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神经干/祖细胞应用于阿尔兹海默症治疗的现状与挑战

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中国生物工程杂志 2024年第7期44卷 58-71页

作者：鲍莉潘辉纪猛吴月红吕正兵浙江理工大学生命科学与医药学院杭州310018 浙江泉生生物工程有限公司杭州310018

阿尔茨海默症(Alzheimer's disease,AD)是一种进行性神经退行性疾病,主要导致认知和记忆能力进行性损害,影响着全球5000多万人,给社会带来的负担正在日益增加。AD的病理学特征复杂多样,包括淀粉样β肽沉积、过度磷酸化Tau蛋白以及突触... 详细信息

阿尔茨海默症(Alzheimer's disease,AD)是一种进行性神经退行性疾病,主要导致认知和记忆能力进行性损害,影响着全球5000多万人,给社会带来的负担正在日益增加。AD的病理学特征复杂多样,包括淀粉样β肽沉积、过度磷酸化Tau蛋白以及突触连接丧失。神经干/祖细胞(neural stem/progenitor cells,NSPCs)是一种特殊类型的细胞,具有自我更新和多能分化的能力,可以分化为多种类型的神经元和神经胶质细胞。NSPC移植疗法因其促进突触连接和功能恢复以改善AD症状而备受关注。概述AD动物模型中NSPC移植治疗的研究现状,总结NSPC治疗AD的最新临床试验进展,讨论NSPC移植面临的问题和挑战,为NSPC治疗AD的临床研究提供参考。

关键词：神经干/祖细胞多能干细胞阿尔茨海默症细胞移植治疗

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运用地方红色资源推进“大思政课”建设的“234”模式

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安徽理工大学学报（社会科学版） 2024年第2期26卷 96-101页

作者：吴月红李海涛安徽工程大学马克思主义学院安徽芜湖241000 安徽工程大学皖江红色文化研究中心安徽芜湖241000

红色资源是中国特色社会主义文化资源的重要组成部分,其蕴含的思想价值、教育价值和时代价值与高校“大思政课”建设在价值导向、思想引领和核心内容上高度契合。文章认为,在遵循坚持党的领导、坚持价值引领、坚持系统观念的原则下,通... 详细信息

红色资源是中国特色社会主义文化资源的重要组成部分,其蕴含的思想价值、教育价值和时代价值与高校“大思政课”建设在价值导向、思想引领和核心内容上高度契合。文章认为,在遵循坚持党的领导、坚持价值引领、坚持系统观念的原则下,通过健全“两大机制”、善用“三支队伍”、建设“四个课堂”,打造运用地方红色资源推进“大思政课”建设的“234”模式,能够不断增强思政课的思想性、理论性和亲和力、针对性。

关键词：地方红色资源 “大思政课” 立德树人模式

多能干细胞治疗视网膜退行性疾病:从实验室到临床转化的现状与挑战

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浙江理工大学学报（自然科学版） 2024年第1期51卷 130-144页

作者：郭艳鲍莉纪猛吴月红浙江理工大学生命科学与医药学院杭州310018 浙江泉生生物工程有限公司杭州310018

视网膜色素上皮细胞(Retinal pigment epithelial cells,RPE)是位于视网膜底部致密的细胞层,其损伤导致年龄相关性黄斑变性(Age-related macular degeneration,AMD)、Stargardt病(Stargardt macular dystrophy,STGD)和色素性视网膜炎(Retinitis pigmentosa,RP)等视网膜疾病,RPE移植已成为治疗RPE损伤性疾病的有效方案。来源于人多能干细胞(Human pluripotent stem cells,hPSC)的视网膜色素上皮细胞,具有与人原代RPE相似的功能和容易制备等优点,已成为RPE移植的最主要细胞来源之一。文章对hPSC-RPE治疗视网膜退行性疾病的临床试验进展进行了总结和归纳,并阐述了目前面临的挑战与风险。

关键词：人多能干细胞视网膜色素上皮细胞年龄相关性黄斑变性 Stargardt病色素性视网膜炎细胞治疗

“全院一张床”模式下科室成本核算的创新做法

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卫生经济研究 2024年第6期41卷 78-81页

作者：曾春来吴月红李晶辉楼诗倩李汉阳洪晓庆丽水市人民医院浙江丽水323000 联众智慧科技股份有限公司浙江杭州310000

“全院一张床”模式打破了医院各科室之间固定床位的壁垒,但同时也模糊了传统科室的边界,对科室成本核算提出了新的挑战。对此,可设置学科医生组和病区护理组两个不同维度的科室成本核算对象,分别进行收入确认、成本归集与分摊,最后进... 详细信息

