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Epitranscriptomic 5-Methylcytosine Profile in PM_(2.5)-induced Mouse Pulmonary Fibrosis

Genomics, Proteomics & Bioinformatics 2020年第1期18卷 41-51页

作者： Xiao Han Hanchen Liu Zezhong Zhang Wenlan Yang Chunyan wu Xueying Liu Fang Zhang Baofa Sun Yongliang {1. Guibin Jiang Yun-Gui Yang Wenjun Ding College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and DevelopmentCollege of Future TechnologyBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China institute of Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

Exposure of airborne particulate matter(PM)with an aerodynamic diameter less than 2.5μm(PM2.5)is epidemiologically associated with lung dysfunction and respiratory symptoms,including pulmonary ***,whether epigenetic mechanisms are involved in PM2.5-induced pulmonary fibrosis is currently poorly ***,using a PM2.5-induced pulmonary fibrosis mouse model,we found that PM2.5 exposure leads to aberrant mRNA5-methylcytosine(m5C)gain and loss in fibrotic lung ***,we showed the m5C-mediated regulatory map of gene functions in pulmonary fibrosis after PM2.5 *** genes act as m5C gain-upregulated factors,probably critical for the development of PM2.5-induced fibrosis in mouse *** genes,including Lcn2,Mmp9,Chi3l1.Adipoq,Atp5j2,Atp5l,Atpif1.Ndufb6,Fgr,Slc1. a1.and Tyrobp,are highly related to oxidative stress response,inflammatory responses,and immune system *** study illustrates the first epitranscriptomic RNA m5C profile in PM2.5-induced pulmonary fibrosis and will be valuable in identifying biomarkers for PM2.5 exposure-related lung pathogenesis with translational potential.

关键词： PM2.5 exposure mRNA m^5C Pulmonary fibrosis Inflammation Immune response

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Combination patterns of precipitation and its concentration degree determining the risk of dengue outbreaks in china

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Advances in Climate Change Research 2023年第5期14卷 768-777页

作者： Yu-Rong wu Xiao-Wen WANG Liang {1. Bo LU Jun-Feng YU Ze-Hua LIU Yi SUN Wan-Nian LIANG Cun-Rui HUANG School of Public Health Sun Yat-sen UniversityGuangzhou 510006China Vanke School of Public Health Tsinghua UniversityBeijing 100084China Shanghai Typhoon institute China Meteorological Administration&Shanghai Key Laboratory of Meteorology and HealthShanghai Meteorological ServiceShanghai 200030China Center for Public Health and Epidemic Preparedness&Response Peking UniversityBeijing 100871China The State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China National Climate Center China Meteorological AdministrationBeijing 100081China institute of Healthy{1. Tsinghua UniversityBeijing 100084China

The amount and distribution of precipitation can determine dengue risk by affecting mosquito breeding;however,previous studies failed to incorporate this bivariate characteristic to examine dengue fever *** the present research,nationwide data on daily dengue cases in china between January 2005 and December 2020 were obtained,and the top 1. cities accounting for 78%of total cases were selected for *** patterns were quantified by weekly precipitation and precipitation concentration degree(PCD).On the basis of the combinations of both parameters,the exposure-response relationships of precipitation with dengue risk were established using generalised additive models,and the high-dengue-risk thresholds of precipitation patterns were further *** burden was assessed by calculating attributable dengue *** the same amount of precipitation,the dispersed precipitation in the pre-summer rainy season leads to a higher dengue risk in *** weekly precipitation of 1.0-1.0 mm and PCD of 0.2-0.4 constitute the highest risk scenario,and the average frequency of precipitation associated with dengue risk in 201.-2020 is 1.6 times higher than that in 2005-201..A total of 3093 attributable dengue cases are *** 2005 to 2020,the amount of dispersed precipitation increased in southern and southwestern china and posed high dengue risks in central *** study has improved the understanding of the health impacts of irregular rainfall under climate *** approach to identifying thresholds provides information for early warning systems and helps reduce the risk of dengue transmission in the long run.

关键词： Climate change Precipitation pattern Precipitation concentration degree Dengue fever Mosquito-borne diseases

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Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma

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Cancer Biology & Medicine 2021年第1期18卷 271-282页

作者： Ruichao Chai Guanzhang Li Yuqing Liu Kenan Zhang Zheng zhao Fan {1. Yuzhou Chang Bo Pang Jingjun Li Yangfang Li Tao Jiang Yongzhi Wang Department of Molecular Neuropathology Beijing Neurosurgical InstituteChinese Glioma Genome Atlas Network(CGGA)Capital Medical UniversityBeijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

