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Westward Migration of Tropical Cyclone Activity in the Western North Pacific during 1982–2020:Features and Possible Causes

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Journal of Meteorological Research 2024年第1期38卷 1-9页

作者： Jian ZHONG Huadong DU yuqin wu Yuehua PENG China Satellite Maritime Tracking and Control Department Jiangyin 2144312 College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 4100733 Dalian Naval Academy Dalian 1160184 Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029

The westward migration of tropical cyclone(TC)activity has been identified in the western North Pacific(WNP),but the related features and causes remain ***,based on the best track data from China,Japan,and the US,and the NCEP–NCAR reanalysis data in 1982–2020,we investigate characteristics of the westward migration of the WNP TC activity with various metrics,and reveal possible causes for the migration of TC tracks through analyzing its seasonality and dependence on environmental *** results show that the WNP TCs show significant westward migrations in a number of metrics,including location of tracks,genesis,the first track point at which TC reaches its lifetime-maximum intensity,and the last track point in the TC *** is found that TC tracks exhibit more significant westward migrations in the easterly steering flow than in the westerly steering ***,the TC longitude shift shows notable seasonal variations,for which the TCs in the easterlies move further west than those in the westerlies during July–September,vice versa during October–*** dependence of the westward migration of TC tracks on background steering flow is associated with the different environmental *** westward shift in the westerly steering is mainly due to the reduced vertical wind shear(VWS),while the weakened zonal easterly steering and reduced VWS are both closely related to the westward migration in the easterly *** results have important implications for understanding current and future variations in TC longitude shift.

关键词： tropical cyclone westward migration steering flow vertical wind shear

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儿童第四脑室及全椎管纤维脂肪性错构瘤1例

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中华解剖与临床杂志 2024年第2期29卷 130-132页

作者：邬玉芹战跃福长沙市第一医院放射科长沙410000 海南省妇女儿童医学中心放射科海口571100 深圳市龙岗区第三人民医院放射科深圳518000

患儿男,8个月18天,因"发现坐立不稳2个月"2018年3月8日于海南省妇女儿童医院神经外科住院治疗。查体:脊柱以腰部为中心向左凸起,躯体代偿性偏向右侧。既往于2017年11月6日颈椎正侧位+腰椎正侧位X线片发现脊柱以第12胸椎为中心向左侧凸弯... 详细信息

患儿男,8个月18天,因"发现坐立不稳2个月"2018年3月8日于海南省妇女儿童医院神经外科住院治疗。查体:脊柱以腰部为中心向左凸起,躯体代偿性偏向右侧。既往于2017年11月6日颈椎正侧位+腰椎正侧位X线片发现脊柱以第12胸椎为中心向左侧凸弯。2018年3月8日双髋关节正位X线片示右侧股骨位置略偏外,头颅MR平扫+增强示四脑室占位、颈段椎管内脊髓后外侧脂肪性占位(良性可能性大);2018年3月10日颈胸椎MR平扫+增强显示第四脑室和整个椎管内存在异常的呈短T1和长T2信号,其内见线状低信号,压脂序列示病灶呈低信号,DWI未见明显异常高信号,病灶未见明显强化,邻近脑干呈明显受压改变(图1),考虑脂肪瘤可能性大。临床诊断为第四脑室及全椎管脂肪瘤。

关键词：第四脑室椎管脑干肿瘤脊髓肿瘤纤维脂肪性错构瘤

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Intelligent Orchestrating of IoT Microservices Based on Reinforcement Learning

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Chinese Journal of Electronics 2022年第5期31卷 930-937页

作者： wu yuqin SHEN Congqi CHEN Shuhan wu Chunming LI Shunbin WEI Ruan College of Computer Science and Technology Zhejiang University College of Information and Electrical Engineering Ningde Normal University Zhejiang Lab College of Control Science and Engineering Zhejiang University

