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LncRNA pol-lnc78 as a ceRNA regulates antibacterial responses via suppression of pol-miR-n199-3p-mediated SARM down-regulation in Paralichthys olivaceus

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Zoological Research 2024年第1期45卷 25-35页

作者： Xian-Hui Ning Bing Han Ye Peng shao-wu Yin College of Marine Science and Engineering Nanjing Normal UniversityNanjingJiangsu 210023China CAS Key Laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdaoShandong 266071China Co-Innovation Center for Marine Bio-Industry Technology of Jiangsu Province LianyungangJiangsu 222005China

Long non-coding RNAs(lncRNAs)function as key modulators in mammalian immunity,particularly due to their involvement in lncRNA-mediated competitive endogenous RNA(ceRNA)*** their recognized significance in mammals,research on lncRNAs in lower vertebrates remains *** the present study,we characterized the first immune-related lncRNA(pol-lnc78)in the teleost Japanese flounder(Paralichthys olivaceus).Results indicated that pol-lnc78 acted as a ceRNA for pol-miR-n199-3p to target the sterile alpha and armadillo motif-containing protein(SARM),the fifth discovered member of the Toll/interleukin 1(IL-1)receptor(TIR)adaptor *** ceRNA network regulated the antibacterial responses of flounder via the Toll-like receptor(TLR)signaling ***,SARM acted as a negative regulator and exacerbated bacterial infection by inhibiting the expression of inflammatory cytokines IL-1βand tumor necrosis factor-α(TNF-α).Pol-miR-n199-3p reduced SARM expression by specifically interacting with the 3’untranslated region(UTR),thereby promoting SARM-dependent inflammatory cytokine expression and protecting the host against bacterial ***,pol-lnc78 sponged pol-miR-n199-3p to ameliorate the inhibition of SARM *** infection,the negative regulators pol-lnc78 and SARM were significantly down-regulated,while pol-miR-n199-3p was significantly up-regulated,thus favoring host antibacterial *** findings provide novel insights into the mechanisms underlying fish immunity and open new horizons to better understand ceRNA crosstalk in lower vertebrates.

关键词： LncRNA SARM miRNA ceRNA Antibacterial response

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Megnetic resonance imaging findings in sporadic Mobius syndrome

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Chinese Medical Journal 2013年第12期126卷 2304-2307页

作者： wu shao-qin MAN Feng-yuan JIAO Yong-hong XIAN Jun-fang WANG Yi-di WANG Zhen-chang wu shao-qin and MAN Feng-yuan contributed equally to this work. Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Background Although neuroradiological findings of M（o）bius syndrome have been reported as a result of brain and brainstem abnormalities,magnetic resonance imaging （MRI） now permits the direct imaging of the cranial nerve （CN） and branches in the *** study presents the MRI findings in patients with sporadic M（o）bius *** Prospectively,CNs were imaged in the cistern using head coils and three dimensional fast imaging employing steady-state acquisition （3D-FIESTA）,yielding a 0.5 mm2 resolution in planes of 0.8 mm thickness in seven patients with sporadic M（o）bius *** cavernous and intraorbital segment of the CN and the extraocular muscles （EOMs） were imaged with T1 weighting in all *** cavernous segment was imaged in coronal planes,while the intraorbit in quasicoronal planes were imaged using surface *** resolution was 0.16 mm2 within 2.0 mm thick *** In the seven patients,the CN were absent or showed hypoplasia in the cistern,cavernous sinus,and *** （CN Ⅵ） and facial （CN Ⅶ） nerves were absent on the affected *** CN IX （glossopharyngeal nerve） in two cases displayed *** from the inferior division of CN Ⅲ were observed to innervate the lateral rectus （LR） bilaterally in three cases and unilaterally in one case,and had intimate continuity with the LR muscle in two cases bilaterally and two cases *** of EOMs was shown in five *** of the medulla on the left side was found in one *** Direct imaging of CNs and EOMs by MRI is useful in diagnosis of M（o）bius *** can directly demonstrate the abnormalities of the CN and orbital *** absence or hypoplasia of CN Ⅵ and CN Ⅶ may be the most common radiologic features in sporadic M（o）bius syndrome,and hypoplasia of CN IX may be an associated *** abnormality of EOMs and aberrant innervations in the orbit should be observed,and may be important for the study of

关键词： Mobius syndrome magnetic resonance imaging sporadic

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Enhancing the anti-corrosion performance and biocompatibility of AZ91D Mg alloy by applying roughness pretreatment and coating with in-situ Mg(OH)_(2)/Mg-Al LDH

