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78例小儿急性上呼吸道感染的临床诊治分析

中国现代药物应用 2024年第2期18卷 54-56页

作者：吴小云吴惠玲福建省漳州市芗城区南坑街道社区卫生服务中心 363000 福建省漳州市南靖县医院 363600

目的分析小儿急性上呼吸道感染的临床诊治方法与效果。方法回顾性分析78例小儿急性上呼吸道感染患儿的临床资料,根据治疗方式的差异分成参照组与实验组,每组39例。参照组采取常规治疗,实验组采取常规联合蒲地蓝治疗。比较两组的治疗效... 详细信息

目的分析小儿急性上呼吸道感染的临床诊治方法与效果。方法回顾性分析78例小儿急性上呼吸道感染患儿的临床资料,根据治疗方式的差异分成参照组与实验组,每组39例。参照组采取常规治疗,实验组采取常规联合蒲地蓝治疗。比较两组的治疗效果、临床症状消失时间、治疗前后的炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-10]水平。结果治疗后,实验组治疗总有效率100.00%明显高于参照组的84.62%,差异具备统计学意义(P0.05);治疗后,实验组CRP(3.53±0.11)mg/L、TNF-α(4.80±1.31)ng/L、IL-1β(22.16±12.06)ng/L、IL-10(74.76±6.76)ng/L均低于参照组的(8.96±2.56)mg/L、(7.76±1.65)ng/L、(55.16±23.64)ng/L、(65.86±8.46)ng/L,差异具备统计学意义(P<0.05)。结论对小儿急性上呼吸道感染开展常规和蒲地蓝联合治疗效果显著,可明显缩短患儿机体康复的时间,促进炎症因子降低,值得推荐。

关键词：小儿急性上呼吸道感染蒲地蓝咽喉肿痛治疗效果

豨莶草提取物对脑缺血/再灌注大鼠的神经保护作用

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中国药理学通报 2024年第1期40卷 70-75页

作者：吴慧玲吴青青陈景泉周彬彬余正双杨泽霖赖文芳洪桂祝福建中医药大学药学院福建福州350122

目的研究豨莶草提取物对脑缺血/再灌注大鼠的神经保护作用,并探讨其作用机制。方法 SD大鼠60只,线栓法制备大脑中动脉闭塞(middle cerebral artery occlusion, MCAO)模型,实验分为假手术(Sham)组,模型(MCAO)组,豨莶草低剂量(XXC-L)、... 详细信息

目的研究豨莶草提取物对脑缺血/再灌注大鼠的神经保护作用,并探讨其作用机制。方法 SD大鼠60只,线栓法制备大脑中动脉闭塞(middle cerebral artery occlusion, MCAO)模型,实验分为假手术(Sham)组,模型(MCAO)组,豨莶草低剂量(XXC-L)、中剂量(XXC-M)、高剂量(XXC-H)组,连续给药7天。mNSS评估大鼠神经功能损伤,MRI检测大鼠缺血侧脑梗死体积,Nissl染色检测Nissl阳性细胞数;Western blot检测Bax、Bcl-2、NeuN蛋白表达;免疫荧光染色检测Tunel、NeuN;RT-qPCR检测IL-1β、TNF-α、IL-6 mRNA表达。结果豨莶草提取物能显著降低MCAO大鼠mNSS评分和缺血侧脑梗死体积(P<0.05,P<0.01),促进缺血侧脑组织Nissl阳性细胞数和NeuN表达、抑制Tunel阳性细胞数(P<0.01);同时,豨莶草提取物能抑制IL-1β、TNF-α、IL-6mRNA及Bax蛋白,促进Bcl-2、NeuN蛋白(P<0.01)。结论豨莶草提取物对MCAO大鼠具有神经保护作用。

关键词：豨莶草提取物脑缺血/再灌注凋亡 NeuN mNSS评分神经保护

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Carbon-based nanomaterials cause toxicity by oxidative stress to the liver and brain in Sprague-Dawley rats

