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Multi-endpoint assays reveal more severe toxicity induced by chloraminated effluent organic matter than chloraminated natural organic matter

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Journal of Environmental Sciences 2024年第1期135卷 310-317页

作者： hai-Yan Wang De-Xiu wu Ye Du Xiao-tong Lv Qian-Yuan wu State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Environmental Protection Key Laboratory of Microorganism Application and Risk Control Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China College of Architecture and Environment Sichuan UniversityChengdu 610000China

Disinfection by chloramination produces toxic byproducts and the difference in toxicity of reclaimed and drinking water treated by chloramination remains *** study investigated cytotoxic effects at the same concentrations of dissolved organic matter and showed that chloraminated effluent organic matter(EfOM)induced 1.7 times higher cytotoxicity than chloraminated natural organic matter(NOM)applied to simulate drinking *** EfOM induced more reactive nitrogen species than chloraminated NOM,and chloraminated EfOM and NOM induced similar and higher levels of reactive oxygen species than the negative control,***,intracellular macromolecule damage indicated by DNA/RNA damage marker 8–hydroxy-(deoxy)guanosine and the intracellular protein carbonyl concentration induced by chloraminated EfOM was higher and slightly more than that induced by chloraminated NOM,*** data were consistent with the effects on cell physiological *** cycle arrest mainly occurred in G2 phase by chloraminated EfOM and *** apoptotic cells,which could return to normal,increased upon exposure to high concentrations of chloraminated EfOM and ***,necrotic cells were significantly increased from 0.5%to 2.5%when the concentration increased from 20-to 60-fold chloraminated EfOM,but were not obviously changed by chloraminated *** results indicated that the comprehensive intracellular changes induced by toxic substances in chloraminated EfOM were more irreversible and induced more cell death than chloraminated NOM.

关键词： Cytotoxicity Intracellular active nitrogen/oxygen Intracellular oxidative damage Cell necrosis Reclaimed water

A novel profile modification HPF-Co gel satisfied with fractured low permeability reservoirs in high temperature and high salinity

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Petroleum Science 2024年第1期21卷 683-693页

作者： Ya-Kai Li Ji-Rui Hou Wei-Peng wu Ming Qu Tuo Liang Wei-Xin Zhong Yu-Chen Wen hai-tong Sun Yi-Nuo Pan China University of Petroleum Beijing Beijing102249China PetroChina Tarim Oilfield Company Korla 841000XinjiangChina Key Laboratory of Improving Oil and Gas Recovery of Ministry of Education Northeast Petroleum University Daqing 163318HeilongjiangChina Xi'an Shiyou University Xi'an 710065ShaanxiChina Northwest Oilfield Company SINOPECUrumqi 830011XinjiangChina

Conformance control and water plugging are a widely used EOR method in mature ***,majority of conformance control and water plugging agents are unavoidable dehydrated situation in high-temperature and high-salinity low permeability ***,a novel conformance control system HPF-Co gel,based on high-temperature stabilizer(CoCl_(2)·H_(2)O,CCH)is *** HPF-Co bulk gel has better performances with high temperature(120℃)and high salinity(1×10^(5)mg/L).According to Sydansk coding system,the gel strength of HPF-Co with CCH is increased to code *** dehydration rate of HPF-Co gel is 32.0%after aging for 150 d at 120℃,showing excellent thermal *** rheological properties of HPF gel and HPF-Co gel are also *** results show that the storage modulus(G′)of HPF-Co gel is always greater than that of HPF *** effect of CCH on the microstructure of the gel is *** results show that the HPF-Co gel with CCH has a denser gel network,and the diameter of the three-dimensional network skeleton is 1.5-3.5μ*** 90 d of aging,HPF-Co gel still has a good three-dimensional *** spectroscopy results show that CCH forms coordination bonds with N and O atoms in the gel amide group,which can suppress the vibration of cross-linked sites and improve the stability at high *** core plugging test determines the optimized polymer gel injection strategy and injection velocity with HPF-Co bulk gel system,plugging rate exceeding 98%.Moreover,the results of subsequent waterflooding recovery can be improved by 17%.