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Journal of Magnesium and Alloys 2024年第6期12卷 2520-2533页

作者： Zexi shao Pubo Li Chao Zhang Bintao wu Chan Tang Mangmang Gao School of Materials and New Energy Ningxia Key Laboratory of Photovoltaic MaterialsNingxia UniversityYinchuan750021PR China Department of Gastroenterology The Third Xiangya HospitalCentral South UniversityChangsha410000PR China

Corrosion-resistant and biocompatible films were fabricated on AZ91D Mg alloy substrates by varying their roughness levels using met-allographic preparation and subsequent hydrothermal *** coated films comprised a mixed structure of Mg(OH)_(2)and Mg-Al layered double hydroxides(LDH)and exhibited excellent *** film thickness increased with decreasing surface *** resistance was evaluated using potentiodynamic polarization and electrochemical impedance *** pretreat-ment influenced the chemical activity of the Mg alloy surface and helped modulate the dissolution rate of the Mg_(17)Al_(12)phase during the hydrothermal *** decreasing roughness of the Mg substrate,the Al^(3+)concentration gradually increased,accelerating the in-situ formation of the Mg(OH)_(2)/LDH composite coating and improving its crystallinity.A thick and dense Mg(OH)_(2)/LDH coating was synthesized on the Mg substrate with the least roughness,substantially improving the corrosion resistance of the AZ91D *** lowest corrosion current density((5.73±2.75)×10^(−8)A·cm^(−2))was achieved,which was approximately three orders of magnitude less than that of bare ***,the coating demonstrated biocompatibility with no evident cytotoxicity,cellular damage,and hemolytic *** study provides an effective method for preparing coatings on Mg alloy surfaces with excellent corrosion resistance and biocompatibility.

关键词： Magnesium alloy Roughness Corrosion resistance Layered double hydroxides Biocompatibility

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Flashover Characteristics of Dry Band-water band on Hydrophobic Surfaces

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 392-400页

作者： Xiaohan wu Fanghui Yin Bin Cao Daiming Yang Shichao shao Liming Wang Tsinghua-Berkeley Shenzhen Institute(TBSI) Shenzhen 518055China Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Shenzhen Polytechnic School Shenzhen 518055China

Due to their outstanding anti-flashover characteristics,composite insulators have been extensively applied in power systems.A lot of research has investigated flashover characteristics of hydrophobic specimens with artificial water ***,the phenomenon is not consistent with that of the contaminated composite *** the test specimens covered with water droplets,there is no obvious leakage current before the flashover and no obvious relationship between flashover voltage and the conductivity of water *** the contaminated composite insulator surface,there are short continuous arcs on the insulators before critical flashover,making insulators look like a luminous *** that under these two conditions,the proportion of water along the insulation distance is different,the flashover characteristic of“dry band-water band”on a hydrophobicity surface is analyzed in the present *** influence of the water band parameter(including length,width,and conductivity)as well as the length of dry band is *** this basis,the arc generation and development process of the surface covered with“dry band-water band”is *** research results improve the understanding of the flashover process on contaminated composite insulators.

关键词： Flashover characteristics hydrophobicity partial arc water band

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Supported Atomically Dispersed Pd Catalyzed Direct Alkoxylation and Allylic Alkylation

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Chinese Journal of Chemistry 2024年第7期42卷 719-724页

作者： Ruixuan qin Ziwen Chen qingyuan wu Nanfeng Zheng Pengxin Liu New Cornerstone Science Laboratory State Key Laboratory for Physical Chemistry of Solid SurfacesCollaborative Innovation Center of Chemistry for Energy Materialsand National&Local Joint Engineering Research Center of Preparation Technology of NanomaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005China Innovation Laboratry for Scences and Technoogies of Energy Materials of Fujan Province(IKKM) Xiamen Fujian 361102China School of Physical Science and Technology Shanghai Tech UniversityShanghai 201210China Fujian Key Laboratory of Rare-earth Functional Materials Fujian Shanhai Collaborative Innovation Center of Rare-earth Functional MaterialsLongyanFujian 366300China

A new approach to allylic alkylation is realized using an atomically dispersed palladium catalyst(Pd1/TiO2-EG).Unlike conventional methods that require derivation of substrates and utilization of additives,this method allows for direct allylic alkylation from allylic alcohols,producing H2O as the sole *** catalyst's high efficiency is attributed to the local hydrogen bonding at the or-ganic-inorganic interface(Pd-EG interface),facilitating hydroxyl group activation forη3π-allyl complex *** system demonstrates successful direct C—O and C—C coupling reactions with high selectivity,requiring no *** study highlights the potential of supported atomically dispersed catalysts for greener and more efficient catalysis,meanwhile,offers unique insights into the distinct behavior of atomically dispersed catalysts in comparison to homogeneous or nanoparticle-based catalysts.

