检索结果-南通市图书馆

Chinese Journal of Integrative Medicine 2024年第8期30卷 742-746页

作者： WANG Qian-yun Cheng Miao BAN Cheng-jun ZHANG Li-shan WANG Hong-wu YANG Bing ZOU heng WANG Ming-zhe The First Clinical Medical College of Beijing University of Chinese Medicine Beijing100700China Department of Respiratory Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China

Bronchopleural fistula(BPF)is defined as a pathological connection between the trachea or bronchus and the pleural *** may occur as a serious complication after lung surgery.^((1))It has a low incidence of 1%-3%^((2.3... 详细信息

关键词： pleural lung surgery

Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第5期19卷 1105-1111页

作者： Tao Liu Ziqian Ma Liang Liu Yilun pei Qichao wu Songjie Xu Yadong Liu Nan Ding Yun Guan Yan Zhang Xueming Chen Department of Orthopedic Surgery Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Orthopedic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Stomatology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Anesthesiology and Critical Care Medicine School of MedicineJohns Hopkins UniversityBaltimoreMDUSA Department of Neurological Surgery School of MedicineJohns Hopkins UniversityBaltimoreMDUSA

Human dental pulp stem cell transplantation has been shown to be an effective therapeutic strategy for spinal cord ***,whether the human dental pulp stem cell secretome can contribute to functional recovery after spinal cord injury remains *** the present study,we established a rat model of spinal cord injury based on impact injury from a dropped weight and then intraperitoneally injected the rats with conditioned medium from human dental pulp stem *** found that the conditioned medium effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury,decreased expression of the microglial pyroptosis markers NLRP3,GSDMD,caspase-1,and interleukin-1β,promoted axonal and myelin regeneration,and inhibited the formation of glial *** addition,in a lipopolysaccharide-induced BV2 microglia model,conditioned medium from human dental pulp stem cells protected cells from pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1β*** results indicate that conditioned medium from human dental pulp stem cells can reduce microglial pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1βpathway,thereby promoting the recovery of neurological function after spinal cord ***,conditioned medium from human dental pulp stem cells may become an alternative therapy for spinal cord injury.

关键词： BV2 conditioned medium dental pulp stem cells GSDMD microglia neuroinflammation NLRP3 pyroptosis spinal cord injury

Ten- year follow- up investigation of stroke risk in systemic lupus erythematosus

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2024年第1期9卷 1-7页

作者： Jin-An Huang Ching-heng Lin Ming-Ju wu Yi-Hsing Chen Kuo-Cheng Chang Chung-Wei Hou Division of Neurology Neurological InstituteTaichung Veterans General HospitalTaichungTaiwan Department of Health Business Administration Hungkuang UniversityTaichungTaiwan Department of Medical Research Taichung Veterans General HospitalTaichungTaiwan Division of Nephrology Department of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan School of Medicine Chung Shan Medical UniversityTaichungTaiwan College of Medicine National Chung Hsing UniversityTaichungTaiwan Division of Allergy Immunology and RheumatologyDepartment of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan School of Medicine National Yang-Ming Chiao Tung UniversityTaichungTaiwan

Background and purpose To analyse the long-term risk of ischaemic stroke and the clinical effects of antithrombotics on the risk of haemorrhagic stroke in patients with systemic lupus erythematosus(SLE).Methods A retrospective cohort study was conducted using a population-based database taken from Taiwan National Health Insurance Research *** with SLE between 2000 and 2008 were registered and matched with two controls by the index date,age,gender and Charlson Comorbidity Index(CCI).These subjects were followed until either stroke event or 31 December *** HRs(aHRs)for strokes were estimated with Cox regression models,and the cumulative incidence of ischaemic stroke was analysed by log-rank test and Kaplan-Meier survival *** In total,8310 patients with SLE and 16620 patients without SLE were *** general,patients with SLE had higher rates of ischaemic stroke(5.4%vs 3.3%)and haemorrhagic stroke(1.5%vs 0.6%)than in *** multivariate analysis adjusted to age,gender,CCI,urbanisation level and antithrombotics uses,aHRs of all strokes,ischaemic stroke and haemorrhagic stroke were 1.73(95%CI:1.54 to 1.94),1.65(95%CI:1.45 to 1.87)and 2.24(95%CI:1.71 to 2.95),respectively,in patients with *** with SLE were significantly more likely to suffer ischaemic stroke than patients without SLE,even 10 years after SLE diagnosis(6.12%vs 3.50%,p<0.001).Antiplatelet use increased the risk of haemorrhagic stroke in SLE group(aHR=1.74,95%CI:1.18 to 2.57).Conclusions Patients with SLE are at greater risk of developing ischaemic stroke that lasts for 10 *** should be carefully administered to prevent cardiovascular events in patients with SLE due to the risk of haemorrhagic stroke.

