检索结果-南通市图书馆

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao Cheng Chuankai Fu Geping Yin Liguang Wang Yongmin wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

Phase transformation of ZrO2 doped with CeO2

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2018年第1期37卷 66-71页

作者： Bo He Ying Li Hong-Yu Zhang duo-Li wu Li-Hong Liang Hua Wei Schooi of Mechatronics Engineering Shenyang AerospaceUniversityShenyang 110136China Institute of Metal research Chinese Academy of SciencesShenyang 110016China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China

Thermal barrier coatings（TBCs） protection is widely used to prolong the lifetime of turbine *** outermost layer of TBCs is ceramic layer, whose function is heat insulation, and the main composition of the ceramic layer is ZrO2. In this study, the micro-Zr02 and the nano-ZrO2 doped with 10 wt% CeO2 as well as microZrO2 and nano-ZrO2 were prepared by air plasma spraying（APS） to study the advantages of the addition of rare earth element. The effect of CeO2 on the phase transformation of ZrO2 was studied. The results show that there are few cracks in micro-and nano-ZrO2 doped with 10 wt% CeO2,and rare earth oxides can affect the phase transformation significantly. The morphologies, hardness and elastic modulus of the four ceramic layers were also discussed.

关键词： Ceramic layer Rare earth oxides Phase transformation CeO2

Multiscale structures and phase transitions in metallic glasses：A scattering perspective

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2017年第1期26卷 42-60页

作者： si Lan Zhenduo wu Xun-Li Wang Department of Physics and Materials Science City University of Hong Kong Kowloon Hong Kong China Herbert Gleiter Institute of Nanoscience Nanjing University of Science and Technology Nanjing 210094 China City University ofHong Kong Shenzhen Research Institute Shenzhen 518057 China

Amorphous materials are ubiquitous and widely used in human society, yet their structures are far from being fully understood. Metallic glasses, a new class of amorphous materials, have attracted a great deal of interests due to their exceptional properties. In recent years, our understanding of metallic glasses increases dramatically, thanks to the development of advanced instrumentation, such as in situ x-ray and neutron scattering. In this article, we provide a brief review of recent progress in study of the structure of metallic glasses. In particular, we will emphasize, from the scattering perspective, the multiscale structures of metallic glasses, i.e., short-to-medium range atomic packing, and phase transitions in the supercooled liquid region, e.g., crystallization and liquid-to-liquid phase transition. We will also discuss, based on the understanding of their structures and phase stability, the mechanical and magnetic properties of metallic glasses.

关键词： metallic glasses phase transitions neutron scattering x-ray scattering

Optimizing the crystallinity and acidity of H-SAPO-34 by fluoride for synthesizing Cu/SAPO-34 NH_3-SCR catalyst

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2016年第3期28卷 244-251页

作者： Jing Ma Zhichun si Xiaodong wu Duan Weng Yue Ma The Key Laboratory of Advanced Materials of Ministry of Education School of Materials Science and EngineeringTsinghua University Advanced Materials Institute Graduate School at ShenzhenTsinghua University

A series of H-SAPO-34 zeolites were synthesized by a hydrothermal method in fluoride *** as-synthesized H-SAPO-34 zeolites were characterized by X-ray diffraction（XRD）,scanning electron microscopy（SEM）,N_2 physisorption,temperature-programmed desorption of NH_3（NH_3-TPD） and nuclear magnetic resonance（NMR） *** results showed that a certain concentration of F- anions promoted the nucleation and crystallization of *** H-SAPO-34 synthesized in the fluoride media showed high crystallinity,uniform particle size distribution,large specific surface area and pore volume,and enhanced ***,Cu/SAPO-34 based on the fluoride-assisted zeolite showed a broadened temperature window for the selective catalytic reduction of NO by NH_3（NH_3-SCR） reaction due to the enhanced acidity of the zeolite and the improved dispersion of copper species.

