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Hierarchical palladium catalyst for highly active and stable water oxidation in acidic media

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National Science Review 2023年第2期10卷 157-164页

作者： Jing Peng Haofeng sun Kun Ni Jiajing {1. Xinyu sun Yueqi su Han Cheng Yuhua Liu Yuqiao guo Wentuan Bi Yan{1. zhu Changzheng {1. Yi Xie Hefei National Laboratory for Physical Science at the Microscale CAS Center for Excellence in NanoscienceiChEM (Collaborative Innovation Center of Chemistry for Energy Materials) and CAS Key Laboratory of Mechanical Behavior and Design of Materials University of Science and Technology of China Institute of Energy Hefei Comprehensive National Science Center

Acidic water electrolysis is of great importance for boosting the development of renewable ***,it severely suffers from the trade-off between high activity and long lifespan for oxygen evolution catalysts on the anode *** is because the sluggish kinetics of oxygen evolution reaction necessitates the application of a high overpotential to achieve considerable current,which inevitably drives the catalysts far away from their thermodynamic equilibrium *** we demonstrate a new oxygen evolution model catalyst-hierarchical palladium(Pd) whose perfor{1.nce even surpasses the bench{1.rk Ir-and Ru-based *** Pd catalyst displays an ultralow overpotential(1.6 mV),excellent durability and mitigated degradation(66 μV h-1. at 1. {1. cm-2in 1.M *** strain on Pd(1.1. facets weakens the binding of oxygen species on electrochemical etching-derived hierarchical Pd and thereby leads to two orders of {1.gnitudes of enhancement of {1.ss activity in comparison to the parent Pd bulk ***,the Pd catalyst displays the bifunctional catalytic properties for both oxygen and hydrogen evolutions and can deliver a current density of 2 A cm-2at a low cell voltage of 1.771.V when fabricated into polymer ele ctrolyte membrane ele ctrolyser.

关键词： palladium oxygen evolution reaction acidic condition strain electrolysis

八段锦对社区老年人平衡功能影响效果的整群随机对照试验研究

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中华流行病学杂志 2024年第2期45卷 250-256页

作者：段蕾蕾赵玉斌耳玉亮叶鹏鹏王薇高欣邓晓金叶汪媛纪翠蓉马新颜高从赵昱红朱素秋苏书贞郭新娥彭娟娟喻彦杨琛苏亚娅赵鸣郭丽花吴逸平罗央努孟瑞琳徐浩锋刘华章阮慧红谢博张慧敏廖宇华陈颜王临虹中国疾病预防控制中心慢性非传染性疾病预防控制中心伤害防控与心理健康室北京100050 石家庄市人民医院石家庄050031 中国医学科学院阜外医院/国家心血管病中心/国家心血管疾病临床医学研究中心北京100037 中国疾病预防控制中心慢病和老龄健康管理处北京102206 石家庄市疾病预防控制中心慢性非传染性疾病防治所石家庄050011 石家庄市长安区疾病预防控制中心石家庄050011 石家庄市长安区疾病预防控制中心慢病防控科石家庄050011 石家庄市中医院护理部石家庄050051 上海市疾病预防控制中心伤害防治科上海200336 上海市浦东新区疾病预防控制中心肿瘤伤害防治科上海200136 浙江省疾病预防控制中心慢性非传染性疾病预防控制所杭州310051 浙江省慈溪市疾病预防控制中心中心办公室宁波315302 广东省疾病预防控制中心慢性非传染性疾病预防控制所广州511483 广州市疾病预防控制中心广州510440 广州市番禺区慢性病防治站慢性非传染性疾病防控科广州511400 深圳市南山区慢性病防治院精神卫生科深圳518054

目的评价八段锦锻炼6个月对社区老年人平衡功能的影响。方法使用两平行组整群随机对照试验的方法对我国5个省(市)40个社区的1.28名60~80岁社区居住老年人进行干预研究。干预组研究对象(20个社区、523名)进行每天1.h、每周5 d、持续6个... 详细信息

