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明胶-CaO-SiO_2-TiO_2生物活性材料的制备与研究

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功能材料 2007年第4期38卷 626-628,632页

作者：殷海荣武丽华张光华陈福陕西科技大学材料科学与工程学院陕西咸阳712081 陕西科技大学化学与化工学院陕西咸阳712081 珠海斗门旭日.建宏陶瓷有限公司广东珠海519110

采用溶胶-凝胶法以明胶、γ-环氧丙基氧丙基三甲氧基硅烷(GPSM)、钛酸异丙酯(TiPT)及硝酸钙为原料合成了一种新的生物活性杂化材料。利用模拟体液(SBF)进行体外生物活性测试表明含钙材料表现出一定的生物活性,并且随钙含量的变化生物活... 详细信息

采用溶胶-凝胶法以明胶、γ-环氧丙基氧丙基三甲氧基硅烷(GPSM)、钛酸异丙酯(TiPT)及硝酸钙为原料合成了一种新的生物活性杂化材料。利用模拟体液(SBF)进行体外生物活性测试表明含钙材料表现出一定的生物活性,并且随钙含量的变化生物活性也不同。通过力学性能测试证明了钛含量适当的材料具有与松质骨相似的力学性能。明胶-CaO-SiO_2-TiO_2杂化材料有望成为一种新型骨修复材料。

关键词：明胶-CaO-SiO2-TiO2 sol-gel法制备生物活性力学性能

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近红外光谱技术在鱼糜等级评定中的应用研究

光谱学与光谱分析 2015年第5期35卷 1239-1242页

作者：吴浩陈伟华王锡昌刘源上海海洋大学食品学院上海水产品加工及贮藏工程技术研究中心上海201306

利用近红外光谱技术,对冷冻和解冻状态的不同等级白姑鱼糜进行等级评定。采用一阶导数法和标准正态变量变换法进行光谱预处理,再对预处理后的数据进行主成分分析,以主成分分析-马氏距离模式识别方法建立不同等级白姑鱼糜的等级评定模型... 详细信息

利用近红外光谱技术,对冷冻和解冻状态的不同等级白姑鱼糜进行等级评定。采用一阶导数法和标准正态变量变换法进行光谱预处理,再对预处理后的数据进行主成分分析,以主成分分析-马氏距离模式识别方法建立不同等级白姑鱼糜的等级评定模型,并对7项理化指标(水分、蛋白质、粗脂肪、盐溶性蛋白、凝胶强度、持水率和白度值)进行了测定。结果表明,主成分分析可以将三个等级白姑鱼糜较好地区分开;冷冻状态白姑鱼糜建立的等级评定模型效果优于解冻状态白姑鱼糜,前者的综合预测正确率为96.3%,后者的综合预测正确率为83.3%;三个等级白姑鱼糜的理化指标存在一定的差异。研究表明,近红外光谱技术可以快速无损评定白姑鱼糜等级。

关键词：鱼糜近红外光谱等级主成分分析-马氏距离理化指标

Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry IX： Clinical Features and Survival of Childhood-Onset Systemic Lupus Erythematosus in China

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Chinese Medical Journal 2017年第11期130卷 1276-1282页

作者： Chan-Yuan wu Cai-Feng Li Qing-Jun wu Jian-hua Xu Lin-Di Jiang Lu Gong Feng-Qi wu Jie-Ruo Gu Jiu-Liang Zhao Meng-Tao Li Yan Zhao Xiao-Feng Zeng CSTAR Co-authors Department of Rheumatology Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing 100730 China Department of Rheumatology Beijing Children Hospital Affiliated to Capital Medical University Beijing 100045 China Department of Rheumatology The First Affiliated Hospital of Anhui Medical University Hefei Anhui 230032 China Department of Rheumatology Zhongshan Hospital Affiliated to Fudan University Shanghai 200032 China Department of Rheumatology Tianjin Medical University General Hospital Tianjin 300052 China Department of Rheumatology Capital Institute of Pediatrics Beijing 100102 China Department of Rheumatology The Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510630 China

