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Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults

Chinese Journal of Integrative Medicine 2021年第9期27卷 666-673页

作者： Mark Levy wu jun-rong SHI Jian-pin CHENG Hao-jie QU Xuan-qiao Ira Bernstein Robert Sinnott TIAN jun-qiang Research and Development Department USANA Health Scienceinc.Salt Lake CityUT(84121)USA Elegant and Olive Health Clinic MarkhamON(L3R 5V6)Canada Department of Family and Community Medicine Humber River HospitalTorontoON(M1V 2W7)Canada

Objective:To preliminarily explore the potential effect ofβ-glucan on Chinese medicine(CM)concept protective qi deficiency(PQD),and the methodology for future definitive ***:To have a standardized assessment of PQD,a list of 13 potentially PQD-relevant parameters were firstly created,each with defined quantitative or categorial *** the data from 37 participants with(21 cases)or without(16 cases)PQD,multivariate logistic modeling was conducted to create a preliminary diagnostic PQD risk ***,21 participants diagnosed with PQD were treated withβ-glucan in a dose of 200 mg/day for 8 *** were collected for trial acceptability measures(rate of recruitment,withdrawal,and compliance),and the participants were assessed for PQD status at baseline and every 2 weeks ***:The preliminary logistic model consisted of 3 parameters(low voice and apathy,aversion to wind and cold,and Cun pulse).The resulting risk score demonstrated a degree of PQD-predicting accuracy that,as evaluated by statistical(discrimination and classification)methods,was higher than those obtained from any of the individual candidate *** 21 PQD participants treated withβ-glucan demonstrated good receptibility and a time-dependent improvement in PQD status as evidenced by the decrease of PQD participant to 9.5%at the end of ***:This study demonstrated the effect of proof-of-concept ofβ-glucan on improving PQD and the proof-of-concept of a multivariate-model-derived diagnostic PQD risk *** also indicated feasibility for future definitive *** like this embody an innovative approach that uses therapies derived from the mainstream biomedicine to enrich therapeutics guided by CM principle.(Trial registration ***03829228).

关键词： β-glucan protective qi deficiency Chinese medicine diagnostic risk score

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β-Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency——A Randomized,Placebo-Controlled,and Double-Blinded Trial

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Chinese Journal of Integrative Medicine 2022年第5期28卷 394-402页

作者： wu jun-rong CHENG Hao-jie SHI Jian-pin YIN Wei-dong WANG jun OU Xuan-qiao CHEN Jin-li Ira Bernstein Mark Levy Rolando Maddela Robert Sinnott TIAN jun-qiang Elegant and Olive Health Clinic MarkhamONL3R 5V6Canada Research and Development Department USANA Health ScienceInc.Salt Lake CityUT84121USA Department of Family and Community Medicine University of TorontoTorontoONM5T 2S8Canada

Objective:To test the hypothesis thatβ-glucan enhances protective qi(PQi),an important Chinese medicine(CM)concept which stipulates that a protective force circulates throughout the body surface and works as the first line of defense against"external pernicious influences".Methods:A total of 138 participants with PQi deficiency(PQD)were randomized to receiveβ-glucan(200 mg daily)or placebo for 12 ***’PQi status was assessed every 2 weeks via conventional diagnosis and a standardized protocol from which a PQD severity and risk score was *** of participants’immune and general health status were also monitored,including upper respiratory tract infection(URTI),saliva secretory Ig A(s Ig A),and self-reported measures of physical and mental health(PROMIS).Results:PQi status was not significantly different between theβ-glucan and placebo treatment groups at baseline but improved significantly in theβ-glucan(***)group in a time-dependent *** intergroup differences[95%confidence interval(CI)]in severity score(scale:1-5),risk score(scale:0-1),and proportion of PQD participants(%)at finish line was 0.49(0.35-0.62),0.48(0.35-0.61),and 0.36(0.25-0.47),***,β-glucan improved URTI symptom(scale:1-9)and PROMIS physical(scale:16.2-67.7)and mental(scale:21.2-67.6)scores by a magnitude(95%CI)of 1.0(0.21-1.86),5.7(2.33-9.07),and 3.0(-0.37-6.37),respectively,over ***:β-Glucan ameliorates PQi in PQD *** using stringent evidence-based methodologies,our study demonstrated that Western medicine-derived remedies,such asβ-glucan,can be employed to advance CM therapeutics.(Clinical *** registry:NCT03782974)