With the recent increase in the number of Internet of things(IoT) services, an intelligent scheduling strategy is needed to manage these services. In this paper, the problem of automatic choreography of microservices in IoT is explored. A type of reinforcement learning(RL) algorithm called TD3 is used to generate the optimal choreography policy under the framework of a softwaredefined network. The optimal policy is gradually reached during the learning procedure to achieve the goal, despite the dynamic characteristics of the network environment. The simulation results show that compared with other methods, the TD3 algorithm converges faster after a certain number of iterations, and it performs better than other non-RL algorithms by obtaining the highest reward. The TD3 algorithm can effciently adjust the traffic transmission path and provide qualified IoT services.

关键词： Internet of things Microservice Traffc scheduling Reinforcement learning

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三胶补血膏治疗晚期非小细胞肺癌化疗相关性贫血临床观察

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中华中医药学刊 2024年第6期42卷 187-190页

作者：杨静庞德湘吕汪霞吴玉琴高文仓浙江中医药大学附属第二医院浙江杭州310053 浙江省肿瘤医院浙江杭州310022

目的观察三胶补血膏治疗晚期非小细胞肺癌化疗相关性贫血的临床疗效。方法研究采用前瞻、随机、单盲、对照研究,共纳入75例患者,随机分为三组,三胶组予三胶补血膏治疗,人促红细胞生成素(EPO)组予治疗,联合组予三胶补血膏联合EPO治疗,2... 详细信息

目的观察三胶补血膏治疗晚期非小细胞肺癌化疗相关性贫血的临床疗效。方法研究采用前瞻、随机、单盲、对照研究,共纳入75例患者,随机分为三组,三胶组予三胶补血膏治疗,人促红细胞生成素(EPO)组予治疗,联合组予三胶补血膏联合EPO治疗,21 d为1个疗程,共观察3个疗程,观察血液学指标(红细胞、血红蛋白、红细胞压积)、中医证候积分、KPS评分。结果最终完成71例,3组治疗前后红细胞、血红蛋白、红细胞压积、中医症候积分、KPS评分均差异有统计学(P=0.006 7;P=0.025 8;P=0.003 1;P<0.05;P=0.039),治疗后三组组内、组间比较以上观察指标均差异有统计学(P<0.05),以EPO组为对照组,三胶组与EPO组比较,联合组与EPO组比较,红细胞、血红蛋白、红细胞压积、中医症候积分、KPS评分均差异有统计学(P<0.05)。3组均未见严重的不良反应,EPO组有1例血栓事件,其他两组均未见不良反应。结论三胶补血膏治疗非小细胞肺癌化疗相关性贫血临床疗效可靠,还可以改善中医证候及生活质量,临床可作为EPO的补充治疗手段,值得进一步临床推广。

关键词：三胶补血膏非小细胞肺癌化疗相关性贫血临床观察

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1951—2017年热带气旋移动速度特征统计分析

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气象科学 2024年第2期44卷 301-307页

作者：钟剑韩苗苗吴玉琴孙一妹中国卫星海上测控部江苏江阴214431

热带气旋移动速度是目前热带气旋研究热点之一。本文利用1951—2017年中国国家气象局最佳路径集资料,系统分析了西北太平洋海域热带气旋不同强度等级移动速度的年代际特征,初步探讨其原因,并对不同强度等级移动速度的分布特征进行系统... 详细信息

热带气旋移动速度是目前热带气旋研究热点之一。本文利用1951—2017年中国国家气象局最佳路径集资料,系统分析了西北太平洋海域热带气旋不同强度等级移动速度的年代际特征,初步探讨其原因,并对不同强度等级移动速度的分布特征进行系统诊断。结果表明,1951—2017年间平均移动速度(所有强度等级平均及对于大部分强度等级)呈现出减慢趋势,且主要体现在强热带气旋等级移动速度减慢;热带气旋向高纬度迁移趋势理论上将使移动速度增大而移动速度仍然减慢,说明气候因素是引起移动速度减慢的一个重要因素;不同强度等级平均移动速度、增强阶段基本相当,减弱阶段随强度减弱在初、中期明显增加,之后又逐渐减小,变性气旋移动速度显著增加;不同强度等级速度概率分布,增强阶段基本相同且相对集中,减弱阶段差异较大且相对分散,变性气旋最为分散。

