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HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression

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Cancer Communications 2023年第9期43卷 981-1002页

作者： Lin He Hao Li Can Li Ze-Kun liu meng Lu Ren-Yu Zhang Dong wu Ding wei Jie Shao Man liu Hao-Lin wei Cong Zhang Zhe wang Ling-min Kong zhi-Nan Chen Huijie Bian National Translational Science Centre for Molecular Medicine & Department of Cell Biology Fourth Military Medical UniversityXi'anShaanxiP. R. China Department of Gastroenterology the General Hospital of Western Theatre CommandChengduSichuanP. R. China State Key Laboratory of Cancer Biology Department of PathologyXijing Hospital and School of Basic MedicineFourth Military Medical UniversityXi'anShaanxiP. R. China

Background The mechanism of hepatitis B virus(HBV)-induced carcinogenesis remains an area of *** accumulation of hepatitis B surface antigen in the endoplasmic reticulum(ER)of hepatocytes stimulates persistent ER *** of the unfolded protein response(UPR)pathway of ER stress may play an important role in inflammatory cancer *** the protective UPR pathway is hijacked by cells as a tool for malignant transformation in HBV-related hepatocellular carcinoma(HCC)is still ***,we aimed to define the key molecule hyaluronan-mediated motility receptor(HMMR)in this process and explore its role under ER stress in HCC *** An HBV-transgenic mouse model was used to characterize the pathological changes during the tumor *** and transcriptomics analyses were performed to identify the potential key molecule,screen the E3 ligase,and define the activation *** real-time PCR and Western blotting were conducted to detect the expression of genes in tissues and cell *** reporter assay,chromatin immunoprecipitation,coimmunoprecipitation,immunoprecipitation,and immunofluorescence were employed to investigate the molecular mechanisms of HMMR under ER *** was used to clarify the expression patterns of HMMR and related molecules in human *** We found sustained activation of ER stress in the HBV-transgenic mouse model of *** was transcribed by c/EBP homologous protein(CHOP)and degraded by tripartite motif containing 29(TRIM29)after ubiquitination under ER stress,which caused the inconsistent expression of mRNA and *** expression of TRIM29 in the HCC progression regulated the dynamic expression of *** could alleviate ER stress by increasing autophagic lysosome *** negative correlation between HMMR and ER stress,positive correlation between HMMR and autophagy,and negative correlation between ER stress and

关键词： autophagy endoplasmic reticulum stress hepatitis B virus hepatocellular carcinoma HMMR TRIM29 ubiquitination and proteasomal degradation

Serum Gamma-glutamyl Transferase Levels Predict Functional Outcomes after Aneurysmal Subarachnoid Hemorrhage

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Biomedical and Environmental Sciences 2017年第3期30卷 170-176页

作者： XU tian wang wei ZHAI Lin ZHANG Yun Feng ZHOU Hong zhi wu xin min LI Ai Hong xiE Li Li NING xiao Jin JI Yu Teng wang Hong Mei KE Kai Fu Department of Neurology Affiliated Hospital of Nantong UniversityNantong 226001JiangsuChina Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjing 210006JiangsuChina Medical record center Affiliated Hospital of Nantong UniversityNantong 226001JiangsuChina Neurology research institute of Nantong University Nantong 226001JiangsuChina

Objective We aim to explore the potential association between serum gamma-glutamyl transferase levels and functional outcome after aneurysmal subarachnoid hemorrhage in a Chinese population. Methods A total of 386 aneurysmal subarachnoid hemorrhage patients were included in the study from September 2007 to February 2015. Baseline serum gamma-glutamyl transferase levels and 6-month follow-up functional outcomes were determined. A poor outcome was defined as a modified ranking scale score of ≥ 3. The multivariable logistic model was used to analyze the relationship between serum gamma-glutamyl transferase and clinical outcomes after aneurysmal subarachnoid hemorrhage. Results The adjusted poor outcome rates of patients with gamma-glutamyl transferase levels of 〈 30 U/L, 30-50 U/L and ≥ 50 U/L were 16.7%, 19.6%, and 34.4%, respectively （P 〈 0.01）. The age-sex and multivariable adjusted odds ratios （95% confidence intervals） of poor prognosis comparing the top group （≥ 50 U/L） with the lowest group （〈 30 U/L） were 5.76 （2.74-12.13）, 6.64 （2.05-21.52）, and 6.36 （1.92-21.02）. A significant linear trend existed between gamma-glutamyl transferase level and aneurysmal subarachnoid hemorrhage prognosis. This association was also observed among nondrinkers. Conclusion Patients with higher gamma-glutamyl transferase levels were more likely to have a poor prognosis. Serum gamma-glutamyl transferase can be considered to be an independent predictor of functional outcomes after aneurysmal subarachnoid hemorrhage.