关键词： β-glucan Chinese medicine protective qi protective qi deficiency

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Spatial and Temporal Variations of Heat Waves in China from 1961 to 2010

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Advances in Climate Change Research 2014年第2期5卷 66-73页

作者： YE Dian-Xiu YIN Ji-Fu CHEN Zheng-Hong ZHENG You-Fei wu rong-jun National Climate Center China Meteorological Administration Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration Nanjing University of Information Science and Technology Hubei Service Center for Meteorological Science & Technology Hebei Meteorological Bureau Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Nanjing University of Information Science & Technology

Daily maximum temperatures from 753 stations across China and the heat wave indicators are used to study the temporal and spatial characteristics of heat wave intensity, frequency and heat wave days in China over the period of1961–2010. The results show that high frequency, long duration and strong intensity of heat waves occurred in the Jianghuai area, Jiangnan area, and eastern Sichuan Basin. The highest frequency and the longest duration are located in northern Jiangxi and northern Zhejiang provinces, and the highest intensity in northern Zhejiang province is even more prominent. The frequency, heat wave days and intensity showed a general increasing trend in the past 50 years, while decadal characteristics are also observed with a decreasing trend from the 1960 s to the early 1980 s and increasing trend from the end of the 1980 s to 2010. The regional variations demonstrate a significant increasing trend in the northern and western parts of North China, central-northern part of Northwest China, the central part of South China, the Yangtze River Delta and the southern Sichuan Basin, with an obvious decreasing trend in the southern Huanghuai area, northern Jianghuai area and Hanjiang River Basin.

关键词： heat wave intensity frequency duration

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Measurement of liver function for patients with cirrhosis by ^13C-methacetin breath test compared with Child-Pugh score and routine liver function tests

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Chinese Medical Journal 2006年第18期119卷 1563-1566页

作者： LIU Yun-xiang HUANG Liu-ye wu Cheng-rong CUI jun Department of Gastroenterology Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University Yantai 264000 China

^13C-methacetin breath test was used for the evaluation of liver function, as for quantitative data could be achieved using this method, it had the characteristics of safety, quantification, and repetition and got recognition gradually through the world. We began this ^13C- methacetin test to assess liver function of patients with cirrhosis from January 2002. The aim of this study was to explore the characteristic of this test for liver function evaluation and explore the correlation of this method with some clinical liver biochemical parameters and Child-Pugh score.

关键词： ^13 C-methacetin breath test cirrhosis liver function

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Application of endoscopic retrograde cholangiopancreatography in biliary-pancreatic diseases

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Chinese Medical Journal 2009年第24期122卷 2967-2972页

作者： HUANG Liu-ye LIU Yun-xiang wu Cheng-rong CUI jun ZHANG Bo Department of Gastroenterology Yantai Yuhuangding HospitalAffiliated to Medical College of Qingdao University YantaiShandong 264000 China

Background Endoscopic retrograde cholangiopancreatography （ERCP） has been used increasingly for the treatment of choledocholithiasis, gallstone pancreatitis, and benign or malignant bile duct or pancreatic duct stenosis. The purpose of this study was to evaluate ERCP for the diagnosis and therapy of biliary-pancreatic diseases. Methods A total of 2075 patients who underwent diagnostic and therapeutic ERCP from june 2001 to March 2009 were analyzed retrospectively. Achievement and complication rates were calculated, and the therapeutic effect was observed. Results In all the 64 cases who underwent diagnostic ERCP, the procedure was successful, in 2011 cases therapeutic ERCP was performed, and the success rate was 94.6%. In the therapeutic ERCP cases, 1434 （93.0%） were successful among the 1542 cases of choledocholithiasis, and 422 （90.0%） of the 469 cases with benign or malignant bile duct or pancreatic duct stenosis, or acute obstructive suppurative cholangitis with stent placement or endoscopic nasobiliary drainage were successful. Fifty-nine （90.8%） cases of the 65 who underwent a pre-cut for pancreatic sphincterotomy were successful. Complication rate was 5.1% and the most frequent complication was acute pancreatitis （4.4%）. Conclusions ERCP is one of the major diagnostic and therapeutic methods for biliary-pancreatic disease. Therapeutic ERCP is a minimally invasive, safe and effective treatment method for various biliary-pancreatic diseases.

