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Si-wu-Tang attenuates liver fibrosis via regulating lncRNA H1.-dependent pathways involving cytoskeleton remodeling and ECM deposition

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Chinese Journal of Natural Medicines 2024年第1期22卷 31-46页

作者： QU Jiaorong XUE Xiaoyong WANG Zhixing MA Zhi JIA Kexin LI Fanghong ZHANG Yinhao wu Ruiyu ZHOU Fei {1. Piwen LI Xiaojiaoyang School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

Liver fibrosis is a dynamic wound-healing response characterized by the agglutination of the extracellular matrix(ECM).Si-wu-Tang(SWT),a traditional Chinese medicine(TCM)formula,is known for treating gynecological diseases and liver *** previous studies demonstrated that long non-coding RNA H1.(H1.)was markedly upregulated in fibrotic livers while its deficiency markedly reversed ***,the mechanisms by which SWT influences H1. remain ***,we established a bile duct ligation(BDL)-induced liver fibrosis model to evaluate the hepatoprotective effects of SWT on various cells in the *** results showed that SWT markedly improved ECM deposition and bile duct reactions in the ***,SWT relieved liver fibrosis by regulating the transcription of genes involved in the cytoskeleton remodeling,primarily in hepatic stellate cells(HSCs),and influencing cytoskeleton-related angiogenesis and hepatocellular *** modulation collectively led to reduced ECM *** extensive bioinformatics analyses,we determined that H1. acted as a miRNA sponge and mainly inhibited miR-200,miR-21.,and let7b,thereby regulating the above cellular regulatory ***,SWT reversed H1.-related miRNAs and signaling pathways,diminishing ECM deposition and liver ***,these protective effects of SWT were diminished with the overexpression of H1. in *** conclusion,our study elucidates the underlying mechanisms of SWT from the perspective of H1.-related signal networks and proposes a potential SWT-based therapeutic strategy for the treatment of liver fibrosis.

关键词： Liver fibrosis LncRNA H1. Si-wu-Tang miRNAs Cytoskeleton ECM deposition

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Winter extreme precipitation over the Tibetan Plateau influenced by Arctic sea ice on interdecadal timescale

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Advances in Climate Change Research 2024年第4期15卷 42-51页

作者： Qing-Quan LI Miao BI Song YANG Qing-Yuan wu Yi-Hui DING Xin-Yong SHEN Xiao-Ting SUN Meng-Chu {1. china Meteorological {1. Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China CMA Key Open Laboratory of Transforming Climate Resources to Economy Chongqing Institute of Meteorological SciencesChongqing 401147China School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen University Zhuhai 519082China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

The Tibetan Plateau(TP)and the Arctic are the most sensitive regions to global climate ***,the interdecadal varibility of winter extreme precipitation over the TP and its linkage with Arctic sea ice are still *** this study,the characteristics and mechisnems of the TP extreme precipitation(TPEP)influenced by Arctic sea ice on interdecadal timescale are studied based on the daily precipitation,monthly sea ice concentration and ERA5 reanalysis data from 1.80 to *** found that the dominant mode of the TPEP in winter mostly exhibits a uniform spatial variation on the interdecadal timescale,with an opposite weak variation in the southeastern TP,and the Arctic sea ice concentration(SIC)before 2002 are larger than that after *** interdecadal variation of TPEP is affected by two teleconnection wave trains regulated by the Barents and Kara Sea *** the light ice years,a remarkable positive geopotential height(HGT)anomaly appears over the Barents-Kara Sea and a remarkable negative HGT anomaly is located over the Lake *** wave trains originating over the Barents-Kara Sea can be *** southern branch forms a wave train through the North Atlantic along the subtropical westerly jet stream,showing a‘+-+-+'pattern of HGT anomalies from Arctic to the *** HGT anomaly controls the western TP,which creates dynamic and water vapor conditions for the *** northern branch forms a wave train through the Lake Baikal and the southeast of the TP,showing a‘+-+'HGT anomaly *** HGT anomaly controls the southeastern TP,which is not conducive to precipitation in the *** the SIC in the Barents-Kara Sea increases,the situation is *** above analysis also reveals the reason for the difference in the east-west distribution of the TPEP.

