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基于图论分析探究2型糖尿病脑网络结构全局拓扑属性的改变

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中国临床医学影像杂志 2024年第8期35卷 537-540页

作者：许珊汪旭洋杨东杨芸林琳沈晶宗建国伍建林大连大学附属中山医院放射科辽宁大连116001

目的:通过扩散谱成像(Diffusion spectrum imaging,DSI)及图论分析探究2型糖尿病(T2DM)患者脑网络全局拓扑属性改变及其与相关临床指标和认知功能评分的相关性。方法:收集符合诊断标准的27例T2DM患者(T2DM组)及招募性别、年龄、受教育... 详细信息

目的:通过扩散谱成像(Diffusion spectrum imaging,DSI)及图论分析探究2型糖尿病(T2DM)患者脑网络全局拓扑属性改变及其与相关临床指标和认知功能评分的相关性。方法:收集符合诊断标准的27例T2DM患者(T2DM组)及招募性别、年龄、受教育年限相匹配的19例健康志愿者(HC组),采用认知量表等检测受试者MoCA、VFT、焦虑相关评分,并收集空腹血糖、甘油三酯、高密度脂蛋白等临床指标。均使用3.0T MRI行DSI扫描,通过DSI-STUDIO软件构建全脑结构网络并计算全局网络拓扑属性。分析两组被试脑网络全局拓扑属性的差异,将年龄、性别作为协变量,采用spearman偏相关分析评估T2DM患者脑结构网络相关特征参数与临床相关指标及认知评分的相关性,以P<0.05为差异具有统计学意义。结果:T2DM组的小世界系数、全局效率、聚类系数及富人俱乐部(rich-club)系数(k=5、15)均低于HC组(P<0.05),而T2DM组特征路径长度高于HC组(P<0.05)。此外,rich-club系数(k=5)与焦虑呈负相关(r=-0.630,P=0.001),rich-club系数(k=15)与FPG呈负相关(r=-0.398,P=0.049)。结论:T2DM患者小世界系数、全局效率及聚类系数的全局传输能力均显示下降并伴纤维富集区域损伤,其中焦虑及空腹血糖的改变可能与全局拓扑属性之间存在一定关联。

关键词：糖尿病,2型脑磁共振检查

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预付式消费中消费者权益保护的法律对策

河北法律职业教育

河北法律职业教育 2024年第9期2卷 89-94页

作者：吴建林刘家玮河北地质大学法政学院河北冀梦律师事务所

预付式消费作为一种新兴的消费模式,在方便消费者同时,也引发了诸多消费者权益保护问题。结合预付式消费的基本理论,分析预付式消费中消费者包括知情权、自主选择权、公平交易权和求偿权在内的权益。对预付式消费中消费者权益保护存在... 详细信息

预付式消费作为一种新兴的消费模式,在方便消费者同时,也引发了诸多消费者权益保护问题。结合预付式消费的基本理论,分析预付式消费中消费者包括知情权、自主选择权、公平交易权和求偿权在内的权益。对预付式消费中消费者权益保护存在的法律问题,如信息披露不充分、强制消费、价格欺诈和求偿困难等提出完善的预付式消费中消费者权益保护的法律对策,包括加强信息披露义务、规范合同条款、强化价格监管和畅通消费维权渠道等。

关键词：预付式消费消费者权益法律保护合同条款

复杂不良地质条件下超长隧道钻爆施工关键技术

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建筑机械 2024年第8期 91-96页

作者：蒋仁国武建林中交一公局集团有限公司北京100024

为解决超长隧道施工时不良地质处治及钻爆施工的难题,文章以新越西隧道为工程背景,首先结合地勘报告与现场情况分析得出该隧道不良地质主要为岩堆、岩溶、采空区、高地应力,特殊岩土为石膏。针对性提出了相应不良地质处治方案,如突水突... 详细信息

