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Blow-up *** Finiteness for an Evolution p-Laplace System with Nonlinear Boundary Conditions

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Communications in Mathematical Research 2009年第4期25卷 309-317页

作者： wu xue-SONG GAO wen-JIE School of Mathematics Jilin University Changchun 130012

In this paper, the authors consider the positive solutions of the system of the evolution p-Laplacian equationswith nonlinear boundary conditionsand the initial data （u0, v0）, where Ω is a bounded domain in Rn with smooth boundary δΩ, p 〉 2, h（·,·） and s（·,· ） are positive C1 functions, nondecreasing in each variable. The authors find conditions on the functions f, g, h, s that prove the global existence or finite time blow-up of positive solutions for every （u0, v0）.

关键词： nonlinear boundary value problem evolution p-Laplace system blowup

Exploring the mechanism of Buxue Yimu Pill on hemorrhagic anemia through molecular docking, network pharmacology and experimental validation

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Chinese Journal of Natural Medicines 2021年第12期19卷 900-911页

作者： XIONG Yan CAO Xu-Yuan LIU Bo-Yu DAI Yong-Qi ZHOU Heng-Jun HE Juan-Juan GONG Yun wu xue-wen TANG Huai-Bo Department of Chemical and Pharmaceutical Engineering School of Chemical EngineeringXiangtan UniversityXiangtan 411105China Zhuzhou Qianjin Pharmaceutical Co. Ltd.Zhuzhou 412000China Department of Chemistry School of ChemistryXiangtan UniversityXiangtan 411105China

Buxue Yimu Pill(BYP) is a classic gynecological medicine in China, which is composed of Angelica sinensis(Oliv.)Diels, Leonurus japonicus Houtt, Astragalus membranaceus(Fisch.) Bunge, Colla corii asini and Citrus reticulata Blanco. It has been widely used in clinical therapy with the function of enriching Blood, nourishing Qi, and removing blood stasis. The current study was designed to determine the bioactive molecules and therapeutic mechanism of BYP against hemorrhagic anemia. Herein, GC-MS and UPLC/Q-TOF-MS/MS were employed to identify the chemical compounds from BYP. The genecards database(https://***/) was used to obtain the potential target proteins related to hemorrhagic anemia. Autodock/Vina was adopted to evaluate the binding ability of protein receptors and chemical ligands. Gene ontology and KEGG pathway enrichment analysis were conducted using the Cluster Profiler. As a result, a total of 62 candidate molecules were identified and 152 targets related to hemorrhagic anemia were obtained. Furthermore, 34 active molecules and 140 targets were obtained through the virtual screening experiment. The data of molecular-target(M-T), target-pathway(T-P), and molecular-target-pathway(M-T-P) network suggested that 32 active molecules enhanced hematopoiesis and activated the immune system by regulating 57 important targets. Pharmacological experiments showed that BYP significantly increased the counts of RBC, HGB, and HCT, and significantly down-regulated the expression of EPO, IL-6, CSF3,NOS2, VEGFA, PDGFRB, and TGFB1. The results also showed that leonurine, leonuriside B, leosibiricin, ononin, rutin, astragaloside I, riligustilide and levistolide A, were the active molecules closely related to enriching Blood. In conclusion, based on molecular docking, network pharmacology and validation experiment results, the enriching blood effect of BYP on hemorrhagic anemia may be associated with hematopoiesis, anti-inflammation, and immunity enhancement.

关键词： Buxue Yimu Pill Hemorrhagic anemia GC-MS UPLC/Q-TOF-MS/MS Molecular docking Network pharmacology Experimental pharmacology

Mechanical property of cylindrical sandwich shell with gradient core of entangled wire mesh

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Defence Technology（防务技术） 2024年第1期31卷 510-522页

作者： Xin xue Chao Zheng Fu-qiang Lai xue-qian wu Institute of Metal-rubber&Vibration Noise School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou350116China Fujian Metallurgical Industry Design Institute Fuzhou350116China

To explore the wide-frequency damping and vibration-attenuation performances in the application of aerospace components,the cylindrical sandwich shell structure with a gradient core of entangled wire mesh was proposed in this ***,the gradient cores of entangled wire mesh in the axial and radial directions were prepared by using an in-house Numerical Control weaving machine,and the metallurgical connection between skin sheets and the gradient core was performed using vacuum ***,to investigate the mechanical properties of cylindrical sandwich shells with axial or radial gradient cores,quasi-static and dynamic mechanical experiments were carried *** primary evaluations of mechanical properties include secant stiffness,natural frequency,Specific Energy Absorption(SEA),vibration acceleration level,and so *** results suggest that the vibration-attenuation performance of the sandwich shell is remarkable when the high-density core layer is at the end of the shell or abuts the inner *** axial gradient material has almost no influence on the vibration frequencies of the shell,whereas the vibration frequencies increase dramatically when the high-density core layer approaches the ***,compared to the conventional sandwich shells,the proposed functional grading cylindrical sandwich shell exhibits more potential in mass reduction,stiffness designing,and energy dissipation.

