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Biomedical and Environmental Sciences 2024年第4期37卷 423-427页

作者： ZHANG Sai CHEN Zhi Xian ZHANG Mo DU Yan ZHOU Jia Yi wu jing YU Yin Hua CAO Qi ZHAO Hong Bo Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China

Placental site trophoblastic tumor(PSTT),a rare gestational trophoblastic neoplasm(GTN),exhibits slow growth,late-onset metastasis,and chemotherapy insensitivity[1,2].The invasive capacity of trophoblasts induces angiogenesis in PSTT,yet the specific mechanism remains unclear[3].PSTT is typically resistant to chemotherapy and hysterectomy stands as the primary therapeutic choice for patients with an overall cure rate of approximately 75%-80%[4,5].Therefore,investigating the precise emergence and progression of PSTT is crucial,aiming to identify novel targets for diagnosis and therapy.

关键词： chemotherapy diagnosis metastasis

A buffer overflow detection and defense method based on RiSC-V instruction set extension

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Cybersecurity 2024年第2期7卷 28-43页

作者： Chang Liu Yan-Jun wu jing-Zheng wu Chen Zhao Intelligent Software Research Center Institute of SoftwareChinese Academy of SciencesBejingChina University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijingChina

Buffer overflow poses a serious threat to the memory security of modern operating systems.It overwrites the con-tents of other memory areas by breaking through the buffer capacity limit,destroys the system execution environ-ment,and provides implementation space for various system attacks such as program control flow hijacking.That makes it a wide range of harms.A variety of security technologies have been proposed to deal with system security problems including buffer overflow.For example,No eXecute(NX for short)is a memory management technology commonly used in Harvard architecture.It can refuse the execution of code which residing in a specific memory,and can effectively suppress the abnormal impact of buffer overflow on control flow.Therefore,in recent years,it has also been used in the field of system security,deriving a series of solutions based on NX technology,such as ExecShield,DEP,StackGuard,etc.However,these security solutions often rely too much on the processor archi-tecture so that the protection coverage is insufficient and the accuracy is limited.Especially in the emerging system architecture field represented by RiSC-V,there is still a lack of effective solutions for buffer overflow vulnerabilities.With the continuous rapid development of the system architecture,it is urgent to develop defense methods that are applicable to different system application environments and oriented to all executable memory spaces to meet the needs of system security development.Therefore,we propose BOP,A new system memory security design method based on RISC-V extended instructions,to build a RISC-V buffer overflow detection and defense system and deal with the buffer overflow threat in RIsC-V.According to this method,NX technology can be combined with program control flow analysis,and Nx bit mechanism can be used to manage the executability of memory space,so as to achieve a more granular detection and defense of buffer overflow attacks that may occur in RISC-V system environment.In addition,The memory management an

关键词： RISc-V Operating system security Buffer overflow Control flow hijacking Nx bit Xibop

LONP1 ameliorates liver injury and improves gluconeogenesis dysfunction in acute-on-chronic liver failure

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Chinese Medical Journal 2024年第2期137卷 190-199页

作者： Muchen wu jing wu Kai Liu Minjie Jiang Fang Xie Xuehong Yin Jushan wu Qinghua Meng Department of Liver Disease Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of General Surgery Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:Acute-on-chronic liver failure(ACLF)is a severe liver disease with complex pathogenesis.Clinical hypoglycemia is common in patients with ACLF and often predicts a worse prognosis.Accumulating evidence suggests that glucose metabolic disturbance,especially gluconeogenesis dysfunction,plays a critical role in the disease progression of ACLF.Lon protease-1(LONP1)is a novel mediator of energy and glucose metabolism.However,whether gluconeogenesis is a potential mechanism through which LONP1 modulates ACLF remains unknown.Methods:In this study,we collected liver tissues from ACLF patients,established an ACLF mouse model with carbon tetrachloride(CCl 4),lipopolysaccharide(LPS),and D-galactose(D-gal),and constructed an in vitro hypoxia and hyperammonemia-triggered hepatocyte injury model.LONP1 overexpression and knockdown adenovirus were used to assess the protective effect of LONP1 on liver injury and gluconeogenesis regulation.Liver histopathology,biochemical index,mitochondrial morphology,cell viability and apoptosis,and the expression and activity of key gluconeogenic enzymes were detected to explore the underlying protective mechanisms of LONP1 in ACLF.Results:We found that LONP1 and the expressions of gluconeogenic enzymes were downregulated in clinical ACLF liver tissues.Furthermore,LONP1 overexpression remarkably attenuated liver injury,which was characterized by improved liver histopathological lesions and decreased serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in ACLF mice.Moreover,mitochondrial morphology was improved upon overexpression of LONP1.Meanwhile,the expression and activity of the key gluconeogenic enzymes were restored by LONP1 overexpression.Similarly,the hepatoprotective effect was also observed in the hepatocyte injury model,as evidenced by improved cell viability,reduced cell apoptosis,and improved gluconeogenesis level and activity,while LONP1 knockdown worsened liver injury and gluconeogenesis disorders.Conclusion:We demonstrated that gluconeogenesis dysfunc