关键词： erythematosus diagnosis likely

Insights into the electron transfer mechanisms of peroxydisulfate activation by modified metal-free acetylene black for degradation of sulfisoxazole

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第8期35卷 349-356页

作者： Chunxiu Yu Zelin wu Hongle Shi Lingyun Gu Kexin Chen Chuan-Shu He Yang Liu heng Zhang Peng Zhou Zhaokun Xiong Bo Lai State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Sichuan Academy of Eco-Environmental Sciences Chengdu 610041China Sino-German Centre for Water and Health Research Sichuan UniversityChengdu 610065China

Herein,a modified metal-free acetylene black(MMF-AB)catalyst was synthesized by a simple solvothermal-calcination method and designed successfully to activate peroxodisulfate(PDS)for the degradation of sulfisoxazole(SIZ).Due to the doping of N,S and O metal-free elements,the modified catalyst showed excellent catalytic performance with 100%SIZ removal within 30 *** first-order reaction rate constants(evaluating catalytic efficiencies and activity)of MMF-AB(kobs=0.105 min^(−1))was 3 times higher than pure-AB(k_(obs)=0.029 min^(−1)).Interestingly,it was demonstrated that the reaction sys-tem is based on the transfer of electrons from SIZ to PDS to realize an electron-transfer-based mechanism by the evidence of premixing,electron paramagnetic resonance(EPR)spectroscopy,salt-bridge experi-ments and electrochemical *** introduction of recyclable filtration device solved the secondary pollution caused by the dispersion of the powdered catalyst in the treated water,which further proved the practicality and superiority of the MMF-AB catalyst.

关键词： Peroxydisulfate Sulfisoxazole Acetylene black Electrochemical Electron transfer

Alkyl Radical Initiated Cyclization/Cascade for Synthesizing Lactam-Substituted Alkyl Sulfones

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第16期42卷 1853-1859页

作者： Li-Jun wu Kai-Yi Zhang pei Yang Chuan-Chong Peng Jin-Hui Liu Qing Li Da-Zhi Sun Shuangfeng Yin College of Sciences Central South University of Forestry and TechnologyChangshaHunan410004 China School of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhotInner Mongolia010021 China

An alkyl radical initiated cyclization/tandem reaction of alkyl bromides and alkyl electrophiles by using potassium metabisulphite(K_(2)S_(2)O_(5))as a connector is developed for the synthesis of various lactam-substituted alkyl ***,this process does not require a metal catalyst or metal powder reductant,highlighting its environmentally friendly *** reaction demonstrates outstanding substrate adaptability and a high tolerance towards diverse functional ***,the biologically active molecules and commercially available drugs with a late-stage modification are also highly compatible with this *** studies revealed that the reaction proceeds through a single-step process involving intramolecular radical cyclization,"SO_(2)"insertion,and external alkyl incorporation.

关键词： Alkyl radical Metal-free catalyzed Cyclization/cascade Potassium metabisulphite Electrophiles Alkyl sulfones Lactams Alkyl bromides Sodium formate

Direct visualization of laser-driven dynamic fragmentation in tin by in situ x-ray diffraction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2024年第5期9卷 109-114页

作者： Jing Yang Xinxin Wang Liang Xu Qiannan Wang Yi Sun Jiangtao Li Lin Zhang Yinghua Li Yuying Yu pei Wang Qiang wu Jianbo Hu Laboratory for Shock Wave and Detonation Physics Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100094China

We present a novel method for investigating laser-driven dynamic fragmentation in tin using in situ X-ray *** experimental results demonstrate the feasibility of the method for simultaneously identifying the phase and temperature of fragments through analysis of the diffraction ***,we observe a deviation from the widely accepted isentropic release assumption,with the temperature of the fragments being found to be more than 100 K higher than expected,owing to the release of plastic work during dynamic *** findings are further verified through extensive large-scale molecular dynamics simulations,in which strain energies are found to be transferred into thermal energies during the nucleation and growth of voids,leading to an increase in *** findings thus provide crucial insights into the impact-driven dynamic fragmentation phenomenon and reveal the significant influence of plastic work on material response during shock release.

关键词： dynamic release diffraction

Fabrication of High-Quality Niobium Superconducting Tunnel Junctions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2011年第8期28卷 289-292页

作者： XU Qin-Yin CAO Chun-Hai LI Meng-Yue JIANG Yi ZHA Shi-Tong KANG Lin XU Wei-Wei CHEN Jian wu pei-heng Research Institute of Superconductor Electronics(RISE) Nanjing UniversityNanjing 210093

For high-quality superconducting tunnel junctions(STJs),it is necessary to reduce leakage current as much as *** describe the fabrication of niobium STJs using the selective niobium(Nb)etching process and various ways to minimize the leakage *** experiment shows that the leakage current mainly comes from shorts in the tunnel barrier layer rather than those around the junction *** systematic analysis of the thin film stress,surface morphology and modified junction structures,we fabricate high-quality Nb STJs with a gap voltage of 2.8 mV and a leakage current at 1 mV as low as 8.1%and 0.023%at 4.2 K and 0.3 K,respectively.