Objective:O6 methylguanine-DNA methyltransferase(MGMT)promoter methylation is a biomarker widely used to predict the sensitivity of IDH-wildtype glioblastoma to temozolomide *** that the IDH status has critical effects on the survival and epigenetic features of glioblastoma,we aimed to assess the role of MGMT promoter methylation in IDH-mutant ***:This study included 1.7 IDH-mutant glioblastomas and used 1.3 IDH-wildtype glioblastomas for *** curves and multivariate Cox regression were used to study the predictive ***:Compared with IDH-wildtype glioblastomas,IDH-mutant glioblastomas showed significantly higher(P1.MGMT promoter *** demonstrated that MGMT promoter methylation status,as determined by a high cutoff value(≥30%)in pyrosequencing,could be used to significantly stratify the survival of 50 IDH-mutant glioblastomas receiving temozolomide therapy(cohort A);this result was validated in another cohort of 25 IDH-mutant glioblastomas(cohort B).The median progression-free survival and median overall survival in cohort A were 9.33 and 1..76 months for unmethylated cases,and 1..37 and 41.61.months for methylated cases,and in cohort B were 6.97 and 9.1. months for unmethylated cases,and 23.40 and 26.40 months for methylated *** addition,we confirmed that the MGMT promoter methylation was significantly(P=0.0001.correlated with longer OS in IDH-mutant patients with GBM,independently of age,gender distribution,tumor type(primary or recurrent/secondary),and the extent of ***:MGMT promoter methylation has predictive value in IDH-mutant glioblastoma,but its cutoff value should be higher than that for IDH-wildtype glioblastoma.

关键词： Glioblastoma O6methylguanine-DNA methyltransferase isocitrate dehydrogenase temozolomide pyrosequencing

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Solvent and additive-free selective aerobic allylic hydroxylation of β-pinene catalyzed by metalloporphyrins

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Chinese Chemical Letters 2017年第3期28卷 575-578页

作者： Shi-Chao Xu Shou-Ji Zhu Liang-wu Bi Yu-Xiang Chen Jing Wang Yan-Ju Lu Yan Gu Zhen-Dong {1. institute of Chemical Industry of Forest Products Chinese Academy of Forestry Nanjing 210042 China Key Lab. of Biomass Energy and Material Jiangsu Province Nanjing 210042 China National Engineering Lab. for Biomass Chemical Utilization Nanjing 210042 China Key and Open Lab. on Forest Chemical Engineering State Forestry Administration Nanjing 210042 China institute of Forestry New Technology Chinese Academy of Forestry Beijing 100091 China 201. Collaborative Innovation Center of Jiangxi Typical Trees Cultivation and Utilization in Jiangni Agricultural University Nanchang 330045 China

Metallodeuteroporphyrins（MDPs） were employed as the catalysts for aerobic oxidation of β-pinene in absence of solvents and additives. Allylic hydroxylation products were found to be the main products from this protocol. The catalytic activity of MDPs with different metal nuclei and the influences of technological conditions on this reaction were investigated. This catalytic system has bright application prospect since only eco-friendly and readily available dioxygen were needed.

关键词： Turpentine transformatio β-Pinene Metalloporphyrin Biomimetic catalysis Aerobic allylic hydroxylation

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Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics

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Frontiers of Medicine 2023年第5期17卷 993-1005页

作者： Chong Li Xinyi Li Ke He Yang wu Xiaoming Xie Jiju Yang Fan Zhang Yang Yue Huifeng Hao Shaokun {1. Xin Li Guihua Tian Dongzhimen Hospital Beijing University of Chinese MedicineBeijing100700China Department of Integration of Chinese and Western Medicine Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital&InstituteBeijing100142China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing100875China

Migraine is one of the most prevalent and disabling neurological disease,but the current pharmacotherapies show limited efficacy and often accompanied by adverse *** is a promising complementary therapy,but further clinical evidence is *** influence of acupuncture on migraine is not an immediate effect,and its mechanism remains *** study aims to provide further clinical evidence for the anti-migraine effects of acupuncture and explore the mechanism involved.A randomized controlled trial was performed among 1. normal controls and 38 *** migraineurs were divided into blank control,sham acupuncture,and acupuncture *** were subjected to two courses of treatment,and each treatment lasted for 5 days,with an interval of 1.day between the two *** effectiveness of treatment was evaluated using pain *** functional magnetic resonance imaging(fMRI)data were analyzed for investigating brain changes induced by *** plasma was collected for metabolomics and proteomics *** and mediation analyses were performed to investigate the interaction between clinical,fMRI and omics *** showed that acupuncture effectively relieved migraine symptoms in a way different from sham acupuncture in terms of curative effect,affected brain regions,and signaling *** anti-migraine mechanism involves a complex network related to the regulation of the response to hypoxic stress,reversal of brain energy imbalance,and regulation of *** brain regions of migraineurs affected by acupuncture include the lingual gyrus,default mode network,and *** effect of acupuncture on patients’metabolites/proteins may precede that of the brain.

