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Surgical treatment of brachiocephalic vessel involvement in Takayasu＇s arteritis

Chinese Medical Journal 2010年第9期123卷 1122-1126页

作者： wu xin duan hong-yong gu yong-quan li jian-xin chen bing wang zhong-gao zhang jian Department of Vascular Surgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Background Takayasu＇s arteritis （TA） is a chronic idiopathic inflammatory disease that affects large and medium size arteries. The brachiocephalic trunk is the most frequently involved site in TA, and multi-vessel lesions are common. Surgical treatment includes vessel reconstruction surgery and percutaneous transluminal angioplasty （PTA）. Herein, we report our preliminary experience with surgical treatment of cerebral ischemia caused by cervical arterial lesions due to *** From January 2000 to December 2007, 38 patients with cerebral ischemia caused by cervical arterial occlusive lesions due to TA were treated surgically. There were three males and 35 females, with an age range of 15-42 years （mean 26.5 years）. All patients had operative repairs undertaken. Twenty eight patients received bypass operation and 10 patients received percutaneous transluminal angioplasty. One case with coronary stenosis received coronary artery bypass simultaneously. Patients were followed up for 11 months to eight *** There were no peri-operative deaths in cerebrovascular reconstruction patients. Symptoms of cerebral ischemia were improved or cured in 25 of 38 patients. There was a low incidence of cerebral reperfusion syndrome. Two patients died at five and seven years after surgery due to heart failure. Another 8 patients （20%） required further surgery for stenosis （5 patients） or anastomotic aneurysms （3 patients）. Percutaneous transluminal angioplasty was performed successfully for treatment of aortic and renal lesions. Repeated angioplasty for revascularization was performed in six PTA cases with restenosis after 5-24 *** When cerebral perfusion has potential to be affected by TA, a definitive corrective procedure is advised when the patient is relatively stable. Although the recurrence rate is very high, percutaneous transluminal angioplasty is the first choice procedure. Bypass operation is optimal for brachiocephalic-vessel involvement in TA. Cere

关键词： Takayasu's arteritis brain ischemia brachiocephalic trunk surgical procedures operative reperfusion syndrome

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang guofu Cao jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen guoming chen Hua-xing chen Huirun chen Jinhui chen Ji-Yuan chen Kai chen Mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen Xiang chen Xiaoyu chen xin chen Xun chen Xurong chen Ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo yong-Heng Zhao Gang Zhao li-Cai Deng Xiao-Wei liu Yi-Peng Jing Gang wang Hao-Tong zhang jian-Rong Shi Xiang-Qun Cui Yao-quan Chu guo-Ping li zhong-Rui Bai Yue wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan chen jian-Jun chen Kun-xin chen li chen Xue-Lei chen Xiao-Yan chen Ying chen Norbert Christlieb Jia-Ru Chu chen-Zhou Cui Yi-Qiao Dong bing Du Dong-Wei Fan Lei Feng jian-Ning Fu Peng gao Xue-Fei Gong Bo-zhong gu Yan-xin guo Zhan-Wen Han Bo-liang He Jin-liang Hou yong-Hui Hou Wen Hou hong-Zhuan Hu Ning-Sheng Hu zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li guang-Wei li Hai-Ning li jian li Qi li Shuang li Sha-Sha li xin-Nan li Yan li Yin-Bi li Ye-Ping li Yuan liang Chien-cheng lin Chao liu Gen-Rong liu guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su hong-Jun Su Zheng-hong Tang Qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang Feng-Fei wang guo-Min wang Hai wang hong-Chi wang jian wang Jia-Ning wang jian-ling wang jian-Ping wang Jun-Xian wang Lei wang Meng-xin wang Shou-guan wang Shu-Qing wang Xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang Peng Wei Ming-Zhi Wei hong wu Ke-Fei wu Xue-bing wu Yu-zhong wu Xiao-Zheng xing ling-Zhe Xu xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng zhang Hua-Wei zhang jian-Nan zhang li-Pin zhang Wei zhang yong zhang Yan-Xia zhang Zheng-Chao zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu yong-Tian Zhu Si-cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong gao Cong li Ruo-Yu liu Ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

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Epidemiology,clinical and laboratory characteristics of currently alive HIV-1 infected former blood donors naive to antiretroviral therapy in Anhui Province,China

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Chinese Medical Journal 2006年第23期119卷 1941-1948页

