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Clinical features and genetic spectrum in Chinese patients with recessive hereditary spastic paraplegia

Translational Neurodegeneration 2019年第1期8卷 230-242页

作者： Qiao wei Hai-Lin Dong Li-Ying Pan Cong-xin Chen yang-tian Yan Rou-min wang Hong-Fu Li zhi-Jun liu Qing-Qing Tao zhi-Ying wu Department of Neurology and Research Center of Neurology in Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of Medicine88 Jiefang RoadHangzhou 310009China Longyan First Hospital Fujian Medical UniversityLongyanChina Department of Neurology and Institute of Neurology Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina Joint Institute for Genetics and Genome Medicine between Zhejiang University and University of Toronto Zhejiang UniversityHangzhouChina

Background:Although many causative genes of hereditary spastic paraplegia(HSP)have been uncovered in recent years,there are still approximately 50% of HSP patients without genetically diagnosis,especially in autosomal recessive(AR)HSP *** studies have been performed to determine the genetic spectrum and clinical profiles of recessive HSP patients in the Chinese ***:In this study,we investigated 24 Chinese index AR/sporadic patients by targeted next-generation sequencing(NGS),Sanger sequencing and multiplex ligation-dependent probe amplification(MLPA).Further functional studies were performed to identify pathogenicity of those uncertain significance ***:We identified 11 mutations in HSP related genes including 7 novel mutations,including two(p.V1979_L1980delinsX,p.F2343 fs)in SPG11,two(p.T55 M,p.S308 T)in AP5Z1,one(p.S242N)in ALDH18A1,one(p.D597fs)in GBA2,and one(p.Q486X)in ATP13A2 in 8 index patients and their family *** in ALDH18A1,AP5Z1,CAPN1 and ATP13A2 genes were firstly reported in the Chinese ***,the clinical phenotypes of the patients carrying mutations were described in *** mutation(p.S242 N)in ALDH18A1 decreased enzyme activity of P5CS and mutations(p.T55 M,p.S308 T)in AP5Z1 induced lysosomal ***:Our results expanded the genetic spectrum and clinical profiles of AR-HSP patients and further demonstrated the efficiency and reliability of targeted NGS diagnosing suspected HSP patients.

关键词： Hereditary spastic paraplegia Autosomal recessive Targeted next-generation sequencing Chinese Genetic spectrum Phenotype

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Short-and long-term outcomes of kidney transplants with kidneys lavaged by retrograde perfusion technique

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Chronic Diseases and Translational Medicine 2015年第3期1卷 -页

作者： xiu-wu Han xiao-Dong Zhang Yong wang xi-Quan tian Jian-Wen wang Bu-He Amin wei Yan Department of Urology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Center of Kidney Transplantation Beijing Shijitan Hospital Affiliated to Capital Medical University Beijing 100038 China

Objective: To evaluate the clinical safety and efficacy of the retrograde perfusion technique in kidney ***: Between January 2001 and June 2011, 24 cases of kidney transplantation with kidneys perfused using the retrograde perfusion technique due to renal artery variations or injury were selected as the observation group (retrograde perfussion roup, RP group).Twenty-two cases of kidney transplantation via conventional perfusion were chosen as the control group (antegrade perfussion group, AP group).There were no statistically significant differences in donor data between the two *** ischemia time, warm ischemia time, renal perfusion time, amount of perfusion fluid, acute renal tubular necrosis, wound infection, urinary fistula, graft kidney function, and the 1-year, 3-year, and 5-year survival rates for the grafted kidney in both groups were observed and ***: The kidney perfusion time was shorter in the RP group than that in the AP group (3.14 ± 1.00 vs.5.02 ± 1.15 min, P =0.030).There were 10 cases of acute renal tubule necrosis in the RP group and 5 in the AP *** length of hospital stay was 40 ± 14 d in the RP group and 25 ± 12 d in the AP *** follow-up time was 3.5-8.5 years (mean 6.25 years).The 1-, 3-, and 5-year survival rates for the grafted kidney were 95.8％, 75.5％, and 65.5％ in the RP group and 97.1％, 82.5％, and 68.4％ in the AP group, respectively (P＞0.05).Conclusions: This study indicates that retrograde perfusion is safe and practicable for cadaveric kidney harvesting and can be regarded as a better alternative or remedial measure for a poorly perfused kidney due to vascular deformity or *** 2015, Chinese Medical Association *** and hosting by Elsevier *** behalf of KeAi Communications Co., *** is an open access article under the CC BY-NC-ND license (http://***/licenses/ by-nc-nd/4.0/).

