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Sustained release of vascular endothelial growth factor A and basic fibroblast growth factor from nanofiber membranes reduces oxygen/glucose deprivation-induced injury to neurovascular units

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Neural Regeneration Research 2024年第4期19卷 887-894页

作者： Yifang wu Jun Sun qi lin Dapeng Wang Jian Hai Department of Neurosurgery Tongji HospitalSchool of MedicineTongji University Department of Pharmacy Institute of Medical SciencesShanghai Jiao Tong University School of Medicine

Upregulation of vascular endothelial growth factor A/basic fibroblast growth factor(VEGFA/b FGF)expression in the penumbra of cerebral ischemia can increase vascular volume,reduce lesion volume,and enhance neural cell proliferation and differentiation,thereby exerting neuroprotective ***,the beneficial effects of endogenous VEGFA/b FGF are limited as their expression is only transiently *** this study,we generated multilayered nanofiber membranes loaded with VEGFA/b FGF using layer-by-layer self-assembly and electrospinning *** found that a membrane containing 10 layers had an ideal ultrastructure and could efficiently and stably release growth factors for more than 1 *** 10-layered nanofiber membrane promoted brain microvascular endothelial cell tube formation and proliferation,inhibited neuronal apoptosis,upregulated the expression of tight junction proteins,and improved the viability of various cellular components of neurovascular units under conditions of oxygen/glucose ***,this nanofiber membrane decreased the expression of Janus kinase-2/signal transducer and activator of transcription-3(JAK2/STAT3),Bax/Bcl-2,and cleaved ***,this nanofiber membrane exhibits a neuroprotective effect on oxygen/glucose-deprived neurovascular units by inhibiting the JAK2/STAT3 pathway.

关键词： brain ischemia brain microvascular endothelial cell nanofiber membrane neurovascular unit

Radiation build-up and dissipation in Raman random fiber laser

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Science China(Information Sciences) 2024年第1期67卷 254-260页

作者： Shengtao lin Zinan WANG Jiaojiao ZHANG Pan WANG Han wu Yifei qi Key Laboratory of Optical Fiber Sensing and Communications University of Electronic Science and Technology of China College of Electronics and Information Engineering Sichuan University

Raman random fiber laser(RRFL) is a complex physical system that arises from the distributed Raman amplification and the intrinsic stochasticity of fiber *** analysis of the underlying lightwave kinetics at steady state has been the focus of considerable ***,the transient state,such as the RRFL build-up and dissipation,is particularly important for revealing the lightwave interaction ***,we investigate for the first time the RRFL dynamics at the transient state and track the RRFL temporal and spectral evolution theoretically and ***,with the contribution of random distributed feedback,RRFL build-up exhibits continuous Verhulst logistic growth curves without cavity-related features,which is significantly different from the step-like growth curve of conventional fiber ***,the radiation build-up duration is inversely related to the pump power,and the spectral evolution of the RRFL undergoes two phases,i.e.,from spectral density increase to spectral *** the steady state to the pump switch-off state,the RRFL output power dissipates immediately,and the remaining Stokes lightwave from the Rayleigh scattering will gradually disappear after one round *** work provides new insights into the transient dynamic features of the RRFL.

关键词： random fiber laser stimulated Raman scattering transient phenomenon nonlinear optics łinebreak biological growth dynamics

Solubility of iron(Ⅲ) and nickel(Ⅱ) acetylacetonates in supercritical carbon dioxide

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Chinese Journal of Chemical Engineering 2024年第1期65卷 29-34页

作者： Haixin Sun Jianlei qi Jianfei Sun lin Li Kunpeng Yu Jintao wu Jianzhong Yin State Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalian 116024China College of Chemical Engineering Inner Mongolia University of TechnologyHohhot 010051China