作者： XU jian-qing wang jian-jun HAN li-feng XU chen RUAN Yu-hua XU Zhen-hou chen Xi liU Zhen-dong wang Jun SU bing DING xin-ping gao bing gu yong-bin CAO Xiao-yun xinG Hui hong Kun-xue PENG hong ZHAO quan-bi YUAN lin FENG Yi zhang gui-yun MA li-ying wu Lan SHAO Yi-ming State Key Laboratory for Infectious Disease Prevention and Control National Center for MDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Reference Laboratory National Center for MDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Anhui Provincial Center for Disease Control and Prevention Hefei230000 China Fuyang Center for Disease Control and Prevention Fuyang 236000 China Yingzhou Center for Disease Control and Prevention Fuyang 236000 China Funan Center for Disease Control and Prevention Fuyang 236000 China

Background Unregulated commercial blood/plasma collection among farmers occurred between 1992 and 1995 in central China and caused the second major epidemic of human immunodeficiency virus type 1 （HIV-1） infection in China. It is important to characterize HIV-l-infected former blood donors and to study characteristics associated with disease progression for future clinical intervention and vaccine development. Methods A cross-sectional study was performed on HIV-l-infected former blood donors （FBDs） and age-matched HIV-seronegative local residents. Demographic, epidemiologic, clinical and key laboratory data were collected from all study participants. Both unadjusted and adjusted multivariate linear regressions were employed to analyze the association of the decrease of CD4^＋ T-cell counts with other characteristics. Results Two hundred and ninety-four HIV-l-infected FBDs and 59 age-matched HIV-seronegative local residents were enrolled in this study. The unregulated blood/plasma collection occurred more than a decade （10.8 --12.8 years） ago, which caused the rapid spread of HIV-1 infection and the high prevalence of co-infection with hepatitis C virus （HCV, 89.5%）, hepatitis B virus （HBV） co-infection was observed in only 11 HIV＋participants （3.7%）. Deterioration in both clinical manifestation and laboratory parameters and increase of viral loads were observed in parallel with the decrease of CD4^＋ T-cell counts. The decrease of total lymphocyte counts （P〈0.001） and hemoglobin levels （P〈0.001） and the appearance of dermatosis （P=0.03） were observed in parallel with the decrease of CD4^＋ T-cell counts whereas viral loads （P〈0.001） and CD8^＋ T-cell counts （P=0.01） were inversely associated with CD4^＋ T-cell counts.Conclusions Co-infection with HCV but not HBV is highly prevalent among HIV-l-infected FBDs. CD4^＋ T-cell counts is a reliable indicator for disease progression among FBDs. Total lymphocyte counts, hemoglobin level and appearance of dermatosis were po

关键词： human immunodeficiency virus blood donors disease progression co-infection hepatitis C

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Evidence for particle acceleration approaching PeV energies in the W51 complex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： LHAASO Collaboration Zhen Cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi W.Bian A.V.Bukevich Q.Cao W.Y.Cao Zhe Cao J.Chang J.F.Chang A.M.chen E.S.chen H.X.chen liang chen lin chen Long chen M.J.chen M.L.chen Q.H.chen S.chen S.H.chen S.Z.chen T.L.chen Y.chen N.cheng Y.D.cheng M.Y.Cui S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.duan J.H.Fan Y.Z.Fan J.Fang J.H.Fang K.Fang C.F.Feng H.Feng L.Feng S.H.Feng X.T.Feng Y.Feng Y.L.Feng S.Gabici B.gao C.D.gao Q.gao W.gao W.K.gao M.M.Ge L.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.gu F.L.guo X.L.guo Y.Q.guo Y.Y.guo Y.A.Han M.Hasan H.H.He H.N.He J.Y.He Y.He Y.K.Hor B.W.Hou C.Hou X.Hou H.B.Hu Q.Hu S.C.Hu D.H.Huang T.Q.Huang W.J.Huang X.T.Huang X.Y.Huang Y.Huang X.L.Ji H.Y.Jia K.Jia K.jiang X.W.jiang Z.J.jiang M.Jin M.M.Kang I.Karpikov D.Kuleshov K.Kurinov B.B.li C.M.li cheng li Cong li D.li F.li H.B.li H.C.li jian li Jie li K.li S.D.li W.L.li W.L.li X.R.li xin li Y.Z.li Zhe li Zhuo li E.W.liang Y.F.liang S.J.lin B.liu C.liu D.liu D.B.liu H.liu H.D.liu J.liu J.L.liu M.Y.liu R.Y.liu S.M.liu W.liu Y.liu Y.N.liu Q.Luo Y.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao Z.Min W.Mitthumsiri H.J.Mu Y.C.Nan A.Neronov L.J.Ou P.Pattarakijwanich Z.Y.Pei J.C.Qi M.Y.Qi B.Q.Qiao J.J.Qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.W.Shu H.C.Song Yu.V.Stenkin V.Stepanov Y.Su D.X.Sun Q.N.Sun X.N.Sun Z.B.Sun J.Takata P.H.T.Tam Q.W.Tang R.Tang Z.B.Tang W.W.Tian C.wang C.B.wang G.W.wang H.G.wang H.H.wang J.C.wang Kai wang Kai wang L.P.wang L.Y.wang P.H.wang R.wang W.wang X.G.wang X.Y.wang Y.wang Y.D.wang Y.J.wang Z.H.wang Z.X.wang Zhen wang Zheng wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.wu H.R.wu Q.W.wu S.wu X.F.wu Y.S.wu S.Q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.xin Y.xing D.R.Xiong Z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.Xue D.H.Yan J.Z.Yan T.Yan C.W.Yang C.Y.Yang F.Yang F.F.Yang L.L.Yang M.J.Yang R.Z.Yang W.X.Yang Y.H.Yao Z.G.Yao L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng M.Zha B.B.zhang F.zhang H.zhang 不详 Key Laboratory of Particle Astrophysics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear Research of Russian Academy of Sciences Moscow 117312Russia Hebei Normal University Shijiazhuang 050024China University of Science and Technology of China Hefei 230026China State Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Physics and Astronomy Yunnan UniversityKunming 650091China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays(CRs)accelerated by the shock of supernova remnant(SNR)W51C and the dense molecular clouds in the adjacent star-forming region,***,the maximum acceleration capability of W51C for CRs remains *** on observations conducted with the Large High Altitude Air Shower Observatory(LHAASO),we report a significant detection ofγrays emanating from the W51 complex,with energies from 2 to 200 *** LHAASO measurements,for the first time,extend theγ-ray emission from the W51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-LAT,the broadbandγ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 TeV or a power-law break at~200 TeV in the CR proton spectrum,most likely providing the first evidence of SNRs serving as CR accelerators approaching the PeV ***,two young star clusters within W51B could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of extreme CR accelerators within the W51 complex and provide new insights into the origin of Galactic CRs.