目的评价八段锦锻炼6个月对社区老年人平衡功能的影响。方法使用两平行组整群随机对照试验的方法对我国5个省(市)40个社区的1.28名60~80岁社区居住老年人进行干预研究。干预组研究对象(20个社区、523名)进行每天1.h、每周5 d、持续6个月的八段锦锻炼和3次预防老年人跌倒健康教育;对照组研究对象(20个社区、505名)仅接受3次预防跌倒健康教育。研究主要指标为Berg平衡量表(BBS)得分,次要指标包括单脚站立时间、双脚前后站立时间、闭目原地踏步时间、计时起立行走时间。结果1.28名研究对象进入分析,包括731.女性(71.1.%)和297名男性(28.89%),年龄(69.87±5.67)岁。与基线调查相比,干预3个月后干预组BBS得分较对照组增加3.05(95%CI:2.23~3.88)分(P1.;干预6个月后干预组BBS得分较对照组增加4.70(95%CI:4.03~5.37)分(P1.。与对照组相比,干预6个月后干预组研究对象的各项次要指标均有改善(P<0.05)。结论八段锦运动可以提高60~80岁社区老年人的平衡功能,运动时间越长,改善效果越好。

关键词：平衡功能整群随机对照试验老年人跌倒预防八段锦

Evaluation of trabecular meshwork-specific promoters in vitro and in vivo using scAAV2 vectors expressing C3 transferase

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1196-1209页

作者： Jun-Kai Tan Ying Xiao guo Liu Long-Xiang Huang Wen-Hao {1. Yan Xia Xi-Zhen Wang Xian-Jun zhu su-Ping Cai Xiao-Bing wu Yun Wang Xu-Yang Liu Xiamen Eye Center Xiamen UniversityXiamen 361004Fujian ProvinceChina Department of Pathology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610032Sichuan ProvinceChina Sichuan Provincial Key Laboratory for Human Disease Gene Study Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina The First Affiliated Hospital of Fujian Medical university Fuzhou 350004Fujian ProvinceChina Beijing FivePlus Molecular Medicine Institute Co. Ltd.Beijing 102600China Shenzhen Key Laboratory of Ophthalmology Shenzhen Eye HospitalSchool of OptometryJinan UniversityShenzhen 518040Guangdong ProvinceChina Department of Ophthalmology Shenzhen People’s Hospitalthe 2nd Clinical Medical CollegeJinan UniversityShenzhen 518020Guangdong ProvinceChina

AIM:To evaluate the potential of two trabecular meshwork(TM)-specific promoters,Chitinase 3-like 1.Ch3L1.and matrix gla protein(MGP),for improving specificity and safety in glaucoma gene therapy based on self-complementary AAV2(scAAV2)vector ***:An scAAV2 vector with C3 transferase(C3)as the reporter gene(scAAV2-C3)was *** scAAV2-C3 vectors were driven by Ch3L1.scAAV2-Ch3L1.C3),MGP(scAAV2-MGP-C3),enhanced MGP(scAAV2-eMGP-C3)and cytomegalovirus(scAAV2-CMV-C3),*** cultured primary human TM cells were treated with each vector at different multiplicities of *** in cell morphology were observed by phase contrast *** stress fibers and Rho GTPases/Rho-associated protein kinase pathway-related molecules were assessed by immunofluorescence staining,real-time quantitative polymerase chain reaction and Western *** vector was injected intracamerally into the one eye of each rat at low and high doses *** vivo green fluorescence was visualized by a Micron III Retinal Imaging *** pressure(IOP)was monitored using a rebound *** responses were evaluated by slit-lamp *** histopathology analysis was examined by hematoxylin and eosin ***:In TM cell culture studies,the vectormediated C3 expression induced morphologic changes,disruption of actin cytoskeleton and reduction of fibronectin expression in TM cells by inhibiting the Rho GTPases/Rhoassociated protein kinase signaling *** the same dose,these changes were significant in TM cells treated with scAAV2-CMV-C3 or scAAV2-Ch3L1.C3,but not in cells treated with scAAV2-eMGP-C3 or *** lowinjected dose,the IOP was significantly decreased in the scAAV2-Ch3L1.C3-injected eyes but not in scAAV2-MGPC3-injected and scAAV2-eMGP-C3-injected *** highinjected dose,significant IOP reduction was observed in the scAAV2-eMGP-C3-injected eyes but not in scAAV2-MGP-C3-injected *** t