为解决超长隧道施工时不良地质处治及钻爆施工的难题,文章以新越西隧道为工程背景,首先结合地勘报告与现场情况分析得出该隧道不良地质主要为岩堆、岩溶、采空区、高地应力,特殊岩土为石膏。针对性提出了相应不良地质处治方案,如突水突泥处治主要通过超前地质预报及超前周边帷幕注浆法加固围岩;岩堆通过钢管桩注浆、加固桩等进行岩体加固。对隧道洞深开挖的微台阶开挖、组合方式开挖施工关键技术及钻爆设计与施工控制进行了研究,主要包括开挖流程、施工控制要点、爆破参数及优化等。本项目运营结果表明,新越西隧道不良地质处治技术及钻爆施工方案显著提升了工程质量,缩短了施工工期,保证了隧道运营的安全性与经济效益。

关键词：隧道工程不良地质钻爆施工微台阶开挖施工技术

大数据背景下工商管理学生数据分析能力素质模型的构建与应用

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教育教学论坛 2024年第6期 17-21页

作者：吴剑琳石锦朱宁中国科学技术大学管理学院安徽合肥230026

在大数据时代背景下,企业对工商管理人才的数据分析能力要求提升,这也对高校现有工商管理学生的培养方式提出了挑战。基于访谈、岗位分析和理论分析,工商管理学生应具备数据分析知识和技能、数据思维和数据态度,据此构建数据分析能力素... 详细信息

在大数据时代背景下,企业对工商管理人才的数据分析能力要求提升,这也对高校现有工商管理学生的培养方式提出了挑战。基于访谈、岗位分析和理论分析,工商管理学生应具备数据分析知识和技能、数据思维和数据态度,据此构建数据分析能力素质模型,并建立相应的测量模型和指标体系,包括数据获取能力、数据预处理能力、数据分析能力、数据应用能力、数据思维和数据态度六个方面,运用数据分析能力素质模型能够为高校培养工商管理学生数据分析能力提供理论支持与实践建议。

关键词：工商管理数据分析能力能力素质模型大数据

基层医务人员突发公共卫生事件韧性评价指标体系的构建

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中国健康教育 2024年第6期40卷 531-537,574页

作者：吴巧慧许军吴霖健刘莉刘琛方浩庭张金华南方医科大学公共卫生学院广东广州510515 南方医科大学南方医院广东广州510515 广东石油化工学院广东茂名525000

目的筛选并构建科学有效的基层医务人员突发公共卫生事件韧性评价体系。方法通过文献阅读法确定备选的指标,采用Delphi专家咨询法对备选指标进行3轮专家意见的征询,然后对筛选后的指标进行第4轮专家征询,最后采用属性层次分析法对韧性... 详细信息

目的筛选并构建科学有效的基层医务人员突发公共卫生事件韧性评价体系。方法通过文献阅读法确定备选的指标,采用Delphi专家咨询法对备选指标进行3轮专家意见的征询,然后对筛选后的指标进行第4轮专家征询,最后采用属性层次分析法对韧性评价指标体系赋予权重。共有25名专家参与Delphi法专家咨询。结果本研究所邀请的专家涉足近8个学科领域,平均专业年限15.69。前3轮征询专家一致性系数Kendall's W分别为0.372,0.409和0.394。建立了3个层级的指标体系:一级指标为基层医务人员的职业素养(权重0.346)、心理资本(权重0.614)和应急态度(权重0.040),二级指标有13个内容,进一步细分为46个三级指标。结论Delphi法结合属性层次分析法用于基层医务人员突发公共卫生事件韧性评估指标体系的筛选是有效可行的。构建的基层医务人员韧性评估体系能系统地评估基层医务人员面对突发公共卫生事件时所具备的韧性,可为提高基层医疗单位的突发公共卫生事件应对能力提供策略依据。

关键词：基层医务人员韧性公共卫生事件 Delphi法属性层次分析法

Optimal Stiffness for Flexible Connectors on A Mobile Offshore Base at Rough Sea States

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China Ocean Engineering 2018年第6期32卷 683-695页

作者： wu lin-jian WANG Yuan-zhan WANG Yu-chi CHEN Jia-yu LI Yi LI Qing-mei XIE Tao State Key Laboratory of Hydraulic Engineering Simulation and Safety Collaborative Innovation Center for Advanced Ship and Deep-Sea ExplorationTianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300072China College of Engineering Ocean University of ChinaQingdao 266100China Chongqing Shipping Engineering Survey and Design Institute of the Yangtze River Chongqing 401147China School of River&Ocean Engineering Chongqing Jiaotong UniversityChongqing 400074China