关键词： UHE c-ray Cosmic rays SNR W51C Star clusters

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改良酶学方法获得异种血管脱细胞支架

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中国组织工程研究与临床康复 2011年第47期15卷 8769-8772页

作者：武欣谷涌泉段红永陈兵李建新吴英锋张淑文汪忠镐张建首都医科大学宣武医院血管外科北京市100053

背景:扩大脱细胞基质的孔径与孔隙率,保证其作为移植物的力学特性,是目前血管组织工程研究的热点之一。目的:观察改良的酶学方法处理异种血管的力学性能和组织相容性。方法:取猪的颈动脉作为基质,采用传统胰蛋白酶-EDTA加1%TritonX-100... 详细信息

背景:扩大脱细胞基质的孔径与孔隙率,保证其作为移植物的力学特性,是目前血管组织工程研究的热点之一。目的:观察改良的酶学方法处理异种血管的力学性能和组织相容性。方法:取猪的颈动脉作为基质,采用传统胰蛋白酶-EDTA加1%TritonX-100和0.1%氨水顺序脱细胞方案,并做了适当的方法改进,延长胰酶处理的时间,分别为胰酶处理4h,5h,6h。结果与结论:经组织学分析,脱细胞基质中无细胞成分,脱细胞的支架结构完整,随着胰酶处理时间的延长,其基质内弹力板破坏明显,孔径和孔隙率逐渐增大,缝合强度与爆破强度相对于自然血管虽略有降低,但差异无显著性意义。组织成分胶原蛋白含量也有所下降,尤其胰酶延长至6h组,其胶原蛋白含量明显低于正常未处理的自然血管(P<0.05)。结果显示延长胰蛋白酶处理时间后得到的脱细胞血管基质,具有良好的孔隙率、生物力学性能和组织相容性。

关键词：脱细胞血管基质胰酶孔隙率生物力学生物相容性支架

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利用脱细胞血管基质体外构建小口径组织工程血管

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中国实验动物学报 2010年第5期18卷 377-382,I0002,I0003页

作者：武欣谷涌泉段红永陈兵李建新吴英锋张淑文汪忠镐张建首都医科大学宣武医院血管外科北京100053

目的探讨利用犬的间充质干细胞诱导分化种子细胞,以异种脱细胞血管基质为基础体外构建小口径血管移植物。方法采用密度梯度离心和贴壁培养的方法从犬骨髓中分离出间充质干细胞并体外培养,诱导分化成内皮样细胞和平滑肌样细胞;采用非离... 详细信息