关键词： self-complementary AAV2 chitinase 3-like 1 matrix gla protein trabecular meshwork C3 transferase

Planarized Polymer Acceptor Featuring High Electron Mobility for Efficient All-Polymer Solar Cells

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Chinese Journal of Polymer Science 2022年第8期40卷 968-978,I0011页

作者： Feng Liu Ri sun Cheng-Yu Wang Liang Zhou Wen-Li su Qi-Hui Yue Shuai sun wu-Yue Liu Hai-Jun Fan Wen-Kai Zhang Yun-Long guo Li-Heng Feng Xiao-Zhang zhu school of Chemistry and Chemical {1. Shanxi UniversityTaiyuan030006China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing100190China Department of Physics and Applied Optics Beijing Area major Laboratory Center for Advanced Quantum StudiesBeijing Normal UniversityBeijing100875China university of Chinese Academy of Sciences Beijing100049China

Significant progress has been achieved for all-polymer solar cells(APSCs)in the last few years by the use of polymerized small molecular acceptors(PSmas).Developing high electron mobility polymer acceptors has been considered a feasible solution to further improve the photovoltaic performance of APSCs and fabricate thick film devices,which contributed to roll-to-roll printing *** this work,we designed and synthesized PSV,an A-DA’D-A small molecule acceptor-based PSma with the vinyl group as a bridged linkage to reduce the steric hindrance between the 1.1.dicyanomethylene-3-indanone(IC)terminal *** comparison with the C-C bond linked polymer acceptor PS,PSV exhibits an almost planar conjugated framework and well-ordered molecular stacking in the thin ***,PSV exhibits superior n-type semiconducting properties with high electron mobility of up to 0.54 cm^(2)·V^(−1.·s^(−1.,which is the highest value among reported *** utilizing PM6 as a polymer donor,PSV-based blend forms a favorable nanomorphology and exhibits high and well-balanced hole/electron mobilities,which is beneficial for exciton separation and charge ***,APSCs based on PM6:PSV achieved high power conversion efficiencies of up to 1..73%,with a simultaneously realized high Voc of 0.923 V,Jsc of 23.2 ma·cm^(-2),and FF of *** superior features enable PSV with excellent thickness-insensitive properties and over 1.%PCE was obtained at 300 *** the best of our knowledge,the high PCE of 1..73%with excellent electron mobility of 0.54 cm^(2)·V^(−1.·s^(−1.is the highest values reported for *** results point to the great significance of developing polymer acceptors with a high electron mobility for boosting the performance of APSCs.

关键词： All-polymer solar cells Polymerized small molecular acceptors Planarization Electron mobility Thick film organic solar cells

1..2% Efficiency all-polymer solar cells with high open-circuit voltage

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Science china Chemistry 2019年第7期62卷 845-850页

作者： Yuan Meng Jingnan wu Xia {1. Wenyan su Lei zhu Jin Fang Zhi-{1. Zhang Feng Liu maojie Zhang Thomas P. Russell Yongfang Li State and Local Joint engineering Laboratory for Novel Functional Polymeric {1.terials Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China Department of Physics and Astronomy and Collaborative Innovation Center of IFSA Shanghai Jiao Tong University Shanghai 200240 China Polymer Science and engineering Department University of Massachusetts Amherst MA 01003 USA materials Sciences Division Lawrence Berkeley National Laboratory Berkeley California 94720 USA CAS Research/Education Center for Excellence in Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Herein,we fabricated all-polymer solar cells(all-PSCs)based on a fluorinated wide-bandgap p-type conjugated polymer PM6 as the donor,and a narrow bandgap n-type conjugated polymer PZ1.as the *** addition to the complementary absorption and matching energy levels,the optimized blend films possess high cystallinity,predominantly face-on stacking,and a {1.itable phase separated *** this active layer,the devices exhibited a high Vocof 0.96 V,a {1.perior Jscof 1..1.ma cm^-2,a fine fill factor(FF)of 68.2%,and thus an excellent power conversion efficiency(PCE)of 1..2%,which is the highest value reported to date for single-junction ***,the devices showed good storage *** 80 d of storage in the N2-filled glovebox,the PCE still remained over 90%of the original ***-area devices(1.1.cm^2)also demonstrated an outstanding performance with a PCE of 9.2%,among the highest values for the reported large-area *** re{1.lts indicate that the PM6:PZ1.blend is a promising candidate for scale-up production of large area high-performance all-PSCs.

