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Investigation on and industrial application of degrading of methanol feed in methanol to propylene process

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Chinese Journal of Chemical Engineering 2018年第10期26卷 2102-2111页

作者： Lixiang jiang Chufu Li ming Xu Aihua Xing Rui Feng Jianjun wu China University of Mining and Technology Xuzhou 221116 China China Energy Investment Corporation Limited Beijing 100011 China Shenhua Ningrnei Coal Group Coal Chemical Industry Company Yinchuan 750411 China National Institute of Clean-and-Low-Carbon Energy Beijing 102209 China

At present, methanol to propylene(MTP) technology developed by Lurgi Company is adopted for commercial plants and refined methanol with the purity ≥99.85 wt% is required as the feed of MTP unit in Lurgi's ***, high energy cost for refined methanol production is one of the bottlenecks to improve the economy of MTP technology. Reducing the grade of feed refined methanol may be an effective method to save energy and reduce operation costs in MTP process. In this work, experiments and process simulation were carried out to investigate the influence and feasibility of degrading the methanol feed. Experiments were conducted to investigate the influence of crude methanol feed on conversion and selectivity of MTP reaction as well as the performance of ZSM-5 catalyst. The experimental results showed that degrading the methanol feed had no obvious influence on the conversion and selectivity of MTP reactions and the catalyst deactivation was caused by the carbon accumulation and metals deposition on the active sites. The process simulation results showed that the influence on the conversion and selectivity as well as the stream load of MTP process was negligible if 98 mol% methanol was used as feed. Finally, industrial experiments were conducted by adjusting the operation parameters to degrade of feed methanol of the commercial 500 kt·a^(-1) MTP unit of Ningmei Group in China. The results of industrial application illustrated that annually 180 kt fuel coal and 150 kt desalted water as well as 1770 MW·h^(-1) electricity would be saved when the water content increased from 0.01% to 0.4%. This work has identified the feasibility to improve MTP technology by degrading the methanol feed.

关键词： MTP Methanol Distillation Simulation and optimization Energy saving

Safe Reconfiguring Data Plane via Supervision over Resource and Flow States

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Chinese Journal of Electronics 2015年第3期24卷 642-647页

作者： GAO Wen ZHOU Boyang wu Chunming ZHOU Haifeng jiang ming HONG Xiaoyan College of Computer Science Zhejiang University Institute of Soft. and Intelli. Tech. Hangzhou Dianzi University Department of Computer Science University of Alabama

In the Software-defined networking(SDN),when multiple control domains are used in control services,the transient state problem can occur causing the service flow interruption when border switches are updated asynchronously. We analyze the uniqueness of this problem for SDN, and propose a light-weight protocol for safe reconfiguration of the border switches in order to improve the availability of the services running in SDN. Our solution is designed as a generic supervision layer added in the control plane to support different types of services. To demonstrate the benefits, we implement a prototype of Informationcentric networks(ICN) with the protocol, and conduct experiments using Planet Lab. The results show the ICN service can continuously serve high volume requests for contents despite the congestions built by the heavy background traffic. The performance gains in terms of the mean and standard deviation of the content retrieve delay are40.5% and 21.56%.

关键词： Software-defined networking Network architecture Network management

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多功能模块化无人机动力测试平台研究

电子质量 2022年第5期 76-79页

作者：薛喜红吴明江艾力夏提·阿不力孜新疆职业大学新疆乌鲁木齐830013

无人机动力系统测试台是无人机开发生产过程中一种重要的试验设备,由于无人机在物流、农业、消防等多个领域的广泛应用,市场对于无人机动力系统测试台的需求与日俱增。多功能模块化无人机动力测试平台能够将功能结构相似的无人机动力测... 详细信息

