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Effect of Silicon Content on Thermodynamics of Austenite Decomposition in C-Si-Mn TRIP Steels

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Journal of Iron and Steel Research International 2006年第3期13卷 57-60,73页

作者： ZHU Li-juan wu di zhao xian-ming State Key Lab of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

Some numerical models such as central atoms model （CAM） and superelement model were used to simulate the thermodynamics of austenite decomposition in the Fe-C-Mn-Si TRIP （transformation induced plasticity） steels. Thermodynamic calculations were carried out under a para-equilibrium （PE） condition. The results show that certain silicon content can accelerate the polygonal ferritic transformation and increase the volume fraction and stability of retained austenite by retarding the precipitation of carbides during the bainitic transformation.

关键词： central atoms model superelement model para-equilibrium austenite decomposition TRIP steel

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu ming-Lei wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo di Wang zhao-xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai wu Li Zhu Sheng Ni Xiong zhao Meng Yan Yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai Qu xian Qin Kun Zhang wuquan Deng Da Sun Wei wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

Surface Temperature Change of U75V 60 kg/m Heavy Rail During Heat Treatment

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Journal of Iron and Steel Research International 2013年第2期20卷 33-37,67页

作者： KANG Hao wu di zhao xian-ming State Key Laboratory of Rolling and Automation Northeastern University

The U75V 60 kg/m heavy rail samples were heated to 900 ℃ in a resistance furnace for a fixed duration of 50 min. Under this condition, the samples were austenitized totally. Then, the samples were dragged out of furnace and cooled for 25 s in the open air. After that, the samples entered into the air spraying channel, and were cooled from the top and both sides by compressed air. During this period, main technical parameters were changed such as the distance between spray nozzles and surface of rail head, air pressure, air spraying time and air temperature. So under laboratory condition, optimal heat-treating parameters of U75V 60 kg/m heavy rail were determined as the distance between spray nozzles and surface of rail head of 15 mm, air pressure of 0.26 MPa, cooling time of 80 s, and air temperature of 28 ℃. The surface temperature at different positions of heavy rail was measured before and after heat treatment, and the temperature changing law was determined. The self tempering occurred on the surface of rail head after heat treatment, and the tempering temperature became the largest （about 3 min） after heat treatment, separately 528, 524 and 536 ℃ at the center, top fillet and bottom fillet of rail head. The heavy rail was cooled in open air after heat treatment; during this period, the temperature gap on the surface of heavy rail became smaller and smaller, and was reduced to zero when being cooled for 20 min.

关键词： temperature change heavy rail heat treatment

Modeling of Austenite Decomposition in Low Si-Mn TRIP Steel During Cooling

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Journal of Iron and Steel Research International 2008年第6期15卷 68-71页

作者： ZHU Li-juan wu di zhao xian-ming College of Materials Science and Engineering Jilin University Changchun 130025 Jilin China The State Key Laboratory of Rolling Technology and Automation Northeastern University Shenyang 110004 Liaoning China

Transformation behavior in low carbon Si Mn TRIP steel was investigated by means of microstructural ob servation and computer modelling. A transformation model in which transformation is controlled by carbon diffusion was suggested, which well described the volume fractional change of ferrite, pearlite, and bainite during continuous cooling. The influence of Si content and austenite grain size was thoroughly investigated. The calculated results indicated that Si retards pearlite transformation, accelerates polygonal ferrite transformation, refines the austenite grain, and increases the ferrite transformation rate.

关键词： TRIP steel transformation incubation time ferrite bainite pearlite

A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu wu Zhongjie Zhu Hongwei zhao Donghong Cui Shanghai Key Laboratory of Psychotic disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

Effect of Air Pressure on Hardened Layer of U75V 60 kg/m Heavy Rail after Heat Treatment

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Journal of Harbin Institute of Technology(New Series) 2013年第1期20卷 52-56页

作者： Hao Kang xian-ming zhao di wu State Key Lab of Rolling and Automation Northeastern University

The samples cut from U75V 60 kg/m heavy rail are heated to 900 ℃ in resistance furnace and then put into air spraying channel to be cooled for 80 s, and change air pressure from 0.16 MPa to 0.33 MPa, and observe the effect of air pressure on hardened layer. The thickness and hardness of hardened layer increases with the increase of air pressure, and the thickness is more than 24 mm at the center and top fillets of rail head, and more than 15 mm at the blow fillets of rail head when air pressure is more than 0.26 MPa. During the tempering after heat treatment, tempering temperature of rail head is more than 570 ℃ when air pressure is separately 0.16 MPa, 0.20 MPa and 0.23 MPa, which is higher than finishing temperature of pearlite transformation at the cooling rate of 3 ℃/s according to CCT curve of U75V steel. When air pressure is separately 0.26, 0.30 and 0.33 MPa, the tempering temperature is 529 ℃ lower than finishing temperature of pearlite transformation at the cooling rate of 3 ℃/s. Under this condition, pearlite transformation is finished totally, so in order to reduce air consumption and control the cost, proper air pressure for U75V 60 kg/m heavy rail heat treating should be 0.26 MPa; the cooling rate increases with the increase of air pressure, and the average cooling rate on the surface of rail head is more than 3.21 ℃/s when air pressure is more than 0.26 MPa, and the largest cooling rate occurs at the top fillets of rail head.

关键词： air pressure hardened layer heavy rail heat treatment

Effects of Offline Relaxation Quenching on Microstructure and Mechanical Properties of a Newly Designed High Performance Steel

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Journal of Iron and Steel Research International 2014年第4期21卷 459-463页

作者： Wen-zhen XIA xian-ming zhao Xiao-ming ZHANG di wu State Key Laboratory of Rolling and Automation Northeastern University

The newly designed high performance tested steel was prepared by the process of vacuum induction furnace smelting and forging. According to the ideas of online relaxation and quenching intercritieal quenching-tempering （Q- L-T） process, effects of offline relaxation process on microstructure and mechanical properties of the tested steel were investigated. Offline results process was simulated using the MMS-300 thermal simulation testing apparatus and heat treating furnace. The results show that the microstructures are composed of bainite and martensite when the specimens are quenched in the austenite region. Once the specimens are ai〉cooled into the dual phase region, ferrite and granular bainite start to form. In the relaxation process, fine Nb（C, N） carbonitrides are precipitated first and then grow and coarsen. The microstructure is affected by process and determines mechanical properties. The Vickers hardness and yield strength （YS） first rise then fall when the relaxation temperature drops in austenite region, and then decline dramatically in dual phase region. When the relaxation time is 20 s, the tensile strength reaches the peak （1034 MPa）, and at that time YS is 872 MPa, elongation is 17.7% and Charpy V-notch impact energy is 171 J at -20℃. When the relaxation time increases to 100 s, the yield and tensile strengths are 750 and 934 MPa respectively, elon- gation is 18.6% and Charpy V-notch impact energy is 165 J at -20℃.

关键词： high performance steel offline relaxation process microstrueture mechanical property