关键词： Retrograde perfusion Allograft vascular deformity Allograft vascular injury Kidney procurement

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Laboratory Safety of Dupilumab,and Its Effect on Inflammatory Biomarkers,in Chinese Adults With Moderate-to-Severe Atopic Dermatitis:An Analysis of a Randomized,Double-Blind Phase III Study

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International Journal of Dermatology and Venereology 2022年第4期5卷 218-225页

作者： Yan Zhao Li-ming wu Qian-Jin Lu xing-Hua Gao xiao-Hong Zhu Xu Yao Lin-Feng Li wei Li yang-Feng Ding zhi-Qiang Song Ling-Ling liu Ning-Ning Dang Chun-Lei Zhang xiao-ming liu Jun Gu Jin-Yan wang Song-Mei Geng Quan-zhong liu Yi-Feng Guo Li Dong Shelley Li Christine Xu John T.O’Malley Elizabeth Laws Nikhil Amin Ashish Bansal min wang Jian-zhong Zhang Department of Dermatology Peking University People’s HospitalBeijing 100044China Hangzhou First People’s Hospital HangzhouZhejiang 310006China The Second xiangya Hospital of Central South University ChangshaHunan 410011China The First Hospital of China Medical University ShenyangLiaoning 110001China wuxi Second People’s Hospital WuxiJiangsu 214002China Hospital for Skin Diseases Institute of DermatologyChinese Academy of Medical SciencesNanjingJiangsu 210042China Beijing Friendship Hospital Capital Medical UniversityBeijing 100050China Huashan Hospital Fudan UniversityShanghai 200040China Shanghai Skin Disease Hospital Shanghai 200040China The Southwest Hospital of AMU Chongqing 400038China Peking University First Hospital Beijing 100034China Jinan Central Hospital JinanShandong 250013China Peking University Third Hospital Beijing 100191China University of Hong Kong-Shenzhen Hospital ShenzhenGuangdong 518040China Changhai Hospital of Shanghai Shanghai 200433China Ningbo No.2 Hospital NingboZhejiang 315099China The Second Affiliated Hospital of xi’an Jiaotong University Xi’anShaanxi 710004China tianjin Medical University General Hospital Tianjin 300052China xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200092China Research&Development SanofiBridgewaterNJ 08807USA Research&Development RegeneronTarrytownNY 10591USA Medical Sanofi ChinaShanghai 200040China.

Objective:Limited information is available on the use of dupilumab for the treatment of atopic dermatitis(AD)in the Chinese ***:We analyzed laboratory data from a previously published randomized,double-blind phase III trial(NCT03912259)to provide further insight into the safety of dupilumab in Chinese adults with moderate to severe *** trial participants received either 300 mg of dupilumab or placebo every 2 weeks for 16 ***,blood chemistry,serum thymus and activation-regulated chemokine(TARC),and total immunoglobulin E(IgE)were ***:In total,82 participants received dupilumab and 83 received *** the exception of eosinophil counts of>0.8×109/L,which were found less frequently with dupilumab(9.8%)than with placebo(18.7%),the hematology and blood chemistry values were generally stable in both treatment *** were no clinically significant differences between the dupilumab and placebo groups,and no participants developed treatment-emergent abnormalities of potential clinical ***,compared with placebo,greater decreases in serum lactate dehydrogenase(mean change,−97.4 vs.−33.5 IU/L),TARC(median percent change,−78.6%vs.−30.8%),and total IgE(median percent change,−53.4%vs.−0.2%)were observed with dupilumab than placebo at week ***:Dupilumab demonstrated a favorable laboratory safety profile in Chinese adults with moderate to severe AD.