This paper investigates a simplified method to determine the optimal stiffness of flexible connectors on a mobile offshore base(MOB) during the preliminary design stage. A three-module numerical model of an MOB was used as a case study. Numerous constraint forces and relative displacements for the connectors at rough sea states with different wave angles were utilized to determine the optimized stiffness of the flexible connectors. The range of optimal stiffnesses for the connectors was obtained based on the combination and intersection of the optimized stiffness results, and the implementation steps were elaborated in detail. The percentage reductions of the optimized and optimal stiffness of the flexible connector were determined to quantitatively evaluate the decreases of the constraint force and relative displacement of the connectors compared with those calculated by using the original range of the connector stiffnesses. The results indicate the accuracy and feasibility of this method for determining the optimal stiffness of the flexible connectors and demonstrate the rationality and practicability of the optimal stiffness results. The research ideas, calculation process, and solutions for the optimal stiffness of the flexible connectors of an MOB in this paper can provide valuable technical support for the design of the connectors in similar semisubmersible floating structures.

关键词： mobile offshore base(MOB) flexible connectors the optimal stiffness rough sea states

Sustained release of vascular endothelial growth factor A and basic fibroblast growth factor from nanofiber membranes reduces oxygen/glucose deprivation-induced injury to neurovascular units

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Neural Regeneration Research 2024年第4期19卷 887-894页

作者： Yifang wu Jun Sun Qi lin Dapeng Wang jian Hai Department of Neurosurgery Tongji HospitalSchool of MedicineTongji University Department of Pharmacy Institute of Medical SciencesShanghai Jiao Tong University School of Medicine

Upregulation of vascular endothelial growth factor A/basic fibroblast growth factor(VEGFA/b FGF)expression in the penumbra of cerebral ischemia can increase vascular volume,reduce lesion volume,and enhance neural cell proliferation and differentiation,thereby exerting neuroprotective ***,the beneficial effects of endogenous VEGFA/b FGF are limited as their expression is only transiently *** this study,we generated multilayered nanofiber membranes loaded with VEGFA/b FGF using layer-by-layer self-assembly and electrospinning *** found that a membrane containing 10 layers had an ideal ultrastructure and could efficiently and stably release growth factors for more than 1 *** 10-layered nanofiber membrane promoted brain microvascular endothelial cell tube formation and proliferation,inhibited neuronal apoptosis,upregulated the expression of tight junction proteins,and improved the viability of various cellular components of neurovascular units under conditions of oxygen/glucose ***,this nanofiber membrane decreased the expression of Janus kinase-2/signal transducer and activator of transcription-3(JAK2/STAT3),Bax/Bcl-2,and cleaved ***,this nanofiber membrane exhibits a neuroprotective effect on oxygen/glucose-deprived neurovascular units by inhibiting the JAK2/STAT3 pathway.

关键词： brain ischemia brain microvascular endothelial cell nanofiber membrane neurovascular unit

冠状动脉CTA结合动态心电图夜间ST段趋势图诊断冠状动脉硬化性心脏病的价值研究

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现代生物医学进展 2024年第4期24卷 718-723页

作者：李枝峻殷广吴建林李欢祝家成重庆医科大学附属第一医院南川医院放射科重庆408400 重庆医科大学附属第一医院南川医院心内科重庆408400 重庆医科大学附属第一医院南川医院设备科重庆408400 重庆三峡医药高等专科学校附属人民医院放射科重庆404000

目的:探讨冠状动脉CTA结合动态心电图夜间ST段趋势图对冠状动脉硬化性心脏病(冠心病)的诊断价值。方法:回顾性分析2022年1月-2023年2月在我院疑似冠心病的患者104例,所有患者均行冠状动脉造影、冠状动脉CTA、动态心电图及临床相关实验... 详细信息

