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Land use and river-lake connectivity: Biodiversity determinants of lake ecosystems

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Environmental Science and Ecotechnology 2024年第5期21卷 329-340页

作者： Huiyu Xie Yu Ma xiaowei Jin Shiqi Jia Xu Zhao Xianfu Zhao Yongjiu Cai Jian Xu Fengchang wu John P.Giesy State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing100012China College of Water Sciences Beijing Normal UniversityBeijing100875China China National Environmental Monitoring Centre Beijing100012China Key Laboratory of Ecological Impacts of Hydraulic-Projects and Restoration of Aquatic Ecosystem of Ministry of Water Resources Institute of HydroecologyMinistry of Water Resources and Chinese Academy of SciencesWuhan430079China Nanjing Institute of Geography and limnology Chinese Academy of SciencesNanjing210008China Department of Integrative Biology Michigan State UniversityEast LansingMI48895USA Department of Veterinary Biomedical Sciences and Toxicology Centre University of SaskatchewanSaskatoonSaskatchewanS7N 5B3Canada Toxicology Centre and Department of Veterinary Biomedical Sciences University of Saskatchewan44 Campus DriveSaskatoonSKS7N 5B3SaskatoonSKCanada

Lake ecosystems confront escalating challenges to their stability and resilience,most intuitively leading to biodiversity loss,necessitating effective preservation strategies to safeguard aquatic ***,the complexity of ecological processes governing lake biodiversity under multi-stressor interactions remains an ongoing concern,primarily due to insufficient long-term bioindicator data,particularly concerning macroinvertebrate *** we utilize a unique,continuous,and in situ biomonitoring dataset spanning from 2011 to 2019 to investigate the spatio-temporal variation of macroinvertebrate *** assess the impact of four crucial environmental parameters on Lake Dongting and Lake Taihu,i.e.,water quality,hydrology,climate change,and land *** two systems are representative of lakes with yangtze-connected and disconnected subtropical floodplains in *** find an alarming trend of declining taxonomic and functional diversities among macroinvertebrate communities despite improvements in water *** contributing factors to this decline include persistent anthropogenic pressures,particularly alterations in human land use around the lakes,including intensified nutrient loads and reduced habitat ***,river-lake connectivity is pivotal in shaping differential responses to multiple *** results highlight a strong correlation between biodiversity alterations and land use within a 2e5 km radius and 0.05e2.5 km from the shorelines of Lakes Dongting and Taihu,*** findings highlight the importance of implementing land buffer zones with specific spatial scales to enhance taxonomic and functional diversity,securing essential ecosystem services and enhancing the resilience of crucial lake ecosystems.

关键词： Taxonomic richness Functional diversity Biotic homogenization River-lake connectivity Multiple stressors

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人工智能时代医疗领域性别公正问题及其治理

科学技术哲学研究 2024年第2期41卷 115-121页

作者：吴红上海交通大学马克思主义学院上海200240

随着社会的发展进步,性别平等与公正问题日益受到人们的关注。医疗领域长期存在性别不公现象,在人工智能时代中亦不例外。从医疗领域内部的角度看,我们需要在全面认识医疗领域的性别差异的基础上,培育医务人员的性别意识,在人工智能时... 详细信息

随着社会的发展进步,性别平等与公正问题日益受到人们的关注。医疗领域长期存在性别不公现象,在人工智能时代中亦不例外。从医疗领域内部的角度看,我们需要在全面认识医疗领域的性别差异的基础上,培育医务人员的性别意识,在人工智能时代中大力推进性别医学研究,目前许多国家与学术机构都朝着这个方面开展了大量工作。从社会治理的角度看,我们应该推进数据公正,加强算法治理,实现社会观念与相关制度的发展进步。通过医疗领域性别公正问题的特殊性研究,我们倡导尽可能将人工智能伦理研究与具体的应用场景相结合,走向一种场景化的伦理探索。

关键词：人工智能医疗性别公正治理

益气活血复方联合西医常规疗法治疗慢性心衰气虚血瘀证患者87例临床观察

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时珍国医国药 2024年第5期35卷 1171-1174页

