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Photonics Research 2024年第5期12卷 986-994页

作者： YONG PAN lijie wu YUAN ZHANG YIHAO ZHANG JIE XU HAIXIA XIE JIANGUO CAO College of Science Xi'an University of Architecture and TechnologyXi'an 710055China

The hot electron transfer resulting in fluorescence enhancement is significantly meaningful for theory and experiment of the study on photoelectric ***,the laser emission based on direct hot electron transfer is difficult to realize because of the low transfer *** achieve a laser with a new-generation mechanism based on hot electron transfer,the photoelectric co-excitation is proposed for improving the efficiency of hot electron *** lasing behavior at 532 nm is realized with a threshold of 5 kw cm^(-2)and 1μA,which can be considered as the hot electron transfer resulting in population inversion ***,the lasing output power is 0.3 *** hot electrons transfer process was described via the transient absorption spectrum according to the improved ground-state bleaching and excited-state absorption signal in device *** comparison with the optical pump only,the quantum efficiencies of hot electron generation(HEG)and hot electron transfer(HET)were increased~31%and 31%,*** importantly,a triple gain mode coupling device including local surface plasmon,hot electron transfer,and array oscillation was *** modes of population inversion enhancement are *** study can provide theoretical and experimental reference for the research of hot electron lasers and devices.

关键词： polarization pump transfer

Cryo-EM structure of cannabinoid receptor CB1-β-arrestincomplex

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Protein & Cell 2024年第3期15卷 230-234页

作者： Yuxia Wang lijie wu Tian Wang Junlin Liu Fei Li Longquan Jiang Zhongbo Fan Yanan Yu Na Chen Qianqian Sun Qiwen Tan Tian Hua Zhi-Jie Liu iHuman Institute ShanghaiTech UniversityShanghai 201210China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Institute of Molecular and Clinical Medicine Kunming Medical UniversityKunming 650500China

Dear Editor,G protein-coupled receptors(GPCRs)play a vital role in regulating almost every aspect of human physiology,making up more than one-third of marketed drug targets(Santos et al.,2017).GPCRs orchestrate their signalling through interactions with three distinct downstream protein families:G proteins,G protein-coupled receptor kinases(GRKs),and arrestins(Santos et al.,2017).While G protein-mediated signalling is initiated upon GPCR stimulation,activated GPCRs return to their basal levels through a GRK-and arrestin-regulated desensitization process(Santos et al.,2017).In addition to modulating receptor desensitization,β-arrestin also regulates downstream events that are distinct from classical G protein signalling(Ahn et al.,2020).

关键词： stimulation return

艾灸治疗慢性炎性内脏痛的机制研究:脊髓p38 MAPK/ELK1信号通路的调节

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Journal of Acupuncture and Tuina Science 2024年第4期22卷 263-272页

作者：张丹李志元于华鹏吴焕淦吴丽洁杨韵杨光谢晨洪珏杨延婷马晓芃 Shanghai Research Institute of Acupuncture and Meridian Shanghai 200030China Shenzhen Hospital Beijing University of Chinese MedicineShenzhen 518100China Eye&ENT Hospital of Fudan University Shanghai 200031China The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310006China Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China

目的:从调节脊髓p38丝裂原活化蛋白激酶(MAPK)/Ets样转录因子1(ELK1)信号通路角度,探讨艾灸治疗慢性炎性内脏痛(CIVP)的中枢机制及其镇痛效应。方法:清洁级雄性Sprague-Dawley大鼠随机分为正常组、模型组、隔药灸组、假隔药灸组、p38 M... 详细信息

