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考虑空间视角的开放式景区行人路径选择模式研究——以南京夫子庙景区为例

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旅游学刊 2021年第3期36卷 118-126页

作者：巫诚诚陈大伟东南大学交通学院江苏南京210096

游客微观路径选择模式的研究对景区管理、活动规划与营销制定均具有重要参考价值。文章基于空间句法对景区路径空间性影响进行量化分析,综合考虑开放式景区游客及非游客群体路径选择的核心影响因素及路径选择模式,建立路径拟合模型,实... 详细信息

游客微观路径选择模式的研究对景区管理、活动规划与营销制定均具有重要参考价值。文章基于空间句法对景区路径空间性影响进行量化分析,综合考虑开放式景区游客及非游客群体路径选择的核心影响因素及路径选择模式,建立路径拟合模型,实现不同群体核心路径的空间生成。研究表明:空间因素(路段连通度、路段控制度及局部选择度)对景区行人路径选择具有重要影响;游客与非游客行人交互作用下,开放式景区主要形成了生活性路径、深度景点游览路径、休闲景点游览路径和通过性路径4类路径;基于空间影响假设进行各类路径拟合,与实际调查路径相比,休闲景点游览路径相似度达到75%,具有较高的准确度。该研究可为景区管理者进行景区路径优化、公共设施优化布置及节庆活动指定方案设计定量化参考。

关键词：路径选择空间句法因子分析聚类分析路径识别

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交叉口非机动车冲突易发点空间预测模型

中国安全科学学报 2021年第8期31卷 165-171页

作者：巫诚诚陈大伟东南大学交通学院江苏南京211189

为定量化识别、预测交叉口区域内的非机动车冲突易发点,利用视域分析方法及随机森林模型,构建针对交叉口非机动车冲突易发点的空间预测模型,预测交叉口区域内的具体冲突点位置及严重程度;通过改进既有的冲突量化指标,量化识别非机动车-... 详细信息

为定量化识别、预测交叉口区域内的非机动车冲突易发点,利用视域分析方法及随机森林模型,构建针对交叉口非机动车冲突易发点的空间预测模型,预测交叉口区域内的具体冲突点位置及严重程度;通过改进既有的冲突量化指标,量化识别非机动车-机动车的交叉冲突、侧向刮擦及事故,并依据非机动车调整机动车的躲避特性参数;以南京市的4处典型交叉口作为案例进行分析验证。研究结果表明:改进后的指标能补充既有冲突指标进行非机动车冲突量化的部分缺失值;基于视域分析及随机森林预测模型,可较好实现对交叉口冲突易发点的量化预测与误差评估;案例的预测冲突易发区域与实际区域的总体误差为6.76%,预测准确性较好。

关键词：城市交叉口非机动车冲突易发点空间预测模型空间句法

Optimal Design of Wetland Ecological Water in the Shuangtaizi Estuary, Panjin

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Optimal Design of Wetland Ecological Water in the Shuangtaiz...

MEX3A、CDX2、MUC2与MUC5AC判断可癌变胃肠化生的应用价值

2011 International Conference of Environmental Science and Engineering（ICESE 2011）

作者： Lin Guoqing Zhang Yanran Sun Yuguo Zheng Xilai wu chengcheng Key Laboratory of Marine Environment and Ecology Ministry of Education Ocean University of China

The protection and utilization of wetland have been more and more important. According to measured water levels, discharge and cross-sections of the Shuangtaizi River network, this paper builds a hydrodynamic model to simulate water and salt movement based on the Mike11. The model was calibrated and validated by measured water levels of July, 2009. A series of irrigation scheme for the reed field were designed according to the hydrological characteristics of the wetland. The results show that volume of water shortage is 65.1 million cubic meters in dry years, 4.2 million cubic meters in average years and 40.5 million cubic meters in wet years. With the expansion of water facilities, the water shortage reduced to 30.6 million cubic meters, 16.3 million cubic meters and 17.4 million cubic meters respectively in dry years, average years and wet years. In wet years and average years, salinity of tidal prism water can satisfy the requirements of irrigation. However, due to high tide salinity in dry years, irrigation can not be directly used for the reed field.

