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Synthesis and Characterization of a Persistent Benzoanthracenyl Radical Derivative

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Chemical Research in Chinese Universities 2023年第2期39卷 208-212页

作者： GUO Yupeng wu xingye HOU Bingxia XIANG Qin NI Yong LI Jinling SUN Zhe Institute of Molecular Plus Department of ChemsitryTianjin UniversityTianjin300072P.R.China School of Materials Science and Engineering Henan University of TechnologyZhengzhou450001P.R.China Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdong518055P.R.China

A highly persistent benzoanthracenyl radical(BAR1)protected by five substituents at strategic positions is ***1 exhibited half-life time of 108 h in air-saturated solution,which allowed for detailed characterization in the *** combined experimental and theoretical study reveals the properties associated with its asymmetric structure and spin ***-electron oxidation of BAR1 afforded stable cationic species BAR1+,whose structure is unambiguously determined by the NMR spectroscopy.

关键词： Graphene fragment Hydrocarbon radical Delocalization Spin distribution Cation

GLP-1受体激动剂利拉鲁肽皮下注射对肥胖雄性小鼠血清性激素水平的影响

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山东医药 2024年第14期64卷 36-39页

作者：柒锐冰蒋嘉钦余劲明吴兴烨陈冰李争明广西医科大学附属武鸣医院内分泌代谢科南宁530199 广西医学科学院广西壮族自治区人民医院内分泌代谢科

目的观察胰高血糖素样肽1(GLP-1)受体激动剂利拉鲁肽皮下注射对肥胖雄性小鼠血清性激素水平的影响。方法取雄性C57BL/6J小鼠18只,随机分为正常组、模型组、干预组,每组各6只。正常组给予普通饲料喂养,模型组和干预组通过给予高脂饲料... 详细信息

目的观察胰高血糖素样肽1(GLP-1)受体激动剂利拉鲁肽皮下注射对肥胖雄性小鼠血清性激素水平的影响。方法取雄性C57BL/6J小鼠18只,随机分为正常组、模型组、干预组,每组各6只。正常组给予普通饲料喂养,模型组和干预组通过给予高脂饲料喂养建立肥胖模型;饲养10周后造模成功,干预组皮下注射利拉鲁肽100μg/(kg·d),正常组和模型组给予等体积生理盐水皮下注射,连续12周。每周测量小鼠体质量;给药结束后使用血糖试纸测量空腹血糖(FBG),ELISA法检测血清胰岛素(INS)、黄体生成素(LH)、促卵泡激素(FSH)、睾酮(T)、游离睾酮(FT)、雌二醇(E2)和性激素结合球蛋白(SHBG),计算胰岛素抵抗指数(HOMA-IR)。结果与正常组比较,模型组0、4、8、12周时体质量均升高(P均0.05)。给药结束后,与正常组比较,模型组血清FBG、INS、HOMA-IR升高(P均<0.01);与模型组比较,干预组血清FBG、INS、HOMA-IR降低(P均<0.01)。与正常组比较,模型组血清LH、FSH、T、FT水平降低,E2、SHBG水平升高(P均<0.05);与模型组比较,干预组血清LH、FSH、T和FT水平升高,E2和SHBG水平降低(P均<0.05)。结论肥胖雄性小鼠的性激素水平存在异常;利拉鲁肽能够改善肥胖雄性小鼠的性激素水平,其机制可能与其显著降糖及减轻体质量的作用有关。

关键词：胰高血糖素样肽1 利拉鲁肽肥胖性激素

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Effect of electroacupuncture at Neiguan(PC6)at different time points on myocardial ischemia reperfusion arrhythmia in rats

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Journal of Traditional Chinese Medicine 2024年第1期44卷 113-121页

作者： SUN Qianhui CHENG Kai DAI xingye YANG Zhiwen wu Xiaoling XU Chang QIU Xinghua GAO Xiaofeng LIU Daonan YANG Qirui School of Acupuncture and Tuina Beijing University of Chinese MedicineBeijing 100029China Beijing MedEx Technology Co. Ltd.Beijing 100029China