作者：刘国华宫丽鸿张艳辽宁中医药大学辽宁沈阳110847 辽宁中医药大学附属医院辽宁沈阳110085 淄博市第一医院山东淄博255200

目的探讨益气活血复方治疗慢性心力衰竭气虚血瘀证患者的临床疗效。方法研究选取就诊于辽宁中医药大学附属医院专家门诊及同期住院并被诊断为慢性心力衰竭气虚血瘀证的患者90例。将90例患者按照就诊及治疗地点不同分为中药组、西药组,每... 详细信息

目的探讨益气活血复方治疗慢性心力衰竭气虚血瘀证患者的临床疗效。方法研究选取就诊于辽宁中医药大学附属医院专家门诊及同期住院并被诊断为慢性心力衰竭气虚血瘀证的患者90例。将90例患者按照就诊及治疗地点不同分为中药组、西药组,每组45例。两组患者均根据指南采用慢性心力衰竭规范化治疗,中药组在此基础上加用益气活血复方,对比两组治疗前后6分钟步行试验(6MWT)、左室射血分数(LVEF)、N末端脑钠肽前体(NT-proBNP)浓度、中医证候积分、基于中国文化改良的明尼苏达心力衰竭生存质量量表(C-MLHFQ)评分等指标变化。结果治疗前,两组患者各项观察指标对比差异无统计学意义,资料具有可比性(P>0.05)。治疗后,与西药组比较,中药组患者6MWT、LVEF、NT-proBNP、中医证候积分、C-MLHFQ等观察指标均优于对照组,差异具有统计学意义(P<0.001)。与本组治疗前比较,两组患者治疗后NT-proBNP、中医证候积分、C-MLHFQ水平均明显降低(P<0.001),而6MWT、LVEF均显著升高(P<0.001);与西药组治疗后比较,中药组患者改善更明显(P<0.001)。结论益气活血复方联合西医常规疗法能够改善慢性心力衰竭气虚血瘀证患者的临床症状,提高患者的运动耐量及生活质量,可以有效改善患者长期预后。

关键词：益气活血复方慢性心衰气虚血瘀证

Distribution of fatty acids in the alpine grassland soils of the Qinghai-Tibetan Plateau

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Science China Earth Sciences 2016年第7期59卷 1329-1338页

作者： DAI Guo hua ZHU Shan Shan liU Zong Guang CHEN li Tong HE Jin Sheng FENG xiao Juan State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau Biology Chinese Academy of Sciences Department of Ecology College of Urban and Environmental Sciences Peking University

As an important biomarker, fatty acids(FAs) have been extensively used to trace the origin of organic matter in sediments and soils. However, studies of the distribution and abundance of FAs in alpine grassland soils are still rare, especially on the Qinghai-Tibetan Plateau(QTP), the highest plateau in the world, which contributes sediments to many large rivers in Asia. This study investigates the composition, distribution and source of FAs with increasing soil depths from 17 typical alpine grassland sites in the QTP. The most abundant FAs included the ubiquitous C16 FA and even-numbered long-chain FAs(C20–C30), indicating mixed inputs from microbial and higher plant sources. Source apportionment showed that higher plants were the dominant contributor of FAs(approximately 40%) in QTP soils. The abundance of FAs decreased with soil depth, with the highest value(1.08±0.09 mg/g C) at a 0–10 cm depth and the lowest value(0.46±0.12 mg/g C) at a 50–70 cm depth, due to much lower plant inputs into the deeper horizons. The total concentration of FAs was negatively correlated to the mean annual temperature(MAT; Plitates the accumulation of fresh FAs in QTP soils. Other environmental parameters, such as the soil mineral content(aluminum and iron oxide), microbial community composition as well as litter quality and quantity, may also exert a strong control on the preservation of FAs in QTP soils and warrant further research to better understand the mechanisms responsible for the preservation of FAs in QTP soils.

