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Strategy for Detecting Systemic Treatment Sensitivity of Primary Liver Cancer Based on a Novel Infrared-emissive Organic Nanoparticle

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Chemical Research in Chinese Universities 2024年第1期40卷 145-152页

作者： wu Jun LI Yongzhi qin Hanjiao GAO Ying YANG Bing SHENG Jiyao ZHANG Xuewen Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Jilin UniversityChangchun130022P.R.China Department of Radiation Oncology the Second Hospital of Jilin UniversityChangchun130022P.R.China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun130012P.R.China

In this study,we synthesized an organic material with near-infrared emission capabilities:4-(2-(4-(9-(4-(diphenylamino)phenyl)naphtho[2,3-c][1,2,5]thiadiazol-4-yl)phenyl)-1H-phenol-1-ylidene)malononitrile(TPA).Furthermore,TPA-PEG2000 fluorescent nanoparticles were prepared via coating the shells with ***-PEG2000 exhibited strong near-infrared emission near 700 nm,with a photoluminescence quantum yield of 15.09%,indicating a high emission *** biology experiments have confirmed its low toxicity and excellent *** cholesterol and phospholipid levels in liver cancer cell membranes with low sensitivity or high drug resistance lead to increased rigidity,reduced membrane fluidity,reduced endocytic efficiency,and reduced ***,the uptake of TPA-PEG2000 nanoparticles into cells and the near-infrared fluorescence intensity can be used to evaluate the sensitivity of systemic liver cancer treatment in a simple and efficient manner.

关键词： Nanoparticle Near-infrared Fluorescence Systemic treatment sensitivity Cell membrane fluidity

Carbon dots confined nanosheets assembled NiCO_(2)S_(4)@CDs cross-stacked architecture for enhanced sodium ion storage

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Chinese Chemical Letters 2024年第7期35卷 508-513页

作者： Binyang qin Mengqi Wang Shimei wu Yining Li Chilin Liu Yufei Zhang Haosen Fan School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China

Na^(+)batteries(SIBs)have been emerging as the most promising candidate for the next generation of secondary ***,the development of high-performance and cost-effective anode materials is urgently needed for the large-scale applications of *** this study,carbon dots confined bimetallic sulfide(NiCO_(2)S_(4))architecture(NiCO_(2)S_(4)@CDs)was proposed and synthesized from assembling nanosheets into cross-stacked superstructure and the subsequent confinement of carbon *** novel decussated structure assembly from nanosheets is greatly beneficial to the structure stability of electrode material during the successive charge/discharge ***,the CDs based carbon conductive network can enhance the electrical conductivity for facilitating the easy transport of electron/Na^(+).Benefitting from these advantages,NiCO_(2)S_(4)@CDs exhibits high-rate performance and an ultralong cycling life in ***,the specific capacity of NiCO_(2)S_(4)@CDs can reach the discharge specific capacity as high as 568.9 mAh/g at 0.5 A/g,which can also maintain 302.7 m Ah/g after 750 cycles at 5.0 A/***,ex-situ characterization techniques such as ex-situ XRD and ex-situ XPS were employed to further explore the sodium storage mechanism of the NiCO_(2)S_(4)@CDs anode.

关键词： Carbon dots Sodium ion batteries NiCo_(2)S_(4)@CDs Cross-stacked architecture Ex-situ XRD and XPS

Effect of coir geotextile and geocell on ephemeral gully erosion in the Mollisol region of Northeast China

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Journal of Arid Land 2024年第4期16卷 518-530页

作者： qin Xijin SUN Yiqiu ZHANG Yan GUAN Yinghui wu Hailong WANG Xinyu WANG Guangyu School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China Tianjin Eco-Environmental Protection Design&Research Institute Tianjin 300042China College of Environmental Science and Safety Engineering Tianjin University of TechnologyTianjin 300384China Faculty of Forestry University of British Columbia2424 Main MallVancouver BC V6T 1Z4Canada

The unique geomorphological features and farming methods in the Mollisol region of Northeast China increase water catchment flow and aggravate the erosion of ephemeral gully(EG).Vegetation suffers from rain erosion and damage during the growth stage,which brings serious problems to the restoration of grass in the early ***,effects of coir geotextile and geocell on EG erosion under four confluence intensities were researched in this *** of the simulated water discharge erosion test showed that when the confluence strength was less than 30 L/min,geocell and coir geotextile had a good effect on controlling EG erosion,and sediment yield of geocell and coir geotextile was reduced by 25.95%–37.82%and 73.73%–88.96%,***,when confluence intensity increased to 40 L/min,protective effect of coir geotextile decreased,and sediment yield rate increased sharply by 189.03%.When confluence intensity increased to 50 L/min,the protective effect of coir geotextile was *** the other hand,geocell showed that the greater the flow rate,the better the protective *** addition,with the increase in confluence intensity,erosion pattern of coir geotextile developed from sheet erosion to intermittent fall and then to completion of main rill,and the protective effect was gradually *** contrast,the protective effect of EG under geocell was gradually enhanced from the continuous rill to the intermittent rill and finally to the intermittent *** study shows that coir geotextile and geocell can prevent EG erosion,and the effect of geocell is better than that of coir geotextile on the surface of EG.