关键词： Entangled wire mesh Gradient cylindrical sandwich shell Vacuum brazing Secant stiffness Damping

Some Convergence Properties for Weighted Sums of Martingale Difference Random Vectors

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1127-1142页

作者： Yi wu xue Jun WANG School of Big Data and Artificial Intelligence Chizhou UniversityChizhou 247000P.R.China School of Big Data and Statistics Anhui UniversityHefei 230601P.R.China

Let{X_(ni),F_(ni);1≤i≤n,n≥1}be an array of R^(d)martingale difference random vectors and{A_(ni),1≤i≤n,n≥1}be an array of m×d matrices of real *** this paper,the Marcinkiewicz-Zygmund type weak law of large numb... 详细信息

关键词： Martingale difference random vectors weighted sums Marcinkiewicz–Zygmund type weak law of large numbers complete convergence strong law of large numbers multivariate simple linear regression model

Mixed D-vine copula-based conditional quantile model for stochastic monthly streamflow simulation

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Water Science and Engineering 2024年第1期17卷 13-20页

作者： wen-zhuo Wang Zeng-chuan Dong Tian-yan Zhang Li Ren Lian-qing xue Teng wu College of Water Resources and Hydrology Hohai UniversityNanjing 210098China Yellow River Research Center Hohai UniversityNanjing 210098China

Copula functions have been widely used in stochastic simulation and prediction of ***,existing models are usually limited to single two-dimensional or three-dimensional copulas with the same bivariate block for all *** address this limitation,this study developed a mixed D-vine copula-based conditional quantile model that can capture temporal *** model can generate streamflow by selecting different historical streamflow variables as the conditions for different months and by exploiting the conditional quantile functions of streamflows in different months with mixed D-vine *** up-to-down sequential method,which couples the maximum weight approach with the Akaike information criteria and the maximum likelihood approach,was used to determine the structures of multivariate Dvine *** developed model was used in a case study to synthesize the monthly streamflow at the Tangnaihai hydrological station,the inflow control station of the Longyangxia Reservoir in the Yellow River *** results showed that the developed model outperformed the commonly used bivariate copula model in terms of the performance in simulating the seasonality and interannual variability of *** model provides useful information for water-related natural hazard risk assessment and integrated water resources management and utilization.

关键词： Stochastic monthly streamflow simulation Mixed D-vine copula Conditional quantile model Up-to-down sequential method Tangnaihai hydrological station

Sample Generation for Security Region Boundary Identification Based on Topological Features of Historical Operation Data

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1087-1095页

作者： Xiaokang wu Wei Xu Feng xue College of Energy and Electrical Engineering Hohai UniversityNanjingChina NARI Group Corporation NanjingChina State Grid Electric Power Research Institute NanjingChina

Since the scale and uncertainty of the power sys-tem have been rapidly increasing,the computation efficiency of constructing the security region boundary(SRB)has become a prominent *** on the topological features of histori-cal operation data,a sample generation method for SRB identi-fication is proposed to generate evenly distributed samples,which cover dominant security *** boundary sample pair(BSP)composed of a secure sample and an unsecure sam-ple is defined to describe the feature of *** resolution,sampling,and span indices are designed to evaluate the cover-age degree of existing BSPs on the SRB and generate samples closer to the *** on the feature of flat distribution of BSPs over the SRB,the principal component analysis(PCA)is adopted to calculate the tangent vectors and normal vectors of ***,the sample distribution can be expanded along the tangent vector and corrected along the normal vector to cover different security ***,a sample set is randomly gen-erated based on the IEEE standard example and another new sample set is generated by the proposed *** results in-dicate that the new sample set is closer to the SRB and covers different security modes with a small calculation time cost.