无人机动力系统测试台是无人机开发生产过程中一种重要的试验设备,由于无人机在物流、农业、消防等多个领域的广泛应用,市场对于无人机动力系统测试台的需求与日俱增。多功能模块化无人机动力测试平台能够将功能结构相似的无人机动力测试平台零部件整合成相应功能单元模块,再对各模块功能、结构、相关属性进行优化,最后集中管理实现共享。文章详细描述了试验台的模块化搭建方案,总体结构设计以及测试系统等。经分析表明:多功能模块化无人机动力测试平台方案采用通用化、模块化和标准化组合设计,具有不同构型,可实现多功能和多应用场景。

关键词：动力系统测试台模块化

Triple-negative breast cancer:new treatment strategies in the era of precision medicine

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Science China(Life Sciences) 2021年第3期64卷 372-388页

作者： Song-Yang wu Hai Wang Zhi-ming Shao Yi-Zhou jiang Department of Breast Surgery Fudan University Shanghai Cancer CenterKey Laboratory of Breast Cancer in ShanghaiDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China

Triple-negative breast cancer(TNBC)remains the most aggressive cluster of all breast cancers,which is due to its rapid progression,high probabilities of early recurrence,and distant metastasis resistant to standard *** the advances in cancer genomics and transcriptomics that can illustrate the comprehensive profiling of this heterogeneous disease,it is now possible to identify different subclasses of TNBC according to both intrinsic signals and extrinsic microenvironment,which have a huge influence on predicting response to established therapies and picking up novel therapeutic targets for each *** this review,we summarize basic characteristics and critical subtyping systems of TNBC,and particularly discuss newly found prospective targets and relevant medications,which were proved promising in clinical trials,thus shedding light on the future development of precision treatment strategies.

关键词： triple-negative breast cancer molecular subtype targeted therapy precision medicine

1980-2020年汾河流域耕地显性转型时空分异及其驱动力

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水土保持研究 2025年第1期32卷 257-265+284页

作者：姜民武志平付建新太原师范学院地理科学学院太原师范学院城镇与区域发展研究所太原师范学院汾河流域地表过程与资源生态安全山西省重点实验室太原师范学院碳中和研究院

[目的]刻画耕地利用转型变化特征，揭示耕地转型发展规律，为汾河流域耕地资源保护和乡村转型发展提供理论支撑和参考依据。[方法]基于1980年、1990年、2000年、2010年、2020年土地利用遥感影像数据，利用耕地转型速度、转移矩阵和地理... 详细信息

[目的]刻画耕地利用转型变化特征，揭示耕地转型发展规律，为汾河流域耕地资源保护和乡村转型发展提供理论支撑和参考依据。[方法]基于1980年、1990年、2000年、2010年、2020年土地利用遥感影像数据，利用耕地转型速度、转移矩阵和地理探测器方法，分析了汾河流域耕地利用转型的时空分异特征，并探测了其驱动因子。[结果]（1） 1980—2020年，流域内耕地面积减少10.59万hm2,其中，耕地转为建设用地的面积最大，草地是转入耕地最多的地类，占转入总面积的59.37%。（2） 1980—2020年，汾河流域耕地利用转型速度呈波动下降趋势，其中中游耕地减少最明显，人地矛盾突出。（3）自然因子对耕地转型影响程度明显强于社会经济因子，其中气温q值最大，达0.72。自然因子之间的交互作用对耕地转型的解释力更强。[结论]汾河流域耕地利用转型受自然和社会经济因素共同影响，先后经历了缓和平稳、转型加剧、矛盾尖锐和收敛平衡不同阶段，空间集聚性特征显著，将指导该流域耕地资源合理、有序利用。

关键词：耕地转型空间转型地理探测汾河流域

Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3244-3266页

作者： Peiran Chen Mandi wu Yaqing He Binghua jiang ming-Liang He Department of Biomedical Sciences City University of Hong KongHKSARHong KongChina Shenzhen Center for Disease Control and Prevention Shenzhen 518055 GuangdongChina Cell Signaling and Proteomic Center Academy of Medical SciencesZhengzhou UniversityZhengzhouHenanChina