关键词： Acute-on-chronic liver failure Lon protease-1 Gluconeogenesis disturbance Mitochondrial dysfunction Metabolism

Therapeutic effect of Wendan Decoction combined with mosapride on gastroesophageal reflux disease after esophageal cancer surgery

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World Journal of Clinical Cases 2024年第13期12卷 2194-2200页

作者： Yu-jing Zhang Shen-Ping wu Department of Oncology Beijing Integrated Traditional Chinese and Western Medicine HospitalBeijing 100039China

BACKGROUND Gastroesophageal reflux disease(GERD)is a common complication of esophageal cancer surgery that can affect quality of life and increase the risk of esophageal stricture and anastomotic leakage.Wendan Decoction(WDD)is a traditional Chinese herbal formula used to treat various gastrointestinal disorders,such as gastritis,functional dyspepsia,and irritable bowel syndrome.Mosapride,a prokinetic agent,functions as a selective 5-hydroxytryptamine 4 agonist,enhancing gastrointestinal motility.AIM To evaluate the therapeutic effects of WDD combined with mosapride on GERD after esophageal cancer surgery.METHODS Eighty patients with GERD were randomly divided into treatment(receiving WDD combined with mosapride)and control(receiving mosapride alone)groups.The treatment was conducted from January 2021 to January 2023.The primary outcome was improved GERD symptoms as measured using the reflux disease questionnaire(RDQ).The secondary outcomes were improved esophageal motility(measured using esophageal manometry),gastric emptying(measured using gastric scintigraphy),and quality of life[measured via the Short Form-36(SF-36)Health Survey].RESULTS The treatment group showed a notably reduced RDQ score and improved esophageal motility parameters,such as lower esophageal sphincter pressure,peristaltic amplitude,and peristaltic velocity compared to the control group.The treatment group showed significantly higher gastric emptying rates and SF-36 scores(in both physical and mental domains)compared to the control group.No serious adverse effects were observed in either group.CONCLUSION WDD combined with mosapride is an effective and safe therapy for GERD after esophageal cancer surgery.It can improve GERD symptoms,esophageal motility,gastric emptying,and the quality of life of patients.Further studies with larger sample sizes and longer follow-up periods are required to confirm these findings.

关键词： Gastroesophageal reflux disease Esophageal cancer surgery Wendan Decoction Mosapride Treatment effects Gastroesophageal reflux disease symptoms

Benchmarking visual SLAM methods in mirror environments

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Computational Visual Media 2024年第2期10卷 215-241页

作者： Peter Herbert jing wu Ze Ji Yu-Kun Lai School of Computer Science and Informatics Cardiff UniversityAbacws BuildingSenghennydd RdCardiff CF244AGUK School of Engineering Cardiff UniversityQueen’s BuildingsThe ParadeCardiff CF243AAUK

Visual simultaneous localisation and mapping(vSLAM)finds applications for indoor and outdoor navigation that routinely subjects it to visual complexities,particularly mirror reflections.The effect of mirror presence(time visible and its average size in the frame)was hypothesised to impact localisation and mapping performance,with systems using direct techniques expected to perform worse.Thus,a dataset,MirrEnv,of image sequences recorded in mirror environments,was collected,and used to evaluate the performance of existing representative methods.RGBD ORB-SLAM3 and BundleFusion appear to show moderate degradation of absolute trajectory error with increasing mirror duration,whilst the remaining results did not show significantly degraded localisation performance.The mesh maps generated proved to be very inaccurate,with real and virtual reflections colliding in the reconstructions.A discussion is given of the likely sources of error and robustness in mirror environments,outlining future directions for validating and improving vSLAM performance in the presence of planar mirrors.The MirrEnv dataset is available at https://***/10.17035/d.2023.0292477898.