关键词： Arctic sea ice Tibetan Plateau Winter extreme precipitation Rossby wave activity Interdecadal variation

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甲状腺相关眼病治疗中不同单克隆抗体有效性与安全性的系统评价再评价

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中国临床药理学与治疗学 2024年第7期29卷 735-743页

作者：刘爽蒋函錞吴晶晶赵荣生北京大学第三医院药学部北京100191 北京大学医学部药物评价中心北京100191 北京大学药学院药事管理与临床药学系北京100191

目的:全面评估甲状腺相关眼病(thyroidassociated ophthalmopathy,TAO)治疗中利妥昔单克隆抗体(rituximab,RTX)、托珠单克隆抗体(tocilizumab,TCZ)、替妥木单克隆抗体(teprotumumab,TMB)的有效性和安全性。方法:采用系统评价再评价方法,系统检索PubMed、Embase、Cochrane Library数据库中关于TAO治疗的系统评价/Meta分析,检索时间均为建库至2024年1.。分别采用PRISMA 2020声明、AMSTAR 2量表和GRADE工具评估纳入研究的报告质量、方法学质量及证据质量。结果:当前关于TAO治疗中3种单克隆抗体的系统评价在报告规范性、方法学质量和证据质量方面仍存在不足。目前仍缺少3种单克隆抗体直接比较的证据,基于间接比较证据,TCZ可能是最好的治疗方法,其次为TMB和RTX。有效性方面,TCZ、TMB可显著降低临床活动性评分、眼球突出度及生活质量,TCZ显著降低复视发生,RTX显著降低疾病应答,RTX及TCZ显著改善疾病失活率,RTX在复视、眼睑裂变化、NOSPECS评分与生活质量方面无显著差异。安全性方面的结论尚不一致,TCZ和TMB可能增加不良事件的发生率,而RTX在安全性方面与糖皮质激素或安慰剂相比无显著差异。结论:本研究为TAO治疗中3种单克隆抗体的选择提供循证依据。尽管TCZ在有效性方面可能具有优势,但考虑到现有证据的限制性,未来仍需更多高质量研究进一步验证和比较不同单克隆抗体在TAO治疗中的有效性和安全性。

关键词：甲状腺相关眼病利妥昔单克隆抗体托珠单克隆抗体替妥木单克隆抗体伞形综述

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Whole-genome Sequencing Reveals Autooctoploidy in Chinese Sturgeon and Its Evolutionary Trajectories

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 51-65页

作者： Binzhong Wang Bin wu Xueqing Liu Yacheng Hu Yao Ming Mingzhou Bai Juanjuan Liu Kan Xiao Qingkai {1. Jing Yang Hongqi Wang Baifu Guo Chun Tan Zixuan Hu Xun zhao Yanhong Li Zhen Yue Junpu Mei Wei Jiang Yuanjin Yang Zhiyuan Li Yong Gao Lei Chen Jianbo Jian Hejun Du Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes Yichang 443100China Chinese Sturgeon Research institute China Three Gorges CorporationYichang 443100China Yangtze River Biodiversity Research Center China Three Gorges CorporationWuhan 430014China BGI-Shenzhen Shenzhen 518083China BGI Genomics BGI-ShenzhenShenzhen 518083China Department of Biotechnology and Biomedicine Technical University of DenmarkLyngby 2800Denmark River Basin Complex administration Center China Three Gorges CorporationYichang 443100China BGI-Sanya BGI-ShenzhenSanya 572025China Yangtze Eco-Environment Engineering Research Center China Three Gorges CorporationBeijing 100038China

The order Acipenseriformes,which includes sturgeons and paddlefishes,represents“living fossils”with complex genomes that are good models for understanding whole-genome duplication(WGD)and ploidy evolution in ***,we sequenced and assembled the first high-quality chromosome-level genome for the complex octoploid Acipenser sinensis(Chinese sturgeon),a critically endangered species that also represents a poorly understood ploidy group in *** results show that *** is a complex autooctoploid species containing four kinds of octovalents(8n),a hexavalent(6n),two tetravalents(4n),and a divalent(2n).An analysis taking into account delayed rediploidization reveals that the octoploid genome composition of Chinese sturgeon results from two rounds of homologous WGDs,and further provides insights into the timing of its ploidy *** study provides the first octoploid genome resource of Acipenseriformes for understanding ploidy compositions and evolutionary trajectories of polyploid fishes.