关键词： Aneurysmal subarachnoid hemorrhage Gamma-glutamyl transferase Functional outcome Predictor

巴戟天寡糖胶囊用于轻、中度抑郁症患者巩固期治疗的临床研究

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中国临床药理学杂志 2024年第6期40卷 815-819页

作者：周书喆韩祖成王秀珍陈燕清呼亚玲余雪芹王斌红樊国珍桑红海英贾智捷王占敏魏琰朱建国宋学勤刘志东况利王洪明田峰李玉欣张玲林海吴斌王超英刘畅孙佳凡闫少校刘君谢守付房茂胜宓为峰张鸿燕北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院)国家药物临床试验机构办公室北京100191 陕西省中医医院精神科陕西西安710003 沈阳市精神卫生中心精神科辽宁沈阳110168 山西中医学院附属医院精神科山西太原030024 山西大医院中医科山西大同037046 重庆市精神卫生中心精神科重庆400036 太原市精神病医院精神科山西太原030045 吉林省神经精神病医院精神科吉林松原138001 长春市第六医院精神科吉林长春130052 辽宁中医药大学附属医院精神科辽宁沈阳110033 河北省荣军医院精神科河北石家庄050899 衡水人民医院神经科河北衡水053099 郑州大学第一附属医院精神科河北郑州450052 天津市第四中心医院精神科天津300142 重庆医科大学附属第一医院精神科重庆400042 成都市第四人民医院精神科四川成都610036 山西医科大学第二医院精神科山西太原030001 河北省精神卫生中心精神科河北保定071030 首都医科大学附属北京安定医院精神科北京100120 西安市中医医院精神科陕西西安710021 西安市精神卫生中心精神科陕西西安710061 湖南省脑科医院精神科湖南长沙410021 吉林大学第一医院精神科吉林长春130061 山西省中西医结合医院精神科山西太原030013 北京回龙观医院精神科北京102208 辽宁中医药大学附属第二医院精神科辽宁沈阳110034 大连市第七人民医院精神科辽宁大连116086 武汉市精神卫生中心精神科湖北武汉430012

目的观察巴戟天寡糖胶囊用于治疗轻、中度抑郁症患者的24周巩固期的疗效和安全性。方法本研究采用开放、单臂、多中心设计,纳入已完成巴戟天寡糖急性期治疗的成人轻、中度抑郁症患者,继续给予巴戟天寡糖胶囊24周,巩固期维持治疗剂量不变... 详细信息

目的观察巴戟天寡糖胶囊用于治疗轻、中度抑郁症患者的24周巩固期的疗效和安全性。方法本研究采用开放、单臂、多中心设计,纳入已完成巴戟天寡糖急性期治疗的成人轻、中度抑郁症患者,继续给予巴戟天寡糖胶囊24周,巩固期维持治疗剂量不变,用汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)、临床总体印象量表-严重度(CGI-S)和亚利桑那性体验量表(ASEX)评估治疗前后的变化,评估患者的缓解率、复燃率及复燃时间,观察患者治疗相关不良事件的发生情况。结果治疗前后患者的HAMD-17评分分别为(6.60±1.87)和(5.85±4.18)分,HAMA评分分别为(6.36±3.02)和(4.93±3.09)分,CGI-S评分分别为(1.49±0.56)和(1.29±0.81)分,ASEX评分分别为(15.92±4.72)和(15.57±5.26)分,在统计学上差异均有统计学意义(均P<0.05)。用药24周末,患者的缓解率为54.59%(202例/370例),复燃率为6.49%(24例/370例),复燃时间为(64.67±42.47)d。巴戟天寡糖胶囊药物不良反应发生率为15.35%(64例/417例)。结论巴戟天寡糖胶囊能用于轻、中度抑郁症患者的巩固期治疗,且具有良好的耐受性和安全性。

关键词：巴戟天寡糖胶囊抑郁症疗效安全性

由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong Li Ruo-Yu liu Ruizhi yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China tianFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

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Signal Transduction and Targeted Therapy 2021年第1期6卷 95-104页

作者： Ke wang wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding wei yang Zhang xiu-Xuan Sun Li Gong Xu yang Lei He Lei Zhang zhiwei yang Jie-Jie Geng Ruo Chen Hai Zhang Bin wang Yu-meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao wu Peng Lin Wan Huang Liangzhi xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui min Huang Jun Zhang Ling Fu xiang-min yang zhongpeng Zhao Shihui Sun Hongjing Gu Zhe wang Chun-Fu wang Yacheng Lu Ying-Ying liu Qing-Yi wang Huijie Bian Ping Zhuzhi-Nan Chen National Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Biotechnology Beijing 100071China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Tangdu Hospital Fourth Military Medical UniversityXi’an 710038China MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter Xi’an Jiaotong UniversityXi’an 710049China Sino Biological Inc. Beijing 100176China Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi’an 710032China School of Basic Medicine Fourth Military Medical UniversityXi’an 710032China

In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until ***-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike *** ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the *** the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its ***,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike *** loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 *** of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular *** loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type ***,virions are observed in lymphocytes of lung tissue from a COVID-19 *** T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by ***,CD147 mediates virus entering host cells by ***,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19.