关键词：最佳路径集资料热带气旋移动速度特征统计

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Insights into the proteomic profile of newly harvested corn and metagenomic analysis of the broiler intestinal microbiota

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Journal of Animal Science and Biotechnology 2022年第3期13卷 787-801页

作者： Dafei Yin Youli Wang Liqun Wang yuqin wu Xiaoyi Bian Samuel E.Aggrey Jianmin Yuan College of Animal Husbandry and Veterinary Medicine Shenyang Agricultural UniversityShenyang 110866China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural University100193 BeijingChina NutriGenomics Laboratory Department of Poultry ScienceUniversity of GeorgiaAthensGA 30602USA

Background:The use of newly harvested corn in feed causes wet droppings in broilers and increased feed cost which was termed as“new season grain problem”.The present study was conducted to evaluate the proteomic profile of newly harvested corn and the subsequent influence on intestinal microbiol community for broiler ***:Newly harvested corn stored for either half a month(HM)or two months(TM)was used,and the pasting properties,total soluble sugars,and proteomic analysis technology was used to explore the influence of storage on natural aging corn ***,seventy-two 7-day-old Ross 308 male broiler chicken were fed with different stored *** metabolizable energy(AME),digesta viscosity,intestinal morphology and microbiota were examined to explore the influence of feed corn storage on broiler ***:Pasting properties in the TM corn exhibited decreased viscoelastic *** studies found a total of 26 proteins that were differentially expressed between the two treatment *** involved in starch and polysaccharides biosynthesis were upregulated in TM compared with *** fed on TM diet had higher relative energy utilization compared to the HM *** increased corn storage,the relative digesta viscosity decreased significantly(P≤0.05).The total number of goblet cells and lymphocytes was lower in chickens fed the TM *** microbiota data showed that the TM chickens had decreased abundance of diarrheal bacteria such as Hungatella hathewayi and Bacteroides fragilis,and increased butyrate-producing bacteria such as Alistipes compared to the HM ***:Storage of newly harvested corn induced the synthetic reaction of large molecules and changed the solubility of starch and protein with increasing soluble sugars and decreasing pasting properties that may improve the fermentation of intestinal microbiota,improve the energy utilization and protect gut health without the risk of diarrhe

关键词： Broilers Corn Metagenome Proteome Storage

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一种稻田开厢平整装置的设计与应用

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南方农机 2024年第2期55卷 151-153页

作者：吴宇琴胡萌林娇潘翠华王富贾俊荆门职业学院湖北荆门448000 荆门(中国农谷)农业科学研究院湖北荆门448000

【目的】水育秧以人工开沟抹平厢面为主,水稻田机械开沟开厢难以成型且厢面平整不一,易导致秧苗出苗不一致,影响育秧质量。【方法】课题组立足生产实际和科研试验标准化需要,以水稻水育秧和水直播的厢面和开沟的尺寸要求为主要指标依据... 详细信息

【目的】水育秧以人工开沟抹平厢面为主,水稻田机械开沟开厢难以成型且厢面平整不一,易导致秧苗出苗不一致,影响育秧质量。【方法】课题组立足生产实际和科研试验标准化需要,以水稻水育秧和水直播的厢面和开沟的尺寸要求为主要指标依据,设计出了一种开厢平整一体化机械装置,并进行了实地调试优化。【结果】该装置可实现开厢平整一体化,且可根据实际需要对厢面宽度和沟宽、沟深进行调节,厢面宽度调节范围为1.5 m~3.0 m,沟宽调节范围为0.3 m~0.5 m,沟深调节范围为0.1 m~0.3 m,满足科研试验水育秧或水稻直播生产的要求。【结论】该装置有效地保障了科研试验的标准化,提高了田间生产的统一水平和开沟开厢的效率,降低了生产用工成本,具有较好的应用前景。