关键词： Atomically dispersed catalyst Alkylation C—C coupling Organic-inorganic Interface Hydrogen bond Tsuji-Trost reaction Green catalysis

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Enhancing the mechanical properties of casting eutectic high -entropy alloys via W addition

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1364-1372页

作者： Xu Yang Dezhi Chen Li Feng Gang qin Shiping wu Ruirun Chen National Key Laboratory for Precision Hot Processing of Metals School of Material Science and EngineeringHarbin Institute of TechnologyHarbin 150001China

The effect of W element on the microstructure evolution and mechanical properties of Al_(1.25)CoCrFeNi3 eutectic high-entropy alloy and Al_(1.25)CoCrFeNi_(3-x)W_(x)(x=0,0.05,0.1,0.3,and 0.5;atomic ratio)high-entropy alloys(HEAs)were *** show that the Al_(1.25)CoCrFeNi_(3-x)W_(x) HEAs are composed of face-centered cubic and body-centered cubic(BCC)*** W content increases,the microstructure changes from eutectic to *** addition of W lowers the nucleation barrier of the BCC phase,decreases the valence electron concentration of the HEAs,and replaces Al in the BCC phase,thus facilitating the nucleation of the BCC *** results show that the addition of W greatly improves the mechanical properties,and solid-solution,heterogeneous-interface,and second-phase strengthening are the main strengthening *** yield strength,tensile strength,and elongation of the Al_(1.25)CoCrFeNi2.95W0.05 HEA are 601.44 MPa,1132.26 MPa,and 15.94%,respectively,realizing a balance between strength and *** fracture mode of the Al_(1.25)CoCrFeNi_(3-x)W_(x) HEAs is ductile–brittle mixed fracture,and the crack propagates and initiates in the BCC *** eutectic lamellar structure impedes crack propagation and maintains plasticity.

关键词： high-entropy alloy microstructure mechanical property fracture behavior

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Effect of the vortical structures on the hydrodynamic performance of a pitching hydrofoil

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Journal of Hydrodynamics 2024年第2期36卷 406-420页

作者： Rui Yuan Hui-yun Hao qin wu Yun-qing Liu Biao Huang School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China

The objective is to study the vortical structural behaviors of a transient pitching hydrofoil and their effects on the hydrodynamic performance. The pitching motion of the hydrofoil is set to pitch up with an almost constant rate from 5° to 15° and then back to 5°, with the Reynolds number 4.4×10^(5) and the frequency 2 Hz. The results show that the main coherent structures around the pitching hydrofoil include small-scale laminar separation bubble (LSB), large-scale second vortex (SV) and trailing edge vortex (TEV) which are all vortical. The relationship between the vortical structure and the lift is investigated with the finite-domain impulse theory. It indicates that the major part of the lift is contributed by the LSB, whereas the shedding and the formation of the SV and TEV cause the fluctuation of the lift. The proper orthogonal decomposition (POD) method is applied to capture the most energetic modes, revealing that the LSB mode occupies a large amount of energy in the flow field. The dynamic mode decomposition (DMD) method accurately extracts the dominant frequency and modal characteristics, with the first mode corresponding to the mean flow, the second mode corresponding to the LSB structure and the third and fourth modes corresponding to the vortex shedding.

关键词： Hydrodynamics vortical structures finite-domain impulse theory proper orthogonal decomposition(POD) dynamic mode decomposition(DMD) Pitching hydrofoil

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Cellular senescence-driven transcriptional reprogramming of the MAFB/NOTCH3 axis activates the PI3K/AKT pathway and promotes osteosarcoma progression

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Genes & Diseases 2024年第2期11卷 952-963页

作者： Zhenhao Zhang Doudou Jing Baijun Xuan Zhicai Zhang Wei wu Zengwu shao Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Orthopedics The Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