关键词： visual simultaneous localisation and mapping(vSLAM) mirror localisation mapping reflection datase

Strengthening pharmacotherapy research for COVID-19-induced pulmonary fibrosis

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World Journal of Clinical Cases 2024年第5期12卷 875-879页

作者： Yan-Miao Liu jing Zhang jing-jing wu Wei-Wei Guo Fu-Shan Tang The First Clinical Institute Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Clinical Pharmacy in Zunyi City Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Department of Respiratory Medicine Central Hospital in Jinchang CityJinchang 737102Gansu ProvinceChina Department of Clinical Pharmacy Key Laboratory of Basic Pharmacology of Guizhou Province and School of PharmacyZunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

The global spread of severe acute respiratory syndrome coronavirus 2 has resulted in a significant number of individuals developing pulmonary fibrosis(PF),an irreversible lung injury.This condition can manifest within a short inter-val following the onset of pneumonia symptoms,sometimes even within a few days.While lung transplantation is a potentially lifesaving procedure,its limited availability,high costs,intricate surgeries,and risk of immunological rejection present significant drawbacks.The optimal timing of medication administration for coronavirus disease 2019(COVID-19)-induced PF remains controversial.Despite this,it is crucial to explore pharmacotherapy interventions,involving early and preventative treatment as well as pharmacotherapy options for advanced-stage PF.Additionally,studies have demonstrated disparities in anti-fibrotic treatment based on race and gender factors.Genetic mutations may also impact therapeutic efficacy.Enhancing research efforts on pharmacotherapy interventions,while considering relevant pharmacological factors and optimizing the timing and dosage of medication administration,will lead to enhanced,personalized,and fair treatment for individuals impacted by COVID-19-related PF.These measures are crucial in lessening the burden of the disease on healthcare systems and improving patients'quality of life.

关键词： COVID-19 Pulmonary fibrosis Pharmacotherapy intervention Medication administration Timing Dosage

Suspected coexistence of perianal necrotizing sweet syndrome in chronic myelomonocytic leukemia:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1176-1183页

作者： Ke-Qiang Yu Hui-Xiang Li jing wu Clinical Medicine School Chengdu University of Chinese MedicineChengdu 610072Sichuan ProvinceChina Institute of Integrated Traditional Chinese and Western Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Chronic myelomonocytic leukemia(CMML)complicated with Sweet syndrome(SS)is a rare hematological neoplasm.However,cases of concomitant development of perianal necrotizing SS(NSS)have not been reported.CASE SUMMARY We report a case of a 49-year-old male patient who underwent sequential procedures for hemorrhoids and perianal abscess.He developed postoperative incision infection and was referred to the department where the authors work.Initially,perianal necrotizing fasciitis secondary to incision infection after perianal abscess surgery was suspected.Despite receiving antibiotic therapy and undergoing surgical debridement,deeper necrotic areas formed in the patient’s perianal wounds,accompanied by persistent high fever.Blood and fungal cultures yielded negative results.The final diagnosis was corrected to be CMML with suspected concomitant perianal NSS.CONCLUSION CMML with perianal NSS is a rare condition,often misdiagnosed as perianal abscess or perianal necrotizing fasciitis.Conventional antibiotic therapy and surgical debridement are ineffective in managing this condition.