关键词： all-polymer solar cells fluorine substitution power conversion efficiency wide bandgap polymer polymer acceptor

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Bruegge{1.nn H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gil{1.n K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.guo L.B.guo M.J.guo R.P.guo Y.P.guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holt{1.nn P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lell{1.nn T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang university Beijing 100191China Bochum Ruhr-university D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon university PittsburghPennsylvania 15213USA Central china Nor{1.l university Wuhan 430079China Central South university Changsha 410083China china Center of Advanced Science and Technology Beijing 100190China china {1. of Geosciences Wuhan 430074China Chung-Ang university Seoul06974Republic of Korea COMSATS university Isla{1.bad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan university Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal {1. Guilin 541004China Guangxi university Nanning 530004China Hangzhou Normal {1. Hangzhou 310036China Hebei university Baoding 071002China Helmholtz Institute mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal {1. Xinxiang 453007China Henan university Kaifeng 475004China Henan university of Science and Technology Luoyang 471003China Henan university of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal {1. Changsha 410081China Hunan university Changsha 410082China Indian Institute of Technology madras Chennai 600036India Indiana university BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia university Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1.taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1.(1.60)π,D^(0)→π(1.00)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1.(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are mea{1.red to be(0.688±0.01._(stat.)±0.01._(syst.))%and(0.951.0.025_(stat.)±0.021.(syst.))%,*** amplitude analysis provides an important model for the binning strategy in mea{1.ring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong Li Ruo-Yu Liu Ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China school of Astronomy and Space Science Nanjing UniversityNanjing 210023China university of Science and Technology of{1. Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 1.0deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 1. PeV.A log-parabola form with the photon indexΓ(E)=(2.71.0.02)+(0.1.±0.02)×log1.(E/1. TeV)is found fitting the gam{1.-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very {1.ssive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing {1.ssive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1.*** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

2022年CHINET三级医院细菌耐药监测

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中国感染与化疗杂志 2024年第3期24卷 277-286页

作者：郭燕胡付品朱德妹汪复蒋晓飞徐英春张小江张峰波季萍谢轶肖玉玲王传清付盼徐元宏黄颖孙自镛陈中举孙景勇陈庆褚云卓田素飞胡志东李金俞云松林洁单斌许云敏郭素芳王艳艳魏莲花李可可张泓潘芬胡云建艾效曼卓超苏丹虹郭大文赵金英喻华黄湘宁刘文恩李艳明金炎邵春红徐雪松李威王山梅楚亚菲张利侠马娟周树平周艳朱镭孟晋华董方吕志勇胡芳芳沈瀚周万青贾伟李刚吴劲松卢月梅李继红孙倩段金菊康建邦马晓波郑燕青郭如意朱焱陈运生孟青王世富胡雪飞黄文辉李娟石泉贵杨娟热孜瓦古丽·阿不力米提黄莉莉邵雪君任晓艳李冬张群陈雪黎日海徐洁丽高凯杰徐璐林琳张卓刘健龙付敏郭映辉张文超王增国贾凯夏云孙珊杨慧敏苗艳周明明张诗海刘红娟陈楠李婵沈继录门万琪王鹏张晓威刘彦彦安勇复旦大学附属华山医院抗生素研究所国家卫健委抗生素临床药理重点实验室上海200040 北京协和医院新疆医科大学第一附属医院四川大学华西医院复旦大学附属儿科医院安徽医科大学第一附属医院华中科技大学同济医学院附属同济医院上海交通大学医学院附属瑞金医院中国医科大学附属第一医院天津医科大学总医院浙江大学医学院附属邵逸夫医院昆明医科大学第一附属医院内蒙古医科大学附属医院甘肃省人民医院上海交通大学医学院附属儿童医院北京医院广州医科大学附属第一医院哈尔滨医科大学附属第一医院四川省人民医院中南大学湘雅医院山东省立医院吉林大学中日联谊医院河南省人民医院陕西省人民医院江西省儿童医院山西省儿童医院首都医科大学附属北京儿童医院贵州省人民医院南京大学医学院附属鼓楼医院宁夏医科大学总医院深圳市人民医院河北医科大学第二医院山西医科大学第二医院厦门大学附属第一医院福建省泉州市第一医院深圳市儿童医院山东大学齐鲁儿童医院南昌大学第一附属医院青海大学附属医院西藏军区总医院乌鲁木齐市第一人民医院(乌鲁木齐儿童医院) 苏州大学附属儿童医院云南省腾冲市人民医院重庆医科大学附属儿童医院广西桂平市人民医院河南省儿童医院沈阳市儿童医院湖南省儿童医院河北省儿童医院西安市儿童医院重庆医科大学附属第一医院陕西省神木市医院浙江省儿童医院安徽省儿童医院天津市儿童医院安徽医科大学第四附属医院长春市儿童医院邢台市第九医院复旦大学附属华山医院检验科国家卫健委抗生素临床药理重点实验室上海200040