关键词： acupuncture migraine fMRI metabolome proteome

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Design,synthesis and evaluation of novel cis-p-menthane type Schiff base compounds as effective herbicides

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Chinese Chemical Letters 2017年第7期28卷 1509-1513页

作者： Shi-Chao Xu Shou-Ji Zhu Jing Wang Liang-wu Bi Yu-Xiang Chen Yan-Ju Lu Yan Gu Zhen-Dong {1. institute of Chemical Industry of Forest Products Chinese Academy of ForestryNanjing 210042China Key Lab of Bioraass Energy and Materialjiangsu ProvinceNanjing 210042China National Engineering Lab.for Biomass Chemical Utilization Nanjing 210042China Key and Open Lab.on Forest Chemical Engineering State Forestry AdministrationNanjing 210042China institute of Forestry New Technology Chinese Academy of ForestryBeijing 100091China 201. Collaborative Innovation Center of jiangxi Typical Trees Cultivation and Utilization in jiangxi Agricultural University Nanchang 330045China

p-Menthane type monoterpene derivatives were identified as bio-based compounds with high herbicidal activities. In order to search novel p-menthane type monoterpene derivatives in good performance, a series of novel cis-p-menthane type Schiff base derivatives were designed and synthesized. All target products were easily available novel compounds and characterized by FT-IR,^1. NMR,^1. C NMR and ESI＋-MS. Their pre-emergence herbicidal activities against annual ryegrass were evaluated. The bioassays indicated that most of the target compounds displayed excellent herbicidal activities in pre-emergence treatment.

关键词： Turpentine derivatives Bio-based herbicides p-Menthane type compounds Schiff base derivatives Herbicidal activity

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库姆塔格沙漠北部沉积物色度特征与沙丘表面明暗色斑成因分析

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地理学报 2024年第9期79卷 2297-2311页

作者：金秉福张云吉哈斯额尔敦苏志珠孔德庸于健成龙费兵强韩旭娇张亚茹李秀彬赵学勇吴波鲁东大学资源与环境工程学院烟台264025 北京师范大学地理科学学部自然资源学院北京100875 山西大学历史文化学院太原030006 韶关学院韶关512005 中国林业科学研究院生态保护与修复研究所北京100091 荒漠生态系统与全球变化国家林业和草原局重点实验室北京100091 中国科学院地理科学与资源研究所北京100101 中国科学院西北生态环境资源研究院兰州730000

库姆塔格沙漠北部沙丘表面多呈现褐黑色至灰褐色,在一些羽毛状沙丘(沙垄)表面常出现明暗交错的色斑景观,成为该沙漠独特标识。本文对采自该区表层沉积物样品进行了粒度分析、色粒的目视分类与色度标定以及沉积物色度的仪器测试。研究表... 详细信息

库姆塔格沙漠北部沙丘表面多呈现褐黑色至灰褐色,在一些羽毛状沙丘(沙垄)表面常出现明暗交错的色斑景观,成为该沙漠独特标识。本文对采自该区表层沉积物样品进行了粒度分析、色粒的目视分类与色度标定以及沉积物色度的仪器测试。研究表明:目视色度指数CI与器测亮度L^(*)和黄度b^(*)有很强的线性对应关系,可以相互替代表达沉积物的颜色和明暗程度。CI和L^(*)与颗粒自身颜色和粒度密切相关,黑色、灰色和褐色来源于碎屑原生岩性和风化物附着物与粗粒径相关性高,表现为色度高、亮度小;而黄色和白色主要为浅色岩石矿物与细粒径相关性高,即色度低、亮度大。沙漠中沉积层理显著,上粗下细的平行层理成为影响沙丘表面色度的重要因素。沙丘表面色度明暗变化是沙粒运动过程中表层粗粒岩屑的蠕动堆积和细粒矿物的风蚀搬运与风动力相适配的结果,色度高的极粗砂(-1.0~0Φ)或极粗砂+粗砂(-1.0~0.5Φ)在表层0~1.m深度内含量只需5%~1.%的相对变化就会使沙丘表面相邻区域产生色度不同的明暗色斑,这种现象与沙漠物质组成、风力分选和沉积物所处地貌部位关系紧密,是多种自然因素综合影响的结果。本文可为揭示库姆塔格沙漠及类似沙漠沙丘表面颜色成因及形成机制提供实验模型和数据参考。

关键词：色度粒度平行层理明暗色斑库姆塔格沙漠

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Effects of water discharge on river-dominated delta growth

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Petroleum Science 2021年第6期18卷 1630-1649页