关键词： ACE2 CD147 intestine

Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)

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Military Medical Research 2022年第5期9卷 515-533页

作者： xian-Tao Zeng Ying-Hui Jin Tong-Zu liu Fang-ming Chen De-Gang Ding meng Fu xin-Quan Gu Bang-min Han xing Huang zhi Hou Wan-Li Hu xin-Li Kang Gong-Hui Li Jian-xing Li Pei-Jun Li Chao-Zhao Liang xiu-Heng liu zhi-Yu liu Chun-xiao liu Jiu-min liu Guang-Heng Luo Yi Luo wei-Jun Qin Jian-Hong Qiu Jian-xin Qiu Xue-Jun Shang Ben-Kang Shi Fa Sun Guo-xiang tian Ye tian Feng wang Feng wang Yin-Huai wang Yu-Jie wang zhi-Ping wang zhong wang Qiang wei min-Hui xiao Wan-Hai Xu Fa-xian Yi Chao-yang Zhu Qian-Yuan Zhuang Li-Qun Zhou xiao-Feng Zou Nian-Zeng xing Da-Lin He xing-Huan wang 无 Department of Urology Institute of UrologyZhongnan Hospital of Wuhan UniversityWuhan430071China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Urology Tianjin Third Central Hospital Affiliated To Nankai UniversityTianjin300170China Department of Urology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou450003China Department of Urology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China Department of Urology China-Japan Union Hospital of Jilin UniversityChangchun130033China Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China Department of Urology Qinghai University Affiliated HospitalXi’ning810012China Department of Urology People’s Hospital of Hainan ProvinceHainan Affiliated Hospital of Hainan Medical University HaikouHaikou570311China Department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016China Department of Urology General Hospital of Ningxia Medical UniversityYinchuan750003China Department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Urology Renmin Hospital of Wuhan UniversityWuhan430060China Department of Urology The Second Hospital of Dalian Medical UniversityDalian116023LiaoningChina Department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhou510282China Department of Urology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China Department of Urology Surgery Guizhou Province People’s HospitalGuiyang550002China Department of Urology Xijing Hospital of Air Force Military Medical UniversityXi’an710032China Department of Urology The 980St Hospital of the PLA Joint Logistics Support Force(Bethune International Peace Hospital of PLA)Shijiazhuang050082China Department of Urology

Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUPKP for BPH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUPKP in the treatment of BPH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUPKP for BPH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. Recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUPKP in the treatment of BPH included indications and contraindications for TUPKP, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different

关键词： Transurethral plasmakinetic resection of prostate Benign prostatic hyperplasia Recommendation Treatment guideline

Identifying SNPs associated with birth weight and days to 100 kg traits in Yorkshire pigs based on genotyping-by-sequencing

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Journal of Integrative Agriculture 2021年第9期20卷 2483-2490页

作者： wu Ping-xian ZHOU Jie wang Kai CHEN De-juan yang xi-di liu Yi-hui JIANG An-an SHEN Lin-yuan JIN Long xiAO wei-hang JIANG Yan-zhi LI ming-zhou ZHU Li ZENG yang-shuang XU Xu QIU xiao-tian LI Xue-wei TANG Guo-qing Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130P.R.China College of Life Science Sichuan Agricultural UniversityYa’an 625014P.R.China Sichuan Animal Husbandry Station Chengdu 610041P.R.China National Animal Husbandry Service Beijing 100125P.R.China

Birth weight(BW)and days to 100 kg(D100)are important economic traits that are both affected by ***,the genetic architecture of these quantitative traits is still ***-by-sequencing(GBS)data containing a large number of single nucleotide polymorphisms(SNPs)have become a powerful tool in genomic *** better understand their complex genetic structure,a total of 600 Yorkshire pigs were sequenced using GBS *** quality control,279787 SNPs were generated for subsequent genome-wide association study(GWAS).A total of 30 genome-wide SNPs(P<1.79 E–07)were identified for ***,a total of 22 and 2 suggestive SNPs(P<3.57 E–06)were detected for D100 and BW,*** these,one locus located on SSC12(position:46226512 bp)were evaluated to affect both BW and D100 in Yorkshire pigs,indicating the pleiotropism in different *** the function of candidate genes,two genes,NSRP1 and DOCK7,were suggested as the most promising candidate genes involved in growth ***,use of GBS is able to identify novel variants and potential candidate genes for BW and D100,and provide an opportunity for improving pig growth traits using genomic selection in pigs.