“全院一张床”模式打破了医院各科室之间固定床位的壁垒,但同时也模糊了传统科室的边界,对科室成本核算提出了新的挑战。对此,可设置学科医生组和病区护理组两个不同维度的科室成本核算对象,分别进行收入确认、成本归集与分摊,最后进行医护成本双向交互分摊,同时核算学科医生组和病区护理组两个维度的科室成本,进而满足绩效考核、优化资源配置等方面的管理需求。

关键词：全院一张床床位管理模式科室成本核算双向交互分摊

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义丰溪湿地植被恢复对土壤理化性质的影响

林业与环境科学 2024年第1期40卷 106-111页

作者：吴悦宏肖泽鑫纪燕玲林文欢朱晓武许业丰汕头市林业科学研究所广东汕头515041

为了解义丰溪湿地植被恢复后土壤理化性质的变化情况,选取义丰溪红树林湿地为研究对象,以光滩为对照,分析不同植被恢复模式下(无瓣海桑Sonneratia apetala纯林、无瓣海桑+桐花树Aegiceras corniculatum+秋茄Kandelia obovata+卤蕨Acrost... 详细信息

为了解义丰溪湿地植被恢复后土壤理化性质的变化情况,选取义丰溪红树林湿地为研究对象,以光滩为对照,分析不同植被恢复模式下(无瓣海桑Sonneratia apetala纯林、无瓣海桑+桐花树Aegiceras corniculatum+秋茄Kandelia obovata+卤蕨Acrostichum aureum混交林)土壤0~30 cm土层的pH、有机质、全氮、碱解氮、全磷、有效磷、全钾和速效钾等养分指标的动态变化。结果表明:植被恢复20 a后,土壤pH值显著下降,土壤有机质、全氮、碱解氮、全磷、有效磷、全钾、速效钾含量显著增加;不同恢复模式下,除pH值外,混交林土壤有机质、全氮、碱解氮、全磷、有效磷、全钾和速效钾含量均显著高于纯林(P<0.05),说明混交林模式的土壤养分含量较高,植被恢复效果较好。因此,在后续的红树林营造修复中应采用混交林模式以确保植被的恢复效果。

关键词：义丰溪湿地红树林植被恢复土壤理化性质

Microbial community structure and nitrogenase gene diversity of sediment from a deep-sea hydrothermal vent field on the Southwest Indian Ridge

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Acta Oceanologica Sinica 2014年第10期33卷 94-104页

作者： wu yuehong CAO Yi WANG Chunsheng wu Min AHARON Oren XU Xuewei Laboratory of Marine Ecosystem and Biogeochemistry Second Institute of Oceanography State Oceanic Administration State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences College of Life Sciences Zhejiang University Department of Plant and Environmental Sciences the Alexander Silberman Institute of Life Sciences The Hebrew University of JerusalemJerusalem 91904 Israel The Hebrew University of Jerusalem The Edmond J. Safra CampusGivat Ram Jerusalem 91904 Israel

A sediment sample was collected from a deep-sea hydrothermal vent field located at a depth of 2 951 m on the Southwest Indian Ridge. Phylogenetic analyses were performed on the prokaryotic community using polymerase chain reaction（PCR） amplification of the 16 S rRNA and nifH genes. Within the Archaea, the dominant clones were from marine benthic group E（MBGE） and marine group I（MGI） belonging to the phyla Euryarchaeota and Thaumarchaeota, respectively. More than half of the bacterial clones belonged to the Proteobacteria, and most fell within the Gammaproteobacteria. No epsilonproteobacterial sequence was observed. Additional phyla were detected including the Actinobacteria, Bacteroidetes, Planctomycetes, Acidobacteria, Nitrospirae, Chloroflexi, Chlorobi, Chlamydiae, Verrucomicrobia, and candidate divisions OD1, OP11, WS3 and TM6, confirming their existence in hydrothermal vent environments. The detection of nifH gene suggests that biological nitrogen fixation may occur in the hydrothermal vent field of the Southwest Indian Ridge. Phylogenetic analysis indicated that only Clusters I and III NifH were present. This is consistent with the phylogenetic analysis of the microbial 16 S rRNA genes, indicating that Bacteria play the main role in nitrogen fixation in this hydrothermal vent environment.