关键词： Clustering analysis principal component analysis(PCA) sample generation security region boundary(SRB)

Nano polystyrene microplastics could accumulate in Nile tilapia(Oreochromis niloticus):Negatively impacts on the intestinal and liver health through water exposure

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Journal of Environmental Sciences 2024年第3期137卷 604-614页

作者： Di wu Xing Lu Li-xue Dong Juan Tian Jin Deng Lei Wei Hua wen Shan Zhong Ming Jiang School of Basic Medical Sciences Wuhan UniversityWuhan 430071China Key Laboratory of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural AffairsYangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan 430223China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071China

Microplastics(MPs)have become a significant concern for their potential ***,the correlation between the size of plastic particles and their toxicity remains ***,we investigate the toxic effects of different sizes(80 nm,800 nm,8μm and 80μm)polystyrene MPs(PS-MPs)on the model organism Nile tilapia(Oreochromis niloticus).The results of bioluminescent imaging indicate that the 80 nm PS-MPs are more likely to invade the body.H&E staining shows severe damage on the intestinal villi and distinct hepatic steatosis in the 80 nm *** U labeling shows that the proliferation activity of intestinal and liver cells reduces significantly in the 80 nm *** gut microbiome analysis shows a severe imbalance of gut microbiota homeostasis in the 80 nm *** analysis of liver transcriptomics and metabolomics shows that the liver lipid metabolism is disordered in the 80 nm *** conclusion,this study confirms that the 80 nm PS-MPs are more likely to induce intestinal and liver *** the above lay the foundation for further study on the pathological damage of MPs to other organisms.

关键词： Microplastics(MPs) Intestinal toxicity Liver toxicity Gut microbiome Lipid metabolism

Comparing short-term outcomes of robot-assisted and conventional laparoscopic total mesorectal excision surgery for rectal cancer in elderly patients

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1271-1279页

作者： Hao Yang Gang Yang wen-Ya wu Fang Wang xue-Quan Yao Xiao-Yu wu The Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Surgical Oncology The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BACKGROUND Da Vinci Robotics-assisted total mesorectal excision(TME)surgery for rectal cancer is becoming more widely *** is no strong evidence that roboticassisted surgery and laparoscopic surgery have similar outcomes in elderly patients with TME for rectal *** To determine the improved oncological outcomes and short-term efficacy of robot-assisted surgery in elderly patients undergoing TME *** A retrospective study of the clinical pathology and follow-up of elderly patients who underwent TME surgery at the Department of Gastrointestinal Oncology at the Affiliated Hospital of Nanjing University of Chinese Medicine was conducted from March 2020 through September *** patients were divided into a robotassisted group(the R-TME group)and a laparoscopic group(the L-TME group),and the short-term efficacy of the two groups was *** There were 45 elderly patients(≥60 years)in the R-TME group and 50 elderly patients(≥60 years)in the L-TME *** were no differences in demographics,conversion rates,or postoperative complication *** L-TME group had a longer surgical time than the R-TME group[145(125,187.5)vs 180(148.75,206.25)min,P=0.005),and the first postoperative meal time in the L-TME group was longer than that in the R-TME(4 vs 3 d,P=0.048).Among the sex and body mass index(BMI)subgroups,the R-TME group had better out-comes than did the L-TME group in terms of operation time(P=0.042)and intraoperative assessment of bleeding(P=0.042).In the high BMI group,catheter removal occurred earlier in the R-TME group than in the L-TME group(3 vs 4 d,P=0.001),and autonomous voiding function was *** The curative effect and short-term efficacy of robot-assisted TME surgery for elderly patients with rectal cancer are similar to those of laparoscopic TME surgery;however,robotic-assisted surgery has better short-term outcomes for individuals with risk factors such as obesity and pelvic *** the learning

关键词： Robotic surgery Laparoscopy Rectal cancer Total mesorectal excision Elderly

Impact response and energy absorption of metallic buffer with entangled wire mesh damper

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Defence Technology（防务技术） 2024年第5期35卷 137-150页

作者： Chao Zheng Jun wu Mangong Zhang Xin xue Institute of Metal Rubber&Vibration Noise School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou 350116China wuhan Second Ship Design and Research Institute Wuhan 430205China

An innovative metallic buffer consisting of series-connected hat-shaped entangled wire mesh damper(EWMD)and parallel springs are proposed in this work to enhance the reliability of engineering *** impact response and the energy dissipation mechanism of hat-shaped EWMD under different quasi-static compression deformations(2-7 mm)and impact heights(100-200 mm)are investigated using experimental and numerical *** results demonstrate distinct stages in the quasi-static mechanical characteristics of hat-shaped EWMD,including stiffness softening,negative stiffness,and stiffness *** loss factor gradually increases with increasing compression deformation before entering the stiffness hardening *** impact loads,the hat-shaped EWMD exhibits optimal impact energy absorption when it enters the negative stiffness stage(150 mm),resulting in the best impact isolation effect of metallic ***,the impact energy absorption significantly decreases when hat-shaped EWMD enters the stiffness hardening ***,quasi-static compression analysis after experiencing different impact loads reveals the disappearance of the negative stiffness ***,with increasing impact loads,the stiffness hardening point progressively shifts to an earlier stage.

关键词： Metallic buffer Hat-shaped EWMD Drop impact Energy absorption characteristics Mechanical behavior