.001).Multivariate analyses showed the similar results after adjusted by clinicopathological factors and another four inflammation-based prognostic ***:The CAR is a potential independent predictor for disease progression and death in patients with operable NSCLC.

关键词： C-reactive protein Albumin Inflammation-based prognostic score Prediction Survival

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高职PLC应用技术项目化教学改革

科技视界 2020年第7期 134-136页

作者：吴君周浙江安防职业技术学院温州325016

传统的PLC课程教学过程偏重于理论的掌握,而忽视了实践动手解决问题能力的培养,针对这个问题,本文以浙江安防职业技术学院安全防范技术专业17级和18级学生为研究对象,对PLC技术课程进行项目化教学改革。以项目为主线,使学生在学习过程... 详细信息

传统的PLC课程教学过程偏重于理论的掌握,而忽视了实践动手解决问题能力的培养,针对这个问题,本文以浙江安防职业技术学院安全防范技术专业17级和18级学生为研究对象,对PLC技术课程进行项目化教学改革。以项目为主线,使学生在学习过程中体验真实的项目,融合理论知识,开展理实一体化教学。使学生增强实操能力,更深刻的掌握专业知识。

关键词：高职项目化教学改革

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异极性荷电粒子的磁凝并系数建模分析

环境科学与技术 2015年第4期38卷 56-59页

作者：王涌吴君周张燕燕浙江工业大学浙江杭州310023

针对非磁性以及弱磁性的非金属粉尘磁凝并效果差的问题,首次提出了异极性荷电粒子在磁场洛伦兹力作用下凝并的方法。即带正负相反电荷的粒子以一定的速度进入磁场,在洛伦兹力的作用下,分别沿着不同圆周顺时针或逆时针的方向运动,从而碰... 详细信息

针对非磁性以及弱磁性的非金属粉尘磁凝并效果差的问题,首次提出了异极性荷电粒子在磁场洛伦兹力作用下凝并的方法。即带正负相反电荷的粒子以一定的速度进入磁场,在洛伦兹力的作用下,分别沿着不同圆周顺时针或逆时针的方向运动,从而碰撞凝并。建立了带电粒子在磁场洛伦兹力作用下凝并的数学模型,求出了凝并系数表达式。通过对凝并系数仿真分析得出:有外加磁场(磁感应强度为0.5 T)情况下的PM10的凝并系数比无外加磁场情况下的PM10凝并系数大33%左右。带电粒子的磁场凝并系数与磁感应强度、粒子粒径、气流速度成正相关,与粒子密度成负相关。

关键词：电除尘磁凝并 PM10 凝并系数

3116工作面覆岩运动规律及离层充填注浆技术研究

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山东煤炭科技 2021年第5期39卷 63-65,69,72页

作者：武俊州潞安化工集团慈林山煤业有限公司夏店煤矿山西长治046000

为防止3116工作面回采对地表建筑物的损坏,采用UDEC数值模拟软件进行覆岩运动规律的分析,结合离层充填注浆技术,进行注浆方案的设计。设计注浆孔孔底与煤层间距86 m,注浆终孔压力为3.4~6 MPa,布置注浆孔9个,并在注浆方案实施后进行地面... 详细信息

为防止3116工作面回采对地表建筑物的损坏,采用UDEC数值模拟软件进行覆岩运动规律的分析,结合离层充填注浆技术,进行注浆方案的设计。设计注浆孔孔底与煤层间距86 m,注浆终孔压力为3.4~6 MPa,布置注浆孔9个,并在注浆方案实施后进行地面沉降量监测分析。结果表明:离层充填注浆方案实施后,建筑物围墙最大下沉量为30 mm,建筑物基本无下沉,充填注浆有效控制了地表的沉降。

关键词：关键层离层注浆

Preoperative serum CA125 is an independent predictor for prognosis in operable patients with non-small cell lung cancer

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电子线路图绘制技术课程案例教学模式实践研究

全国肿瘤流行病学和肿瘤病因学学术会议

作者： Lisha Ying junzhou wu Dan Zhang Zhupeng Li Dan Li Xiaodan Pan Hang Lv Jianguo Feng Dan Su Cancer Research Institute Zhejiang Cancer Hospital Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province College of Pharmaceutical Science Zhejiang Chinese Medical University Tissue Bank Zhejiang Cancer Hospital National Clinical Research Base of Traditional Chinese Medicine Zhejiang Hospital of Traditional Chinese MedicineZhejiang Chinese Medical University