关键词： Qinghai-Tibetan Plateau Soil organic matter Biomarker Fatty acids Distribution sources

冠菌素诱导橡胶树次生乳管分化的形成层细胞CUT&Tag文库构建和初步分析

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热带作物学报 2024年第10期45卷 2010-2024页

作者：张世鑫葛立鑫吴绍华晁金泉杨署光史敏晶张华田维敏中国热带农业科学院橡胶研究所/热带作物生物育种全国重点实验室/农业农村部橡胶树生物学与遗传资源利用重点实验室/海南省热带作物栽培生理学重点实验室海南海口571101 西藏农牧学院西藏林芝860000 中国科学院西双版纳热带植物园云南勐腊666303

CUT&Tag技术是一种研究蛋白质-DNA互作的新方法,使用超高活性的新型pG-Tn5转座酶,在抗体引导下精准靶向切割目的蛋白附近的DNA序列,从而进行cDNA建库和测序分析。此技术在人类和动物研究中应用广泛,由于植物细胞结构特殊,该技术在植物... 详细信息

CUT&Tag技术是一种研究蛋白质-DNA互作的新方法,使用超高活性的新型pG-Tn5转座酶,在抗体引导下精准靶向切割目的蛋白附近的DNA序列,从而进行cDNA建库和测序分析。此技术在人类和动物研究中应用广泛,由于植物细胞结构特殊,该技术在植物研究中应用较少。在前期研究中,我们发现组蛋白乙酰化修饰参与茉莉酸诱导橡胶树次生乳管分化的调控,但其分子机制尚未阐明。本研究利用冠菌素(COR)诱导橡胶树萌条维管形成层分化次生乳管的实验系统,通过酶解法获取高质量的形成层区细胞原生质体,使用组蛋白H3乙酰化修饰抗体对次生乳管分化过程中发生组蛋白乙酰化修饰的区域进行原位识别,采用CUT&Tag技术成功构建COR处理橡胶树树皮形成层细胞的cDNA文库。对构建cDNA文库进行质检和测序分析,发现文库质量较好,并通过差异基因的GO和KEGG富集分析,发现生长素、类黄酮代谢和蛋白质泛素化等相关基因得到富集。本研究结果为使用CUT&Tag技术构建植物组织的cDNA文库提供操作方法,为解析组蛋白乙酰化修饰调控橡胶树次生乳管分化的分子机制提供理论基础。

关键词：巴西橡胶树次生乳管分化维管形成层原生质体组蛋白乙酰化 CUT&Tag

Degenerate Orbit Flip Homoclinic Bifurcations with Higher Dimensions

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Acta Mathematica Sinica,English Series 2006年第6期22卷 1651-1656页

作者： Ran Chao wu Jian hua SUN Department of Mathematics Nanjing University Nanjing 210093 P. R. China

Bifurcations of a degenerate homoclinic orbit with orbit flip in high dimensional system are studied. By establishing a local coordinate system and a Poincare map near the homoclinic orbit, the existence and uniqueness of 1-homoclinic orbit and 1-periodic orbit are given. Also considered is the existence of 2-homoclinic orbit and 2-periodic orbit. In additon, the corresponding bifurcation surfaces are given.

关键词： Orbit flip Homoclinic bifurcations Poincaré map

Alu antisense RNA ameliorates methylglyoxal-induced human lens epithelial cell apoptosis by enhancing antioxidant defense

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 178-190页

作者： Pei-Yuan wu Ning Ji Chong-Guang wu xiao-Die Wang Xin liu Zhi-Xue Song Murad Khan Suleman Shah Ying-hua Du Xiu-Fang Wang li-Fang Yan Department of Genetics Hebei Medical UniversityHebei Key Lab of Laboratory AnimalShijiazhuang 050017Hebei ProvinceChina Department of Ophthalmology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