关键词：稻田开厢平整装置育秧调节装置

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NLR、LDH、IL-6在肺炎支原体肺炎患儿病情及预后评估中的价值

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发育医学电子杂志 2024年第4期12卷 278-283页

作者：吴玉芹黄荣卫刘兴祝杨燕飞王智海昆明市儿童医院特需病区云南昆明630228

目的探讨肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)患儿中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、乳酸脱氢酶(lactate dehydrogenase,LDH)、白细胞介素-6(lnterleukin-6,IL-6)水平在预后评估中的价值。方法采用前瞻性研究方法,选取2020年9月至2021年2月昆明市儿童医院收治的180例MPP患儿作为观察组,其中普通患儿104例,重症患儿76例;另选取同期健康体检儿童60例作为对照组。比较观察组和对照组NLR、LDH、IL-6水平,评价NLR、LDH、IL-6对MPP患儿病情严重程度的评估价值。根据MPP预后情况,将患儿分为预后不良组(n=35)和预后良好组(n=145)。比较不同预后MMP患儿的临床资料、NLR、LDH、IL-6水平,分析MPP患儿预后影响因素及NLR、LDH、IL-6与临床肺部感染评分(Clinical Pulmonary Infection Score,CPIS)、白细胞计数(white blood cell count,WBC)、降钙素原(procalcitonim,PCT)及C反应蛋白(C-reactive protein,CRP)的相关性。统计学方法采用t检验、χ^(2)检验、Logistic回归分析、受试者操作特征(receiver operating characteristic,ROC)曲线分析、Spearman模型分析。结果观察组普通、重症患儿及对照组儿童NLR分别为1.5±0.3、2.2±0.3、1.2±0.2,LDH水平分别为(439.8±30.1)U/L、(528.6±35.6)U/L、(125.8±28.9)U/L,IL-6水平分别为(18.3±1.3)ng/L、(25.8±2.1)ng/L、(9.5±1.2)ng/L;观察组普通、重症患儿NLR、LDH、IL-6水平高于对照组(NLR:t=10.135、27.514,LDH:t=86.323、103.974,IL-6:t=44.834、84.297,P值均<0.05),且观察组普通患儿NLR、LDH、IL-6水平低于重症患儿(NLR:t=20.599,LDH:t=26.252,IL-6:t=48.065,P值均<0.05)。NLR、LDH、IL-6联合评估的曲线下面积(area under the curve,AUC)最大,为0.911,灵敏度、特异度分别为82.89%、89.42%;CPIS评分(OR=7.232,95%CI:5.055~10.347)、WBC(OR=6.839,95%CI:4.752~9.844)、PCT(OR=8.882,95%CI:6.375~12.374)、CRP(OR=11.520,95%CI:8.125~16.333)、NLR(OR=11.517,95%CI:7.852~16.894)、LDH(OR=11.881,95%CI:7.698~18.337)、IL-6(OR=12.424,95%CI:8.025~19.235)均为MPP患儿预后的独立危险因素(P值均<0.05);MPP患儿NLR、LDH、IL-6水平与CPIS评分、WBC、PCT、CRP均呈正相关(P值均<0.05)。结论MPP患儿NLR、LDH、IL-6水平明显升高,可作为MPP病情及预后评估的潜在指标。

关键词：肺炎支原体肺炎中性粒细胞与淋巴细胞比值乳酸脱氢酶白细胞介素-6 病情严重程度预后

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Methionine deficiency and its hydroxy analogue influence chicken intestinal 3-dimensional organoid development

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Animal Nutrition 2022年第1期8卷 38-51页