关键词： Low permeability reservoir High-temperature resistant gel Complexation reaction Polymer gel injection strategy Plugging rate Enhanced oil recovery

Sustained release of vascular endothelial growth factor A and basic fibroblast growth factor from nanofiber membranes reduces oxygen/glucose deprivation-induced injury to neurovascular units

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Neural Regeneration Research 2024年第4期19卷 887-894页

作者： Yifang wu Jun Sun Qi Lin Dapeng Wang Jian hai Department of Neurosurgery Tongji HospitalSchool of MedicineTongji University Department of Pharmacy Institute of Medical SciencesShanghai Jiao Tong University School of Medicine

Upregulation of vascular endothelial growth factor A/basic fibroblast growth factor(VEGFA/b FGF)expression in the penumbra of cerebral ischemia can increase vascular volume,reduce lesion volume,and enhance neural cell proliferation and differentiation,thereby exerting neuroprotective ***,the beneficial effects of endogenous VEGFA/b FGF are limited as their expression is only transiently *** this study,we generated multilayered nanofiber membranes loaded with VEGFA/b FGF using layer-by-layer self-assembly and electrospinning *** found that a membrane containing 10 layers had an ideal ultrastructure and could efficiently and stably release growth factors for more than 1 *** 10-layered nanofiber membrane promoted brain microvascular endothelial cell tube formation and proliferation,inhibited neuronal apoptosis,upregulated the expression of tight junction proteins,and improved the viability of various cellular components of neurovascular units under conditions of oxygen/glucose ***,this nanofiber membrane decreased the expression of Janus kinase-2/signal transducer and activator of transcription-3(JAK2/STAT3),Bax/Bcl-2,and cleaved ***,this nanofiber membrane exhibits a neuroprotective effect on oxygen/glucose-deprived neurovascular units by inhibiting the JAK2/STAT3 pathway.

关键词： brain ischemia brain microvascular endothelial cell nanofiber membrane neurovascular unit

Pars plana vitrectomy for retinal detachment using perfluoro-n-octane as intraoperative tamponade:a multicenter,randomized,non-inferiority trial

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 82-91页

作者： Xin Shi Wei-Jun Wang Ying Fan hai-Yun Liu Hong Wang Yu-Hui Chen Ao Rong Zhi-feng wu Xun Xu Kun Liu Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200085China Shanghai Jieshi Medical Technology Co.Ltd. Shanghai 201201China Department of Ophthalmology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Ophthalmology Wuxi No.2 People’s Hospital(Jiangnan University Medical CenterJUMC)Wuxi 214002Jiangsu ProvinceChina

AIM:To evaluate the efficacy and safety of perfluoro-n-octane(PFO)for ophthalmic surgery versus F-Octane as an intraoperative tamponade in pars plana vitrectomy(PPV)in management of retinal ***:This multicenter,prospective,randomized,double-masked,parallel-controlled,non-inferiority trial was conducted in three ophthalmology clinical centers in *** with retinal detachment,who were eligible for PPV were consecutively *** were assigned to PFO for ophthalmic surgery or F-Octane for intraocular tamponade in a 1:1 ***-corrected visual acuity(BCVA),intraocular pressure(IOP)measurement,and dilated fundus examination were performed preoperatively and at 1,7±1,28±3d *** primary outcome was complete retinal reattachment rate at postoperative day *** non-inferiority margin was set at 9.8%.The secondary outcomes included intraoperative retinal reattachment rate,and mean changes in IOP and BCVA from baseline to 1,7±1,28±3d postoperatively,*** analyses were presented for all randomly assigned participates in this ***:Totally 124 eligible patients completed the study between Mar.14,2016 and Jun.7,*** of them were randomly assigned to the PFO for ophthalmic surgery group,and 64 were assigned to the F-Octane *** characteristics were comparable between the two *** groups achieved 100%retinal reattachment at postoperative day one(difference 0,95%CI:-6.21%to 5.75%,P=1).The pre-defined noninferiority criterion was *** significant difference was observed in intraoperative retinal reattachment rate(difference 1.77%,P=0.61),mean changes in IOP(difference 0.36,-0.09,2.22 mm Hg at 1,7±1,28±3d postoperatively,with all P>0.05)and BCVA(difference 0.04,-0.02,0.06 logMAR at 1,7±1,28±3d postoperatively,all P>0.05)between the two *** apparent adverse events related to the utilization of PFO were ***:In patients with retinal detachment undergoing PPV,PFO

关键词： perfluoro-n-octane vitreoretinal surgery intraocular tamponade ophthalmic surgery retinal detachment

Quasinormal modes and ringdown waveforms of a Frolov black hole

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Communications in Theoretical Physics 2024年第10期76卷 101-107页