OBJECTIVE:To observe the effects of electroacupuncture at Neiguan(PC6)at different time points on reperfusion arrhythmia(RA)after myocardial ischemia and reperfusion in rats,and to investigate the correlation of this protective effect with nerve growth factor(NGF),tyrosine kinase A(Trk A),tyrosine hydroxylase(TH),and norepinephrine(NE).METHODS:A total of 72 Sprague-Dawley male rats were randomly divided into six groups(n=12 rats/group):normal group(Norm),sham operation group(Sham),ischemia reperfusion group(I/R),pre-ischemic electroacupuncture group(EAI),pre-reperfusion electroacupuncture group(EAII),post-reperfusion electroacupuncture group(EAIII).The myocardial ischemia-reperfusion injury(MIRI)model was induced by occlusion of left anterior descending coronary artery for 20 min followed by reperfusion for 40 min in *** no intervention in the Norm group and only threading without ligation in the Sham *** pretreatment at 20 min/d for 7 d before ligation in the EAⅠgroup,20 min of electroacupuncture before reperfusion in the EAII group and 20 min of electroacupuncture after reperfusion in the EAIII *** electrocardiogram(ECG)of each group was recorded throughout the whole process,and the success of the MIRI model was determined based on the changs of J-point and T-wave in the *** arrhythmia score was used to record premature ventricular contractions,ventricular tachycardia and ventricular fibrillation during the reperfusion period to assess the reperfusion induced *** expression levels of NGF,Trk A,TH protein were measured by Western ***,the expression levels of plasma and myocardial NE levels were detected by enzyme linked immunosorbent ***:The differences between Norm group and Sham group were not statistically significant in all *** score,myocardial NGF,Trk A,TH,and NE expression were significantly higher in the I/R group compared with the Sham *** score,myocardial NGF,T

关键词： myocardial reperfusion injury reperfusion arrhythmia electroacupuncture point PC6(Neiguan) nerve growth factor protein-tyrosine kinases norepinephrine

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胃肠间质瘤患者的全程化信息化管理

中华胃肠外科杂志 2020年第9期23卷 858-860页

作者：吴星烨张军重庆医科大学附属第一医院胃肠外科 400016

胃肠间质瘤(GIST)是胃肠道最常见的间叶源性肿瘤。随着对GIST诊疗的进步,患者生存期显著延长,疾病进入“慢性病”范畴。因此,如何对患者进行有效的全程化信息化管理是每一位GIST同仁面临的重要问题。我们认为:每一位GIST患者都有进行全... 详细信息

胃肠间质瘤(GIST)是胃肠道最常见的间叶源性肿瘤。随着对GIST诊疗的进步,患者生存期显著延长,疾病进入“慢性病”范畴。因此,如何对患者进行有效的全程化信息化管理是每一位GIST同仁面临的重要问题。我们认为:每一位GIST患者都有进行全程化管理的需求,这也是保障患者疗效的重要因素;信息化管理的理念、符合GIST疾病特点的管理系统以及专职的GIST疾病管理员,是实现全程化管理的保障,也是实现GIST诊治同质化的必备条件。

关键词：胃肠间质瘤全程化管理信息化管理

Survivin:an overexpression protein with notable cellular localization and multiple roles in colon cancer

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The Chinese-German Journal of Clinical Oncology 2010年第9期9卷 519-523页

作者： Xuehu Wang Zhongxue Fu Yu Zhao Wei Shen xingye wu Chunyi Wang Department of General Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing 400016China

Objective:Survivin has attracted abundant interest in tumor research since it was discovered in *** several studies indicated that the relationship between survivin expression and tumor behavior is still not fully *** our main aim was to observe the localization of survivin in colon cancer and its influence on the colon cancer ***:We screened the expression and localization of survivin in SW480 by immunofluorescence and ***, we constructed the recombinant adenovirus (Ad-survivin/shRNA), which contained the short hairpin RNA (shRNA) of survivin and transfected it into SW480 *** detected survivin gene expression after shRNA interference by RT-PCR and Western blot, and its influence on the proliferation, apoptosis and cell cycle was analyzed by MTT, colony-formation, and flow ***:Survivin was expressed at a high level in SW480 cells and the sub-cellular localization was in the *** adenovirus could suppress survivin expression efficiency and inhibit proliferation, induce apoptosis, and affected the mitosis in ***:Survivin plays an important role in controlling tumor growth by a variety of molecular regulatory *** survivin silence could induce apoptosis, effect the mitotic cycle and inhibit cell proliferation.

关键词： colon cancer survivin RNA interference (RNAi) mitosis apoptosis

Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine

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Genes & Diseases 2017年第2期4卷 43-63页

作者： Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu xingye wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke wu Ying wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Laboratory of Craniofacial Biology and Development Section of Plastic and Reconstructive SurgeryDepartment of SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical UniversityChongqing 400016China Department of Laboratory Medicine and Clinical Diagnostics The Affiliated Yantai HospitalBinzhou Medical UniversityYantai 264100China Department of Immunology and Microbiology Beijing University of Chinese MedicineBeijing 100029China

With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted *** numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human *** is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene *** has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two *** all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue *** applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial *** fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral *** review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative *** challenges and future directions regarding the use of adenoviral vectors are also *** is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine.

