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N-methyl-D-aspartate receptor subunit 1 protein expression in the hippocampus and temporal cortex of kainic acid-induced epilepsy rats

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Neural Regeneration Research 2010年第14期5卷 1045-1049页

作者： Zan Wang Hongyu Jiang Suisheng wu Hongmei meng li Ji li Cui Weihong lin Department of Neurology First Hospital of Jilin University Changchun 130021 Jilin Province China

BACKGROUND： The N-methyl-D-aspartate receptor subunit 1 （NMDAR1） contributes to the incidence of epilepsy. However, the relationship between epilepsy-induced brain injury and NMDAR1 remains poorly understood. OBJECTIVE： To investigate changes in NMDAR1 protein expression in the hippocampus and temporal cortex of kainic acid-induced epilepsy rats. DESIGN, TIME AND SETFING： A randomized, controlled, animal experiment was performed at the Department of Physiology and Department of Pathology, Basic Medical College of Jilin University from March 2002 to March 2003. MATERIALS： Rabbit anti-NMDAR1 antibody was purchased from wuhan Boster Biological Technology, China. METHODS： A total of 80 healthy, male, Wistar rats, aged 22 weeks, were randomly assigned to sham-surgery （n = 10） and model （n = 70） groups. Epilepsy models were established by injecting kainic acid （1μL） into the right amygdala, and rats were sacrificed at 2, 6, 24, 72 hours, and 7, 15, 30 days after surgery, with 10 animals at each time point. The rats in the sham-surgery group were injected with 1μL phosphate buffered saline into the right amygdala. MAIN OUTCOME MEASURES： NMDAR1 protein expression in the hippocampus and temporal cortex at 2, 6, 24, 72 hours and 7, 15, 30 days after epilepsy was detected using immunohistochemistry and flow cytometry analysis. RESULTS： In the sham-surgery group, a few NMDARl-positive cells were distributed in the hippocampus and temporal cortex. In the model group, NMDARl-positive cells were increased in the hippocampus and temporal cortex at 2 hours following kainic acid-induced epilepsy. They were significantly increased at 6 hours, and slightly decreased at 7 days （CA3 region and temporal cortex）, but remained greater than the sham-surgery group. This continued until day 30 （P 〈 0.01 ）. In addition, there were more NMDAR1 positive cells in the hippocampal CA3 and dentate gyrus than the temporal cortex （P 〈 0.01）. CONCLUSION： In epilepsy model rats, NMDAR1 protein ex

关键词： kainic acid epilepsy N-methyI-D-aspartate receptor rat subunit neural regeneration

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Tianjin Hi-tech Industrial Park

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China Today 2003年第4期52卷 28-33页

作者： wu XINYI & li meng

TIANJIN is North China's biggest industrial and commercial city,and is economic center of the Bohai Bay *** is also a comprehensive trade port,encompassing the laregest container wharf in North *** old industrial base... 详细信息

关键词：中国天津高新技术园区贸易港口渤海湾花园工业园区火炬创业园经济效益社会效益

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Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： Yun li Junfang wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： meng Cong Jing-Jing Hu Yan Yu Xiao-li li Xiao-Ting Sun li-Ting Wang Xia wu ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Diagnosis and treatment of acute rejection in the first case of human living-related small bowel transplantation with a long-term survival in China

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World Journal of Gastroenterology 2005年第34期11卷 5332-5335页

作者： Wei-liang Song Wei-Zhong Wang Guo-Sheng wu meng-Bin li Ji-Peng li Gang Ji Guang-Long Don Hong-Wei Zhang Department of Gastrointestinal Surgery Xijing HospitalFourth Military Medical University Xi'an 710032 Shaanxi Province China

AIM： To report the comprehensive diagnosis and treatment of acute rejection in the first case of living-related small bowel transplantation with a long-term survival in China. METHODS： A 18-year-old boy with short gut syndrome underwent living-related small bowel transplantation, with the graft taken from his father （44-year old）. A segment of 150-cm distal small bowel was resected from the donor. The ileo-colic artery and vein from the donor were anastomosed to the infrarenal aorta and vena cava of the recipient respectively. The intestinal continuity was restored with an end-to-end anastomosis between the recipient jejunum and donor ileum, and the distal end was fistulized. FK506, MMF and prednisone were initially used for post-transplant immunosuppression. Endoscopic observation and mucosal biopsies of the graft were carried out through the terminal ileum enterostomy; serum was collected to detect the levels of IL-2R, IL-4, IL-6 and IL-8. The change of the graft secretion and absorption was observed. RESULTS： Acute rejection was diagnosed promptly and cured. The patient was in good health, 5 years after living- related small bowel transplantation. CONCLUSION： The correct diagnosis and treatment of acute rejection are the key to the long-term survival after living-related small bowel transplantation.