作者： Youli Wang Qihang Hou yuqin wu Yanwei Xu Yan Liu Jing Chen Lingling Xu Yuming Guo Shuai Gao Jianmin Yuan State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China Key Laboratory of Animal Gene Breeding and Reproductivity National Engineering Laboratory of Animal BreedingCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China Beijing Dafa Chia Tai Co.Ltd. Beijing101206China Sichuan New Hope Liuhe Co.Ltd Chengdu610100China

Methionine and its hydroxy analogue(MHA)have been shown to benefit mouse intestinal *** intestinal organoid is a good model that directly reflects the impact of certain nutrients or chemicals on intestinal ***,we aimed to establish a chicken intestinal organoid culture method first and then use the model to explore the influence of methionine deficiency and MHA on intestinal organoid *** results showed that 125-mm cell strainer exhibited the highest efficiency for chicken embryo crypt *** found that transforming growth factor-b inhibitor(A8301)supplementation promoted enterocyte differentiation at the expense of the proliferation of intestinal stem cells(ISC).The mitogen-activated protein kinase p38 inhibitor(SB202190)promoted intestinal organoid formation and enterocyte differentiation but suppressed the differentiation of enteroendocrine cells,goblet cells and Paneth ***,the suppression of enteroendocrine cell and Paneth cell differentiation by SB202190 was alleviated at the presence of *** glycogen synthase kinase 3 inhibitor(CHIR99021),valproic acid(VPA)alone and their combination promoted chicken intestinal organoid formation and enterocyte differentiation at the expense of the expression of Paneth cells and goblet *** serum significantly improved organoid formation,especially in the presence of A8301,SB202190,CHIR99021,and VPA,but inhibited the differentiation of Paneth cells and enteroendocrine *** serum at a concentration of 0.25%meets the requirement of chicken intestinal organoid development,and the beneficial effect of chicken serum on chicken intestinal organoid culture could not be replaced by fetal bovine serum and insulin-like growth ***,commercial mouse organoid culture medium supplemented with A8301,SB202190,CHIR99021,VPA,and chicken serum promotes chicken organoid *** on the chicken intestinal organoid model,we found that methionine deficienc

关键词： Chicken intestinal organoid Chicken serum Methionine

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Autocatalytic strategy for tuning drug release from peptide-drug supramolecular hydrogel

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Chinese Chemical Letters 2023年第10期34卷 204-208页

作者： yuqin wu Tian Xia Xiaohui Ma Lei Lei Lulu Du Xiaoning Xu Xiangyi Liu Yueting Shi Xingyi Li Deqing Lin Institute of Biomedical Engineering School of Ophthalmology&Optometry and Eye HospitalWenzhou Medical UniversityWenzhou 325027China

Peptide-drug conjugates(PDCs) composed of peptide, spacer and drug have gained extensive attention in the field of drug delivery owing to its precise control over the drug payload and architecture. However,the achievement of controllable and rapid drug release at targeted site by PDCs is still a great challenge for pharmaceutist. Herein, we introduced the histidine residue into PDCs to generate a supramolecular hydrogel via a p H-trigger strategy, which exhibited an autocatalytic effect to precisely tune drug release from PDCs hydrogel. Using indomethacin(Idm) as model drug, various PDCs(Y(Idm)EEH, Y(Idm)EEK and Y(Idm)EER) were synthesized and their self-assembling properties were investigated in terms of critical aggregation concentration(CAC), transmission electron microscopy(TEM) and rheometer. Introduction of histidine residue into PDCs presented a robust catalytic activity on the ester hydrolysis of p-nitrophenyl acetate in aqueous solution, as well conferred the autocatalytic capacity to hydrolyze the PDCs into active parent drug(Idm). Overall, we reported an autocatalytic activity of histidine residue to precisely tune drug release from PDCs hydrogels.

关键词： Peptide-drug conjugates Supramolecular hydrogel Autocatalysis Hydrolysis Drug release

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