检索结果-南通市图书馆

维普期刊数据库博看期刊

The effect of fasting plasma glucose on in-hospital mortality after acute myocardial infarction in patients with and without diabetes:findings from a prospective,nationwide,and multicenter registry

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2024年第5期21卷 523-533页

作者： Rui FU Ying-xuan ZHU Kong-Yong CUI Jin-Gang YANG Hai-Yan XU Dong YIN Wei-Hua SONG Hong-Jian WANG Cheng-Gang ZHU Lei FENG Wei wu Kai-HongCHEN Yan-Yan ZHAO Ye LU Ke-Fei DOU Yue-Jin YANG on behalf of the CAMI Registry Investigators Cardiometabolic Medicine Center Fuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Research&Biometrics Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Coronary Heart Disease Center Fuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Guangzhou Traditional Chinese Medical College First Affiliated HospitalGuangdong ProvinceChina Department of Cardiology Longyan Hospital First HospitalFujian ProvinceChina 不详

OBJECTIVES To evaluate the predictive value of fasting plasma glucose(FPG)for in-hospital mortality in patients with acute myocardial infarction(AMI)with different glucose metabolism *** We selected 5,308 participants with AMI from the prospective,nationwide,multicenter CAMI registry,of which 2,081 were diabetic and 3,227 were *** were divided into high FPG and low FPG groups according to the optim-al cutoff values of FPG to predict in-hospital mortality for diabetic and nondiabetic cohorts,*** primary endpoint was in-hospital *** Overall,94 diabetic patients(4.5%)and 131 nondiabetic patients(4.1%)died during hospitalization,and the optimal FPG thresholds for predicting in-hospital death of the two cohorts were 13.2 mmol/L and 6.4 mmol/L,*** with individuals who had low FPG,those with high FPG were significantly associated with higher in-hospital mortality in diabet-ic cohort(10.1%vs.2.8%;odds ratio[OR]=3.862,95%confidence interval[CI]:2.542-5.869)and nondiabetic cohort(7.4%vs.1.7%;HR=4.542,95%CI:3.041-6.782).After adjusting the potential confounders,this significant association was not ***-more,FPG as a continuous variable was positively associated with in-hospital mortality in single-variable and multivariable models regardless of diabetic *** FPG to the original model showed a significant improvement in C-statistic and net reclassification in diabetic and nondiabetic *** This large-scale registry indicated that there is a strong positive association between FPG and in-hospital mor-tality in AMI patients with and without *** might be useful to stratify patients with AMI.

关键词： patients fasting infarction

Controllable step-flow growth of GaN on patterned freestanding substrate

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2024年第2期45卷 46-50页

作者： Peng wu Jianping Liu Lei Hu Xiaoyu Ren Aiqin Tian Wei Zhou Fan Zhang xuan Li Masao Ikeda Hui Yang Key Laboratory of Nanodevices and Applications Suzhou Institute of Nano-tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China

A new kind of step-flow growth mode is proposed,which adopts sidewall as step source on patterned GaN *** terrace width of steps originated from the sidewall was found to change with the growth temperature and ammonia *** growth mechanism is explained and simulated based on step motion *** work helps better understand the behaviors of step advancement and puts forward a method of precisely modulating atomic steps.

关键词： step-flow growth GaN terrace width step motion

在线全文

学校读者我要写书评

暂无评论

深层坞原理对于智能体育的介入机制

西南大学学报（自然科学版） 2024年第5期46卷 186-194页

作者：吴璇孙逸飞西南大学体育学院重庆400715

随着人工智能技术的进步,“避风港原则”已难以有效应对体育领域的数据信息侵权问题.该文提出应对数据侵权或信息侵权的保障策略——深层坞原理,通过与产业链各环节主体的深度对接,实施对受侵权数据或信息的“下潜”保护,有效遏制或降... 详细信息

随着人工智能技术的进步,“避风港原则”已难以有效应对体育领域的数据信息侵权问题.该文提出应对数据侵权或信息侵权的保障策略——深层坞原理,通过与产业链各环节主体的深度对接,实施对受侵权数据或信息的“下潜”保护,有效遏制或降低侵权损害,其内在逻辑和设计思路也适应未来智能化发展的需求.深层坞原理在当前数字化发展产业链中,既能在前端激发智能化生产活力,又能在后端强化监管制度和机制建设,提高侵权成本、协调数字体育用户与数据实际控制者权力失衡问题.在未来强人工智能发展阶段,深层坞原理也将随之演进,利用未来智能对未来智能机器进行管理,展现其未来发展潜力.