关键词： genotyping-by-sequencing GWAS birth weight days to 100 kg Yorkshire pigs

Epigenome-wide DNA methylation analysis reveals differentially methylation patterns in skeletal muscle between Chinese Chenghua and Qingyu pigs

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Journal of Integrative Agriculture 2022年第6期21卷 1731-1739页

作者： wang Kai wu Ping-xian wang Shu-jie JI xiang CHEN Dong JIANG An-an xiAO wei-hang JIANG Yan-zhi ZHU Li ZENG yang-shuang XU Xu QIU xiao-tian LI ming-zhou LI Xue-wei TANG Guo-qing Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130P.R.China College of Life Science Sichuan Agricultural UniversityYa’an 625014P.R.China Sichuan Animal Husbandry Station Chengdu 610041P.R.China National Animal Husbandry Service Beijing 100125P.R.China Chongqing Academy of Animal Science Chongqing 402460P.R.China

Chenghua(CH)pig and Qingyu(QY)pig are typical Chinese native fatty *** pig is mainly distributed in Chengdu Plain,while QY pig is widely distributed throughout the mountain areas around the Sichuan *** are significant differences in their phenotypic traits,including body image,growth performance,and meat *** study compared several meat quality traits of CH and QY pigs and conducted a genome-wide DNA methylation analysis using reduced representation bisulfite sequencing(RRBS).It was observed that the pH at 45 min(pH_(45min),P=5.22e-13),lightness at 45 min(L^(*)_(45min),P=4.85e-5),and lightness at 24 h(L^(*)_(24h),P=3.57e-5)of CH pigs were higher than those of QY *** detected 10699 differentially methylated cytosines(DMCs)and 2760 differentially methylated genes(DMGs)associated with these *** analysis showed that these DMGs were mainly enriched in the AMPK signaling pathway,Type II diabetes mellitus,Insulin signaling pathway,mTOR signaling pathway,and Insulin ***,15 DMGs were associated with fat metabolism(ACACA,CAB39,CRADD,CRTC2,FASN,and GCK),muscle development(HK2,IKBKB,MTOR,PIK3CD,PPARGC1A,and RPTOR),or meat quality traits(PCK1,PRKAG2,and SLC2A4).The findings may help to understand further the epigenetic regulation mechanisms of meat quality traits in pigs and provide new basic data for the study of local pigs.

关键词： DNA methylation reduced representation bisulfite sequencing(RRBS) Chenghua pig Qingyu pig

Tungsten-containing high-entropy alloys: a focused review of manufacturing routes, phase selection, mechanical properties, and irradiation resistance properties

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Tungsten 2021年第2期3卷 181-196页

作者： tian-xin Li Jun-wei Miao En-Yu Guo He Huang Jun wang Yi-Ping Lu Tong-min wang zhi-Qiang Cao Ting-Ju Li Key Laboratory of Solidifi cation Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Institute of Materials China Academy of Engineering PhysicsMianyang 621907China State Key Laboratory of Solidifi cation Processing Northwestern Polytechnical UniversityXi’an 710072China High Entropy Alloy Materials Engineering Research Center(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China

Alloying is one of the most effective means to confer superior properties to metal *** far too long,conventional W-based alloys were generally improved by the addition of minor *** exploitation of conventional W-based alloy is restricted to the corner of multielement phase diagrams with tiny compositional ***-entropy alloys(HEAs)are a novel kind of alloys consisting of multi-principal alloying elements(usually more than 4)and have attracted increasing attention,since they were first reported in *** emergence of HEAs filled the gap of the unexplored central region of multielement phase *** them,tungsten-containing HEAs(TCHEAs)exhibit excellent mechanical properties,especially at extraordinarily elevated ***,recent studies showed that TCHEAs had outstanding irradiation resistance *** might serve as a promising candidate for plasma-facing materials in the fusion *** characteristics of TCHEAs are different from other HEAs due to the addition of tungsten with ultrahigh-melting ***,this paper aimed to introduce the manufacturing routes of TCHEAs;review the phase selection,mechanical properties,and irradiation resistance properties of TCHEAs;and propose the future prospects of TCHEAs.

关键词： Tungsten-containing high-entropy alloys Irradiation resistance properties Mechanical properties Manufacturing routes Phase selection