关键词： Chinese sturgeon Whole-genome sequencing Autooctoploid Polyploidization and diploidization Whole-genome duplication

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Two new species of Exogone and Sphaerosyllis (Polychaeta, Syllidae)from the Huanghai Sea

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Acta Oceanologica Sinica 1992年第1期11卷 131-137页

作者： zhao Jing {1. Baoling First institute of Oceanography, State Oceanic administration, Qingdao 266003, china

-In a study of meiofauna polychaete from the Huanghai Sea, two new species belonging to Exogane and Sphaerosyllis were found and described in this paper. The two new species differ from the other species in the two ge... 详细信息

关键词： Two new species of Exogone and Sphaerosyllis Polychaeta Syllidae)from the Huanghai Sea

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Puerariae Radix protects against ulcerative colitis in mice by inhibiting NLRP3 inflammasome activation

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Food Science and Human Wellness 2024年第4期13卷 2266-2276页

作者： Yu Ga Yuanyuan Wei Qingyu zhao Yimeng Fan Yannan Zhang Zhifang Zhang Sijia Hao Lixia Wang Zhifen Wang Jinlong Han Shuang {1. Zhihui Hao Innovation Centre of Chinese Veterinary Medicine College of Veterinary MedicineChina Agricultural UniversityBeijing 100086China National Center of Technology Innovation for Medicinal Function of Food National Food and Strategic Reserves AdministrationBeijing 100193China Inner Mongolia Medical University Hohhot 010059China china Agricultural University Yantai {1. Yantai 264670China Shandong Academy of Agricultural Sciences Jinan 250100China

Ulcerative colitis(UC)is a common inflammatory disease of the gastrointestinal *** Chinese medicine(TCM)has long been used in Asia as a treatment for UC and Puerariae Radix(PR)is a reliable anti-diarrheal *** aims of this study were to investigate the protective effect of PR using the dextran sulfate sodium salt(DSS)-induced UC model in mice and identify molecular mechanisms of PR *** chemical constituents of PR via ultra-performance liquid chromatography/tandem mass spectrometry and identified potential PR and UC targets using a network pharmacology(NP)approach were obtained to guide mouse experiments.A total of 1.0 peaks were identified from PR including 48 flavonoids,46 organic acids,1. amino acids,8 phenols,8 carbohydrates,7 alkaloids,6 coumarins and 43 other *** results showed that caspase-1.was the most dysregulated of the core genes associated with UC.A PR dose of 0.1.6 mg/g administered to DSS treated mice reversed weight loss and decreased colon lengths found in UC *** also alleviated intestinal mucosal shedding,inflammatory cell infiltration and mucin *** treatment suppressed upregulation of NOD-like receptor protein 3(NLRP3),cysteinyl aspartate-specific proteases-1.caspase-1.,apoptosis-associated speck-like(ASC)and gasdermin D(GSDMD)at both the protein and m RNA expression *** addition of a small molecule dual-specificity phosphatase inhibitor NSC 95397 inhibited the positive effects of *** results indicated that PR exerts a protective effect on DSS-induced colitis by inhibiting NLRP3 inflammasome activation in mice.

关键词： Puerariae Radix Ulcerative colitis Molecular mechanisms Pyroptosis NOD-like receptor protein 3 inflammasome

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Hydrogen sulfide ameliorates vascular calcification induced by vitamin D3 plus nicotine in rats

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Acta Pharmacologica Sinica 2006年第3期27卷 299-306页

作者： Sheng-ying wu~(2,6) Chun-shui PAN~3 Bin GENG~3 Jing {1.~3 Fang YU~3 Yong-zheng PANG~3 Chao-shu TANG~4 Yong-fen QI~(3,4,5) ~2institute of Cardiovascular Disease,Peking University First Hospital.beijing 1.0034 ~3Department of Physiology and Pathophysiology,Peking University Health Science Center,beijing 1.0083,china,~4Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,beijing 1.0083,china 2institute of Cardiovascular Disease Peking University First Hospital Beijing 100034 China 3Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100083 China 3Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100083 China 3Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100083 China 3Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100083 China 3Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100083 China 4Key Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing 100083 China 4Key Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing 100083 China