关键词： endoscopic retrograde cholangiopancreatography biliary disease pancreatic disease

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地表臭氧和土壤水分亏缺对植物的交互效应研究进展

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生态学杂志 2017年第3期36卷 846-853页

作者：吴荣军江苏省农业气象重点实验室南京信息工程大学南京210044 南京信息工程大学应用气象学院南京210044

全球气候变暖背景下,地表臭氧浓度上升,干旱化趋势明显。本文简要介绍了地表臭氧和土壤水分亏缺对地表植被和农作物的胁迫效应,重点评述了其交互作用下自然植被和农作物的气孔响应及抗氧化响应特征,理清了土壤水分亏缺条件下臭氧对植物... 详细信息

全球气候变暖背景下,地表臭氧浓度上升,干旱化趋势明显。本文简要介绍了地表臭氧和土壤水分亏缺对地表植被和农作物的胁迫效应,重点评述了其交互作用下自然植被和农作物的气孔响应及抗氧化响应特征,理清了土壤水分亏缺条件下臭氧对植物的伤害效应,因植物种类和小麦品种的不同而得出两种相反的结论:一种观点认为,干旱导致脱落酸增加,从而诱导气孔关闭,减轻臭氧伤害效应;而另一种观点认为,臭氧促进乙烯合成,出现气孔呆滞行为,干旱保护作用缺失。同时,综述了土壤水分亏缺条件下臭氧胁迫效应评估方法的发展,理清了开展土壤水分亏缺与臭氧交互效应评估方法的研究思路。最后,提出了加强交互效应研究的可能研究方向和途径。

关键词：臭氧干旱脱落酸气孔呆滞交互效应

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一类三角Bézier曲线的形状特征

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图学学报 2019年第3期40卷 549-555页

作者：吴荣军西安邮电大学理学院

在几何造型的许多应用中,良好的曲线形状应该消除不必要的奇点和拐点,因此往往需要预知与分析参数曲线的各种形状特征,以避免出现奇异形状的设计风险。为了快速确定参数曲线的形状特征,利用锥面的齐次性简化了参数曲线的形状条件,得出... 详细信息

在几何造型的许多应用中,良好的曲线形状应该消除不必要的奇点和拐点,因此往往需要预知与分析参数曲线的各种形状特征,以避免出现奇异形状的设计风险。为了快速确定参数曲线的形状特征,利用锥面的齐次性简化了参数曲线的形状条件,得出了一类带2个形状参数的二次三角Bézier曲线的尖点条件锥和2张重结点边界条件锥;3张特征锥面及其切平面将特征空间划分为不同的特征区域。曲线的形状特征完全由特征点在特征空间的分布区域决定。用垂直于坐标轴的平面切割特征空间,可得到基于包络与拓扑映射方法的所有形状条件分布图。进而讨论了形状参数变化对各特征区域的影响,相关结果可使设计者明确如何配置控制顶点或者调节形状参数,使得生成曲线为全局凸或局部凸曲线,或具有所需要的奇点与拐点,或将当前曲线形状调节为另一种所需的形状。

关键词：三角Bézier曲线形状特征尖点锥重结点锥

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Analgesic effects and structural elucidation of two new flavone C-glycosides from Artemisa sacrorum

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Chinese Journal of Natural Medicines 2015年第10期13卷 786-790页

作者： WANG Qing-Hu HAN Na-Ren-Chao-Ke-Tu DAI Na-Yin-Tai wu rong-jun wu Jie-Si College of Traditional Mongolian Medicine Inner Mongolia University for Nationalities

The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The Et OAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities of the isolated compounds were assessed in rats with hot plate test and paw pressure assay. Two new flavone C-glycosides, named as Sacroroside A and B(Compounds 1 and 2) were isolated from the Et OAc crude extract of the aerial parts of Artemisa sacrorum Ledeb. They showed significant analgesic effects. In conclusion, Compounds 1 and 2 are new natural products, which show significant analgesic effects in a dose-dependent manner.