Background:The role of serum CA125 and CEA in the prognosis of non-small cell lung cancer（NSCLC） remains controversial,especially in early stage *** aim of this study is to analyze the prognostic value of CA125 and CEA in operable *** and Methods:We retrospectively analyzed 645 patients with NSCLC who underwent curative surgical resection for lung cancer at Zhejiang Cancer Hospital of China from 2006 to *** enzyme immunoassay was used to measure preoperative serum CA125 and *** analyses and a multivariable proportional hazard Cox regression model were applied to assess the prognostic significance of the different ***-Meier was used to analyze survival ***:Both CA125 and CEA were correlated with stage,but also CA125 was different by grade,and CEA was related to *** Kaplan-Meier survival curves were showed that patients with elevated CA125 or CEA had unfavorable disease progression-free and overall survival time compared to those with normal CA125 or ***,multivariate Cox analysis revealed that elevated CA125 had significantly higher risk for relapse（HR,1.76;p=0.001） and death（HR,1.80;p=0.000）,while no significant differences were observed with elevated CEA for relapse（HR,1.06;p=0.736） and death（HR,1.25;p=0.119）.Conclusions:CA125 and CEA seem to play important roles in disease progression and CA125 may be an independent predictive marker for prognosis in patients with NSCLC.

关键词： CA125 CEA Non-small cell lung cancer Prognosis

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信息与电脑 2022年第7期34卷 254-256页

作者：吴君周浙江安防职业技术学院浙江温州325016

案例教学模式是教师根据教学内容和教学对象的特点,设计合适、贴切的案例,将知识点融入案例,让学生在案例操作中学习知识、掌握知识、运用知识,注重培养学生的实操技能,达到理实一体的教学目的。笔者重点探讨了案例教学模式在电子线路... 详细信息

案例教学模式是教师根据教学内容和教学对象的特点,设计合适、贴切的案例,将知识点融入案例,让学生在案例操作中学习知识、掌握知识、运用知识,注重培养学生的实操技能,达到理实一体的教学目的。笔者重点探讨了案例教学模式在电子线路图绘制技术课程教学中的应用。实践表明,采用案例教学模式,不仅有利于提高学生识别电子元器件的能力、绘制电子线路图的熟练程度以及自学能力,还有利于激发学生的学习兴趣。

关键词：电子线路图绘制技术课程案例教学模式实践

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异极性荷电粒子磁电分级凝并建模分析

现代制造技术与装备 2019年第9期55卷 120-122页

作者：吴君周金国伟浙江安防职业技术学院

针对AC电场聚合器能耗大的问题,提出了一种凝并器结构——磁电分级凝并聚合器。聚合器前半段为永磁铁产生磁场,后半段为AC电场;减少AC电场长度为,增加了磁场凝并环节,进而减少了AC电场能耗。另外,建立粒子的荷电—磁电分级凝并数学模型... 详细信息

针对AC电场聚合器能耗大的问题,提出了一种凝并器结构——磁电分级凝并聚合器。聚合器前半段为永磁铁产生磁场,后半段为AC电场;减少AC电场长度为,增加了磁场凝并环节,进而减少了AC电场能耗。另外,建立粒子的荷电—磁电分级凝并数学模型,得出PM2.5粒子磁电分级凝并前后粒径变化关系表达式。仿真分析得出,磁电分级凝并前后粒子粒径增大2~6倍;凝并后的粒子粒径与粒子密度成负相关,与粒子质量浓度成正相关。

关键词： PM2.5 磁电分级凝并

基于随机森林与长短期记忆网络结合的蓝莓黑腹果蝇发生预测

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山东农业科学 2024年第8期56卷 158-164页

作者：高驰涵张梅陈哲张群英伍俊舟贵州大学电气工程学院贵州贵阳550025 贵州省植物园贵州贵阳550004

黑腹果蝇侵害严重影响蓝莓产量,现已成为遏制贵州省蓝莓产业发展的主要原因之一,快速、准确预测黑腹果蝇发生有利于及时采取防控措施,但目前对蓝莓园黑腹果蝇发生预测的研究尚少。为此,本研究提出了一种蓝莓黑腹果蝇发生预测模型。首先... 详细信息

黑腹果蝇侵害严重影响蓝莓产量,现已成为遏制贵州省蓝莓产业发展的主要原因之一,快速、准确预测黑腹果蝇发生有利于及时采取防控措施,但目前对蓝莓园黑腹果蝇发生预测的研究尚少。为此,本研究提出了一种蓝莓黑腹果蝇发生预测模型。首先,利用Pearson相关系数分析温度、湿度、风速等相关气候特征指标与黑腹果蝇发生的相关性;然后,利用随机森林算法选出影响黑腹果蝇发生的重要气候特征指标;最后,提出一种随机森林和长短期记忆网络相结合的虫害预测模型。将该模型与其他传统模型的预测效果进行对比,结果表明其在预测黑腹果蝇发生方面表现出良好的性能,均方根误差为2.1203,平均绝对误差为1.8659,决定系数为0.9795。本研究结果可为预测黑腹果蝇发生并及时采取相应防治策略提供技术支持。

关键词：黑腹果蝇蓝莓虫害发生预测随机森林长短期记忆网络 Pearson相关系数气候特征

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