关键词： atopic dermatitis dupilumab laboratory safety Chinese

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International consensus on natural orifice specimen extraction surgery(NOSES)for gastric cancer(2019)

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Gastroenterology Report 2020年第1期8卷 5-10,I0001页

作者： Xu Guan Zheng liu Amjad Parvaiz Antonio Longo Avanish Saklani Ali AShafik Jian-Chun Cai Charles Ternent Lin Chen Cuneyt Kayaalp Fatih Sumer Fernanda Nogueira Feng Gao Fang-Hai Han Qing-Si He Ho-Kyung Chun Chang-ming Huang Hai-yang Huang Rui Huang zhi-wei Jiang Jim S Khan Joaquim Manuel da Costa Pereira JosephWNunoo-Mensah Jung Tack Son Liang Kang Keisuke Uehara Ping Lan Le-Ping Li Han Liang Bing-Rong liu Juan liu Dan Ma ming-Yin Shen Mohammad Rashidul Islam Narimantas Evaldas Samalavicius Kai Pan Petr Tsarkov xin-Yu Qin Ricardo Escalante Sergey Efetov Seung Kyu Jeong Suk-Hwan Lee Dong-Hui Sun Li Sun Tatiana Garmanova Yan-Tao tian gui-Yu wang Guo-Jun wang Guo-Rong wang xiao-Qiang wang William Tzu-Liang Chen Woo Yong Lee Su Yan Zu-Li yang Gang Yu Pei-wu Yu Dan Zhao Yun-Shi zhong Jian-Ping wang xi-Shan wang The International Alliance of NOSES Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Poole Hospital NHS Trust PooleUK European Center of Coloproctology and Pelvic Diseases-Multimedica Hospital MilanItaly Department of GI Surgical Oncology Tata Memorial HospitalMumbaiIndia Department of Colorectal Surgery Cairo UniversityCairoEgypt Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamenFujianP.R.China Section of Colon and Rectal Surgery Creighton University School of MedicineOmahaNEUSA Department of General Surgery Chinese People’s Liberation Army General HospitalBeijingP.R.China Department of Gastrointestinal Surgery Inonu UniversityMalatyaTurkey Department of Surgery Hospital de BragaBragaPortugal Department of Colorectal Cancer Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Gastroenterological Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of General Surgery Shandong University Qilu HospitalJinanShandongP.R.China Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea Department of Gastric Surgery Fujian Medical University Union HospitalFuzhouFujianP.R.China Department of General Surgery Jiangsu Province Hospital of Traditional Chinese MedicineNanjingJiangsuP.R.China Department of Colorectal Surgery PortsmouthHospitals NHSTrustQueen Alexandra HospitalPortsmouthUK King’s College Hospital LondonUK Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Division of Surgical Oncology Department of SurgeryNagoya University School of MedicineNagoyaJapan Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongP.R.China Department of Gastric Cancer

At present,natural orifice specimen extraction surgery(NOSES)has attracted more and more attention worldwide,because of its great advantages including minimal cutaneous trauma and post-operative pain,fast post-operative recovery,short hospital stay,and positive psychological ***,NOSES for the treatment of gastric cancer(GC)is still in its infancy,and there is great potential to improve its theoretical system and clinical ***,several key points including oncological outcomes,bacteriological concerns,indication selection,and standardized surgical procedures are raised with this innovative ***,it is necessary to achieve an international consensus to regulate the implementation of GC-NOSES,which is of great significance for healthy and orderly development of NOSES worldwide.

关键词： gastric cancer natural orifice specimen extraction surgery transanal specimen extraction transvaginal specimen extraction transoral specimen extraction consensus