Background： Approximately 15-20% cases of systemic lupus erythematosus （SLE） are diagnosed in children. There have been a Few studies reporting the epidemiological data of pediatric-onset SLE （cSLE） in China, neither comparing the differences between cSLE and adult-onset SLE （aSLE）. The aim of this study was to describe the impact of age of onset on clinical features and survival in cSLE patients in China based on the Chinese SLE Treatment and Research group （CSTAR） database. Methods： We made a prospective study of 225 cSLE patients （aged 〈16 years） and 1759 patients aged 16-50 years based on CSTAR registry. We analyzed initial symptoms, clinical presentations, SLE disease activity, damages, and outcomes ofcSLE, as well as compared with aSLE patients. Results： The mean age ofcSLE patients was 12.16 ± 2.92 years, with 187 （83.1%） females. Fever （P 〈 0.001） as well as mucocutaneous （P 〈 0.001 ） and renal （P = 0.006） disorders were found to be significantly more frequent in cSLE patients as initial symptoms, while muscle and joint lesions were significantly less common compared to aSLE subjects （P 〈 0.001 ）. The eSLE patients were found to present more fi＇equently with malar rash （P = 0.001; odds ratio {OR], 0.624; 95% confidence interval [CI ], 0.470 0.829） but less tYequently with arthritis （P 〈 0.001 ; OR, 2.013; 95% CI, 1.512-2.679） and serositis （P = 0.030; OR, 1.629; 95% CI, 1.053 2.520）. There was no significant difl＇erence in SLE disease activity index scores between cSLE and aSLE groups （P = 0.478）. Cox regression indicated that childhood onset was the risk factor for organ damage in lupus patients （hazard ratio 0.335 [0.170 0.658], P = 0.001）. The survival curves between the cSLE and aSLE groups had no significant difference as determined by the log-rank test （0.557, P = 0.455）. Conclusions： cSLE in China has different clinical features and more inflammation than aSLE patients. Damage may be less in children and there is no difl＇erence in 5- year survival bet

关键词： Childhood Onset: Outcomes Systemic Lupus Erythematosus

Research on Optimizing the Hidden Layer Structure of ANN-Based Model and Its Application in Predicting End-Quench Curves of Steels

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Journal of Shanghai Jiaotong university(Science) 2000年第1期5卷 342-346页

作者： Liang wu, Weisheng Gu School of Mechanical Engineering. Dong hua University, Shanghai 200050, China

In this paper, a method of optimizing the number of hidden layer neurons has been put forward. This optimizing method is suitable for three layers B-p network. The purpose of this optimizing method is to reduce the predicting errors when the model is used as predicting model. As an example of application, a predicting model of steel end-quench curves has been designed by using this optimizing method. The result shows that the optimization of ANN hidden layer architecture has an effect on reducing predicting errors.

关键词： Optimization ANN Prediction End-Quench Curves Model

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一种双电源每相单管开关磁阻电机功率变换器

电机与控制学报 2013年第12期17卷 7-12页

作者：吴建华丁伟东浙江大学电气工程学院浙江杭州310027

为了降低开关磁阻电机控制器的成本,提出一种双电源每相单管开关磁阻电机功率变换器。该功率变换器每相只采用一个功率开关管和一个续流二极管,并采用双电源供电,可以动态调节续流电压,有利于缩短续流时间,提高电机功率密度,抑制转矩波... 详细信息

为了降低开关磁阻电机控制器的成本,提出一种双电源每相单管开关磁阻电机功率变换器。该功率变换器每相只采用一个功率开关管和一个续流二极管,并采用双电源供电,可以动态调节续流电压,有利于缩短续流时间,提高电机功率密度,抑制转矩波动。以一台具有阶梯气隙转子、带风机负载的两相开关磁阻电机为应用对象,阐述了所提功率变换器的工作原理和控制策略,对电机系统进行了仿真和实验研究。研究结果表明,所提功率变换器具有结构紧凑、成本低、各相可独立控制以及抑制转矩波动的特点。实验结果验证了所提功率变换器的可行性。