关键词： deep-sea hydrothermal vent microbial diversity 16S rRNA gene nifH gene

Isolation and Phylogenetic Analysis of Halophilic Archaeon AJ6

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Frontiers in Biology 2006年第1期1卷 29-34页

作者： Xu Xiaohong wu Min Cao Yi wu yuehong Zhang Ting Ningbo Institute of Technology Zhejiang UniversityNingboZhejiang Province 315100China College of Life Sciences Zhejiang UniversityNingboZhejiang Province 315100China

Halophilic archaeon AJ6 was isolated and purified from the Altun Mountain National Nature Reserve of the Xinjiang Uygur Autonomous *** AJ6 is a Gram-negative rod whose size is 0.2–0.6 by 1.6–4.2μm,wherein a few cells are *** optimum salt concentration for its growth is 20%NaCl and 0.6%Mg^(2+),and the optimum pH is 6.0–***,physiological,and biochemical characteristics of strain AJ6 were *** 16S rRNA encoding gene(16S rDNA)sequence of strain AJ6 was amplified by PCR,and its nucleotide sequence was determined subsequently.“Clustalw”and“PHYLIP”software bags were used to analyze the 16S rDNA sequence;the homology was compared,and then the phylogenetic tree was *** results indicate that strain AJ6 is a novel species of the genus *** GenBank accession number of the 16S rDNA sequences of strain AJ6 is AY277584.

关键词： extremely halophilic archaea salt lake Altun Mountain National Nature Reserve 16S rDNA gene phylogeny

S-wave velocity structure beneath Changbaishan volcano inferred from receiver function

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Earthquake Science 2009年第4期22卷 409-416页

作者： Jianping wu yuehong Ming Lihua Fang Weilai Wang Institute of Geophysics China Earthquake Administration Beijing 100081 China

The S wave velocity structure in Changbaishan volcanic region was obtained from teleseismic receiver function modeling. The results show that there exist distinct low velocity layers in crust in volcano area. Beneath WQD station near to the Tianchi caldera the low velocity layer at 8 km depth is 20 km thick with the lowest S-wave velocity about 2.2 km/s At EDO station located 50 km north of Tianchi caldera, no obvious crustal low velocity layer is detected. In the volcanic region, the thickness of crustal low velocity layer is greater and the lowest velocity is more obvious with the distance shorter to the caldera. It indicates the existence of the high temperature material or magma reservoir in crust near the Tianchi caldera. The receiver functions and inversion result from different back azimuths at CBS permanent seismic station show that the thickness of near surface low velocity layer and Moho depth change with directions. The near surface low velocity layer is obviously thicker in south direction. The Moho depth shows slight uplifting in the direction of the caldera located. We con- sider that the special near surface velocity structure is the main cause of relatively lower prominent frequency of volcanic earthquake waveforms recorded by CBS station. The slight uplifting of Moho beneath Tianchi caldera indicates there is a material exchanging channel between upper mantle and magma reservoir in crust.

关键词： Changbaishan volcano seismic velocity structure receiver function

Effects of Freeze-Thaw Cycles on Physical and Mechanical Properties of Glulam Exposed to Outdoor Environment

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Journal of Renewable Materials 2021年第7期9卷 1293-1307页

作者： Ruyuan Yang Haitao Li Assima Dauletbek Mahmud Ashraf Rodolfo Lorenzo Youfu Sun yuehong wu College of Materials Science and Engineering Nanjing Forestry UniversityNanjingChina College of Civil Engineering Nanjing Forestry UniversityNanjingChina University College London LondonWC1E 6BTUK School of Engineering Deakin UniversityGeelongVIC 3216Australia

This paper presents an experimental investigation to identify suitable indices to assess durability of glulam when subjected to freeze-thaw cycles in an exposed *** this study,two types of glulam specimens were tested for their performance when subjected to different levels of aging due to freezing and *** of aging treatment on various parameters including thickness swelling rate,static bending strength,elastic modulus,shear strength,and peeling rate of adhesive layer were *** results showed that freeze-thaw aging treatment did not affect the water-resistance of the specimens as measured by thickness swelling rate and had little effect on the dimensional stability of the ***,the applied aging treatment weakened the bending resistance of the glulam specimens with more pronounced effects on on low-density *** the other hand,bond strength of high-density wood was relatively more affected due to the appliedfreeze-thaw *** highdensity wood,it is suggested that the shear strength of the adhesive layer be taken as an important index to determine the durability of freeze-thaw cycles *** low-density wood,on the other hand,the static bending strength can be used as an index to determine the durability of glulam under freeze-thaw cycles aging.

关键词： Freeze-thaw cycles structural glulam durability wood failure percentage accelerated aging