关键词： geocell coir geotextile ephemeral gully confluence intensity erosion control

Prevention and treatment of gerbil hepatitis E using the programmable CRISPR-Cas13d system

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Genes & Diseases 2024年第4期11卷 94-97页

作者： Chengcheng Zhao chong Lia Sa Li Hanyu wu Pengyao Ren Tianlong Liu Xiaoxiang Hu Ran Zhang State Key Laboratory of Animal Biotech Breeding College of Biological SciencesChina Agricultural UniversityBeijing 100193China Laboratory of Veterinary Pathology and Nanopathology College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China

In recent years,the global incidence of hepatitis E virus(HEV)has been rising,leading to increased morbidity and mortality associated with ***13,a CRISPR effector,shows promise as an antiviral agent against singlestranded RNA ***13d,a type VI-D effector,exhibits higher efficiency in suppressing RNA viruses compared to other type VI ***,its in vivo activity against RNA viruses in mammals remains unknown.

关键词： mortality hepatitis treatment

Quality of life after pancreatic surgery

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World Journal of Gastroenterology 2024年第8期30卷 943-955页

作者： Shi-Zhen Li Ting-Ting Zhen Yi wu Min Wang Ting-Ting qin Hang Zhang Ren-Yi qin Department of Biliary-Pancreatic Surgery Affiliated Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Pancreatic surgery is challenging owing to the anatomical characteristics of the *** attention has been paid to changes in quality of life(QOL)after pancreatic *** To summarize and analyze current research results on QOL after pancreatic *** A systematic search of the literature available on PubMed and EMBASE was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** studies were identified by screening the references of retrieved *** on patients’QOL after pancreatic surgery published after January 1,2012,were *** included prospective and retrospective studies on patients'QOL after several types of pancreatic *** results of these primary studies were summarized *** A total of 45 articles were included in the study,of which 13 were related to pancreaticoduodenectomy(PD),seven to duodenum-preserving pancreatic head resection(DPPHR),nine to distal pancreatectomy(DP),two to central pancre-atectomy(CP),and 14 to total pancreatectomy(TP).Some studies showed that 3-6 months were needed for QOL recovery after PD,whereas others showed that 6-12 months was more *** TP and PD had similar influences on QOL,patients needed longer to recover to preoperative or baseline levels after *** QOL was better after DPPHR than ***,the superiority of the QOL between patients who underwent CP and PD remains *** decrease in exocrine and endocrine functions postoperatively was the main factor affecting the *** invasive surgery could improve patients’QOL in the early Core Tip:This review summarizes and analyzes current research results on quality of life(QOL)after pancreatic *** article covers the discussion and analysis of the QOL of various pancreatic *** kind of surgical procedure has better QOL is *** long-term benefits on QOL of minimally invasive su

关键词： Quality of life Pancreaticoduodenectomy Duodenum-preserving pancreatic head resection Distal pancreatectomy Central pancreatectomy Total pancreatectomy

Review of Sc microalloying effects in Al-Cu alloys

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 1098-1114页

作者： Shenghua wu chong Yang Peng Zhang Hang Xue Yihan Gao Yuqing Wang Ruihong Wang Jinyu Zhang Gang Liu Jun Sun State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China School of Materials Science and Engineering Xi’an University of TechnologyXi’an 710048China School of Aerospace Engineering North University of ChinaTaiyuan 030051China

Artificially controlling the solid-state precipitation in aluminum (Al) alloys is an efficient way to achieve well-performed properties,and the microalloying strategy is the most frequently adopted method for such a *** this paper,recent advances in lengthscale-dependent scandium (Sc) microalloying effects in Al-Cu model alloys are *** coarse-grained Al-Cu alloys,the Sc-aided Cu/Sc/vacancies complexes that act as heterogeneous nuclei and Sc segregation at the θ′-Al_(2)Cu/matrix interface that reduces interfacial energy contribute significantly to θ′*** grain size refinement to the fine/ultrafine-grained scale,the strongly bonded Cu/Sc/vacancies complexes inhibit Cu and vacancy diffusing toward grain boundaries,promoting the desired intragranular θ′*** nanocrystalline scale,the applied high strain producing high-density vacancies results in the formation of a large quantity of (Cu Sc,vacancy)-rich atomic complexes with high thermal stability,outstandingly improving the strength/ductility synergy and preventing the intractable low-temperature *** review recommends the use of microalloying technology to modify the precipitation behaviors toward better combined mechanical properties and thermal stability in Al alloys.

