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SARCS-4程序系统临界物理模拟实验验证

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核动力工程 2018年第3期39卷 166-170页

作者：李满仓陈长姚栋魏彦琴吴文斌赵文博黄世恩倪东洋巨海涛郑洪涛秦冬张知竹汪量子吴磊中国核动力研究设计院核反应堆系统设计技术国家级重点实验室成都610213

SARCS-4程序系统是中国核动力研究设计院自主研发的新一代中子学程序包,需对程序展开工程验证,完善理论模型,提高计算精度。利用成熟燃料元件,设计并制造出与新型燃料组件结构相似的模拟组件。利用模拟组件构造了3种堆芯布置并进行模拟... 详细信息

SARCS-4程序系统是中国核动力研究设计院自主研发的新一代中子学程序包,需对程序展开工程验证,完善理论模型,提高计算精度。利用成熟燃料元件,设计并制造出与新型燃料组件结构相似的模拟组件。利用模拟组件构造了3种堆芯布置并进行模拟实验,验证SARCS-4程序系统的正确性和可靠性。按照单变量准则和多样化准则,考察控制棒、可燃毒物棒、围板和堆芯布置等因素。模拟实验临界棒位校核分析表明:堆芯泄漏、围板效应、控制棒和可燃毒物棒效应是影响校核精度的主要因素,SARCS-4计算程序系统对模拟实验的整体计算精度相对较高,特殊布置堆芯仍需进一步提高计算精度,后续将通过进一步的实验和研究开展持续验证和改进。

关键词：中子学程序包 SARCS-4 临界物理实验模拟实验

6G New Multiple Access Technology

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China Communications 2024年第1期21卷 I0002-I0005页

作者： Yifei Yuan Yongpeng wu Lei Wang Zhifeng Yuan Wei Bai Yuanwei Liu Tsinghua University in China Carnegie Mellon University USA wuhan University WuhanChina Southeast University NanjingChina Carleton University OttawaONCanada Nanjing University of Post and Telecommunications Shanghai Jiaotong University ShanghaiChina the School of Electronic Engineering and Computer Science Queen Mary University of London

As a basic technology at physical layer of mobile communications,non-orthogonal multiple access has been attracting wide attention across the academia and the *** the standardization of the fifth-generation(5G)of mobile communications,3GPP conducted preliminary study on non-orthogonal multiple access without reaching the consensus to standardize the technology.

关键词： technology Access attracting

Attitude Tracking Control for Rigid Spacecraft with Arbitrary Convergence Time

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Journal of Systems Science & Complexity 2024年

作者： XU Yu-Tian wu Ai-Guo Guangdong Provincial Key Laboratory of Intelligent Morphing Mechanisms and Adaptive Robotics Harbin Institute of Technology (Shenzhen) Key University Laboratory of Mechanism & Machine Theory and Intelligent Unmanned Systems of Guangdong Harbin Institute of Technology (Shenzhen) Department of Automation Harbin Institute of Technology (Shenzhen) Shenzhen 518055 China4HIT Wuhu Robot Technology Research Institute

In this paper, attitude tracking control with arbitrary convergence time for rigid spacecraft is considered. First, a novel time-varying sliding function is proposed to achieve free-will arbitrary time convergence when the system states reside on the sliding surface. With such a sliding function, an attitude tracking controller is designed to guarantee that the states of the closed-loop system converge to the sliding surface within a predetermined time in the presence of external disturbances. The free-will arbitrary time convergences of the closed-loop system and sliding function are illustrated by numerical simulations.

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海上升压站利用基础作为自然接地体的仿真研究

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电瓷避雷器 2019年第3期 105-110,117页

作者：方超颖郑钟楠钱健谢文炳吴文斌文习山王羽国网福建电力有限公司电力科学研究院福州350000 武汉大学电气工程学院武汉430072

海上升压站是大容量海上风电场的重要组成部分。为了抗台风和抗海底冲刷的需要,选址在近海海域和潮间带海域的海上升压站分别选取导管架和多桩作为基础类型。海水的深度,海水的电阻率,海床的电阻率以及潮间带地区的海床土壤结构,均会对... 详细信息