作者： Yan-Bao Zhang Yi-Ke Liu Jia Yi Xue-Jian Liu institute of {1. China Earthquake AdministrationBeijing100081China Key Laboratory of Petroleum Resources Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China china {1. Disaster Prevention Center China Earthquake AdministrationBeijing100029China The Pennsylvania State University Department of GeosciencesUniversity ParkPA16802USA

River-dominated deltas are commonly developed at modern bays and lakes and ancient petroliferous *** discharge is an important variable at pay zone scales in river-dominated delta reservoirs,which affects deltaic sand distributions and ***,it's unclear how it influences riverdominated delta *** paper integrates Delft3 D simulations and modern analogs to analyze the effects of water discharge,considering growth time,sediment supply,and coupled effects of sediment *** water discharges lead to the formation of lobate deltas,and the water discharge of 1.000 m~3/s is a referenced threshold ***-grained,highly-cohesive sediments increase the threshold values of water discharge at which the deltas become lobate from digitate,and vice *** the same simulation time,high water discharges favor more rugose shorelines,more distributary channels(especially secondary distributaries),and longer and wider deltas with more land ***,for the same sediment supply,high water discharges have few effects on shoreline roughness and the number of distributary channels.

关键词： River-dominated delta Water discharge Morphology Distributary channel Hydrocarbon exploration

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Impact of the cold surge event in January 2021.on the power system of china

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Advances in Climate Change Research 2022年第6期13卷 803-810页

作者： Chang-Yi LIU Bo LU Lu JIN Hao CHEN Jie wu Yang XIANG Zhi-Yuan MA Zi-Jian {1. Fang YANG Qing LIU Jiang-Tao LI Global Energy Interconnection Development and Cooperation Organization(GEIDCO) Beijing 100031China National Climate Centre China Meteorological AdministrationBeijing 100081China Renmin University of Chin1 Beijing 100872China State Grid Energy Research institute Co. Ltd.Beijing 102211China

During 6-1. January 2021.a recorded strong cold surge took place in china,with over 800 observational stations reaching their historical *** previous studies that focused on the response of either the power load or generation separately,this study quantitatively revealed the impacts on the balance between the demand and supply sides of the *** the demand side,the sensitivity of power load was found to increase substantially higher in southern china(0.533 GW°C^(−1.)than in the northern region(0.1.9 GW°C^(−1.)due to the limited municipal heating *** the supply side,the hourly wind power generation dropped from the highest of 1.0 GW on 6 January to the lowest of 54 GW on 9 January due to the reduction in wind *** addition,a reduction in solar power generation was observed during 8-1. ***,the balance of the power system was influenced by this cold *** an effective adaptation measure,results further showed that early warning by three weeks ahead can be obtained by an operational climate *** sensitivity of china's power system to such cold surge events may increase remarkably due to the expected increase in the proportion of wind and solar power generation in future new-type power ***,close cooperation between climate scientists and power engineers is needed to build the resilience of the power system to the cold extremes.

关键词： Cold surge event Power load Renewable power generation Sub-seasonal prediction Adaptation

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Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent

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Acta Pharmaceutica Sinica B 2020年第3期10卷 434-446,574页

作者： Hongxuan Feng Linghao Hu Hongwen Zhu Lingxue Tao Lei wu Qinyuan {1. Yemi Gao Qi Gong Fei Mao Xiaokang Li Hu Zhou Jian Li Haiyan Zhang CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China University of Chinese Academy of Sciences Beijing 100049China

Ischemic stroke is a severe disorder resulting from acute cerebral *** we demonstrated that post-ischemic treatment with ciclopirox olamine(CPX),a potent antifungal clinical drug,alleviated brain infarction,neurological deficits and brain edema in a classic rat model of ischemic *** dose post-ischemic administration of CPX provided a long-lasting neuroprotective effect,which can be further enhanced by multiple doses administration of *** also effectively reversed ischemia-induced neuronal loss,glial activation as well as blood-brain barrier(BBB)*** quantitative phosphoproteomic analysis,1.0 phosphosites in 1.2 proteins were identified to be significantly regulated by CPX treatment in oxygen glucose deprivation(OGD)-exposed SH-SY5 Y cells,which revealed that phosphokinases and cell cycle-related phosphoproteins were largely ***,we demonstrated that CPX markedly enhanced the AKT(protein kinase B,PKB/AKT)and GSK3β(glycogen synthase kinase 3β)phosphorylation in OGD-exposed SH-SY5 Y cells,and regulated the cell cycle progression and nitric oxide(NO)release in lipopolysaccharide(LPS)-induced B V-2 cells,which may contribute to its ameliorative effects against ischemia-associated neuronal death and microglial *** study suggests that CPX could be a promising compound to reduce multiple ischemic injuries;however,further studies will be needed to clarify the molecular mechanisms involved.

关键词： Blood-brain barrier Brain ischemia Cell cycle Inflammation Neuroprotection

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