关键词：开关磁阻电机双电源每相单管功率变换器低成本

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青海东部黄河上游谷地种子植物区系

云南植物研究 2006年第1期28卷 1-12页

作者：吴玉虎吴瑞华中国科学院西北高原生物研究所青海西宁810001

黄河上游谷地位于青海省的东部,约处北纬35°20′～36°25′,东经100°55′～102°50′。属青藏高原和黄土高原的过渡地带,海拔1780～4969m,面积约13480km2,属于大陆性气候或高原大陆性气候类型。本区共有野生种子植物86科、404属、102... 详细信息

黄河上游谷地位于青海省的东部,约处北纬35°20′～36°25′,东经100°55′～102°50′。属青藏高原和黄土高原的过渡地带,海拔1780～4969m,面积约13480km2,属于大陆性气候或高原大陆性气候类型。本区共有野生种子植物86科、404属、1027种。分别占青海省总科数的95.56%、总属数的79.53%、总种数的44.95%。区系特征如下:(1)种类相对较丰富,木本丰富。(2)植物种的中国特有性高,地区特有性不高。(3)就属的层面而言,中国种子植物区系15个分布区类型,特别是6个热带类型在青海境内唯一于本区都有出现。(4)属和种的分析表明,本区属于以北温带成分,特别是欧亚大陆温、寒地带典型成分为优势的,兼具温性、寒温和高寒类型的温带区系性质。(5)许多种、属和多数热带类型均以本区为边缘分布区,因而区系的边缘性质明显。(6)在植物区系地理方面,本区(特别是孟达林区)为华北区系、横断山区系、青藏高原的高山区系和柴达木高寒荒漠区系的交汇过渡地带,过渡区系性质明显。所以,本区作为远离青藏高原腹地的边缘地带和过渡区系,保持了其高原、高山类型的区系性质,应属距我国北方区系最为接近而高寒区系性质最弱的唐古特地区植物区系。

关键词：青海黄河上游谷地植物区系区系特征区系分区

阵列式对电极介电电泳芯片及其用于细胞分离富集研究

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高等学校化学学报 2009年第5期30卷 876-881页

作者：徐溢曹强曾雪吴永杰张文品新型微纳器件与系统技术国防重点学科实验室微纳系统及新材料技术国际研发中心重庆大学化学化工学院重庆400030

基于介电电泳原理,设计并制作了一种新型的能够用于细胞分离和富集的微流控介电电泳芯片.该芯片由沉积有金电极的石英基片和带有微管道的聚二甲基硅氧烷(PDMS)盖片组成.通过在管道底部布置间距不同的对电极阵列,增大了正介电电泳力在管... 详细信息

基于介电电泳原理,设计并制作了一种新型的能够用于细胞分离和富集的微流控介电电泳芯片.该芯片由沉积有金电极的石英基片和带有微管道的聚二甲基硅氧烷(PDMS)盖片组成.通过在管道底部布置间距不同的对电极阵列,增大了正介电电泳力在管道中的有效作用范围,能够在降低施加电压的同时,实现对流动体系中细胞样品的捕获.在3 V和3 MHz条件下,该DEP芯片对人血红细胞的捕获效率达到83%;进一步通过将肝癌细胞捕获在芯片电极上可实现对红细胞和肝癌细胞混合样品的分离,在5 V和400 kHz条件下对肝癌细胞的捕获效率达到86%.