海上升压站是大容量海上风电场的重要组成部分。为了抗台风和抗海底冲刷的需要,选址在近海海域和潮间带海域的海上升压站分别选取导管架和多桩作为基础类型。海水的深度,海水的电阻率,海床的电阻率以及潮间带地区的海床土壤结构,均会对入地电流的流散产生影响,有必要研究海上升压站利用基础作为自然接地体的可行性。建立了以导管架和多桩基础作为海上升压站的自然接地体的仿真模型,将导体分段,求解各微段导体的格林函数,再叠加求解出模型的接地电阻。在此基础上,利用指数函数模型拟合,得出接地电阻与各影响因素的关系。计算结果表明,海上升压站利用基础作为自然接地体能够满足实际工程的需要,为实际海上升压站的接地设计提供参考。

关键词：海上升压站导管架基础多桩基础接地电阻

Oncogene goosecoid is transcriptionally regulated by E2F1 and correlates with disease progression in prostate cancer

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中华医学杂志(英文版) 2024年第15期137卷 1844-1856页

作者： Ge Yue Ma Sheng Zhou Qiang Xiong Zezhong Wang Yanan Li Le Chao Zheng Zhang Junbiao Li Tengfei wu Zixi Gao Yuan Qu Guanyu Xi Zirui Liu Bo wu Xi Wang Zhihua Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Urology Qinghai University Affiliated Hospital Qinghai University Medical College Xining Qinghai China Department of Oncology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Urology First Hospital of Laohekou City Xiangyang Hubei China

Background: Although some well-established oncogenes are involved in cancer initiation and progression such as prostate cancer (PCa), the long tail of cancer genes remains to be defined. Goosecoid (GSC) has been implicated in cancer development. However, the comprehensive biological role ofGSC in pan-cancer, specifically in PCa, remains unexplored. The aim of this study was to investigate the role ofGSC in PCa ***: We performed a systematic bioinformatics exploration ofGSC using datasets from The Cancer Genome Atlas, Genotype-Tissue Expression, Gene Expression Omnibus, German Cancer Research Center, and our in-house cohorts. First, we evaluated the expression ofGSC and its association with patient prognosis, and identifiedGSC-relevant genetic alterations in cancers. Further, we focused on the clinical characterization and prognostic analysis ofGSC in PCa. To understand the transcriptional regulation ofGSC by E2F transcription factor 1 (E2F1), we performed chromatin immunoprecipitation quantitative polymerase chain reaction (qPCR). Functional experiments were conducted to validate the effect ofGSC on the tumor cellular phenotype and sensitivity to ***: GSC expression was elevated in various tumors and significantly correlated with patient prognosis. The alterations ofGSC contribute to the progression of various tumors especially in PCa. Patients with PCa and highGSC expression exhibited worse progression-free survival and biochemical recurrence outcomes. Further,GSC upregulation in patients with PCa was mostly accompanied with higher Gleason score, advanced tumor stage, lymph node metastasis, and elevated prostate-specific antigen (PSA) levels. Mechanistically, the transcription factor,E2F1, stimulatesGSC by binding to its promoter region. Detailed experiments further demonstrated thatGSC acted as an oncogene and influenced the response of PCa cells to trametinib ***: GSC was highly overexpressed and strongly correlate

关键词： Goosecoid Prostate cancer Prognosis E2F transcription factor 1 Trametinib

Potential effects of aerosol generation and transmission during bedside endoscope cleaning

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 628-632页

作者： Tingting SHENG Xin wu Li CEN Ye LU Chenying ZHOU Qing GU Nursing Department the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Gastroenterology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051China

Airborne transmission is among the most frequent types of nosocomial *** years have witnessed frequent outbreaks of airborne diseases,such as severe acute respiratory syndrome(SARS)in 2002,Middle East respiratory syndrome(MERS)in 2012,and coronavirus disease 2019(COVID-19),with the latter being on the rampage since the end of 2019 and bringing the effect of aerosols on health back to the fore(Gralton et al.,2011;Wang et al.,2021).An increasing number of studies have shown that certain highly transmissible pathogens can maintain long-term stability and efficiently spread through aerosols(Leung,2021;Lv et al.,2021).As reported previously,influenza viruses that can spread efficiently through aerosols remain stable for a longer period compared to those that *** World Health Organization(WHO)has stated that aerosol-generating procedures(AGPs)play an important role in aerosol transmission in hospitals(Calderwood et al.,2021).AGPs,referring to medical procedures that produce aerosols,including dental procedures,endotracheal intubation,sputum aspiration,and laparoscopic surgeries,have been reported to be significantly associated with an increased risk of nosocomial infection among medical personnel(Hamilton,2021).