目的探讨利用犬的间充质干细胞诱导分化种子细胞,以异种脱细胞血管基质为基础体外构建小口径血管移植物。方法采用密度梯度离心和贴壁培养的方法从犬骨髓中分离出间充质干细胞并体外培养,诱导分化成内皮样细胞和平滑肌样细胞;采用非离子型去垢剂和胰蛋白酶去除猪颈动脉血管壁结构细胞,对脱细胞基质进行组织学、力学检测及孔隙率评估。在生物反应器内采用旋转种植的方法将犬骨髓间充质干细胞诱导的内皮样细胞种植到脱细胞基质上,体外构建小口径组织工程血管。结果犬的骨髓间充质干细胞体外能够定向诱导分化为平滑肌样细胞和内皮样细胞,可以作为血管组织工程的种子细胞。经过脱细胞处理后,光镜和电镜观察证实血管壁的细胞成分完全去除。具有良好的孔径和孔隙率。支架在生物力学、孔隙率等方面符合构建组织工程血管支架的要求。在生物反应器内剪切力条件下可以初步构建出组织工程血管。结论小口径血管移植物可以将间充质干细胞诱导种子细胞,以异种脱细胞血管支架作为基质,在搏动性生物反应器内培养的方法进行构建。

关键词：间充质干细胞脱细胞支架生物反应器组织工程

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可降解组织工程血管支架成功用于犬股动脉移植

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中国实验动物学报 2011年第3期19卷 250-254,279页

作者：武欣谷涌泉段红永陈兵李建新吴英锋张淑文汪忠镐张建首都医科大学宣武医院血管外科北京100053

目的采用可降解的聚己内酯接枝肝素材料,负荷b-FGF(碱性成纤维细胞生长因子),体外构建的小口径组织工程血管,完成犬的股动脉移植动物实验。方法利用可降解的聚己内酯接枝肝素材料,电纺丝技术制备组织工程血管支架,并对支架负荷b-FGF生... 详细信息

目的采用可降解的聚己内酯接枝肝素材料,负荷b-FGF(碱性成纤维细胞生长因子),体外构建的小口径组织工程血管,完成犬的股动脉移植动物实验。方法利用可降解的聚己内酯接枝肝素材料,电纺丝技术制备组织工程血管支架,并对支架负荷b-FGF生长因子,并进行材料的内皮细胞粘附实验。将体外构建的小口径组织工程血管,完成犬的股动脉移植动物实验,观察通畅率和移植术后组织工程血管的改变。结果可降解聚己内酯接枝肝素材料支架,负荷细胞生长因子(b-FGF),利于内皮细胞粘附。构建的组织工程血管进行体外动物实验构建,3个月移植物通畅率好,移植后取材,有新生内膜迁移和胶原纤维浸入。结论利用可降解聚己内酯接枝肝素材料构建小口径支架,初步符合构建组织工程血管支架的要求。

关键词：可降解聚己内酯材料血管支架组织工程抗凝股动脉移植通畅性犬

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生物可降解聚合物结合碱性成纤维细胞生长因子与内皮细胞的黏附

引用

中国组织工程研究与临床康复 2011年第8期15卷 1336-1340页

作者：武欣谷涌泉张建叶霖段红永吴英峰陈兵李建新张淑文冯增国汪忠镐首都医科大学宣武医院血管外科北京市100053 北京理工大学材料学院北京市100081

背景:可降解材料的应用是体外构建小口径组织工程血管的重要研究部分。如何对可降解材料进行改性,以利于材料本身体外抗凝与促进内皮细胞黏附,是目前血管组织工程研究的热点之一。目的:利用可降解聚己内酯接枝肝素材料体外负载碱性成纤... 详细信息

背景:可降解材料的应用是体外构建小口径组织工程血管的重要研究部分。如何对可降解材料进行改性,以利于材料本身体外抗凝与促进内皮细胞黏附,是目前血管组织工程研究的热点之一。目的:利用可降解聚己内酯接枝肝素材料体外负载碱性成纤维细胞生长因子,观察其对于内皮细胞黏附的影响。方法:应用聚己内酯可降解材料,将肝素活化后并与聚己内酯的端羟基发生酯化反应从而被锚定在聚己内酯两端。经过电纺丝技术,制备血管支架。同时利用肝素和生长因子间的静电吸附作用,使支架负载碱性成纤维细胞生长因子。采用低密度内皮细胞短期静态种植,观察负载细胞生长因子的可降解聚己内酯材料对内皮细胞生长黏附情况的影响。结果与结论:成功地制备了负载成纤维细胞生长因子的可降解聚己内酯接枝肝素支架。内皮黏附实验证实,该支架利于内皮细胞黏附。提示可降解聚己内酯接枝肝素材料负荷碱性细胞生长因子支架对内皮细胞有很好的体外黏附性。

关键词：可降解聚已内酯肝素支架内皮细胞碱性成纤维细胞生长因子组织工程

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