关键词： tidal river network reed wetlands Shuangtaizi estuary ecological water

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中国现代医生 2024年第10期62卷 1-5页

作者：张梦媛刘佳蕊张忠焦兰岚张珉薄威勾佳钰吴诚诚杨旭东王旭光沈阳医学院病理教研室辽宁沈阳110034

目的探讨MEX3A与胃癌和肠上皮化生(以下简称肠化生)分化特性的相关性及其联合尾型同源盒转录因子2(caudal-related homeobox transcription factor 2,CDX2)、黏蛋白2(mucin 2,MUC2)和黏蛋白5AC(mucin 5AC,MUC5AC)判断可癌变肠化生的作用。方法选取2010年1月至2014年12月沈阳医学院附属中心医院、沈阳医学院附属第二医院外科手术切除的胃癌及癌旁石蜡包埋组织样本410例,根据病理诊断将其分为对照组(轻度浅表性胃炎,79例)、肠化生组(149例)和胃癌组(182例)。免疫组织化学检测各组MEX3A、CDX2、MUC2和MUC5AC的表达。结果 MEX3A高表达于胃癌组及肠化生组,特别是弥漫型胃癌、低分化胃癌和Ⅲ型肠化生(P<0.05);CDX2和MUC2高表达于胃癌组和肠化生组,特别是肠型胃癌、高中分化胃癌、Ⅰ型和Ⅱ型肠化生(P<0.05);MUC5AC高表达于对照组,低表达于胃癌组和肠化生组,特别是肠型胃癌、Ⅰ型和Ⅲ型肠化生(P<0.05)。胃癌和肠化生分化程度与MEX3A和MUC5AC表达均呈负相关,与CDX2和MUC2表达呈正相关(P<0.05)。胃癌组织中MEX3A与CDX2、MUC2表达呈负相关,与MUC5AC表达呈正相关(P<0.05);肠化生组织中MEX3A与CDX2、MUC2表达呈负相关(P<0.05),CDX2与MUC2表达呈正相关(P<0.05)。结论 MEX3A与胃癌和肠化生分化程度呈负相关,胃癌具有MEX3A高表达、CDX2和MUC2低表达的特点。

关键词：肠化生胃癌 MEX3A 尾型同源盒转录因子2 黏蛋白2 黏蛋白5AC

Deleterious variants in RNF111 impair female fertility and induce premature ovarian insufficiency in humans and mice

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Science China(Life Sciences) 2024年第7期67卷 1325-1337页

作者： chengcheng Song Yingying Qin Yan Li Bingyi Yang Ting Guo Wenqing Ma Dian Xu Keyan Xu Fangfang Fu Li Jin Yanhua wu Shuyan Tang Xiaojun Chen Feng Zhang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic EngineeringInstitute of Medical Genetics and GenomicsFudan UniversityShanghai 200011China Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250021China State Key Laboratory of Reproductive Medicine and Offspring Health Key Laboratory of Reproductive Endocrinology of Ministry of EducationNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthShandong UniversityJinan 250021China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Demonstration Center for Experimental Biology Education School of Life SciencesFudan UniversityShanghai 200433China Department of Gynecology the Tenth People’s Hospital of Tongji UniversityShanghai 200072China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health Hospital of China Welfare InstituteShanghai 200030China

Premature ovarian insufficiency(POI)is a heterogeneous female disorder characterized by the loss of ovarian function before the age of *** represents a significant detriment to female ***,the known POI-causative genes currently account for only a fraction of *** elucidate the genetic factors underlying POI,we conducted whole-exome sequencing on a family with three fertile POI patients and identified a deleterious missense variant in *** a subsequent replication study involving 1,030 POI patients,this variant was not only confirmed but also accompanied by the discovery of three additional predicted deleterious RNF111 *** variants collectively account for eight cases,representing 0.78%of the study cohort.A further study involving 500 patients with diminished ovarian reserve also identified two additional RNF111 ***,RNF111 encodes an E3 ubiquitin ligase with a regulatory role in the TGF-β/BMP signaling *** analysis revealed that RNF111/RNF111 is predominantly expressed in the oocytes of mice,monkeys,and *** further investigate the functional implications of RNF111 variants,we generated two mouse models:one with a heterozygous missense mutation(Rnf111+/M)and another with a heterozygous null mutation(Rnf111^(+/-)).Both mouse models exhibited impaired female fertility,characterized by reduced litter sizes and small ovarian ***,RNA-seq and quantitative proteomics analysis unveiled that Rnf111 haploinsufficiency led to dysregulation in female gonad development and negative regulation of the BMP signaling pathway within mouse *** conclusion,our findings strongly suggest that monoallelic deleterious variants in RNF111 can impair female fertility and induce POI in both humans and mice.

关键词： POI RNF111 female fertility ovarian reserve

Miller Cycle with Early Intake Valve Closing in Marine Medium-Speed Diesel Engines

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Journal of Marine Science and Application 2022年第1期21卷 151-160页

作者： Shengli Wei chengcheng wu Shuzhe Yan Tongyuan Ding Jie Chen School of Automotive and Traffic Engineering Jiangsu UniversityZhenjiang 212013China

In this study,a one-dimensional simulation was performed to evaluate the performance of in-cylinder combustion to control NO_(x) emissions on a four-stroke,six-cylinder marine medium-speed diesel *** the combustion temperature is an important in-cylinder measure to decrease NO_(x) emissions of marine diesel *** Miller cycle is an effective method used to reduce the maximum combustion temperature in a cylinder and accordingly decrease NO_(x) ***,the authors of this study designed seven different early intake valve closing(EIVC)Miller cycles for the original engine,and analyzed the cycle effects on combustions and emissions in high-load *** results indicate that the temperature in the cylinder was significantly reduced,whereas fuel consumption was almost *** the IVC was properly advanced,the ignition delay period increased and the premixed combustion accelerated,but the in-cylinder average pressure,temperature and NO_(x) emissions in the cylinder were lower than the original ***,closing the intake valve too early led to high fuel *** addition,the NO_(x) emissions,in-cylinder temperature,and heat release rate remarkably ***,the optimal timing of the EIVC varied with different *** higher the load was,the earlier the best advance angle ***,the Miller cycle is an effective method for in-engine NO_(x) purification and does not entail significant cost.