Aim:To investigate the role of the endogenous cystathionine γ-synthase(CSE)/hydrogen sulfide(H2S)pathway in vascular calcification in ***:A ratvascular calcification model was established by administration of vitamin D3 plusnicotine(VDN).The amount of CSE and osteopontin(OPN)mRNA was deter-mined by using semi-quantitative reverse-transcription polymerase chain *** calcium content,45Ca2+accumulation and alkaline phosphatase(ALP)activitywere measured.H,S production and CSE activity were ***:yonKossa staining produced strong positive black/brown staining in areas amongthe elastic fibers of the medial layer in the calcified *** calcium content,45Ca2+accumulation and ALP activity in calcified arteries increased by 6.77-,1.42-,and 1.87-fold,respectively,compared with *** expression of the OPNgene was upregulated(P1..Expression of the CSE gene was ***,calcium content,45Ca2+uptake and ALP activity in the VDN plus NaHSgroup was lower than that in the VDN *** content of calcium and45Ca2+accumulation and activity of ALP in the aorta were 34.8%,40.75% and 63.5% lowerin the low-dosage NariS group than in the VDN group,respectively(P1.,andthe calcium content and deposition of45Ca2+and activity of ALP was 83.9%,37.8 % and 46.2% lower in the aorta in the high-dosage NariS group than in theVDN group,respectively(P1..The expression of the OPN gene ***:The production of H,S,and CSE activity were de-creased and CSE gene expression was downregulated in rats with vascularcalcification.H2S can ameliorate vascular calcification,suggesting that the H2S/CSE pathway plays a regulatory role in the pathogenesis of vascular calcification.

关键词： hydrogen sulfide cystathionine-lyase vascular calcification mRNA

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Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction

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Chinese Journal of Natural Medicines 2024年第5期22卷 402-415页

作者： XIU Ye WANG Sihao ZHANG Ping LI Chengwei wu Zhixin WEN Jincai XU Yingjie LV Guiji {1. Xiaomei DONG Xu CHEN Yichong LI Junjie WANG Yan ZOU Liang XIAO Xiaohe BAI {1.fang School of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China china Military {1. of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Pharmacy Medical Supplies Center of PLA General HospitalBeijing 100039China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100039China

In the realm of autoimmune and inflammatory diseases,the cyclic GMP-AMP synthase(cGAS)stimulator of interferon genes(STING)signaling pathway has been thoroughly investigated and *** this,the clinical approval of drugs targeting the cGAS-STING pathway has been *** Total glucosides of paeony(TGP)is highly anti-inflammatory and is commonly used in the treatment of rheumatoid arthritis(RA),emerged as a subject of our *** found that the TGP markedly reduced the activation of the cGAS-STING signaling pathway,triggered by various cGAS-STING agonists,in mouse bone marrow-derived macrophages(BMDMs)and Tohoku Hospital Pediatrics-1.THP-1.*** inhibition was noted alongside the suppression of interferon regulatory factor 3(IRF3)phosphorylation and the expression of interferon-beta(IFN-β),C-X-C motif chemokine ligand 1.(CXCL1.),and inflammatory mediators such as tumor necrosis factor-alpha(TNF-α)and interleukin-6(IL-6).The mechanism of action appeared to involve the TGP’s attenuation of the STING-IRF3 interaction,without affecting STING oligomerization,thereby inhibiting the activation of downstream signaling *** vivo,the TGP hindered the initiation of the cGAS-STING pathway by the STING agonist dimethylxanthenone-4-acetic acid(DMXAA)and exhibited promising therapeutic effects in a model of acute liver injury induced by lipopolysaccharide(LPS)and D-galactosamine(D-GalN).Our findings underscore the potential of the TGP as an effective inhibitor of the cGAS-STING pathway,offering a new treatment avenue for inflammatory and autoimmune diseases mediated by this pathway.

关键词： Total glucosides of gaeony cGAS-STING pathway Inflammation LPS/D-GalN STING inhibitor

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冈底斯中东部底垫-俯冲转换带附近地壳上地幔结构远震P波层析成像研究

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地质学报 2018年第7期92卷 1335-1351页

作者：史健宇史大年吴珍汉赵文津宋洋薛光琦宿和平中国地质科学院矿产资源研究所国土资源部成矿作用与资源评价重点实验室北京100037 中国地质科学院北京100037

利用冈底斯中-东部1.7个宽频带天然地震台站记录到的数据和远震P波走时层析成像方法,获得了该区域的P波速度扰动图像。层析成像结果显示研究区地壳和上地幔地震波速度结构存在着复杂的空间变化。首先,在藏南拆离系断层(STD)以北的特提... 详细信息