As a common precursor for supercritical CO_(2)(scCO_(2))deposition techniques,solubility data of organometallic complexes in scCO_(2)is crucial for the preparation of ***,metal acetylacetonates have shown great potential for the preparation of single-atom catalytic *** this study,the solubilities of iron(Ⅲ)acetylacetonate(Fe(acac)3)and nickel(Ⅱ)acetylacetonate(Ni(acac)2)were measured at the temperature from 313.15 to 333.15 K and in the pressure range of 9.5–25.2 MPa to accumulate new solubility *** was measured using a static weight loss *** semi-empirical models proposed by Chrastil and Sung et *** used to correlate the solubility data of Fe(acac)3 and Ni(acac)*** equations obtained can be used to predict the solubility of the same system in the experimental range.

关键词： Iron(III)acetylacetonate Nickel(II)acetylacetonate Supercritical carbon dioxide Solubility measurement Correlation model Phase equilibrium

Development of component stiffness equations for thread-fixed one-side bolt connections to an enclosed rectangular hollow section column under tension

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Frontiers of Structural and Civil Engineering 2024年第4期18卷 568-586页

作者： Fu-Wei wu Yuan-qi LI Department of Structural Engineering Tongji UniversityShanghai 200092China State Key Laboratory of Disaster Reduction in Civil Engineering Tongji UniversityShanghai 200092China

The derivation and validation of analytical equations for predicting the tensile initial stiffness of threadfixed one-side bolts(TOBs),connected to enclosed rectangular hollow section(RHS)columns,is presented in this *** unknown stiffness components are considered:the TOBs connection and the enclosed RHS ***,the trapezoidal thread of TOB,as an equivalent cantilevered beam subjected to uniformly distributed loads,is analyzed to determine the associated *** on the findings,the thread-shank serial-parallel stiffness model of TOB connection is *** analysis of the tensile stiffness of the enclosed RHS face due to two bolt forces,the four sidewalls are treated as rotation constraints,thus reducing the problem to a two-dimensional plate *** to the load superposition method,the deflection of the face plate is resolved into three components under various boundary and load *** to the plate deflection theory of Timoshenko,the analytical solutions for the three deflections are derived in terms of the variables of bolt spacing,RHS thickness,height to width ratio,***,the validity of the above stiffness equations is verified by a series of finite element(FE)models of T-stub *** proposed component stiffness equations are an effective supplement to the component-based method.

关键词： initial stiffness component based method thread-fixed one-side bolt rectangular hollow sections analytical equation

Constructing high-toughness polyimide binder with robust polarity and ion-conductive mechanisms ensuring long-term operational stability of silicon-based anodes

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Journal of Energy Chemistry 2024年第6期93卷 580-591,I0014页

作者： Yongjun Kang Nanxi Dong Fangzhou Liu Daolei lin Bingxue Liu Guofeng Tian Shengli qi Dezhen wu State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China ENFI R&D Institute China ENFI Engineering CorporationBeijing 100038China China Automotive Battery Research Institute Co. Ltd.Beijing 101407China Changzhou Institute of Advanced Materials Beijing University of Chemical TechnologyChangzhou 213164JiangsuChina

Silicon-based materials have demonstrated remarkable potential in high-energy-density batteries owing to their high theoretical ***,the significant volume expansion of silicon seriously hinders its utilization as a lithium-ion ***,a functionalized high-toughness polyimide(PDMI) is synthesized by copolymerizing the 4,4'-Oxydiphthalic anhydride(ODPA) with 4,4'-oxydianiline(ODA),2,3-diaminobenzoic acid(DABA),and 1,3-bis(3-aminopropyl)-tetramethyl disiloxane(DMS).The combination of rigid benzene rings and flexible oxygen groups(-O-) in the PDMI molecular chain via a rigidness/softness coupling mechanism contributes to high *** plentiful polar carboxyl(-COOH) groups establish robust bonding *** ionic transport is achieved by incorporating the flexible siloxane segment(Si-O-Si),which imparts high molecular chain motility and augments free volume holes to facilitate lithium-ion transport(9.8 × 10^(-10) cm^(2) s^(-1) vs.16 × 10^(-10) cm^(2) s~(-1)).As expected,the SiO_x@PDMI-1.5 electrode delivers brilliant long-term cycle performance with a remarkable capacity retention of 85% over 500 cycles at 1.3 A g^(-1).The well-designed functionalized polyimide also significantly enhances the electrochemical properties of Si nanoparticles ***,the assembled SiO_x@PDMI-1.5/NCM811 full cell delivers a high retention of 80% after 100 *** perspective of the binder design strategy based on polyimide modification delivers a novel path toward high-capacity electrodes for high-energy-density batteries.