Osteosarcoma is the most common primary malignancy of bones and primarily occurs in adolescents and young ***,a second smaller peak of osteosarcoma incidence was reported in the elderly aged more than *** patients with osteosarcoma exhibit different characteristics compared to young patients,which usually results in a poor *** mechanism underlying osteosarcoma development in elderly patients is intriguing and of significant value in clinical *** cells can accelerate tumor progression by metabolic *** research has shown that methylmalonic acid(MMA)was significantly up-regulated in the serum of older individuals and played a central role in the development of aggressive *** found that the significant accumulation of MMA in elderly patients imparted proliferative potential to osteosarcoma *** expression of MAFB was excessively up-regulated in osteosarcoma specimens and was further enhanced in response to MMA accumulation as the patient ***,we first confirmed a novel molecular mechanism between cellular senescence and cancer,in which the MMA-driven transcriptional reprogramming of the MAFB-NOTCH3 axis accelerated osteosarcoma progression via the activation of PI3K-AKT ***,the down-regulation of the MAFB-NOTCH3 axis increased the sensitivity and effect of AKT inhibitors in osteosarcoma through significant inhibition of AKT *** conclusion,we confirmed that MAFB is a novel age-dependent biomarker for osteosarcoma,and targeting the MAFB-NOTCH3 axis in combination with AKT inhibition can serve as a novel therapeutic strategy for elderly patients with osteosarcoma in experimental and clinical trials.

关键词： Cellular senescence Elderly patients MAFB-NOTCH3axis Methylmalonic acid Osteosarcoma PI3K-AKTpathway

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Deciphering gastric inflammation-induced tumorigenesis through multi-omics data and AI methods

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Cancer Biology & Medicine 2024年第4期21卷 312-330页

作者： Qian Zhang Mingran Yang Peng Zhang Bowen wu Xiaosen Wei shao Li Institute for TCM-X MOE Key Laboratory of BioinformaticsBioinformatics DivisionBNRISTDepartment of AutomationTsinghua UniversityBeijing 100084China

Gastric cancer(GC), the fifth most common cancer globally, remains the leading cause of cancer deaths worldwide. Inflammation-induced tumorigenesis is the predominant process in GC development;therefore, systematic research in this area should improve understanding of the biological mechanisms that initiate GC development and promote cancer hallmarks. Here, we summarize biological knowledge regarding gastric inflammation-induced tumorigenesis, and characterize the multi-omics data and systems biology methods for investigating GC development. Of note, we highlight pioneering studies in multi-omics data and state-of-the-art network-based algorithms used for dissecting the features of gastric inflammation-induced tumorigenesis, and we propose translational applications in early GC warning biomarkers and precise treatment strategies. This review offers integrative insights for GC research, with the goal of paving the way to novel paradigms for GC precision oncology and prevention.

关键词： Gastric cancer inflammation-induced tumorigenesis multi-omics artificial intelligence network-based methods

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Goaf risk prediction based on IAOA-SVM and numerical simulation:A case study

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Underground Space 2024年第2期15卷 153-175页

作者： Mingliang Li Kegang Li Yuedong Liu Shunchuan wu qingci qin Rui Yue Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunming 650093China Yunnan Key Laboratory of Sino-German Blue Mining and Utilization of Special Underground Space Kunming 650093China Yunnan Diqing Mining Co.Ltd. Shangrila 674400China

In regard to goaf risk prediction,due to the low accuracy and single prediction method,this study proposes a method that combines the improved arithmetic optimization algorithm(IAOA)–support vector machines(SVM)with GoCAD–FLAC^(3D)numerical ***,goaf risk is comprehensively *** the perspectives of geological and engineering conditions,eight factors that affect goaf stability and 176 sets of sample data were *** utilized eight influencing factors such as rock mass structure,geological structure,and goaf burial depth as inputs,and the goaf risk level as the ***,an IAOA–SVM goaf risk prediction model was *** 30 goaf areas of Yangla Copper Mine in Yunnan Province were selected as the research ***,the rationality of mechanical parameter values in the numerical model was verified using the parameter inversion ***,based on the GoCAD–FLAC^(3D)numerical simulation method,the goaf risk analysis in Yangla Copper Mine was ***,using numerical simulation verification,the goaf filling effect was ***,the prediction results of the IAOA–SVM model were compared with that of other intelligent *** results indicate that the numerical simulation results of the GoCAD–FLAC^(3D)model are consistent with those of IAOA–SVM and the actual results,which further verifies the effectiveness and superiority of the IAOA–SVM prediction ***,an innovative approach for goaf risk prediction is developed.

关键词： Rock mechanics Goaf risk prediction IAOA SVM Numerical simulation

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