AIM:To determine whether an antisense RNA corresponding to the human Alu transposable element(Aluas RNA)can protect human lens epithelial cells(HLECs)from methylglyoxal-induced ***:Cell counting kit-8(CCK-8)and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assays were used to assess HLEC *** viability/death was detected using a Calcein-AM/PI double staining kit;the annexin V-FITC method was used to detect HLEC *** cytosolic reactive oxygen species(ROS)levels in HLECs were determined using a reactive species assay *** levels of malondialdehyde(MDA)and the antioxidant activities of total-superoxide dismutase(T-SOD)and glutathione peroxidase(GSH-Px)were assessed in HLECs using their respective ***-q PCR and Western blotting were used to measure m RNA and protein expression levels of the ***:Aluas RNA rescued methylglyoxal-induced apoptosis in HLECs and ameliorated both the methylglyoxalinduced decrease in Bcl-2 m RNA and the methylglyoxalinduced increase in Bax m *** addition,Aluas RNA inhibited the methylglyoxal-induced increase in Alu sense RNA *** RNA inhibited the production of ROS induced by methylglyoxal,restored T-SOD and GSHPx activity,and moderated the increase in MDA content after treatment with *** RNA significantly restored the methylglyoxal-induced down-regulation of Nrf2 gene and antioxidant defense genes,including glutathione peroxidase,heme oxygenase 1,γ-glutamylcysteine synthetase and quinone oxidoreductase *** RNA ameliorated methylglyoxal-induced increases of the m RNA and protein expression of Keap1 that is the negative regulator of ***:Aluas RNA reduces apoptosis induced by methylglyoxal by enhancing antioxidant defense.

关键词： human Alu antisense RNA human lens epithelial cells methylglyoxal toxicity antioxidant defense apoptosis

褪黑素对子宫内膜异位症病灶抑制作用的研究进展

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海军军医大学学报 2024年第9期45卷 1083-1088页

作者：寿鹤君段华首都医科大学附属北京妇产医院/北京妇幼保健院妇科微创中心北京100006

子宫内膜异位症是指子宫内膜腺体及间质在宫腔外的部位种植或生长,其病理机制包括免疫炎性改变、氧化应激、上皮-间质转化及新生血管生成等。子宫内膜异位症好发于育龄期女性,严重影响患者的生殖健康和生活质量,目前主要通过手术及长期... 详细信息

子宫内膜异位症是指子宫内膜腺体及间质在宫腔外的部位种植或生长,其病理机制包括免疫炎性改变、氧化应激、上皮-间质转化及新生血管生成等。子宫内膜异位症好发于育龄期女性,严重影响患者的生殖健康和生活质量,目前主要通过手术及长期药物管理进行治疗。褪黑素是一种内源性吲哚胺类激素,通过作用于不同的信号转导通路发挥抗氧化、抗炎、调节免疫功能和促进细胞凋亡等多种生理功能,在癌症、心血管疾病、神经系统疾病等疾病的治疗中备受关注。近年来研究发现褪黑素可通过抑制雌激素合成、拮抗血管生成等作用抑制子宫内膜异位症的发展,并能有效缓解盆腔疼痛。本文就褪黑素在子宫内膜异位症中作用的研究进展进行综述,以期为子宫内膜异位症的药物治疗提供新的思路。

关键词：子宫内膜异位症褪黑素氧化应激血管生成雌激素

Lanthanide-oxo clusters for efficient catalytic reduction of carboxamides

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Science China Chemistry 2023年第2期66卷 443-448页

作者： Zhen-Zhang Weng Chao-long Chen long-wu Ye La-Sheng long Lan-Sun Zheng Xiang-Jian Kong Collaborative Innovation Center of Chemistry for Energy Materials State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China

The reduction of carboxamides into high value-added amines is a very interesting but great challenging *** we demonstrate that polynuclear lanthanide-oxo clusters Ln16(Ln=Eu and Gd)can be used as efficient catalyst to reduce primary and secondary carboxamides to amines with excellent yield of 71%-98%and broad substrates *** methodology can extend to the gram-scale synthesis of phenethylamine drug with 93%*** on the isolation and characterization of catalytic intermediates,a catalytic mechanism involving multipath reaction is *** work provides efficient lanthanide cluster catalysts for the reduction of carboxamides to amines.

关键词： lanthanide clusters amide reduction metal-hydride BH3 catalytic mechanism