关键词： Endoscopy Endoscopic surgery Aerosol transmission Bedside endoscope precleaning

Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

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Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang wu Jing-Sheng LAN Shuo CHEN You-Yi HUANG Lan-Jin wu Zhi-Qing QIN Ying HUANG Wan-Zhong HUANG Ting ZENG Xin HAO Hua-Bin SU Qiang SU Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

Modeling and analysis of pointing error for non-landing vehicle-mounted photoelectric theodolite

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Optoelectronics Letters 2024年第5期20卷 294-298页

作者： GAO Qingjia WANG Chong LIU Yanjun WANG Xiaoming wu Tongbang ZHANG Haoyuan Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Troop 95859 the Chinese People's Liberation ArmyJiuquan 735018China

In order to achieve high accuracy measurement for non-landing vehicle-mounted photoelectric theodolite(NVPT) with continuous zoom optical system, a theoretical model of pointing error is presented. Starting with the working mode, the error source of the whole closed loop which affects the pointing error is analyzed. The measurement equation is derived using a coordinate transformation. The pointing error model is then obtained with the help of Monte Carlo method. The error of an NVPT prototype is measured, showing that the pointing error can be predicted accurately. A high precision NVPT with continuous zoom optical system is successfully designed and analyzed, with an accuracy of 11.9″ at azimuth and 10.9″ at elevation, when the optical focal length is set between 1 000 mm and 4 000 mm.

关键词： error mounted system

Quantitative analysis of the protective performance of bicycle helmet with multidirection impact protection system in oblique impact tests

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Chinese Journal of Traumatology 2024年第4期27卷 226-234页

作者： Yong Han Hao Yang He wu Di Pan Bing-Yu Wang School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen361024Fujian provinceChina Fujian Key Laboratory of Bus Advanced Design and Manufacturing Xiamen361024Fujian provinceChina School of Aerospace Engineering Xiamen UniversityXiamen361005Fujian provinceChina

Purpose:The current study aimed to assess the protective performance of helmets equipped with multidirectional impact protection system(MIPS)under various oblique impact ***:Initially,a finite element model of a bicycle helmet with MIPS was developed based on thescanned geometric parameters of an actual bicycle ***,the validity of model wasconfirmed using the KASK WG11 oblique impact test *** different impact angles(30°,45°,and 60°)and 2 varying impact speeds(5 m/s and 8 m/s)were employed in oblique tests to evaluateprotective performance of MIPS in helmets,focusing on injury assessment parameters such as peaklinear acceleration(PLA)and peak angular acceleration(PAA)of the ***:The results demonstrated that in all impact simulations,both assessment parameters werelower during impact for helmets equipped with MIPS compared to those *** PAA wasconsistently lower in the MIPS helmet group,whereas the difference in PLA was not significant in the noMIPS helmet *** instance,at an impact velocity of 8 m/s and a 30°inclined anvil,the MIPS helmetgroup exhibited a PAA of 3225 rad/s^(2) and a PLA of 281 *** contrast,the no-MIPS helmet group displayeda PAA of 8243 rad/s^(2) and a PLA of 292 ***,both PAA and PLA parameters decreased with theincrease of anvil *** a 60°anvil angles,PAA and PLA values were 664 rad/s^(2) and 20.7 g,respectively,reaching their ***:The findings indicated that helmets incorporating MIPS offer enhanced protection againstvarious oblique impact *** assessing helmets for oblique impacts,the utilization of larger angleanvils and rear impacts might not adequately evaluate protective performance during an impact *** findings will guide advancements in helmet design and the refinement of oblique impact testprotocols.

关键词： Oblique impact Multi-direction impact protection system WG11 oblique impact test Angular acceleration