关键词：阵列式对电极介电电泳芯片细胞分离与富集

Electrochemical reduction mechanism of Zn^(2+)in molten NaCl-KCl eutectic

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Transactions of Nonferrous Metals Society of China 2022年第9期32卷 3088-3098页

作者： Xiao-bin wu Zeng-li ZHU Hui KONG You-qi FAN Si-wei CHENG Zhong-sheng hua School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243032China Anhui Provincial Key Laboratory of Metallurgical Engineering&Resources Recycling Anhui University of TechnologyMa’anshan 243002China

A process comprising selective chlorination and molten salt electrolysis was proposed to develop an efficient and environmental-friendly technology for zinc recovery from metallurgical *** theoretical feasibility of this technology was firstly estimated based on thermodynamic ***,the electrochemical behavior of Zn^(2+)on tungsten electrode was investigated in molten NaCl-KCl eutectic at 973 K by many electrochemical transient *** results showed that the reduction of Zn^(2+)on tungsten electrode was found to be a one-step process exchanging two electrons with the initial reduction potential of-0.74 V(vs Ag/AgCl),and the electrode process was considered as quasi-reversible and controlled by *** diffusion coefficient of Zn^(2+)ions in the melts was determined in the order of 10^(-5)cm^(2)/***,the electrolytic preparation of zinc was carried out by potentiostatic electrolysis in molten NaCl-KCl-ZnCl_(2)eutectic at-1.6 V(vs Ag/AgCl).Spheroidic granular metal with silver-white luster was attained after electrolysis for 9.5 h,and identified as pure *** present study confirms that it is practically feasible to extract pure zinc metal by direct electrolysis of ZnCl_(2)in molten NaCl-KCl eutectic,and provides a valuable theoretical reference for the efficient recovery of zinc from metallurgical dusts.

关键词： electrochemical reduction zinc ions electrochemical behavior molten NaCl-KCl eutectic metallurgical dusts

Effects of Tanreqing Capsule on the negative conversion time of nucleic acid in patients with COVID-19:A retrospective cohort study

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Journal of Integrative Medicine 2021年第1期19卷 36-41页

作者： Xing Zhang Yan Xue Xuan Chen Jia-min wu Zi-jian Su Meng Sun Lu-jiong Liu Yi-bao Zhang Yi-le Zhang Gui-hua Xu Miao-yan Shi Xiu-ming Song Yun-fei Lu Xiao-rong Chen Wei Zhang Qi Chen Department of Respiratory Disease Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China

Objective:Traditional Chinese medicine plays a significant role in the treatment of the pandemic of coronavirus disease 2019(COVID-19).Tanreqing Capsule(TRQC)was used in the treatment of COVID-19 patients in the Shanghai Public Health Clinical *** study aimed to investigate the clinical efficacy of TRQC in the treatment of ***:A retrospective cohort study was conducted on 82 patients who had laboratory-confirmed mild and moderate COVID-19;patients were treated with TRQC in one designated *** treatment and control groups consisted of 25 and 57 cases,*** treatment group was given TRQC orally three times a day,three pills each time,in addition to conventional Western medicine treatments which were also administered to the control *** clinical efficacy indicators,such as the negative conversion time of pharyngeal swab nucleic acid,the negative conversion time of fecal nucleic acid,the duration of negative conversion of pharyngeal-fecal nucleic acid,and the improvement in the level of immune indicators such as T-cell subsets(CD3,CD4 and CD45)were ***:COVID-19 patients in the treatment group,compared to the control group,had a shorter negative conversion time of fecal nucleic acid(4 vs.9 days,P=0.047)and a shorter interval of negative conversion of pharyngeal-fecal nucleic acid(0 vs.2 days,P=0.042).The level of CD3+T cells increased in the treatment group compared to the control group([317.09±274.39]vs.[175.02±239.95]counts/l L,P=0.030).No statistically significant differences were detected in the median improvement in levels of CD4+T cells(173 vs.107 counts/l L,P=0.208)and CD45+T cells(366 vs.141 counts/l L,P=0.117)between the treatment and control ***:Significant reductions in the negative conversion time of fecal nucleic acid and the duration of negative conversion of pharyngeal-fecal nucleic acid were identified in the treatment group as compared to the control group,illustrating the potentia

关键词： Tanreqing Capsule Coronavirus disease 2019 COVID-19 diagnostic testing Negative conversion rate