关键词： Polyimide binder High toughness Robust ionic transport Silicon-based anodes Lithium-ion batteries

PICOTEES:a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants from Chinese children cohorts

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Journal of Genetics and Genomics 2024年第2期51卷 243-251页

作者： Xinran Dong Yulan Lu Lanting Guo Chuan Li qi Ni Bingbing wu Huijun Wang lin Yang Songyang wu qi Sun Hao Zheng Wenhao Zhou Shuang Wang Center for Molecular Medicine Children's Hospital of Fudan UniversityShanghai 201102China Key Laboratory of Birth Defects Children's Hospital of Fudan UniversityShanghai 201102China Department of Bioinformatics Hangzhou Nuowei Information Technology Co.LtdHangzhouZhejiang 310000China The Third Research Institute of the Ministry of Public Security Shanghai 200031China Xiamen Campus of Children's Hospital of Fudan University XiamenFujian 361006China Institutes for Systems Genetics West China HospitalChengduSichuan 610041China Shanghai Putuo People's Hospital Tongji UniversityShanghai 200060China

The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, but it requires significant trust between users and providers. To alleviate privacy concerns, the most commonly used strategy is to anonymize sensitive data. Unfortunately, studies have shown that anonymization is insufficient to protect against reidentification attacks. Recently, privacy-preserving technologies have been applied to preserve application utility while protecting the privacy of biomedical data. We present the PICOTEES framework, a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants (https://***:3000/). PICOTEES enables privacy-preserving queries of the phenotype spectrum for a single variant by utilizing trusted execution environment technology, which can protect the privacy of the user's query information, backend models, and data, as well as the final results. We demonstrate the utility and performance of PICOTEES by exploring a bioinformatics dataset. The dataset is from a cohort containing 20,909 genetic testing patients with 3,152,508 variants from the Children's Hospital of Fudan University in China, dominated by the Chinese Han population (>99.9%). Our query results yield a large number of unreported diagnostic variants and previously reported pathogenicity.

关键词： Privacy protecti on Rare diseases in children Genetic testing Web system Trusted executi on envir onment

Adaptive sampling for corrugated plate digitization using a laser displacement sensor

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Science China(Technological Sciences) 2024年第5期67卷 1510-1523页

作者： wu ChengXing qi qi CHEN BaiJin YANG JiXiang DING Han State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China

The surface quality of a corrugated plate directly determines the heat transfer property of the thermal power mechanical *** detection methods are impractical for real-world production,being slow and *** contrast,the point laser displacement sensor,employing the optical triangle method,emerges as a promising device for assessing parts with variable curvature and highly reflective *** its benefits,high-density sampling by an innate frequency introduces challenges such as data redundancy and a poor signal-to-noise ratio,potentially affecting the efficiency and precision of subsequent data *** address these challenges,adjustable frequency data sampling has been developed for this sensor,allowing adaptive sampling for corrugated plate *** process begins with surface digitization to extract discrete points,which are transformed into intersection curves using the B-spline fitting ***,dominant points are identified,considering multigeometric constraints for curvature and arch ***,the sampling signal is adjusted based on the distribution information of dominant *** results indicate that the proposed method effectively minimizes redundant sampling without compromising the accurate capture of essential geometric features.