关键词：人工智能深层坞原理泛智能化深度对接自适应

基于改进麻雀搜索算法的分数阶PID参数整定

在线全文

学校读者我要写书评

暂无评论

控制与决策 2024年第4期39卷 1177-1184页

作者：陈炫儒吴立飞杨晓忠华北电力大学数理学院北京102206 华北电力大学控制与计算机工程学院北京102206

针对分数阶PID控制器的设计问题,提出一种改进麻雀搜索算法(ISSA)对分数阶PID控制器进行参数整定.在麻雀搜索算法(SSA)中引入Chebyshev混沌映射,提高SSA的种群多样性和全局搜索能力;采用自适应t分布和萤火虫算法,设置转换概率p使二者交... 详细信息

针对分数阶PID控制器的设计问题,提出一种改进麻雀搜索算法(ISSA)对分数阶PID控制器进行参数整定.在麻雀搜索算法(SSA)中引入Chebyshev混沌映射,提高SSA的种群多样性和全局搜索能力;采用自适应t分布和萤火虫算法,设置转换概率p使二者交替执行,提高SSA的收敛精度和寻优性能.对10个基准测试函数进行寻优,结果表明相较于已有的4种经典算法,ISSA在收敛速度、收敛精度、全局搜索能力等方面均有较大提升.最后,对两类被控系统进行仿真分析,相比现有成果,证实了ISSA算法对求解分数阶PID控制器参数整定问题的有效性和实用性.

关键词：分数阶PID控制器改进麻雀搜索算法自适应t分布萤火虫算法基准函数寻优参数整定

Reporting quality evaluation of clinical practice guidelines for pulmonary nodules with the RIGHT checklist

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第5期137卷 625-627页

作者： xuan wu Wenqiang Wang Quncheng Zhang Ya Sun Nan Wei Li Yang Yuanjian Yang Huizhen Yang Haiyang Liu Xiaoju Zhang Department of Respiratory and Critical Care Medicine Zhengzhou University People’s HospitalHenan Provincial People’s HospitalZhengzhouHenan 450003China Department of Internal Medicine Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450001China Department of Internal Medicine Xinxiang Medical UniversityXinxiangHenan 453003China

To the Editor:Pulmonary nodules are defined as localized opacities of up to 30 mm in diameter,surrounded by pulmonary parenchyma or located adjacent to the pleura.^([1])The ideal management for pulmonary nodules is to diagnose and treat malignant nodules as early as possible and minimize radiation exposures,based on the general *** practice guidelines(CPGs)always provide efficient recommendations based on systematic reviews of high-quality evidence and reporting to optimize patient care.^([2])Accumulating evidence shows that adherence to the guidelines improves patient outcomes.^([3])However,the reporting quality of CPGs seems poor.^([4])Several instruments have been generated to evaluate the quality of CPGs.

关键词： pulmonary Clinical clinical

在线全文

学校读者我要写书评

暂无评论

婚内赠与协议的扩张解释与撤销权限度

内江师范学院学报 2024年第7期39卷 105-112页

作者：吴璇西南政法大学民商法学院重庆401120

婚内赠与协议兼具身份和财产的双重法律属性,在实践中常陷入与夫妻约定财产制相混淆及如何适用任意撤销权的困境。若当事人未明示协议属于婚内赠与还是夫妻约定财产制,可对婚内赠与协议作扩张解释,使其包含当事人真意不明的婚内财产约... 详细信息

婚内赠与协议兼具身份和财产的双重法律属性,在实践中常陷入与夫妻约定财产制相混淆及如何适用任意撤销权的困境。若当事人未明示协议属于婚内赠与还是夫妻约定财产制,可对婚内赠与协议作扩张解释,使其包含当事人真意不明的婚内财产约定。婚内赠与协议的认定完成后,可参照适用《民法典》合同编的赠与规则,并根据赠与目的的不同,将其类型化区分为出于纯粹情感目的的赠与和出于道德义务目的的赠与。以道德义务的客观化吸纳婚内赠与的伦理性特征,形成任意撤销权的限制适用。同时,还应允许夫妻双方主张仅对婚内赠与实行部分撤销,且允许赠与人的法定撤销权行使,以实现夫妻利益衡平,优化婚内赠与的纠纷解决机制。

关键词：婚内赠与协议撤销权道德义务

在线全文

学校读者我要写书评

暂无评论

食管癌围手术期免疫治疗进展

中国综合临床 2024年第4期40卷 259-264页

作者：董鑫吴世凯金璿北京大学第一医院肿瘤内科北京100034

中国是食管癌高发国家之一,不同于欧美国家,我国食管癌在组织学分类上以食管鳞状细胞癌为主。手术是非转移性食管鳞癌的主要治疗手段,然而对于局部晚期食管癌,单纯手术治疗效果欠佳。研究证实新辅助治疗能够改善患者的生存,已成为局部... 详细信息

中国是食管癌高发国家之一,不同于欧美国家,我国食管癌在组织学分类上以食管鳞状细胞癌为主。手术是非转移性食管鳞癌的主要治疗手段,然而对于局部晚期食管癌,单纯手术治疗效果欠佳。研究证实新辅助治疗能够改善患者的生存,已成为局部晚期可切除食管癌患者的标准治疗。随着免疫治疗时代的到来,免疫检查点抑制剂联合化疗已成为晚期食管癌的一线标准治疗,其与传统的新辅助治疗方案相结合,可能为食管癌治疗带来新的希望。

关键词：食管癌鳞癌新辅助治疗免疫检查点抑制剂

Prognostic and immunological roles of heat shock protein A4 in lung adenocarcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第1期15卷 45-61页