作者： Zhijun Song Huajie Gong hai-Li Li Guoyang Fu Li-Gang Zhu Jian-Pin wu Center for Gravitation and Cosmology College of Physical Science and Technology Yangzhou University Basic Teaching Department Shenyang Institute of Engineering Department of Physics and Astronomy Shanghai Jiao Tong University

In this paper we investigate scalar perturbation over a Frolov black hole（BH）, which is a regular BH induced by the quantum gravity effect. The quasinormal frequencies of a scalar field always consistently reside in the lower half-plane, and the time-domain evolution of the field demonstrates a decaying behavior, with the late-time tail exhibiting a power-law pattern. These observations collectively suggest the stability of a Frolov BH against scalar ***, our study reveals that the quantum gravity effect leads to slower decay modes. For the case of the angular quantum number l = 0, the oscillation exhibits non-monotonic behavior with the quantum gravity parameter α0. However, once l ≥ 1, the angular quantum number surpasses the influence of the quantum gravity effect.

关键词： black hole Frolov black hole quantum gravity effects quasinormal modes

Experimental Study on Engineering Behavior of Solidified Soil for Scour Repair and Protection

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China Ocean Engineering 2024年第4期38卷 625-635页

作者： wu Xiao-ni LI Ru-yu SHU Jian TANG Chao CHEN Jin-jian WANG Hui-li JIANG hai-li WANG Xiao State Key Laboratory of Ocean Engineering Department of Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Road and Bridge Group Co. Ltd.Shanghai 200433China Shanghai Engineering Research Center of Urban Infrastructure Renewal Shanghai 200032China Jiangsu Kunze Technology Co. Ltd.Nanjing 210000China

A new scour countermeasure using solidified slurry for offshore foundation has been proposed *** solidified slurry is pumped to seabed area around foundation for scour protection or pumped into the developed scour holes for scour repair as the fluidized material solidifies *** the pumping operation and solidification,the engineering behaviors of solidified slurry require to be considered synthetically for the reliable application in scour repair and protection of ocean engineering such as the pumpability related flow value,flow diffusion behavior related rheological property,anti-scour performance related retention rate in solidification and bearing capacity related strength property after *** this study,a series of laboratory tests are conducted to investigate the effects of mix proportion(initial water content and binder content)on the flow value,rheological properties,density,retention rate of solidified slurry and unconfined compressive strength(UCS).The results reveal that the flow value increases with the water content and decreases with the binder *** the solidified slurry exhibits Bingham plastic behavior when the shear rate is larger than 5 s^(-1).The Bingham model has been employed to fit the rheology test results,and empirical formulas for obtaining the density,yield stress and viscosity are established,providing scientific support for the numerical assessment of flow and diffusion of solidified *** rate of solidified slurry decreases with the water flow velocity and flow value,which means the pumpability of solidified slurry is contrary to anti-scour *** unconfined compressive strength after solidification reduces as the water content increases and binder content decreases.A design and application procedure of solidified soil for scour repair and protection is also proposed for engineering reference.

关键词： scour repair and protection solidified soil pumpability strength flow properties anti-scour performance

改性黄麻纤维协同水泥固化重金属铅污染土的强度及毒理性分析

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岩土力学 2024年第8期45卷 2242-2250页

作者：李敏路通于禾苗吴海铭李琦河北工业大学土木与交通学院天津300401 西安理工大学自动化与信息工程学院陕西西安710048

改性纤维兼具良好的吸附能力和机械强度,在污染土治理方面具有广泛的应用前景。优选黄麻作为纤维材料,分别采用均苯四甲酸二酐、聚苯胺和双氧水进行改性,结合无侧限抗压强度、土体阳离子交换量(cation exchange capacity,CEC)、电导率(e... 详细信息