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Biomarkers of aging

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Science China(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao mengting Chen min Chen wei Chen xiao Chen Yanhao Chen Yu Chen Yutian Chen zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng liu xiaoqian liu Zuojun liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie xinhua Qiao xinpei Sun xiaoqiang Tang Jianfang wang Qiaoran wang Siyuan wang Xuan wang Yaning wang Yuhan wang Rimo wu Kai xia Fu-Hui xiao Lingyan Xu Yingying Xu Haoteng Yan Liang yang Ruici yang Yuanxin yang Yilin Ying Le Zhang weiwei Zhang Wenwan Zhang xing Zhang Zhuo Zhang min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li xin Li Baohua liu Feng liu Lin liu Qiang liu Qiang liu xingguo liu Yong liu xianghang Luo Shuai Ma xinran Ma zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei tian Shusen wang Si wang xia wang xiaoning wang Yan-Jiang wang Yunfang wang Catherine CL Wong Andy Peng xiang Yichuan xiao Zhengwei xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang weiqi Zhang Yong Zhang Yun-wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu weiguo Zou Gang Pei Guang-Hui liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-xin liu Yue Huang Guang-Cheng xiao Qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-Nan Zhang Shu-Mei Jia Fang-Jun Lu xiang Ma Lian Tao wei Zhang Li Chen Li-ming Song Ti-Pei Li Yu-Peng Xu Xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai zhi Chang Gang Chen tian-xiang Chen Yi-Bao Chen Yu-Peng Chen wei Cui wei-wei Cui Jing-Kang Deng Yong-wei Dong Yuan-Yuan Du min-Xue Fu Guan-Hua Gao He Gao min Gao ming-Yu Ge Yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-wei Han Jia Huo Lu-Hua Jiang wei-Chun Jiang Jing Jin Yong-Jie Jin Ling-Da Kong Bing Li Cheng-Kui Li Gang Li Mao-Shun Li wei Li xian Li xiao-Bo Li Xu-Fang Li yang-Guo Li Zheng-wei Li xiao-Hua Liang Jing-Yuan Liao Bai-Sheng liu Guo-Qing liu Hong-wei liu xiao-Jing liu Yi-Nong liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin meng Yi Nang Jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang xin-Ying Song Liang Sun Ying Tan You-Li Tuo Chen wang Guo-Feng wang Juan wang Ling-Jun wang Weng-Shuai wang Yu-Sa wang xiang-yang Wen Bai-yang wu Bo-Bing wu Mei wu Shuo xiao Shao-Lin xiong He Xu Jia-wei yang Sheng yang Yan-Ji yang Yi-Jung yang Qi-Bin Yi Qian-Qing Yin Yuan You Ai-Mei Zhang Cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-Zhao Zhang Yi Zhang Yi-Fei Zhang Yong-Jie Zhang Yuan-Hang Zhang Yue Zhang Zhao Zhang zhi Zhang Zi-Liang Zhang Hai-Sheng Zhao xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou Jian-Feng Zhou Yu-Xuan Zhu Ren-Lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

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Disappearance of Superconductivity and a Concomitant Lifshitz Transition in Heavily Overdoped Bi_2Sr_2CuO_6 Superconductor Revealed by Angle-Resolved Photoemission Spectroscopy

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Chinese Physics Letters 2019年第1期36卷 60-64页

作者： Ying Ding Lin Zhao Hong-Tao Yan Qiang Gao Jing liu Cheng Hu Jian-wei Huang Cong Li Yu Xu Yong-Qing Cai Hong-Wao Rong Ding-Song wu Chun-Yao Song Hua-Xue Zhou xiao-Li Dong Guo-Dong liu Qing-Yan wang Shen-Jin Zhang zhi-min wang Feng-Feng Zhang Feng yang Qin-JunPeng Zu-Yan Xu Chuang-tian Chen X.J.Zhou Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Technical Institute of Physics and Chemistry Chinese Academy of Sciences Collaborative Innovation Center of Quantum Matter

By partially doping Pb to effectively suppress the superstructure in single-layered cuprate Bi_2Sr_2CuO_(6+δ)(Pb-Bi2201) and annealing them in vacuum or in high pressure oxygen atmosphere, a series of high quality Pb-Bi2201 single crystals are obtained with T_c covering from 17 K to non-superconducting in the overdoped region. High resolution angle resolved photoemission spectroscopy measurements are carried out on these samples to investigate the evolution of the Fermi surface topology with doping in the normal state. Clear and complete Fermi surfaces are observed and quantitatively analyzed in all of these overdoped Pb-Bi2201 samples. A Lifshitz transition from holelike Fermi surface to electron-like Fermi surface with increasing doping is observed at a doping level of ~0.35. This transition coincides with the change that the sample undergoes superconducting-to-non-superconducting *** results reveal the emergence of an electron-like Fermi surface and the existence of a Lifshitz transition in heavily overdoped Bi2201 samples. This provides important information in understanding the connection between the disappearance of superconductivity and the Lifshitz transition in the overdoped region.