关键词： H-SAPO-34 Fluoride media Crystallinity Acidity Selective catalytic reduction(SCR)of NO

Holocene temperature variation recorded by branched glycerol dialkyl glycerol tetraethers in a loess-paleosol sequence from the north-eastern Tibetan Plateau

在线全文

学校读者我要写书评

暂无评论

Frontiers of Earth Science 2023年第4期17卷 1012-1025页

作者： Tianxiao WANG duo wu Tao WANG Lin CHEN Shilong GUO Youmo LI Chenbin ZHANG Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Alpine Paleoecology and Human Adaptation Group(ALPHA) Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Reconstructing Holocene temperature evolution is important for understanding present temperature variations and for predicting future climate change,in the context of global *** evolution of Holocene global temperature remains disputed,due to differences between proxy reconstructions and model simulations,a discrepancy known as the῾Holocene temperature conundrum᾽.More reliable and quantitative terrestrial temperature records are needed to resolve the spatial heterogeneity of existing *** this study,based on the analysis of branched glycerol dialkyl glycerol tetraethers(brGDGTs)from a loess-paleosol sequence from the Ganjia Basin in the north-eastern Tibetan Plateau(NETP),we quantitatively reconstructed the mean annual air temperature(MAAT)over the past 12 *** MAAT reconstruction shows that the temperature remained low during the early Holocene(12−8 ka),followed by a rapid warming at around 8 *** 8 to 4 ka,the MAAT record reached its highest level,followed by a cooling trend from the late Holocene(4−0 ka).The variability of the reconstructed MAAT is consistent with trends of annual temperature records from the Tibetan Plateau(TP)during the *** attribute the relatively low temperatures during the early Holocene to the existence of ice sheets at high-latitude regions in the Northern Hemisphere and the weaker annual mean insolation at 35°*** the mid to late Holocene,the long-term cooling trend in the annual temperature record was primarily driven by declining summer *** study provides key geological evidence for clarifying Holocene temperature change in the TP.

关键词： sHolocene Ganjia Basin loess temperature variation BrGDGTs

Review of cavity optomechanics in the weak-coupling regime: from linearization to intrinsic nonlinear interactions

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2015年第5期58卷 16-28页

作者： XIONG Hao si LiuGang LV XinYou YANG XiaoXue wu Ying wuhan National Laboratory for Optoelectronics and School of Physics Huazhong University of Science and Technology

Recently, cavity optomechanics has become a rapidly developing research field exploring the coupling between the optical field and mechanical oscillation. Cavity optomechanical systems were predicted to exhibit rich and nontrivial effects due to the nonlinear optomechanical interaction. However, most progress during the past years have focused on the linearization of the optomechanical interaction, which ignored the intrinsic nonlinear nature of the optomechanical coupling. Exploring nonlinear optomechanical interaction is of growing interest in both classical and quantum mechanisms, and nonlinear optomechanical interaction has emerged as an important new frontier in cavity optomechanics. It enables many applications ranging from single-photon sources to generation of nonclassical states. Here, we give a brief review of these developments and discuss some of the current challenges in this field.

关键词： cavity optomechanics nonlinear interactions weak-coupling regime radiation pressure

Recent Progress and Regulation Strategies of Layered Materials as Cathode of Aqueous Zinc-Ion Batteries

在线全文

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第3期7卷 14-31页

作者： Yuan Yuan si wu Xiaoxue Song Jin Yong Lee Baotao Kang School of Chemistry and Chemical Engineering University of JinanJinan 250022China Department of Chemistry Sungkyunkwan UniversitySuwon 16419Korea Shandong Hi-Speed Engineering Test Co. Ltd.Jinan 250022China

Aqueous zinc-ion batteries(ZIBs)have shown great potential in the fields of wearable devices,consumer electronics,and electric vehicles due to their high level of safety,low cost,and multiple electron *** layered cathode materials of ZIBs hold a stable structure during charge and discharge reactions owing to the ultrafast and straightforward(de)intercalation-type storage mechanism of Zn^(2+)ions in their tunable interlayer spacing and their abilities to accommodate other guest ions or ***,the challenges of inadequate energy density,dissolution of active materials,uncontrollable byproducts,increased internal pressure,and a large de-solvation penalty have been deemed an obstacle to the development of *** this review,recent strategies on the structure regulation of layered materials for aqueous zinc-ion energy storage devices are systematically ***,critical science challenges and future outlooks are proposed to guide and promote the development of advanced cathode materials for ZIBs.

关键词： layered cathode materials modifying strategies structure regulation zinc-ion batteries

Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第2期13卷 932-945页

作者： si Zou Yetao Gong Xiujie Li Yanbin wu Jinzhong wu Jianguo wu Ka-Hing Wong College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Research Institute for Future Food The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong Kong 999077China

Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative *** SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application ***,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse *** elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also *** results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting ***-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 ***,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial ***,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective *** a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.

关键词： PTR-SeNPs(polysaccharide-proteincomplex functionalized selenium nanoparticles) Acetaminophen-induced hepatotoxicity Nuclear factor erythroid 2-related factor 2 Cytochrome P450 enzyme 2E1 Mitochondria