关键词： Rejection Comprehensive diagnosis Small bowel transplantation

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Smart Cellulose‑Based Janus Fabrics with Switchable liquid Transportation for Personal Moisture and Thermal Management

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Nano-Micro Letters 2025年第1期17卷 333-347页

作者： Jianfeng Xi Yanling Lou liucheng meng Chao Deng Youlu Chu Zhaoyang Xu Huining Xiao Weibing wu Jiangsu Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsJiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass MaterialsNanjing Forestry UniversityNanjing 210037People’s Republic of China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering University of New BrunswickFrederictonNB E3B 5A3Canada Macromolecular Chemistry and Bavarian Polymer Institute University of BayreuthBayreuth 95440Germany

The Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human ***,the development of smart and dynamic fabrics capable of managing personal moisture/thermal comfort in response to changing external environments remains a ***,a smart cellulose-based Janus fabric was designed to dynamically manage personal moisture/*** cotton fabric was grafted with N-isopropylacrylamide to construct a temperature-stimulated transport ***,hydrophobic ethyl cellulose and hydrophilic cellulose nanofiber were sprayed on the bottom and top sides of the fabric to obtain wettability *** fabric exhibits anti-gravity directional liquid transportation from hydrophobic side to hydrophilic side,and can dynamically and continuously control the transportation time in a wide range of 3–66 s as the temperature increases from 10 to 40℃.This smart fabric can quickly dissipate heat at high temperatures,while at low temperatures,it can slow down the heat dissipation rate and prevent the human from becoming too *** addition,the fabric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic *** smart fabric offers an innovative approach to maximizing personal comfort in environments with significant temperature variations.

关键词： Directional water transport Cotton fabric Anti-gravity directional liquid transportation Janus wettability

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一类一阶周期边值问题多个正解的存在性

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四川大学学报（自然科学版） 2022年第1期59卷 19-23页

作者：吴梦丽西安电子科技大学数学与统计学院西安710126

本文研究了一阶周期边值问题{-u'(t)+a(t)u(t)=λf(u(t)),00是一个参数,a∈C(R,[0,∞))是一个T-周期函数且∫T0a(t)dt>0,f∈C([0,∞),(0,∞))且单调递增.在f0=limu→0^(+)f(u))/u=0f_(∞)=lim u→∞f(u)/u=0的条件下,本文证明存在一个λ... 详细信息

关键词：正解存在性多解性上下解拓扑度

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A Hybrid Approach for Pavement Crack Detection Using Mask R-CNN and Vision Transformer Model

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Computers, Materials & Continua 2025年第1期82卷 561-577页

作者： Shorouq Alshawabkeh li wu Daojun Dong Yao Cheng liping li Faculty of Engineering China University of GeosciencesWuhan430074China

Detecting pavement cracks is critical for road safety and infrastructure *** methods,relying on manual inspection and basic image processing,are time-consuming and prone to *** deep-learning(DL)methods automate crack detection,but many still struggle with variable crack patterns and environmental *** study aims to address these limitations by introducing the Masker Transformer,a novel hybrid deep learning model that integrates the precise localization capabilities of Mask Region-based Convolutional Neural Network(Mask R-CNN)with the global contextual awareness of Vision Transformer(ViT).The research focuses on leveraging the strengths of both architectures to enhance segmentation accuracy and adaptability across different pavement *** evaluated the performance of theMaskerTransformer against other state-of-theartmodels such asU-Net,TransformerU-Net(TransUNet),U-NetTransformer(UNETr),SwinU-NetTransformer(Swin-UNETr),You Only Look Once version 8(YoloV8),and Mask R-CNN using two benchmark datasets:Crack500 and *** findings reveal that the MaskerTransformer significantly outperforms the existing models,achieving the highest Dice SimilarityCoefficient(DSC),precision,recall,and F1-Score across both ***,the model attained a DSC of 80.04%on Crack500 and 91.37%on DeepCrack,demonstrating superior segmentation accuracy and *** high precision and recall rates further substantiate its effectiveness in real-world applications,suggesting that the Masker Transformer can serve as a robust tool for automated pavement crack detection,potentially replacing more traditional methods.

关键词： Pavement crack segmentation transportation deep learning vision transformer Mask R-CNN image segmentation

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Measurement and engineering application of adsorbed water content in fine-grained soils

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Journal of Central South University 2021年第5期28卷 1555-1569页

作者： ZHANG Rui XIAO Yu-peng wu meng-li ZHENG Jian-long MILKOS B C National Engineering Laboratory of Highway Maintenance Technology Changsha University of Science&TechnologyChangsha 410114China School of Traffic and Transportation Engineering Changsha University of Science&TechnologyChangsha 410114China

In this paper,the content and density of adsorbed water in fine-grained soil are *** to the test results,the calculation method of compaction degree of the solid-phase and void ration of soil is *** kinds of fine-grained soils from different regions in China were selected,and the adsorbed water content and density of four kinds of fine-grained soils were determined by thermogravimetry and volumetric flask ***,SEM and XRD experiments were used to analyze the differences in the ability of each soil sample to absorb *** order to study the compression characteristics of adsorbed water,four saturated soil samples were tested by consolidation *** results show that the desorption temperature range of the adsorbed water and its density were equal to 100−115℃and 1.30 g/cm^(3),*** water plays a positive role in keeping the compressibility of fine-grained soil at a low rate when it has high water ***,adsorbed water can be a stable parameter and is difficult to discharge during the operation period of *** settlement of fine-grained soil embankment is predicted by engineering example,and compared with the result of conventional calculation *** results show that it is more close to the field monitoring results by using the improved void ratio of soil as the parameter.

关键词： adsorbed water volumetric flask method thermogravimetric analysis method void ratio settlement

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时标上三阶非线性p-Laplacian泛函动力方程的正解

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兰州大学学报（自然科学版） 2010年第6期46卷 100-104页

作者：武利猛杨军燕山大学理学院河北秦皇岛066004 华东师范大学数学系上海200241 河北省数学研究中心河北石家庄050000

考虑了时标上p-Laplacian泛函动力方程边值问题:(?)借助于锥上的Avery-Peterson不动点定理,得到了此问题存在三个正解的一些新的结果,同时给出了例子验证了主要结果.

关键词：时标边值问题正解不动点定理

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