目的监测2022年CHINET三级医院临床分离菌对抗菌药物的敏感性。方法国内58所三级医院临床分离菌采用纸片扩散法或商品化药敏试验自动测试仪按CHINET统一监测技术方案进行抗菌药物敏感性试验。结果按CLSI M1.02022年版折点标准判断。结... 详细信息

目的监测2022年CHINET三级医院临床分离菌对抗菌药物的敏感性。方法国内58所三级医院临床分离菌采用纸片扩散法或商品化药敏试验自动测试仪按CHINET统一监测技术方案进行抗菌药物敏感性试验。结果按CLSI M1.02022年版折点标准判断。结果收集2022年1.1.-1.月31.上述医院临床分离菌共31.01.株,其中革兰阳性菌占29.5%,革兰阴性菌占70.5%。金黄色葡萄球菌、表皮葡萄球菌和其他凝固酶阴性葡萄球菌(除假中间葡萄球菌和施氏葡萄球菌外)中甲氧西林耐药株的检出率分别为28.3%、76.7%和77.9%。MRSA中有94.0%的菌株对甲氧苄啶-磺胺甲噁唑敏感;MRSE中有90.8%的菌株对利福平敏感,未发现万古霉素耐药株。肠球菌属中粪肠球菌对多数测试抗菌药物的耐药率均显著低于屎肠球菌,两者中均有少数万古霉素耐药株。2022年儿童和成人中分离的非脑膜炎肺炎链球菌中PSSP的检出率分别为94.2%和95.7%。除克雷伯菌属细菌对碳青霉烯类的耐药率范围为21.7%~23.1.外,其他细菌的耐药率多在1..1.以下。除天然耐药菌株外,其他肠杆菌目细菌对替加环素、黏菌素和多黏菌素B高度敏感,耐药率范围为0.1.~1..3%。铜绿假单胞菌对美罗培南的耐药率从201.年的23.5%下降至2022年的1..0%;鲍曼不动杆菌对美罗培南的耐药率亦从201.年的79.0%下降至2022年的72.5%。结论三级医院临床分离菌对常见抗菌药物的耐药率仍呈增长趋势,但碳青霉烯类耐药肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌等多种重要耐药细菌的检出率近年来呈现连续下降趋势,提示加强细菌耐药监测,开展多学科联动的方式对控制耐药细菌的流行播散是行之有效的。

关键词：三级医院细菌耐药监测药物敏感性试验碳青霉烯类耐药革兰阴性杆菌

201.-2021.CHINET临床分离沙雷菌属细菌耐药性变迁

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中国感染与化疗杂志 2024年第1期24卷 43-52页