关键词： Artemisa sacrorum Ledeb Sacroroside A Sacroroside B Analgesic effect

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不同类型植被绿度始期的遥感模拟及变化规律

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生态学杂志 2016年第6期35卷 1617-1626页

作者：吴荣军鲁艺南京信息工程大学应用气象学院南京210044 江苏省农业气象重点实验室南京210044

植被绿度始期是研究植被生长周期与气候变化关系的一个重要参量。本文选取中国的青藏高原地区、中东部地区和东北地区作为研究区域,基于1983—2012年NOAA/AVHRR上的NDVI累积频率曲线,利用Logistic函数进行拟合计算植被的绿度始期,并结合... 详细信息

植被绿度始期是研究植被生长周期与气候变化关系的一个重要参量。本文选取中国的青藏高原地区、中东部地区和东北地区作为研究区域,基于1983—2012年NOAA/AVHRR上的NDVI累积频率曲线,利用Logistic函数进行拟合计算植被的绿度始期,并结合MODIS Collection 5地表覆盖类型数据,分析了不同区域内不同类型植被绿度始期的变化特征及差异性。结果表明:草地、灌木林、落叶乔木林和农田类型的绿度始期总体呈现提前趋势;在同一区域内,不同类型植被的绿度始期出现的时间不同;在不同区域内,同一类型植被绿度始期的年际变化表现不同的趋势,草地的绿度始期总体呈现提前的趋势,青藏高原地区提前趋势明显,变化率达到6.11 d·10 a^(-1),中东部地区为5.37 d·10 a^(-1),东北地区为2.13 d·10 a^(-1);落叶乔木林的年际变化幅度大致和草地相似,随着纬度的升高和海拔的降低,其绿度始期的提前变化速率会逐渐变小,灌木和农田在东北出现了绿度始期的推迟趋势,多年延迟的变化率为1.49和1.03 d·10 a^(-1)。

关键词：绿度始期 Logistic函数累积频率

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含2个S副间隙6-SPS机构奇异性分析

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振动与冲击 2016年第7期35卷 130-137页

作者：赵德胜吴荣军西安邮电大学自动化学院西安710121

6-SPS机构位姿矩阵采用四元数法描述,并将该矩阵和矢量坐标扩展为4维形式,推导出无间隙机构的运动方程,得到了机构运动的新型雅克比矩阵J_A和J_B;在此基础上,利用连续接触模型得到了两个含间隙S副共连杆和异杆时机构的运动系数矩阵。分... 详细信息

6-SPS机构位姿矩阵采用四元数法描述,并将该矩阵和矢量坐标扩展为4维形式,推导出无间隙机构的运动方程,得到了机构运动的新型雅克比矩阵J_A和J_B;在此基础上,利用连续接触模型得到了两个含间隙S副共连杆和异杆时机构的运动系数矩阵。分别把各个运动系数的行列式展开,得到含间隙机构第一类奇异和第二类奇异的轨迹方程,利用MATLAB得到了机构在给定位置时的第一类位姿奇异轨迹和第二类位姿奇异三维轨迹曲面;通过将两类含间隙机构奇异轨迹曲面的比较,发现机构间隙对第二类奇异的影响大于对第一类奇异的影响;在两类奇异轨迹中,当S副异杆时,机构间隙的影响均大于S副共连杆时的影响。以无间隙机构奇异轨迹曲面上奇异点作为参考点,通过含间隙机构奇异轨迹曲面上与参考点相对应奇异点的相互比较,发现存在一个关于参考点的奇异域。

关键词：四元数奇异位形含间隙并联机构雅克比矩阵奇异域

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