关键词： Angular resolved light emission spectrometry Concomitant Lifshitz Transition Bi2Sr2CuO6

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Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： Jie wu Shu-wei Duan Hong-tao yang Yue-yi Deng wei Li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan Lin zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng liu Li-hua wang Rong wang Nian-song wang xiao-hong Cheng Li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang Hong-yu Chen Wen-hu liu Hong-li Lin meng Liang Lu Ma ming Chen Li-qun Song Jian Chen Qing Zhu Chang-ying xing Yun Li Ji-ning Gao Rong-shan Li Ying Li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai xiang-mei Chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(Pmin from the baseline did not change statistically *** average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:SYKFT decreased the proteinur

关键词： Herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy

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Consensus on the digestive endoscopic tunnel technique

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World Journal of Gastroenterology 2019年第7期25卷 744-776页

作者： Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-tian Zhang Yu Bao wei-Gang Chen Philip WY Chiu Tong Dang wei Gong Shu-Tang Han Jian-Yu Hao Shui-xiang He Bing Hu1 Bing Hu2 xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang liu Hai-Feng liu Jun liu xiao-Gang liu zhi-Guo liu Ying-Cai Ma gui-Yong Peng Long Rong wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun gui-Qi wang Wen wang Qi wu Hong Xu Mei-Dong Xu Ai-ming yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang xiao-Feng Zhang Ya-Qi Zhai Department of Gastroenterology and Hepatology Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Gastroenterology the First Affiliated Hospital of Xi’an Jiao Tong UniversityXi’an 710000Shaanxi ProvinceChina Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Endoscopy Eastern Hepatobiliary Surgical Hospital Affiliated to Naval Medical UniversityShanghai 200438China Department of Gastroenterology the Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Gastroenterology Peking University Third HospitalBeijing 100191China Division of Gastroenterology and Hepatology the Johns Hopkins University School of MedicineBaltimoreMD 21218United States Department of Gastrointestinal Endoscopy Prince of Wales Hospitalthe Chinese University of Hong KongHong KongChina Department of Gastroenterology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Gastroenterology Second Xiangya Hospital of Central South UniversityChangsha 410000Hunan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Gastroenterology General Hospital of Chinese People’s Armed Police ForcesBeijing 100039China Division of Gastroenterology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Gastroenterology Sichuan Provincial People’s HospitalChengdu 610072Sichuan ProvinceChina Department of Gastroenterology Xijing HospitalAir Force Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Digestion Qinghai Provincial People’s HospitalXining 810007Qinghai ProvinceChina Department of Gastroenterology Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Gastroenterology Peking Univ

With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) *** present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative *** International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations).

关键词： Digestive endoscopic tunnel technique Endoscopic submucosal tunnel dissection Per-oral endoscopic myotomy Submucosal tunnelling endoscopic resection Gastrointestinal tract

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空气氧化法生产焦锑酸钠的氧化后液中砷和锑的脱除

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中南大学学报（自然科学版） 2005年第4期36卷 576-581页

作者：杨天足刘伟锋赖琼林江名喜王志明王卫东中南大学冶金科学与工程学院湖南长沙410083 华锡集团金城江矿山机械厂广西河池547000

研究了空气氧化法生产焦锑酸钠的氧化后液中脱除砷和锑的方法,并探讨了提高副产品硫代硫酸钠产量的途径。研究结果表明:采用硫酸和SO2中和脱除砷和锑,终点pH值分别控制在6.0和7.0,砷的脱除率分别为26.9%和19.3%,锑的脱除率分别为94.5%和... 详细信息

研究了空气氧化法生产焦锑酸钠的氧化后液中脱除砷和锑的方法,并探讨了提高副产品硫代硫酸钠产量的途径。研究结果表明:采用硫酸和SO2中和脱除砷和锑,终点pH值分别控制在6.0和7.0,砷的脱除率分别为26.9%和19.3%,锑的脱除率分别为94.5%和93.5%;而采用硫酸亚铁、水合肼和硫化钠3种试剂脱除砷和锑,过量系数分别为1.0,2.0和1.0时砷的脱除率分别为70.0%,50.0%和60.0%,锑的脱除率分别为96.7%,95.6%和96.7%;在加硫磺反应中,当过量系数为1.1和时间为90min时,硫向硫代硫酸钠的转化率能达到83.3%。

关键词：空气氧化法焦锑酸钠硫代硫酸钠除杂

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