关键词： Adenovirus Adenoviral vector Cell therapy Gene transfer Gene therapy Oncolytic virus Regenerative medicine Vaccine development

Clinical and economic benefits of a pharmacist in a multidisciplinary team for Chinese outpatients with gastrointestinal stromal tumors

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Journal of Chinese Pharmaceutical Sciences 2021年第7期30卷 598-605页

作者： Yi Zhou xingye wu Juan Li Wei Cheng Xiaosong Li Yifan Shen Jun Zhang Department of Pharmacy the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Gastrointestinal Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China The Center for Clinical Molecular Medical Detection the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

The multidisciplinary approach is beneficial to the treatment of gastrointestinal stromal tumors(GISTs).However,pharmacists are seldom incorporated into a multidisciplinary team(MDT)of *** the present study,we evaluated the clinical and economic benefits of a pharmacist in an MDT of *** was a retrospective study that included 240 GIST patients receiving imatinib *** GIST MDT pharmacist developed and validated an HPLC method to monitor the trough concentrations of imatinib in GIST ***,the pharmacist also provided patient education and pharmaceutical care services and collected the data for *** 240 GIST patients received the services provided by the *** trough concentrations in 25.42%of the 240 patients were less than 1100 ng/m *** main genotypes of 121 in the 240 patients were KIT exon 11 mutations,wild type,and KIT exon 9 ***,13 GIST patients with trough concentrations less than 1100 ng/m L were confirmed to have low *** adverse reactions were primarily mild and tolerable,except that 13 GIST patients were adjusted to lower doses because of the intolerable adverse *** daily cost could be lowered by monitoring the trough concentrations and dose ***,a pharmacist included in a GIST MDT could increase the compliance of Chinese GIST patients to imatinib therapy and improve the efficacy,safety,and economy of imatinib therapy.

关键词： Pharmacist Imatinib Multidisciplinary team Gastrointestinal stromal tumor Trough concentration

Corrigendum to “The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs” [Genes & Diseases 5 (2018) 62–74]

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Genes & Diseases 2023年第2期10卷 627-629页

作者： Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke wu Ying wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C. Haydon Hue H. Luu Lan Zhou Russell R. Reid Tong-Chuan He xingye wu Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine Chongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Clinical Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006China Departments of Clinical Laboratory Medicine General SurgeryOrthopedic SurgeryNephrologyand CardiologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China The Children's Hospital Chongqing Medical UniversityChongqing 400014China Department of Laboratory Medicine and Clinical Diagnostics The Affiliated Yantai HospitalBinzhou Medical UniversityYantai 264100China Department of Immunology and Microbiology Beijing University of Chinese MedicineBeijing 100029China Key Laboratory of Orthopaedic Surgery of Gansu Province and the Department of Orthopaedic Surgery The Second Hospital of Lanzhou UniversityLanzhou 730030China Department of Surgery The Affiliated Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biochemistry and Molecular Biology China Three Gorges University School of MedicineYichang 443002China Department of Orthopaedic Surgery Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China Department of Orthopaedic Surgery Xiangya Second Hospital of Central South UniversityChangsha 410011China Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing 401147China The Affiliated Hospital of Stomatology of Chongqing Medical University Chongqing 401147China Department of Surgery Laboratory of Craniofacial Biology and DevelopmentSection of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

The authors regret having an image assembly error in Figure 5Ca,in which the image for the "Oh dBiFP-AdRFp"group was erroneously duplicated with an overlapping image from the"36h BiFP dBIFP-AdR-simH19"*** confirm the error is restricted to the image assembly,and the underlying data and conclusions are correct and *** authors would like to apologize for any inconvenience caused.

关键词： image Figure unchanged

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PRDX1在结直肠癌中的表达及其临床意义

重庆医学 2011年第32期40卷 3276-3277,3279页

作者：蒋尧傅仲学吴星烨重庆市渝州监狱医院 400026 重庆医科大学附属第一医院外三科 400016

目的探讨过氧化氧化还原蛋白1(PRDX1)在结直肠癌组织及远处正常组织中的表达情况及其与患者临床病理资料间的关系。方法采用免疫组织化学对32例结直肠癌组织及相应的远处正常组织中PRDX1的表达情况进行检测,随机抽取8例标本采用蛋白质... 详细信息

目的探讨过氧化氧化还原蛋白1(PRDX1)在结直肠癌组织及远处正常组织中的表达情况及其与患者临床病理资料间的关系。方法采用免疫组织化学对32例结直肠癌组织及相应的远处正常组织中PRDX1的表达情况进行检测,随机抽取8例标本采用蛋白质印迹的方法进行验证;将PRDX1的表达情况与患者的性别、年龄、肿瘤分期、淋巴结转移等临床病理资料进行统计学分析。结果免疫组织化学显示,PRDX1蛋白主要表达于细胞质,在结直肠癌远处正常组织中的表达(15.63%,5/32)与结直肠癌组织中(65.63%,21/32)比较,差异有统计学意义(P0.05),然而PRDX1蛋白的表达与Ⅲ期结直肠癌患者或者有淋巴结转移的患者之间有明显的相关性(P<0.05)。结论 PRDX1在结直肠癌组织中高表达,可能参与了肿瘤的进展,检测其表达情况在结直肠癌的诊治中可能具有一定的作用。

关键词：结直肠肿瘤活性氧过氧化氧化还原蛋白1