The coronavirus disease 2019(COVID-19)caused by coronavirus SARS-CoV-2 infection has become a global pandemic due to the high viral transmissibility and pathogenesis,bringing enormous burden to our *** patients infect... 详细信息

关键词： infection alterations therapeutic

Thermal stability of permafrost under U-shaped crushed rock embankment of the Qinghai-Tibet Railway

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Advances in Climate Change Research 2024年第1期15卷 158-169页

作者： Kun-ming XU Guan-Li jiang Ji CHEN Qing-Bai wu State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Beiluhe Observation Station of Frozen Soil Environment and Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China

The U-shaped crushed rock embankment(UCRE),of which widely utilized in the permafrost regions along the Qinghai-Tibet Railway,has the capability to rapidly reduce the ground temperature of the underlying ***,there remains uncertainty regarding the adaptation of UCRE to climate change and its long-term cooling *** study focuses on nine UCRE monitoring sites along the Qinghai-Tibet Railway to analyze the dynamic variations of the ground temperature underlying permafrost from 2006 to *** efficiency of UCRE in stabilizing permafrost temperature in different permafrost zones is evaluated by considering the permafrost table,ground temperature,and MAGT,as well as the temperature difference between the top and bottom of the crushed rock layer and the ground temperature variation index(GTVI).The results show that UCRE is suitable for application in extremely unstable warm permafrost regions where the MAGT is higher than-0.5℃.Moreover,UCRE effectively diminishes the disparity in permafrost thermal stability between the sunny and shaded shoulders of the *** short-term and long-term effect of cooling permafrost is experiencing a change related with permafrost ***,in stable cold permafrost regions with MAGT lower than-1.5℃,the long-term cooling effect of UCRE on permafrost seems to gradually di-minishes,but UCRE continues to fulfill the role of stabilizing the underlying permafrost thermal state over the *** results show that UCRE can quickly restore and stabilize the thermal state of permafrost in the early stages of construction,and adapt to the influence of future climate *** findings provide important guidance for understanding the variations of permafrost thermal stability beneath the embankment in permafrost regions,as well as for improving the embankment stability and operational safety of the Qinghai-Tibet Railway.

关键词： Qinghai-Tibet Railway U-shaped crushed rock embankment Climate change Permafrost zone Ground temperature variation index Long-term coolingrole

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

Influence of Surface Roughness of Galvanized Steel Sheet on Self-lubricated Coating

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Journal of Iron and Steel Research International 2014年第3期21卷 342-347页

作者： Xin LIU wu-gang YU Qi-fu ZHANG She-ming jiang National Engineering Laboratory of Advanced Coating Technology for Metal Materials Central Iron and Steel Research Institute School of Materials Science and Engineering University of Science and Technology Beijing

Three different thicknesses of self-lubricated coatings were prepared on galvanized steel sheets with differ- ent surface roughness （Ra）. Performances of the coatings were evaluated by various laboratory tests. Scanning elec- tron microscopy （SEM）, atomic force microscope （AFM）, neutral salt spraying test （NSST）, reciprocating friction and wear test were taken in order to characterize the coatings. Results show that the self-lubricated coating has good corrosion resistance and lubricating property. In 0. 857--1. 629 /~m of Ra value, the relationship between friction co- efficients of the self lubricated steel sheets and the surface roughness of the galvanized steel sheets likes a parabolic curve, and has a peak value of friction coefficient in certain range of Ra. Affected by the hereditary surface topogra- phy of the galvanized steel sheet, dents on the surface of sel^lubricated steel become deeper and larger with the in crease of the surface roughness of the galvanized steel sheets. The influence of the surface roughness of the galvanized steel sheet on the corrosion resistance of the self lubricated coating steel is similar to that on friction coefficient of selPlubricated coatings, like a parabolic curve.

关键词： surface roughness self-lubricated friction coefficient corrosion resistance