目的:从调节脊髓p38丝裂原活化蛋白激酶(MAPK)/Ets样转录因子1(ELK1)信号通路角度,探讨艾灸治疗慢性炎性内脏痛(CIVP)的中枢机制及其镇痛效应。方法:清洁级雄性Sprague-Dawley大鼠随机分为正常组、模型组、隔药灸组、假隔药灸组、p38 MAPK抑制剂组和二甲基亚砜(DMSO)组。采用2,4,6-三硝基苯磺酸合50%乙醇灌肠制备CIVP大鼠模型。隔药灸组给予隔附子饼灸治疗;假隔药灸组处理同隔药灸组,但不点燃艾炷;p38 MAPK抑制剂组在大鼠L5-L6间鞘内注射SB203580;DMSO组在L5-L6间鞘内注射2%DMSO。通过腹壁撤回反射(AWR)评分、机械刺激缩足阈值(MWT)及热缩足潜伏期(TWL)观察各组大鼠痛行为变化;应用苏木素-伊红染色镜下观察各组大鼠结肠组织形态学变化;采用免疫印迹法和实时荧光定量聚合酶链反应检测各组大鼠脊髓凋亡信号调节激酶1(ASK1)、MAPK激酶(MKK)3/6、p38 MAPK、ELK1和丝裂原应激活化蛋白激酶1(MSK1)磷酸化蛋白和mRNA的表达。结果:与正常组比较,CIVP大鼠结肠炎性损伤严重,病理损伤评分明显升高;不同压力结直肠扩张(CRD)刺激下AWR评分均增加,MWT及TWL均降低;脊髓p38 MAPK、ELK1、MSK1、ASK1、MKK3/6磷酸化蛋白和mRNA表达显著增加(P0.05)。结论:隔药灸能通过下调CIVP大鼠脊髓ASK1、MKK3、p38 MAPK、ELK1磷酸化蛋白和mRNA的表达发挥镇痛效应。抑制脊髓p38 MAPK/ELK1信号通路活化可能是隔药灸缓解疼痛,治疗CIVP的机制之一。

关键词：灸法药饼灸疗法炎症性肠病内脏痛内脏高敏感 P38丝裂原活化蛋白激酶信号通路大鼠

组分百日咳抗原中间品中内毒素含量动态显色定量检测方法的建立及验证

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中国生物制品学杂志 2024年第2期37卷 209-214页

作者：赵明刘婷马昱吴丽洁付慧李世慧北京生物制品研究所有限责任公司北京100176

目的建立组分百日咳抗原中间品中内毒素含量的动态显色定量检测方法,并对方法进行验证,以期更好地对组分百白破疫苗进行质量控制。方法建立动态显色法(美洲鲎试剂)检测百日咳各抗原中间品脱毒后的内毒素含量,对方法的线性、专属性、... 详细信息

目的建立组分百日咳抗原中间品中内毒素含量的动态显色定量检测方法,并对方法进行验证,以期更好地对组分百白破疫苗进行质量控制。方法建立动态显色法(美洲鲎试剂)检测百日咳各抗原中间品脱毒后的内毒素含量,对方法的线性、专属性、准确性、重复性、中间精密度进行验证,并对动态显色法定量检测结果与凝胶法检测结果进行对比。结果动态显色法线性相关系数的绝对值(|r|)大于0.99;最大有效稀释倍数下中间品的干扰试验回收率在50%~200%之间,脱毒后百日咳类毒素(pertussis toxin,PT)稀释至10、100、1 000倍,丝状血凝素(filamentous hemagglutinin,FHA)稀释至3 000、5 000、10 000倍,百日咳黏附素(pertussis adhesin,PRN)稀释至50、75、100倍对试验均无干扰作用;PT、FHA和PRN的准确性验证回收率分别为125%、110%和99%,重复性验证变异系数(CV)分别为7.21%、8.31%和5.84%,中间精密度验证CV分别为6.04%、16.29%和12.23%。动态显色法检测3批百日咳抗原中间品细菌内毒素含量与凝胶法检测结果一致,均小于脱毒后百日咳抗原中间品中细菌内毒素限值。结论建立的动态显色法具有良好的线性、专属性、准确性及精密性,检测结果准确,可用于脱毒后组分百日咳抗原中间品中内毒素含量的检测。

关键词：内毒素动态显色法百日咳抗原中间品鲎试剂

中国20个城市2~<7岁儿童血清维生素A和维生素D水平现况调查

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中华儿科杂志 2024年第3期62卷 231-238页

作者：吴琼辉陈倩杨亭陈洁陈立向雪利贾飞勇武丽杰郝燕李玲张婕柯晓燕衣明纪洪琦陈津津方拴锋王益超王琦李廷玉重庆医科大学附属儿童医院儿童营养研究中心、国家儿童健康与疾病临床医学研究中心、儿童发育疾病研究教育部重点实验室、儿童营养与健康重庆市重点实验室重庆400014 吉林大学第一医院发育行为儿科长春130031 哈尔滨医科大学公共卫生学院儿少卫生与妇幼保健学教研室哈尔滨150001 华中科技大学同济医学院附属同济医院儿童保健科武汉430030 海南省妇女儿童医学中心儿童康复科海口570206 西安市儿童医院儿童保健中心西安710003 南京医科大学附属脑科医院儿童心理卫生研究中心南京210000 青岛大学附属医院儿童保健科青岛266000 深圳市宝安区妇幼保健院儿童心理行为科深圳518000 上海交通大学附属儿童医院儿童保健科上海市儿童医院上海200000 郑州大学附属儿童医院儿童保健科郑州450018 湖南省妇幼保健院国家卫生健康委员会出生缺陷研究与预防重点实验室长沙410008 德阳市妇幼保健院儿童保健科德阳618000