关键词： aluminum alloy microalloying effect length-scale dependence precipitation mechanical properties

Foodborne toxin Aflatoxin B_(1)induced glomerular podocyte inflammation through proteolysis of RelA,downregulation of miR-9 and CXCR4/TXNIP/NLRP3 pathway

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Food Science and Human Wellness 2024年第4期13卷 2289-2309页

作者： Jie Zhang Shuang Yang Baocai Xu Zihui qin Xinyi Guo Ben Wei qinghua wu Kamil Kuca Tushuai Li Wenda wu School of Biology and Food Engineering Changshu Institute of TechnologySuzhou 215500China Center for Clinical Mass Spectrometry School of Pharmaceutical SciencesSoochow UniversitySuzhou 215123China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China MOE Joint International Research Laboratory of Animal Health and Food Safety College of Veterinary MedicineNanjing Agricultural UniversityNanjing 210095China Department of Chemistry Faculty of ScienceUniversity of Hradec KraloveHradec Kralove 50003Czech Republic College of Life Science Yangtze UniversityJingzhou 434025China wuxi Medical College Jiangnan UniversityWuxi 214122China wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute wuxi Branch Wuxi 214013China

Aflatoxin B_(1)(AFB_(1))is a naturally-occurring mycotoxin and recognized as the most toxic foodborne toxin,particularly causing damages to *** podocytes are terminally differentiated epithelial ***_(1)induces podocyte inflammation,proteinuria and renal *** the mechanism of AFB_(1)-induced podocyte inflammation and murine kidney dysfunction,we detected that AFB_(1)increased ubiquitindependent degradation of the transcription factor RelA through enhanced interaction of RelA with E3 ubiquitin ligase tripartite motif containing 7(TRIM7)in mouse podocyte clone-5(MPC-5)and mouse *** of RelA resulted in decreasing microRNA-9(miR-9)and activating the chemokine receptor 4(CXCR4),thioredoxin interacting protein(TXNIP),and NOD-like receptor pyrin domain-containing 3(NLRP3)signaling axis(CXCR4/TXNIP/NLRP3 pathway),leading to podocyte *** also determined that downregulation of miR-9 led to CXCR4 expression and the downstream TXNIP/NLRP3 pathway *** of miR-9 or deletion of CXCR4 suppressed AFB_(1)-induced CXCR4/TXNIP/NLRP3 pathway,resulting in alleviating podocyte inflammation and kidney *** findings indicated that ubiquitin-dependent proteolysis of RelA,downregulation of miR-9,and activation of CXCR4/TXNIP/NLRP3 pathway played an essential role in AFB_(1)-induced glomerular podocyte *** study revealed a novel mechanism,via RelA,for the control of AFB_(1)’s nephrotoxicity,leading to an effective protection of food safety and public health.

关键词： Aflatoxin B_(1) Podocyte inflammation miRNA-9 Chemokine(C-X-C motif)receptor 4 RelA ubiquitin-dependent degradation

Eco-friendly polysaccharide coatings for antifouling and dragreduction and potential application for marine devices

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Friction 2024年第4期12卷 726-744页

作者： Hao YANG Liguo qin Wenhui ZHAO Fagla Jules MAWIGNON Hui GUO Yongkang wu Yali ZHANG Guangneng DONG Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Institute of Design Science and Basic ComponentsSchool of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Biomedical Information of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Department of Endocrinology First Affiliated Hospital of Medical CollegeXi'an Jiaotong UniversityXi’an 710061China

Traditional antifouling agents usually have a certain toxic effect on marine environments and non-target *** this study,Dictyophora indusiata polysaccharide(DIP)was applied as a natural antifouling surface modifier to prepare the surface coating for marine *** DIP coatings were prepared:*** spore polysaccharide(DISP),*** volva polysaccharide(DIVP),and *** embryonic body polysaccharide(DIEP).The antifouling,tribological,and anticorrosion behavior of the coatings were *** revealed that the three kinds of DIP coatings had excellent antifouling properties,which could effectively prevent the adhesion of Chlorella and the attachment of water-based and oily stains on the ***,the coatings showed great mechanical stability and could maintain an extremely low coefficient of friction(COF<0.05)after continuous *** drag reduction rate of the coated surfaces reached 5%,showing a powerful lubrication ***,the DIP coatings presented an outstanding corrosion resistance,where the equivalent circuit impedances were 4-9 orders of magnitude higher than the control *** research showed a promising prospect of surface coating fabrication with DIP for marine devices to achieve the purpose of antifouling and drag reduction.

关键词： Dictyophora indusiata polysaccharide(DIP)coating antifouling anticorrosion lubrication and drag reduction

A Novel Approach for Rapid Evaluating Cavitation Erosion Resistance of Metallic Materials

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1231-1237页

作者： Yu Li Zhenbo qin Xiaoyang Du Da-Hai Xia Zepeng Gao Yiwen Zhang Zhong wu Wenbin Hu Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300072China Key Laboratory of Advanced Ceramics and Machining Technology(Ministry of Education) Tianjin UniversityTianjin300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou350207China

For the evaluation of cavitation erosion resistance of metallic materials,it has always been a time-consuming technical *** paper innovatively proposed a parameter named cavitation hardening rate to characterize the plastic deformation and work hardening behavior of metallic materials during the cavitation process and then found a positive correlation between cavitation hardening rate and strain hardening ***,the relationship between cavitation volume loss and strain hardening index was obtained,and a simple and rapid evaluation method for cavitation erosion resistance was established.

关键词： Cavitation erosion Evaluation method Cavitation hardening rate Volume loss