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Nuclear Science and Techniques 2024年第6期35卷 54-64页

作者： Ying-Ying Xu Chan Jin Meng wu Jian-Ye Zhou hui-ling Wei Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Institute of Particle and Nuclear Physics College of PhysicsHenan Normal UniversityXinxiang 453007China

Carbon-based nanomaterials have important research significance in various disciplines,such as composite materials,nanoelectronic devices,biosensors,biological imaging,and drug ***,the human and ecological risks associated with carbon-based nanomaterials have received increasing ***,the biological safety of carbon based nanomaterials has not been systematically *** this study,we used different types of carbon materials,namely,graphene oxide(GO),single-walled carbon nanotubes(SWCNTs),and multiwalled carbon nanotubes(MWCNTs),as models to observe their distribution and oxidative damage in *** results of Histopathological and ultrastructural examinations indicated that the liver and lungs were the main accumulation targets of these ***-μ-XRF analysis revealed that SWCNTs and MWCNTs might be present in the *** shows that the three types of carbon-based nanomaterials could cross the gas-blood barrier and eventually reach the liver *** addition,SWCNTs and MWCNTs could cross the blood-brain barrier and accumulate in the cerebral *** increase in ROS and MDA levels and the decrease in GSH,SOD,and CAT levels indicated that the three types of nanomaterials might cause oxidative stress in the *** suggests that direct instillation of these carbon-based nanomaterials into rats could induce ROS *** addition,iron(Fe)contaminants in these nanomaterials were a definite source of free ***,these nanomaterials did not cause obvious damage to the rat brain *** deposition of selenoprotein in the rat brain was found to be related to oxidative stress and Fe *** information may support the development of secure and reasonable applications of the studied carbon-based nanomaterials.

关键词： Carbon-based nanomaterials Oxidative stress Trace element distribution TEM SR-μ-XRF

Transcriptomic insights into growth promotion effect of Trichoderma afroharzianum TM2-4 microbial agent on tomato plants

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Journal of Integrative Agriculture 2021年第5期20卷 1266-1276页

作者： ZHAO Juan LIU Ting LIU Wei-cheng ZHANG Dian-peng DONG Dan wu hui-ling ZHANG Tao-tao LIU De-wen Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097P.R.China

Plant growth promoting fungi are receiving increased attention as valuable beneficial microorganisms in crop cultivation due to their capacity to produce bioactive substances,promote plant growth and enhance immune defense *** this study,a novel Trichoderma isolate,designated as TM2-4,was screened from healthy tomato rhizosphere soil and identified as Trichoderma *** filtrate of the isolate TM2-4 displayed obvious bioactive substance production and an evident effect in promoting tomato seed germination,with hypocotyl length,radical length and vigor index increased by 28.7,19.4 and 62.1%,respectively,after a 100-fold dilution *** assess the promotion effect and related mechanism of isolate TM2-4,the plant biological indexes and gene expression profiles of tomato plants treated with or without *** TM2-4 microbial agent were investigated by greenhouse pot experiment and RNA *** results demonstrated that *** TM2-4 significantly promoted tomato plant growth in terms of plant height,dry weight,number of leaves per plant and root activity,through efficient colonization in the rhizosphere and root system of the *** analyses identified a total of 984 differentially expressed genes in *** microbial agent inoculated tomato roots,which were mainly engaged in the biological process of phytohormone homeostasis,antioxidant activity,as well as metabolic pathways including phenylpropanoid biosynthesis and glutathione *** findings provide useful information for understanding the mechanism of isolate TM2-4 for tomato plant growth promotion,which would facilitate further development of *** TM2-4 microbial agent for use in vegetable crop production.

