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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： you wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

THE SECOND-ORDER HYDROELASTIC ANALYSIS OF A SWATH SHIP MOVING IN LARGE-AMPLITUDE WAVES

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Journal of Hydrodynamics 2006年第6期18卷 631-639页

作者： TIAN Chao wu you-Sheng School of Naval Architecture Ocean and Civil Engineering Shanghai Jiaotong University Shanghai 200030China China Ship Scientific Research Center Wuxi 214082 China

Based on the second order hydroelasticity theory of ships, the numerical methods and the calculated results of the non-linear hydroelastic responses of a ship traveling in rough seas were investigated. The non-linear hydrodynamic actions induced by the rigid body rotations and the variations of instantaneous wetted surface area were included in the second order analysis. The first order wave potentials and responses, which are sure to make the major contributions to the second order hydrodynamic actions, were obtained by employing the translating and pulsating source Green function and the Kelvin steady wave flow solution based on the linear three-dimensional hydroelasticity theory. The influences of the forward speed and the steady wave flow on the responses, and the differences of the predicted non-linear responses were illustrated by the numerical examples of a SWATH ship traveling with forward speed of 12 kn in irregular waves.

关键词： hydroelaticity, non-linear responses, second order forces, translating and pulsating source, SWATH (Small Waterplane Area Twin Hull) ship

体认翻译学视域下“水”隐喻英译研究——以许渊冲《李白诗选》英译本为例

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语言与文化研究

语言与文化研究 2025年第1期33卷 169-173页

作者：吴优李国宏西华大学外国语学院成都610039

在李白诗歌中,存在大量水隐喻。本研究将在体认翻译学视域下,以许渊冲译《李白诗选》为语料,将水隐喻按照本体、结构和方位隐喻三个类型来探究其具体的隐喻翻译策略。研究发现:1)李白诗歌中本体隐喻相对较多,诗人多倾向于将具体可见的... 详细信息

在李白诗歌中,存在大量水隐喻。本研究将在体认翻译学视域下,以许渊冲译《李白诗选》为语料,将水隐喻按照本体、结构和方位隐喻三个类型来探究其具体的隐喻翻译策略。研究发现:1)李白诗歌中本体隐喻相对较多,诗人多倾向于将具体可见的事物映射到抽象不可见的情感中,极具感染力。2)水隐喻翻译主要有两种策略:一是映射对等翻译策略,即基于体验的普遍性,占27.8%;二是偏移等效翻译策略,即基于认知加工的差异性,占72.2%。3)译者多采用偏移等效的翻译策略,主张传递古诗的“言外之意”,使译文更为英语读者所接受。本研究一方面论证了体认翻译学的价值所在,另一方面也为李白诗歌翻译实践提供一点借鉴,促进中华文化更好地“走出去”。

关键词：体认翻译学水隐喻翻译策略李白诗歌许渊冲

A new analysis approach to the output constraint and its application in high-order nonlinear systems

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Science China(Information Sciences) 2023年第5期66卷 299-300页

作者： you wu Xuejun XIE Institute of Automation Qufu Normal University

Many practical nonlinear systems need to consider the output constraint due to performance requirements and safety specifications. In the past decade, barrier Lyapunov function (BLF) and nonlinear mapping (NM), which were first defined in [1,2], respectively, have become two representative tools to handle the output constraint. The biggest merit of the NM-based approach is to directly deal with the original output constraint rather than indirectly limit the relevant error signal in the BLF-based approach.

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A waveform modification method for testing dynamic properties of rock under high temperature

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 833-844页

作者： Tubing Yin Chao Wang you wu Bingqiang wu School of Resources and Safety Engineering Central South UniversityChangsha410083China

In this study,a waveform modification method was proposed using a self-designed heating device combined with the split Hopkinson pressure bar(SHPB)technique for determination of dynamic behaviors of rock at high ***,the temperature gradient distribution on the incident bar was measured according to the variation of elastic modulus of the bar with temperature,and the relationship between the longitudinal wave velocity and temperature of the bar was obtained based on onedimensional stress wave *** incident bar with a temperature gradient was divided into a series of microelements,and then the transmission coefficient of the whole incident bar was ***,the stress wave was modified by the transmission coefficient from 25℃ to 600℃.This method was used to study the dynamic properties of rock at high temperature,which not only preserves a classical SHPB device,but also effectively ensures the accuracy of the experimental results.A dynamic Brazilian disc experiment was carried out to explore the influences of loading rate and temperature on dynamic tensile strength of sandstone at high temperature using the proposed waveform modification method.