关键词： Medium-speed diesel engine Miller cycle Combustion NO_(x)emission Early intake valve closing(EIVC)

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基于微分响应的流域产流分单元修正方法

湖泊科学 2021年第6期33卷 1906-1913页

作者：张小琴吴成城佘亮亮包为民河海大学水文水资源学院南京210098 宁波弘泰水利信息科技有限公司宁波315000

为考虑洪水预报误差的空间变化,提出一种基于微分响应的流域产流分单元修正方法.该方法建立了各单元流域产流与流域出口流量之间的微分响应关系,采用正则化最小二乘法结合逐步迫近进行反演求解,将产流误差估计量分配给相应单元流域实现... 详细信息

为考虑洪水预报误差的空间变化,提出一种基于微分响应的流域产流分单元修正方法.该方法建立了各单元流域产流与流域出口流量之间的微分响应关系,采用正则化最小二乘法结合逐步迫近进行反演求解,将产流误差估计量分配给相应单元流域实现流域产流分单元修正.将构建的方法应用于大坡岭流域和七里街流域进行新安江模型产流修正,比较分析了流域产流分单元修正、流域面平均产流修正和自回归修正的效果.结果表明:流域产流分单元修正效果优于流域面平均产流修正;随着预见期的增大,产流微分响应修正效果优于自回归修正.该方法通过汇流系统将流域出口断面流量信息进行分解用于修正各单元流域产流,有利于提高实时洪水预报精度.

关键词：洪水预报产流修正微分响应误差空间变化新安江模型

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全封闭扇冷式感应电动机通风结构方案

机械工程学报 2018年第22期54卷 160-167页

作者：丁树业仵程程刘建峰李忠雨哈尔滨理工大学电气与电子工程学院哈尔滨150080

为了揭示全封闭扇冷式(Totalenclosedfan-cooled,TEFC)感应电动机底脚拉筋结构对电动机流场流变特性以及温升分布性能的影响,近而寻求拉筋结构最优化通风冷却性能,以一台TEFC感应电动机为例,在对该电动机进行温升试验测试及温度场数值... 详细信息

为了揭示全封闭扇冷式(Totalenclosedfan-cooled,TEFC)感应电动机底脚拉筋结构对电动机流场流变特性以及温升分布性能的影响,近而寻求拉筋结构最优化通风冷却性能,以一台TEFC感应电动机为例,在对该电动机进行温升试验测试及温度场数值分析研究的基础上,依据结构特征建立电动机轴向半域流体场以及温度场耦合求解模型,采用有限体积元法对多种拉筋结构方案下的电动机内流体场及温度场进行数值计算。通过对各方案下电动机定子铁心、定子绕组、机壳等部件温升特征以及电动机域内流变特性的比较分析,明确了电动机机壳拉筋对电动机内流体场以及温度场的影响规律,给出了机壳拉筋结构优化方案。

关键词：全封闭扇冷式感应电动机通风性能温度场数值研究结构优化

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回答美学的“高更问题”

南开学报（哲学社会科学版） 2021年第6期 78-92页

作者：郭勇健吴程程厦门大学中文系福建厦门361005 厦门大学哲学系

所谓美学的"高更问题",也就是"美学从哪里来,美学是什么,美学到哪里去"?回答"美学从哪里来"的问题,需要区分美学学科和美学思想。作为学科的美学起源于德国;文化虽有创始者,却无固定主人,因此美学起源于德国,却走向全世界";美学在中国"... 详细信息

所谓美学的"高更问题",也就是"美学从哪里来,美学是什么,美学到哪里去"?回答"美学从哪里来"的问题,需要区分美学学科和美学思想。作为学科的美学起源于德国;文化虽有创始者,却无固定主人,因此美学起源于德国,却走向全世界";美学在中国"与"中国美学"的对立可能只是一个虚构的对立;对当代中国学者而言,美学有"双重来源",详言之,美学问题和框架来自德国,美学材料和元素却可以来自中国。回答"美学是什么"的问题,当从美学的研究对象和思维层次两方面着手。美学研究美、审美、艺术三大问题;美学处于反思的思维层次,是"第二级的思考"。广义的美学包括经验性美学和哲学美学,狭义的美学是哲学美学。哲学美学是"本来意义的美学"。关于"美学到哪里去"的问题,我们发现美学的发展往往根源于其哲学基础的变动,20世纪80年代美学热结束之后中国的美学研究已出现了一个明显的趋势,可称之为"从实践论到现象学"的转向;但是新的现象学美学与以往欧洲的现象学美学大不相同,它将呈现为"现象学的大美学观"。这一"现象学大美学"将完整地回答美、审美、艺术这三大问题,在性质上跨越形而上学的三大领域,是一个将本体论美学、认识论美学、价值论美学囊括其中的"大美学"体系。

关键词：美学高更问题现象学美学本体论认识论价值论