关键词： leakage tunnel film

Electronic-scale assessment of high-temperature oxidation mechanisms in a novel Fe-based alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第4期31卷 982-997页

作者： Wei-di Luo Ting-ping Hou Xuan Liang Dong Zhang heng-fu Lin Yu Li Tian-liang Zhao Cheng-yang Hu Serhii Yershov Kai-ming wu The State Key Laboratory of Refractories and Metallurgy.wuhan University of Science and Technology.wuhan 430081 HubeiChina Hubei Province Key Laboratory of Systems Science in Meallurgial Process Wuhan University of Science and Technology.Wuhan 430081.Hubei.China International Research Institute for Steel Technology Wuhan University of Science and Technology.Wuhan 430081.HubeiChina Collaborative Innovation Center for Advanced Steels w uhan University of Science and Technology.Wuhan 430081.HuleiChina

The development of alloys with high antioxidation performance is limited by the ambiguous details of the oxidation ***,based on the structures of internal oxides detected by high-resolution transmission electron microscopy,a hybrid method combining first-principles calculation,climb image nudged elastic band method and quasi-harmonic Debye model has been implemented to explain the oxidation mechanism with an emphasis on the origin of delamination and *** results showed that the delamination of oxides corresponds to the acceleration of diffusion of Cr element caused by lamellar *** reduction in the cracking occurrence at high temperature mainly results from the smaller bulk modulus of ***,the stronger chemical bonds promoted by lamellar structures also correspond to the higher crackingresistance.

关键词： Oxidation Crystal structure Diffusion Cracking-First-principles calculation

基于双层网络结构综合考虑社交关系与偏好相似性的电影推荐方法

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国管理科学 2024年第3期32卷 248-256页

作者：武恒武彤西北大学文学院陕西西安710127 南京航空航天大学经济与管理学院智能决策与数字化运营工业和信息化部重点实验室江苏南京211106

当前电影推荐方法缺乏对用户间多种关联关系的考虑,导致用户好友关系稀疏,推荐效果不佳。为此,本文基于双层网络结构提出一种综合考虑社交关系与偏好相似性的电影推荐方法。首先,根据不同关系类型对电影网站用户社交关系和偏好相似关系... 详细信息

当前电影推荐方法缺乏对用户间多种关联关系的考虑,导致用户好友关系稀疏,推荐效果不佳。为此,本文基于双层网络结构提出一种综合考虑社交关系与偏好相似性的电影推荐方法。首先,根据不同关系类型对电影网站用户社交关系和偏好相似关系进行分层处理,通过用户间的关注关系构造社交网络。接着,基于用户评价电影集合的相似性度量用户偏好相似性,构造偏好相似网络,继而构建综合考虑用户社交关系与偏好相似关系的双层网络结构。最后,利用Louvain社区发现方法对大群体用户进行降维分析,基于邻居用户影响力对社群用户进行个性化推荐。经豆瓣数据实验分析,本文所提方法能够有效缓解用户社交关系稀疏性问题,高效识别用户感兴趣社群,并基于社区邻居评价信息为目标用户提供更具新颖度的推荐列表。

关键词：双层网络社交关系偏好相似性电影推荐

IL-17 induces NSCLC cell migration and invasion by elevating MMP19 gene transcription and expression through the interaction of p300-dependent STAT3-K631 acetylation and its Y705-phosphorylation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第4期32卷 625-641页

作者： WEN GE YA LI YUTING RUAN NINGXIA wu pei MA TONGPENG XU YONGQIAN SHU YINGWEI WANG WEN QIU CHENHUI ZHAO Department of Immunology Nanjing Medical UniversityNanjing210000China Key Laboratory of Immunological Environment and Disease Nanjing Medical UniversityNanjing210000China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210000China Jiangsu Key Laboratory of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing210000China

The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer(NSCLC).Although researchers have disclosed that interleukin 17(IL-17)can increase matrix metalloproteinases(MMPs)induction causing NSCLC cell metastasis,the underlying mechanism remains *** the study,we found that IL-17 receptor A(IL-17RA),p300,p-STAT3,Ack-STAT3,and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17.p300,STAT3 and MMP19 overexpression or knockdown could raise or reduce IL-17-induced p-STAT3,Ack-STAT3 and MMP19 level as well as the cell migration and *** investigation revealed that STAT3 and p300 bound to the same region(−544 to−389 nt)of MMP19 promoter,and p300 could acetylate STAT3-K631 elevating STAT3 transcriptional activity,p-STAT3 or MMP19 expression and the cell mobility exposed to ***,p300-mediated STAT3-K631 acetylation and its Y705-phosphorylation could interact,synergistically facilitating MMP19 gene transcription and enhancing cell migration and ***,the animal experiments exhibited that the nude mice inoculated with NSCLC cells by silencing p300,STAT3 or MMP19 gene plus IL-17 treatment,the nodule number,and MMP19,Ack-STAT3,or p-STAT3 production in the lung metastatic nodules were all ***,these outcomes uncover that IL-17-triggered NSCLC metastasis involves up-regulating MMP19 expression via the interaction of STAT3-K631 acetylation by p300 and its Y705-phosphorylation,which provides a new mechanistic insight and potential strategy for NSCLC metastasis and therapy.

关键词： NSCLC cell migration and invasion IL-17 p300 STAT3 MMP19 Acetylation and phosphorylation