关键词： High temperature Split Hopkinson pressure bar(SHPB) Dynamic loading Rock materials Mechanical properties

Phenotypic Classification of Well-Differentiated Gastric Adenocarcinoma

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Chinese Journal of Cancer Research 2009年第4期21卷 278-289页

作者： Ying wu Zhong-wu Li Ji-you Li Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department ofPathology Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142China

Objective： To investigate the genotypes of well-differentiated non-cardiac gastric adenocarcinoma and their clinicopathological significance. Methods： Sixty-four cases of well-differentiated non-cardiac gastric adenocarcinoma were included in this study. The expressions of intestinal phenotypic markers including CDX2, MUC2, Li-cadherin, CD10, Hepatocyte（Hep） and Villin, and gastric phenotypic markers including MUC5AC and pS2 were detected immunohistochemically. Based on the expressions of phenotypic markers, 64 cases can be divided into four phenotypes. Cases only expressing intestinal phenotypic markers were classified as intestinal phenotype; cases only expressing gastric phenotypic markers as gastric phenotype; cases expressing both intestinal and gastric phenotypic markers as gastrointestinal phenotype; and cases expressing neither intestinal nor gastric phenotypic marker as null phenotype. The association of phenotype and clinic-pathological parameters was analyzed. We also detected the expressions of markers related to the development and progression of cancer, including Rb, P53, c-Met, MIF, TGF-β-RII, β-catenin, CD44v6 and E-cadherin. Results： Of 64 cases, 33（51.6%） were intestinal type, 3（4.7%） were gastric type, 25（39.1%） were gastrointestinal type and 3（4.7%） were null type. Fifty-eight cases were either intestinal or gastrointestinal type, which accounted for 90.6% of all the cases. In addition, there was an association between phenotype and biological behaviors （invasion or metastasis）. The biological behaviors of intestinal and gastrointestinal type were better than gastric type. Compared with intestinal, gastric and gastrointestinal types, the biological behaviors of null type were the most aggressive. The biological behaviors of gastric carcinoma tended to be better as the number of expression of intestinal markers increased. Expression of markers related to the development and progression of cancer was not significantly correlated with phenotypes a

关键词： Gastric carcinoma Phenotype Immunohistochemistry Biological behavior

Probing the catalytic activity of M-N_(4−x)O_(x) embedded graphene for the oxygen reduction reaction by density functional theory

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Frontiers of Chemical Science and Engineering 2021年第5期15卷 1206-1216页

作者： Fan Ge Qingan Qiao Xin Chen you wu State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China School of Chemistry and Materials Science Ludong UniversityYantai264025China Center for Computational Chemistry and Molecular Simulation College of Chemistry and Chemical EngineeringSouthwest Petroleum UniversityChengdu610500China Oil&Gas Field Applied Chemistry Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringSouthwest Petroleum UniversityChengdu610500China

In this work,the detailed oxygen reduction reaction(ORR)catalytic performance of M-N_(4−x)O_(x)(M=Fe,Co,and Ni;x=1−4)has been explored via the detailed density functional theory *** results suggest that the formation energy of M-N_(4−x)O_(x)shows a good linear relationship with the number of doped O *** adsorption manner of O_(2)on M-N_(4−x)O_(x)changed from end-on(x=1 and 2)to side-on(x=3 and 4),and the adsorption strength gradually *** on the results for binding strength of ORR intermediates and the Gibbs free energy of ORR steps on the studied catalysts,we screened out two highly active ORR catalysts,namely Co-N_(3)O_(1)and Ni-N_(2)O_(2),which possess very small overpotentials of 0.27 and 0.32 V,*** activities are higher than the precious Pt *** structure analysis reveals one of the reasons for the higher activity of Co-N_(3)O_(1)and Ni-N_(2)O_(2)is that they have small energy gaps and moderate highest occupied molecular orbital energy ***,the results of the density of states reveal that the O doping can improve the electronic structure of the original catalyst to tune the adsorption of the ORR intermediates.