利用冈底斯中-东部1.7个宽频带天然地震台站记录到的数据和远震P波走时层析成像方法,获得了该区域的P波速度扰动图像。层析成像结果显示研究区地壳和上地幔地震波速度结构存在着复杂的空间变化。首先,在藏南拆离系断层(STD)以北的特提斯喜马拉雅地壳中存在着较强的低速异常,但是该低速异常的北端在远离裂谷带的地方并没有明显越过雅鲁藏布江缝合线(YZS),这与前人的观测结果略有不同;在亚东-古露(YGR)和措美-桑日(CSR)裂谷带的下方存在低速异常,但异常强度都没有前者大;在两个裂谷带之间的拉萨地块中-南部,地壳表现为强高速特征。这些结果表明,影响青藏高原地壳构造演化的"地壳通道流(Crustal Channel Flow)"在藏南主要分布在特提斯喜马拉雅地区,在雅鲁藏布江缝合线以北的冈底斯地区,可能主要局限于沿裂谷带分布。其次,被解释为印度岩石圈地幔的上地幔高速异常,在研究区西部,抵达了雅鲁藏布江缝合线以北1.0km或更远的地方,而在研究区东部,并没有越过雅鲁藏布江缝合线,而是停留在缝合线以南~1.0km的高喜马拉雅下方,印证了前人给出的印度板块俯冲角度在研究区附近存在东西向变化的层析成像结果。此外,我们的层析成像结果还印证了冈底斯东南侧的上地幔低速异常根植于上地幔底部,我们认为该现象可能与巽他块体的顺时针旋转引起向东俯冲的缅甸弧向西后撤有关。

关键词：青藏高原冈底斯带远震P波层析成像地壳和上地幔结构地壳通道流

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Amplifying protection against acute lung injury:Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair

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Chinese Herbal Medicines 2024年第3期16卷 422-434页

作者： Junjie Li Ming Dong Qing Yao Xu Dong Yuanyuan Chen Jincai Wen Yingjie Xu Zhixin wu Xiaomei {1. Ye Xiu Xiaoyan Zhan {1.fang Bai Xiaohe Xiao Chengde Medical University Chengde 067000China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China china Military {1. of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China National Key Laboratory of Kidney Diseases The Fifth Medical Center of PLA General HospitalBeijing 100039China School of Stomatology Heilongjiang Key Lab of Oral Biomedicine Materials and Clinical Application&Experimental Center for Stomatology EngineeringJiamusi UniversityJiamusi 154007China Southern Medical University Guangzhou 510515China

Objective:Acute lung injury(ALI)is characterized by inflammation and currently lacks an efficacious pharmacological *** medicine combination of Lonicerae Japonicae Flos(LJF)and Forsythiae Fructus(FF)demonstrates combined properties in its anti-infective,anti-inflammatory,and therapeutic effects,particularly in alleviating respiratory *** previous studies,Chinese medicine has shown promising efficacy in lipopolysaccharides(LPS)-induced ***,there have been no reports of LJF and FF pairing for lung *** aim of this study is to compare the efficacy of herb pair Lonicerae Japonicae Flos-Forsythiae Fructus(LF)with LJF or FF alone in the treatment of ALI,and to explore whether LJF and FF have a combined effect in the treatment of lung injury,along with the underlying mechanism ***:A total of 36 mice were divided into six groups(control,model,LJF,FF,LF,dexamethasone)based on the treatments they received after undergoing sham-operation/LPS tracheal instillation.H&E staining and pulmonary edema indexes were used to evaluate lung injury *** exudate cells(AECs)were counted based on cell count in bronchoalveolar lavage fluid(BALF),and neutrophil percentage in BALF was measured using flow ***(MPO)activity in BALF was measured using enzyme-linked immunosorbent assay(ELISA),while the production of IL-1.,TNF-α,and IL-6 in the lung and secretion level of them in BALF were detected by quantitative polymerase chain reaction(qPCR)and *** effect of LJF,FF,and LF on the expression of Caspase-1.and IL-1.proteins in bone marrow derived macrophages(BMDMs)supernatant was assessed using Western blot method under various inflammasome activation *** addition,the concentration of IL-1.and changes in lactatedehydrogenase(LDH)release levels in BMDMs supernatant after LJF,FF,and LF administration,respectively,were measured using ***,the effects of LJF,FF and LF on STING and IRF3 phosphor

关键词： acute lung injury BMDMS inflammasomes Lonicerae Japonicae Flos-Forsythia Fructus drug pair STING

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