改性纤维兼具良好的吸附能力和机械强度,在污染土治理方面具有广泛的应用前景。优选黄麻作为纤维材料,分别采用均苯四甲酸二酐、聚苯胺和双氧水进行改性,结合无侧限抗压强度、土体阳离子交换量(cation exchange capacity,CEC)、电导率(electrical conductivity,EC)、pH值等指标探究改性黄麻纤维协同水泥的固化效能,并借助醋酸缓冲溶液法分析其毒理性演变规律。结果表明,适宜的改性黄麻纤维协同水泥固化铅污染土可同步实现强度提升和毒性释放的控制,协同固化污染土较单一水泥固化污染土,无侧限抗压强度提高了76.78%,浸出毒性量降低了64.73%,且10次冻融循环作用下浸出毒性的波动缩小至1/3。黄麻纤维水解所生成碱性纤维素会引起水泥固化污染土pH的增大,羧基类酸性官能团的改性有助于借助中和作用进一步促进水化反应,增强水化硅酸钙(calcium silicate hydrate,CSH)凝胶的生成。黄麻特别是改性纤维的引入对于EC和CEC的增益显著,纤维水泥协同固化作用下EC提高量可达单一水泥固化提高量的2.25倍,是增强吸附固化稳定性的关键。但由于纤维团聚、微粒间聚合及金属离子间静电斥力的影响,固化污染土强度和浸出毒性与纤维掺量及纤维长度并非呈正相关关系,3种改性方式中酸酐改性黄麻纤维吸附固化效果受纤维长度和掺量影响较小,且在强度和毒性控制指标方面均表现良好,统筹考虑工程应用和生态发展需求,纤维掺量0.9%+纤维长度18 mm的酸酐改性黄麻纤维适合用于协同水泥进行重金属污染土的固化处置。

关键词：重金属污染土固化/稳定化强度毒理性改性纤维水泥

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微服务系统服务依赖发现技术综述

软件学报 2024年第1期35卷 118-135页

作者：张齐勋吴一凡杨勇贾统李影吴中海北京大学信息科学技术学院北京100871 北京大学软件与微电子学院北京102600 北京大学软件工程国家工程研究中心北京100871 北京大学人工智能研究院北京100871

微服务架构得到了广泛的部署与应用,提升了软件系统开发的效率,降低了系统更新与维护的成本,提高了系统的可扩展性.但微服务变更频繁、异构融合等特点使得微服务故障频发、其故障传播快且影响大,同时微服务间复杂的调用依赖关系或逻辑... 详细信息

微服务架构得到了广泛的部署与应用,提升了软件系统开发的效率,降低了系统更新与维护的成本,提高了系统的可扩展性.但微服务变更频繁、异构融合等特点使得微服务故障频发、其故障传播快且影响大,同时微服务间复杂的调用依赖关系或逻辑依赖关系又使得其故障难以被及时、准确地定位与诊断,对微服务架构系统的智能运维提出了挑战.服务依赖发现技术从系统运行时数据中识别并推断服务之间的调用依赖关系或逻辑依赖关系,构建服务依赖关系图,有助于在系统运行时及时、精准地发现与定位故障并诊断根因,也有利于如资源调度、变更管理等智能运维需求.首先就微服务系统中服务依赖发现问题进行分析,其次,从基于监控数据、系统日志数据、追踪数据等3类运行时数据的角度总结分析了服务依赖发现技术的技术现状;然后,以基于服务依赖关系图的故障根因定位、资源调度与变更管理等为例,讨论了服务依赖发现技术应用于智能运维的相关研究.最后,对服务依赖发现技术如何准确地发现调用依赖关系和逻辑依赖关系,如何利用服务依赖关系图进行变更治理进行了探讨并对未来的研究方向进行了展望.

关键词：服务依赖故障诊断微服务

When Crowdsourcing Meets Data Markets:A Fair Data Value Metric for Data Trading

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Journal of Computer Science & Technology 2024年第3期39卷 671-690页

作者：刘洋溯郑臻哲吴帆陈贵海 Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China CCF ACM IEEE

Large-quantity and high-quality data is critical to the success of machine learning in diverse *** with the dilemma of data silos where data is difficult to circulate,emerging data markets attempt to break the dilemma by facilitating data exchange on the ***,on the other hand,is one of the important methods to efficiently collect large amounts of data with high-value in data *** this paper,we investigate the joint problem of efficient data acquisition and fair budget distribution across the crowdsourcing and data *** propose a new metric of data value as the uncertainty reduction of a Bayesian machine learning model by integrating the data into model *** by this data value metric,we design a mechanism called Shapley Value Mechanism with Individual Rationality(SV-IR),in which we design a greedy algorithm with a constant approximation ratio to greedily select the most cost-efficient data brokers,and a fair compensation determination rule based on the Shapley value,respecting the individual rationality *** further propose a fair reward distribution method for the data holders with various effort levels under the charge of a data *** demonstrate the fairness of the compensation determination rule and reward distribution rule by evaluating our mechanisms on two real-world *** evaluation results also show that the selection algorithm in SV-IR could approach the optimal solution,and outperforms state-of-the-art methods.

关键词： data trading crowdsourcing mechanism design Shapley value