关键词： M-N-C catalyst oxygen doping oxygen reduction reaction catalytic activity density functional theory

New perspective in statistical modeling of wall-bounded turbulence

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Acta Mechanica Sinica 2010年第6期26卷 847-861页

作者： Zhen-Su She Xi Chen you wu Fazle Hussain State Key Laboratory for Turbulence and Complex Systems and Department of Mechanical and Aerospace Engineering College of EngineeringPeking University100871 BeijingChina Department of Mechanical Engineering University of Houston HoustonTX 77204-4792USA

Despite dedicated effort for many decades,statistical description of highly technologically important wall turbulence remains a great *** models are unfortunately incomplete,or empirical,or *** a review of the existing theories of wall turbulence,we present a new framework,called the structure ensemble dynamics （SED）,which aims at integrating the turbulence dynamics into a quantitative description of the mean *** SED theory naturally evolves from a statistical physics understanding of non-equilibrium open systems,such as fluid turbulence, for which mean quantities are intimately coupled with the fluctuation *** from the ensemble-averaged Navier-Stokes（EANS） equations,the theory postulates the existence of a finite number of statistical states yielding a multi-layer picture for wall ***,it uses order functions（ratios of terms in the mean momentum as well as energy equations） to characterize the states and transitions between *** of the SED analysis to an incompressible channel flow and a compressible turbulent boundary layer shows that the order functions successfully reveal the multi-layer structure for wall-bounded turbulence, which arises as a quantitative extension of the traditional view in terms of sub-layer,buffer layer,log layer and wake. Furthermore,an idea of using a set of hyperbolic functions for modeling transitions between layers is proposed for a quantitative model of order functions across the entire flow *** conclude that the SED provides a theoretical framework for expressing the yet-unknown effects of fluctuation structures on the mean quantities,and offers new methods to analyze experimental and simulation *** with asymptotic analysis,it also offers a way to evaluate convergence of *** SED approach successfully describes the dynamics at both momentum and energy levels, in contrast with all prevalent approaches describing the mean velocity profile

关键词： Wall turbulence Statistical modeling Structure ensemble dynamics Order function Multi-layer

Pylorus-preserving gastrectomy for early gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 653-658页

作者： Ke-Kang Sun Yong-you wu Department of Gastrointestinal Surgery The Affiliated Kunshan Hospital to Jiangsu UniversitySuzhou 215300Jiangsu ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Soochow UniversitySuzhou 215008Jiangsu ProvinceChina

Pylorus-preserving gastrectomy(PPG)has been widely accepted as a function-preserving gastrectomy for middle-third early gastric cancer(EGC)with a distal tumor border at least 4 cm proximal to the *** procedure essentially preserves the function of the pyloric sphincter,which requires to preserve the upper third of the stomach and a pyloric cuff at least 2.5 *** suprapyloric and infrapyloric vessels are usually preserved,as are the hepatic and pyloric branches of the vagus *** with distal gastrectomy,PPG has significant advantages in preventing dumping syndrome,body weight loss and bile reflux *** postoperative complications after PPG have reached an acceptable *** can be considered a safe,effective,and superior choice in EGC,and is expected to be extensively performed in the future.

关键词： Gastric cancer Pylorus-preserving gastrectomy Oncological safety Gastric stasis

Left-definite boundary conditions of Sturm-Liouville problems when the interval shrinks to a point

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Applied Mathematics(A Journal of Chinese Universities) 2011年第1期26卷 29-37页

作者： GAO Yun-lan WANG Zhong wu Hong-you Department of Mathematics Inner Mongolia University of Technology Huhhot 010051 China Department of Mathematics ZhaoQing University Zhaoqing 526061 China Department of Mathematics Northern Illinois University DeKalb IL60115 USA

On the condition that the interval of the problem shrinks to a point, we investigated the separated boundary conditions Sα,β of left-definite Sturm-Liouville problem, and answered the following question： Is there a co ∈ J such that Sα,β is always left-definite or semi-left-definite for the Sturm-Liouville equation for each c ∈ （a, co）？

关键词： Left-definite Sturm-Liouville problem semi-left-definite Sturm-Liouville problem separatedboundary condition.