作者：李金胡志东杨洋胡付品朱德妹汪复谢轶康梅张朝霞季萍沈瀚周万青刘文恩李艳明俞云松林洁郭大文赵金英徐雪松鄢超徐元宏黄颖徐英春张小江王传清王爱敏王山梅楚亚菲喻华黄湘宁李继红卓超苏丹虹张利侠马娟郭素芳贾伟李刚倪语星孙景勇孙自镛陈中举单斌杜艳褚云卓田素飞汪瑞忠房华金炎邵春红刘江山张泓王春胡云建艾效曼胡芳芳魏莲花邹凤梅朱镭孟晋华胡雪飞段金菊康建邦俞碧霞董芳郑红艳沈继录吴劲松卢月梅赵勇龚萍马晓波郑燕青郭如意朱焱冯佼薛顺虹陈运生孟青顾洪芹温开镇张贻荣周树平周艳王世富廖龙凤姜琳贺雯窦睿岳春雷黄文辉天津医科大学总医院天津300052 复旦大学附属华山医院抗生素研究所四川大学华西医院新疆医科大学第一附属医院南京大学医学院附属鼓楼医院中南大学湘雅医院浙江大学医学院附属邵逸夫医院哈尔滨医科大学附属第一医院吉林大学中日联谊医院安徽医科大学第一附属医院北京协和医院复旦大学附属儿科医院河南省人民医院四川省人民医院河北医科大学第二医院广州医科大学附属第一医院陕西省人民医院内蒙古医科大学附属医院宁夏医科大学总医院上海交通大学医学院附属瑞金医院华中科技大学同济医学院附属同济医院昆明医科大学第一附属医院中国医科大学附属第一医院上海市浦东新区人民医院山东省立医院甘肃省金昌市中西医结合医院上海交通大学附属儿童医院北京医院贵州省人民医院甘肃省人民医院山西省儿童医院南昌大学附属第一医院山西医科大学第二医院浙江省宁波市镇海龙赛医院首都医科大学附属北京儿童医院安徽医科大学附属第四医院深圳市人民医院湖北省秭归县人民医院厦门大学附属第一医院福建省泉州市第一医院四川省邻水县人民医院青海省互助县人民医院深圳儿童医院山东省广饶县人民医院福建省晋江市医院江西省儿童医院山东大学齐鲁儿童医院江西省赣县区人民医院河南省辉县市人民医院辽宁省营口市经济技术开发区中心医院安徽省亳州市利辛县人民医院吉林省九台区人民医院青海省青海大学附属医院

目的了解国内主要地区临床分离沙雷菌属细菌对常用抗菌药物的耐药率及变迁。方法由CHINET中国细菌耐药性监测网参与成员单位将临床分离菌采用纸片扩散法或自动化商业药敏测试系统按CHINET统一技术方案进行仪器法药物敏感性试验。结果201...

目的了解国内主要地区临床分离沙雷菌属细菌对常用抗菌药物的耐药率及变迁。方法由CHINET中国细菌耐药性监测网参与成员单位将临床分离菌采用纸片扩散法或自动化商业药敏测试系统按CHINET统一技术方案进行仪器法药物敏感性试验。结果201.年1.—2021.1.月从我国不同地区53所医院临床分离到的沙雷菌属1.226株。分离的菌株数从201.年959株上升到2021.3588株,自门急诊患者中分离到的沙雷菌占7.3%(1.65/1.226),住院患者菌株占92.7%(1.961.1.226)。1.226株沙雷菌属细菌中呼吸道标本占比最高(57.5%±2.5%),其次为血液标本(1..5%±1.5%)。7年连续监测发现除氨苄西林、头孢唑林及呋喃妥因外其他抗菌药物细菌耐药率均有所下降,亚胺培南和美罗培南虽然耐药率数值有所反复,但仍从8.1.和8.3%降到5.3%和5.2%。成年患者来源的菌株对头孢哌酮-舒巴坦、头孢他啶-阿维巴坦、头孢噻肟、亚胺培南、呋喃妥因和替加环素耐药率三级医院高于二级医院,其他抗菌药物耐药率均低于二级医院。分离自儿童患者的沙雷菌对头孢哌酮-舒巴坦、哌拉西林-他唑巴坦、阿米卡星、甲氧苄啶-磺胺甲唑和替加环素的耐药率低于5%。分离自ICU的菌株对抗菌药物的耐药率普遍高于其他监测科室。7年监测碳青霉烯类耐药肠杆菌目菌株检出率为8.2%。结论7年中沙雷菌属细菌耐药率呈缓慢下降趋势,继续加强标本及时送检及合理使用抗菌药物对细菌耐药率下降起着尤为重要的作用,落实医院感染控制可有效降低耐药细菌的发生。

关键词：沙雷菌属抗菌药物细菌耐药性监测