关键词： corrugated plate laser displacement sensor adaptive sampling dominant point curvature arch height

Magnitude and direction of temperature variability affect hospitalization for myocardial infarction and stroke:population-based evidence from Guangzhou,China

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 1-11页

作者： Zhou Yang Murui Zheng Ze-lin Yan Hui Liu Xiangyi Liu Jie-qi Jin Jiagang wu Chun-Quan Ou State Key Laboratory of Organ Failure Research Department of BiostatisticsGuangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China Guangzhou Center for Disease Control and Prevention Guangzhou 510440China

Relationships between nonoptimal temperatures and cardiovascular disease(CVD)mortality have been well ***,evidence of the association between temperature variability(TV)and CVD morbidity is *** study aimed to quantify the risk and burden of CVD-related hospitalization associated with the magnitude and direction of *** on meteorology and population-based hospitalizations for myocardial infarction(MI)and stroke were collected in Guangzhou,China,from 2013 to *** temperature variability(HTV)was measured as the standard deviation of hourly temperature records over specific exposure *** direction(upward or downward)of HTV was defined as the average daily mean temperature change relative to that of the previous day during the exposure ***-Poisson regression was applied to assess the impact of HTV after adjusting for the daily mean temperature,and the hospitalization fractions attributable to HTV were calculated.A 1℃-increase in HTV was significantly associated with a 2.24%and 1.72%increase in hospitalizations for MI and hemorrhagic stroke(HS)at lag 0–1 d,respectively,and a 1.55%increase in hospitalizations for ischemic stroke(IS)at lag 0–3 *** the study period,5.99%,4.64%,and 4.53%of MI,HS,and IS hospitalizations,respectively,were attributable to *** upward TV exerts acute effects on CVD hospital admissions,whereas the impact of downward TV generally *** findings highlight the importance of the magnitude and direction of temperature fluctuations,in addition to the mean level,in assessing the adverse health impacts of temperature variations.

关键词： Hourly temperature variability Cardiovascular Hospitalization Direction China

A GNSS Anti-Spoofing Technique Based on the Spatial Distribution Characteristic of the Residual Vectors

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Tsinghua Science and Technology 2024年第2期29卷 457-468页

作者： qi'an wu Xiaowei Cui Mingquan Lu Pengxiang Yang Peng wu Department of Electronic Enginnering Tsinghua UniversityBeijing 100084China Xi’an Modern Control Technology Research Institute Xi’an 710065China

Anti-spoofing is becoming a crucial technique for applications with high navigation accuracy and reliability ***-spoofing technique based on Receiver Autonomous Integrity Monitoring(RAIM)is a good choice for most Global Navigation Satellite System(GNSS)receivers because it does not require any change to the hardware of the ***,the conventional RAIM method can only detect and mitigate a single spoofing *** improved RAIM methods can deal with more spoofing signals,but the computational complexity increases dramatically when the number of satellites in view increase or need additional *** paper proposes a new RAIM method,called the SRV-RAIM method,which has a very low computation complexity regardless of the number of satellites in view and can deal with any number of spoofing *** key to the new method is the spatial distribution characteristic of the Satellites'Residual Vectors(SRV).In replay or generative spoofing scenarios,the pseudorange measurements of spoofing signals are consistent,the residual vectors of real satellites and those of spoofing satellites have good separation characteristics in spatial *** on this characteristic,the SRV-RAIM method is proposed,and the simulation results show that the method can separate the real signals and the spoofing signals with an average probability of 86.55%in the case of 12 visible satellites,regardless of the number of spoofing *** to the conventional traversal-RAIM method,the performance is only reduced by 3.59%,but the computational cost is reduced by 98.3%,so most of the GNSS receivers can run the SRV-RAIM algorithm in time.

关键词： Global Navigation Satellite System(GNSS) anti-spoofing Receiver Autonomous Integrity Monitoring(RAIM) Satellites'Residual Vectors(SRV)