作者： xuan wu Shen-Ying Yang Yi-Hua Zhang Jin-Zhou Fang Shuai Wang Zhi-Wei Xu Xiao-Ju Zhang Department of Respiratory and Critical Care Medicine Zhengzhou University People’s HospitalZhengzhou 450008Henan ProvinceChina Graduate School Xinxiang Medical UniversityXinxiang 453003Henan ProvinceChina Department of Pulmonary and Critical Care Medicine Zhengzhou University People’s HospitalZhengzhou 450008Henan ProvinceChina

BACKGROUND Heat shock protein A4(HSPA4)belongs to molecular chaperone protein family which plays important roles within variable cellular activities,including cancer initiation and ***,the prognostic and immunological significance of HSPA4 in lung adenocarcinoma(LUAD)has not been revealed *** To explore the prognostic and immunological roles of HSPA4 to identify a novel prognostic biomarker and therapeutic target for *** We assessed the prognostic and immunological significance of HSPA4 in LUAD using data from The Cancer Genome Atlas *** association between HSPA4 expression and clinical-pathological features was assessed through Kruskal-Wallis and Wilcoxon signed-rank ***/multivariate Cox regression analyses and Kaplan-Meier curves were employed to evaluate prognostic factors,including HSPA4,in *** set enrichment analysis(GSEA)was conducted to identify the key signaling pathways associated with *** correlation between HSPA4 expression and cancer immune infiltration was evaluated using single-sample gene set enrichment analysis(ssGSEA).RESULTS Overexpressing HSPA4 was significantly related to advanced pathologic TNM stage,advanced pathologic stage,progression disease status of primary therapy outcome and female subgroups with *** addition,increased HSPA4 expression was found to be related to worse disease-specific survival and overall *** analysis indicated a significant correlation between HSPA4 and cell cycle regulation and immune response,particularly through diminishing the function of cytotoxicity cells and CD8 T *** ssGSEA algorithm showed a positive correlation between HSPA4 expression and infiltrating levels of Th2 cells,while a negative correlation was observed with cytotoxic cell infiltration *** Our findings indicate HSPA4 is related to prognosis and immune cell infiltrates and may act as a novel prognostic biomarker and therapeutic target for LUAD.

关键词： Heat shock protein A4 Lung adenocarcinoma Tumor-infiltration Prognosis T helper cells

Double-blinded,randomized clinical trial of Gegen Qinlian decoction pinpoints Faecalibacterium as key gut bacteria in alleviating hyperglycemia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Precision Clinical Medicine 2024年第1期7卷 21-33页

作者： Zezheng Gao Wenhui Zhang Lisha He Han Wang Yufei Li Xiaotian Jiang Sha DI Xinmiao Wang xuan Zhang Lin Han Yanwen Liu Chengjuan Gu Mengyi wu Xinhui He Lei Cheng Jun Wang Xiaolin Tong Linhua Zhao Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Endocrinology Guang anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Chengdu University of Traditional Chinese Medicine Chengdu 611137China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China Centre for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Endocrinology Affiliated Hospital of Changchun University of Chinese MedicineChangchun 13000oChina Biologicals Science and Technology Institute Baotou Teacher's CollegeBaotou 014030China Department of Endocrinology Zhengzhou T.C.M.HospitalZhengzhou 450007China Shenzhen Hospital Guangzhou University of Chinese Medicine(Futian)Shenzhen 518000China Department of Cardiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Cardiology Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650000China Key Laboratory of Development and Application of Rural Renewable Energy Biogas Institute of Ministry of Agriculture and Rural AffairsChengdu 610041China

Background:Accumulating evidence suggests that metabolic disorders,including type 2 diabetes mellitus(T2DM),can be treated with traditional Chinese medicine formulas,such as the Gegen Qinlian decoction(GQD).This study elucidates the mechanisms by which gut microbes mediate the anti-diabetic effects of ***:We conducted a double-blind randomized clinical trial involving 120 untreated participants with *** the 12-week intervention,anthropometric measurements and diabetic traits were recorded every 4 *** microbiota and serum metabolites were measured before and after the intervention using 16S rDNA sequencing,liquid chromatography-mass spectrometry,and Bio-Plex ***:Anti-diabetic effects were observed in the GQD group in the human ***,glycated hemoglobin,fasting plasma glucose,and two-hour postprandial blood glucose levels were significantly lower in the GQD group than in the placebo ***,Faecalibacterium was significantly enriched in the GQD group,and the short-chain fatty acid levels were higher and the serum inflammation-associated marker levels were lower in the GQD group compared to the placebo ***,Faecalibacterium abundance negatively correlated with the levels of serum hemoglobin,fasting plasma glucose,and pro-inflammatory ***,the diabetes-alleviating effect of Faecalibacterium was confirmed by oral administration of Faecalibacterium prausnitzi(DSMZ 17677)in ***:GQD improved type 2 diabetes primarily by modulating the abundance of Faecalibacterium in the gut microbiota,alleviating metabolic disorders and the inflammatory state.

关键词： double-blinded randomized controlled trial type 2 diabetes mellitus Gegen Qinlian decoction Faecalibacterium metabolic disorders inflammation