目的:探讨冠状动脉CTA结合动态心电图夜间ST段趋势图对冠状动脉硬化性心脏病(冠心病)的诊断价值。方法:回顾性分析2022年1月-2023年2月在我院疑似冠心病的患者104例,所有患者均行冠状动脉造影、冠状动脉CTA、动态心电图及临床相关实验室检查。以冠状动脉造影结果作为诊断冠心病的金标准,分析比较冠状动脉CTA、动态心电图夜间ST段趋势图及两者联合诊断冠心病的诊断效能和一致性。结果:104例疑似冠心病的患者确诊93例(89.42%)。冠状动脉CTA诊断冠心病的敏感性为90.32%,特异性为72.73%,阳性预测值为96.55%,阴性预测值为47.06%,准确率为88.46%,与冠状动脉造影的Kappa值为0.813,一致性好。动态心电图夜间ST段趋势图诊断冠心病的敏感性为84.95%,特异性为63.64%,阳性预测值为95.18%,阴性预测值为33.33%,准确率为82.69%,与冠状动脉造影的Kappa值为0.724,一致性较好。有夜间ST段动态改变的冠心病检出率(84.95%,79/93)明显高于无夜间ST段动态改变的冠心病检出率(15.05%,14/93),差异有统计学意义(P<0.001)。冠状动脉CTA结合动态心电图夜间ST段趋势图诊断冠心病的敏感性为96.77%,特异性为90.91%,阳性预测值为98.90%,阴性预测值为76.92%,准确率为96.15%,与冠状动脉造影的Kappa值为0.923,一致性好。结论:冠状动脉CTA结合动态心电图夜间ST段趋势图诊断冠心病的临床价值优于冠状动脉CTA或动态心电图夜间ST段趋势图单独检查。

关键词：冠状动脉CTA 动态心电图夜间ST段趋势图冠状动脉硬化性心脏病

Terrain or climate factor dominates vegetation resilience?Evidence from three national parks across different climatic zones in China

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Forest Ecosystems 2024年第4期11卷 526-542页

作者： Shuang Liu lingxin wu Shiyong Zhen Qinxian lin Xisheng Hu jian Li College of Transportation and Civil Engineering Fujian Agriculture and Forestry UniversityFuzhou 350002China College of JunCao Science and Ecology Fujian Agriculture and Forestry UniversityFuzhou 350002China College of Forestry Fujian Agriculture and Forestry UniversityFuzhou 350002China

Vegetation resilience(VR),providing an objective measure of ecosystem health,has received considerable attention,however,there is still limited understanding of whether the dominant factors differ across different climate *** took the three national parks(Hainan Tropical Rainforest National Park,HTR;wuyishan National Park,WYS;and Northeast Tiger and Leopard National Park,NTL)of China with less human interference as cases,which are distributed in different climatic zones,including tropical,subtropical and temperate monsoon climates,***,we employed the probabilistic decay method to explore the spatio-temporal changes in the VR and their natural driving patterns using Geographically Weighted Regression(GWR)model as *** results revealed that:(1)from 2000 to 2020,the Normalized Difference Vegetation Index(NDVI)of the three national parks fluctuated between 0.800 and 0.960,exhibiting an overall upward trend,with the mean NDVI of NTL(0.923)>HTR(0.899)>WYS(0.823);(2)the positive trend decay time of vegetation exceeded that of negative trend,indicating vegetation gradual recovery of the three national parks since 2012;(3)the VR of HTR was primarily influenced by elevation,aspect,average annual temperature change(AATC),and average annual precipitation change(AAPC);the WYS'VR was mainly affected by elevation,average annual precipitation(AAP),and AAPC;while the terrain factors(elevation and slope)were the main driving factors of VR in NTL;(4)among the main factors influencing the VR changes,the AAPC had the highest proportion in HTR(66.7%),and the AAP occupied the largest area proportion in WYS(80.4%).While in NTL,elevation served as the main driving factor for the VR,encompassing 64.2%of its ***,our findings indicated that precipitation factors were the main driving force for the VR changes in HTR and WYS national parks,while elevation was the main factors that drove the VR in *** research has promoted a deeper understanding of the dri

关键词： National parks Vegetation resilience NDVI Probabilistic decay model Driving factors