关键词： Chronic myelomonocytic leukemia Sweet syndrome Necrotizing fasciitis Perianal abscess Case report

Metastatic clear cell sarcoma of the pancreas:A rare case report

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World Journal of Clinical Cases 2024年第8期12卷 1448-1453页

作者： Yu-jing Liu Chen Zou Yong-You wu General Surgery II Suzhou HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversitySuzhou 215000Jiangsu ProvinceChina Department of General Surgery The Affiliated People's Hospital of Jiangsu UniversitySuzhou 215000Jiangsu ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Soochow UniversitySuzhou 215008Jiangsu ProvinceChina

BACKGROUND Clear cell sarcoma(CCS)is a rare soft-tissue sarcoma.The most common metastatic sites for CCS are the lungs,bones and brain.CCS is highly invasive and mainly metastasizes to the lung,followed by the bone and brain;however,pancreatic metastasis is relatively rare.CASE SUMMARY We report on a rare case of CCS with pancreatic metastasis in a 47-year-old man.The patient had a relevant medical history 3 years ago,with abdominal pain as the main clinical manifestation.No abnormalities were observed on physical examination and the tumor was found on abdominal computed tomography.Based on the medical history and postoperative pathology,the patient was diagnosed with CCS with pancreatic metastasis.The patient was successfully treated with surgical interventions,including distal pancreatectomy and sple-nectomy.CONCLUSION This report summarizes the available treatment modalities for CCS and the importance of regular postoperative follow-up for patients with CCS.

关键词： Clear cell sarcoma Pancreas Metastasis Follow-up Case report

Advances in single-cell sequencing technology in microbiome research

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Genes & Diseases 2024年第4期11卷 201-219页

作者： Yinhang wu jing Zhuang Yifei Song Xinyi Gao Jian Chu Shuwen Han Huzhou Central Hospital Affiliated Central Hospital Huzhou UniversityHuzhouZhejiang 313000China Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer of Huzhou HuzhouZhejiang 313000China The Fifth Affiliated Clinical Medical College of Zhejiang Chinese Medical University HangzhouZhejiang 313000China Zhejiang Provincial People's Hospital and Affiliated People's Hospital Hangzhou Medical CollegeHangzhouZhejiang 310000China

With the rapid development of histological techniques and the widespread applica-tion of single-cell sequencing in eukaryotes,researchers desire to explore individual microbial.genotypes and functional expression,which deepens our understanding of microorganisms.In this review,the history of the development of microbial detection technologies was revealed and the difficulties in the application of single-cell sequencing in microorganisms were dissected as well.Moreover,the characteristics of the currently emerging microbial single-cell sequencing(Microbe-seq)technology were summarized,and the prospects of the application of Microbe-seq in microorganisms were distilled based on the current development status.Despite its mature development,the Microbe-seq technology was still in the optimization stage.A retrospective study was conducted,aiming to promote the widespread application of single-cell sequencing in microorganisms and facilitate further improvement in the technol-ogy.

关键词： Bacterialantibiotic resistance Host immunity Host-phage interaction Microbial single-cell sequencing Microorganisms Single cell Single-cell sequencing technology

CALTM:A Context-Aware Long-Term Time-Series Forecasting Model

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 873-891页

作者： Canghong Jin Jiapeng Chen Shuyu wu Hao wu Shuoping Wang jing Ying School of Computer and Computing Science Hangzhou City UniversityHangzhou310015China School of Computer Science and Engineering Macao University of Science and TechnologyMacao999078China College of Computer Science and Technology Zhejiang UniversityHangzhou310058China

Time series data plays a crucial role in intelligent transportation systems.Traffic flow forecasting represents a precise estimation of future traffic flow within a specific region and time interval.Existing approaches,including sequence periodic,regression,and deep learning models,have shown promising results in short-term series forecasting.However,forecasting scenarios specifically focused on holiday traffic flow present unique challenges,such as distinct traffic patterns during vacations and the increased demand for long-term forecastings.Consequently,the effectiveness of existing methods diminishes in such scenarios.Therefore,we propose a novel longterm forecasting model based on scene matching and embedding fusion representation to forecast long-term holiday traffic flow.Our model comprises three components:the similar scene matching module,responsible for extracting Similar Scene Features;the long-short term representation fusion module,which integrates scenario embeddings;and a simple fully connected layer at the head for making the final forecasting.Experimental results on real datasets demonstrate that our model outperforms other methods,particularly in medium and long-term forecasting scenarios.

关键词： Traffic volume forecasting scene matching multi module fusion