关键词： Trichoderma afroharzianum Solanum lycopersicum L. plant growth promotion transcriptome analyses qRTPCR

Bibliometric analysis of hotspots and trends of global myopia research

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 940-950页

作者： Xing-Yang wu hui-hui Fang Yan-wu Xu Yan-ling Zhang Shao-Chong Zhang Wei-Hua Yang Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina School of Future Technology South China University of TechnologyGuangzhou 510641Guangdong ProvinceChina

AIM:To gain insights into the global research hotspots and trends of ***:Articles were downloaded from January 1,2013 to December 31,2022 from the Science Core Database website and were mainly statistically analyzed by bibliometrics ***:A total of 444 institutions in 87 countries published 4124 *** 2013 and 2022,China had the highest number of publications(n=1865)and the highest H-index(61).Sun Yat-sen University had the highest number of publications(n=229)and the highest H-index(33).Ophthalmology is the main category in related *** from 2020 to 2022 highlight keywords of options and reference,child health(pediatrics),myopic traction mechanism,public health,and machine learning,which represent research ***:Myopia has become a hot research *** and Chinese institutions have the strongest academic influence in the field from 2013 to *** main driver of myopic research is still medical or *** study highlights the importance of public health in addressing the global rise in myopia,especially its impact on children’s *** present,a unified theoretical system is still *** surgical and therapeutic solutions must be proposed for people with different characteristics to manage and intervene refractive *** addition,the benefits of artificial intelligence(AI)models are also reflected in disease monitoring and prediction.

关键词： bibliometric analysis myopia global trends

PHASE Ⅱ STUDY OF GEMCITABINE COMBINED WITH PLATINUM CHEMOTHERAPY FOR RECURRENT EPITHELIAL OVARIAN CANCER

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Chinese Medical Sciences Journal 2007年第3期22卷 177-182页

作者： Peng Peng Keng Shen Jia-xin Yang Ming wu hui-fang Huang ling-ya Pan Jing-he Lang Department of Obstetrics ＆ Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To evaluate the anti-tumor effect and toxicity of gemcitabine combined with platinum chemotherapy on recurrent epithelial ovarian cancer. Methods Phase Ⅱ study of gemcitabine combined with platinum chemotherapy was carried out in 22 patients with recurrent epithelial ovarian cancer. Median age of patients was 50. 5 years old. Seven patients were platinum-sensitive and 15 patients were platinum-resistant or -refractory. All patients received gemcitabine combined with carboplatin or oxa/iplatin chemotherapy. Patients＇ response rate （RR） and toxicity of gemcitabine combined with platinum chemotherapy were evaluated. Results A total of 98 gemcitabine-based chemotherapy cycles were performed. Total RR was 36. 4%, RR of platinum-sensitive patients was 4/7 and platinum-resistant and -refractory patients was 4/15. The estimated median survival time was 10.0 months （95% CI. 7.0-13.0） after initiation of gemcitabine combined with platinum chemotherapy. There was no significant difference in survival time between platinum-resistant/refractory group and platinum-sensitive group （P = 0. 061 ）. Side effects of gemcitabine combined with platinum chemotherapy were observed in 81.8% of patients. Grade Ⅱ/Ⅲ anemia （54. 5% ） and grade Ⅲ/Ⅳ neutropenia （54. 5% ） were most common toxicities. Ten （45.5%） patients had to delay their chemotherapy cycles or reduce the dose of chemotherapeutic drugs because of the severe side effects. Fourteen （63.6%） patients received granulocyte colony-stimulating factor to relieve neutropenia, and 8 （ 36. 4% ） patients received component blood transfusion to treat anemia or thrombocytopenia. There was no treatment-associated death. Conclusion Gemcitabine combined with platinum chemotherapy appears to be an effective and well-tolerant treatment for recurrent epithelial ovarian cancer, including platinum-resistant or -refractory diseases.

关键词： second-line chemotherapy gemcitabine ovarian cancer phase Ⅱ

Multifunctional carbon materials from rugose rose for energy storage and water purification

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 1-13页

作者： Peng-hui Li hui Zhou Wen-Juan wu Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China College of Light Industry and Food Engineering Nanjing Forestry UniversityNanjing 210037China College of Chemical Engineering East China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering Shanghai 200237China

With the advancement of social process,the resource problem is becoming more prominent,biomass materials come into being,and it is becoming more and more important to explore and prepare efficient and multifunctional biomass materials to alleviate the problems of energy storage and water *** this paper,nitrogen-doped hierarchical porous carbon materials(NRRC)were produced by one-step carbonization of withered rose as raw material and melamine as nitrogen source with KOH-activated *** resulting nitrogen-doped porous carbon material had the most abundant pores and the best microspherical graded pore structure,with a specific surface area of up to 1393 m2·g^(-1),a pore volume of 0.68 cm3·g^(-1),and a nitrogen-doped content of 5.52%.Electrochemical tests showed that the maximum specific capacitance of NRRC in the three-electrode system was 346.4 F·g^(-1)(0.5 A·g^(-1)),which was combined with favorable capacitance retention performance and cycling *** NRRC//NRRC symmetric supercapacitors were further assembled,and the maximum energy density of a single device was 23.88 Wh·kg^(-1),which still maintains excellent capacitance retention and cyclic charging/discharging *** example,the capacitance retention rate was always close to 96.27%with almost negligible capacitance loss after 10000 consecutive charge/discharge cycles(current density:10 A·g^(-1)).Regardless of the three-electrode or two-electrode system,the super capacitive performance of NRRC porous carbon materials was comparable to the electrochemical performance of many reported biomass porous carbon materials,which showed better energy storage advantages and practical application *** addition,NRRC porous carbon materials had excellent water purification *** dye adsorption test confirmed that NRRC had a high adsorption capacity(491.47 mg·g^(-1))for methylene *** undoubtedly also showed a potential and promising avenue for high value-added utilization

关键词： rose carbon adsorption electrode material electrochemical performance

Principal components of nuclear mass models

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 65-71页

作者： Xin-hui wu Pengwei Zhao Department of Physics Fuzhou UniversityFuzhou 350108China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

Principal component analysis(PCA)is employed to extract the principal components(PCs)present in nuclear mass models for the first *** effects from different nuclear mass models are reintegrated and reorganized in the extracted *** PCs are recombined to build new mass models,which achieve better accuracy than the original theoretical mass *** comparison indicates that using the PCA approach,the effects contained in different mass models can be collaborated to improve nuclear mass predictions.

关键词： nuclear mass principal component analysis nuclear models statistical methods

Unmanned Ship Identification Based on Improved YOLOv8s Algorithm

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Computers, Materials & Continua 2024年第3期78卷 3071-3088页

作者： Chun-Ming wu Jin Lei wu-Kai Liu Mei-ling Ren ling-Li Ran Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology School of Electrical EngineeringNortheast Electric Power UniversityJilin132012China School of Biomedical Engineering Taiyuan University of TechnologyTaiyuan030600China

Aiming at defects such as low contrast in infrared ship images,uneven distribution of ship size,and lack of texture details,which will lead to unmanned ship leakage misdetection and slow detection,this paper proposes an infrared ship detection model based on the improved YOLOv8 algorithm(R_YOLO).The algorithm incorporates the Efficient Multi-Scale Attention mechanism(EMA),the efficient Reparameterized Generalized-feature extraction module(CSPStage),the small target detection header,the Repulsion Loss function,and the context aggregation block(CABlock),which are designed to improve the model’s ability to detect targets at multiple scales and the speed of model *** algorithm is validated in detail on two vessel *** comprehensive experimental results demonstrate that,in the infrared dataset,the YOLOv8s algorithm exhibits improvements in various performance ***,compared to the baseline algorithm,there is a 3.1%increase in mean average precision at a threshold of 0.5(mAP(0.5)),a 5.4%increase in recall rate,and a 2.2%increase in mAP(0.5:0.95).Simultaneously,while less than 5 times parameters,the mAP(0.5)and frames per second(FPS)exhibit an increase of 1.7%and more than 3 times,respectively,compared to the CAA_YOLO ***,the evaluation indexes on the visible light data set have shown an average improvement of 4.5%.

关键词： Unmanned ships R_YOLO EMA CSPStage YOLOv8s