目的调查我国20个城市2~<7岁儿童血清维生素A和维生素D水平。方法横断面研究,2018年9月至2019年9月在中国20个城市中共招募2924名2~<7岁健康儿童,按年龄分为2~<3岁、3~<5岁和5~<7岁组。对入组儿童进行人口经济学特征及相关健康知识问卷... 详细信息

目的调查我国20个城市2~<7岁儿童血清维生素A和维生素D水平。方法横断面研究,2018年9月至2019年9月在中国20个城市中共招募2924名2~<7岁健康儿童,按年龄分为2~<3岁、3~<5岁和5~<7岁组。对入组儿童进行人口经济学特征及相关健康知识问卷调查,测定儿童体重和身高,采用高效液相色谱-串联质谱法检测儿童血清维生素A、D水平。采用χ^(2)检验和多因素Logistic回归分析维生素A、D缺乏和不足的影响因素。结果2924名儿童年龄4.33(3.42,5.17)岁,男1726名(59.03%)、女1198名(40.97%)。总体儿童维生素A、D缺乏率分别为2.19%(64/2924)和3.52%(103/2924),不足率分别为29.27%(856/2924)和22.20%(649/2924)。10.50%(307/2924)的儿童维生素A、D均不充足。3~<5岁和5~<7岁组儿童维生素A(χ^(2)=7.91、8.06,均P=0.005)、维生素D(χ^(2)=71.35、115.10,均P<0.001)不足率均高于2~<3岁组儿童。近3个月补充维生素A、D分别是维生素A、D不充足的保护因素(OR=0.68、0.22,95%CI 0.49~0.95、0.13~0.40,均P<0.05)。家庭年收入<6万元的儿童中维生素A、D不足率显著高于家庭年收入≥6万元的儿童(χ^(2)=34.11、10.43,均P<0.01);西北和西南分别为2~<7岁维生素A和维生素D不足率最高的地区(χ^(2)=93.22、202.54,均P<0.001)。结论我国20个城市中2~<7岁儿童维生素A、D不足率均较高。年龄、家庭经济水平、近期补充以及地区经济水平等因素均可影响维生素A、D营养状况。应高度关注学龄前儿童的维生素A、D营养状况。

关键词：维生素A 维生素D 儿童多中心研究

Space-frequency-polarization-division multiplexed wireless communication system using anisotropic space-time-coding digital metasurface

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National Science Review 2022年第11期9卷 149-160页

作者： Jun Chen Ke Xiangyu Chen Wankai Tang Ming Zheng Chen Lei Zhang Li Wang Jun Yan Dai Jin Yang Jun Wei Zhang lijie wu Qiang Cheng Shi Jin Tie Jun Cui State Key Laboratory of Millimeter Waves Southeast University Institute of Electromagnetic Space Southeast University Frontiers Science Center for Mobile Information Communication and Security Southeast University National Mobile Communications Research Laboratory Southeast University Southeast University wuxi Campus

In the past few years, wireless communications based on digital coding metasurfaces have gained research interest owing to their simplified architectures and low cost. However, in most of the metasurface-based wireless systems, a single-polarization scenario is used, limiting the channel capacities. To solve the problem, multiplexing methods have been adopted, but the system complexity is inevitably increased. Here,a space-frequency-polarization-division multiplexed wireless communication system is proposed using an anisotropic space-time-coding digital metasurface. By separately designing time-varying control voltage sequences for differently oriented varactor diodes integrated on the metasurface, we achieve frequency-polarization-division multiplexed modulations. By further introducing different time-delay gradients to the control voltage sequences in two polarization directions, we successfully obtain space-frequency-polarization-division multiplexed modulations to realize a wireless communication system with a new architecture. The new communication system is designed with compact dual-polarized meta-elements, and can improve channel capacity and space utilization. Experimental results demonstrate the high-performance and real-time transmission capability of the proposed communication system,confirming its potential application in multiple-user collaborative wireless communications.

关键词： polarization-division multiplexing frequency-division multiplexing space-division multiplexing space-time coding wireless communication

Extracting Vegetation Phenology Metrics in Changbai Mountains Using an Improved Logistic Model

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Chinese Geographical Science 2011年第3期21卷 304-311页

作者： LI Ming wu Zhengfang QIN lijie MENG Xiangjun School of Urban and Environmental Sciences Northeast Normal University Changchun 130024 China

Remotely sensing images are now available for monitoring vegetation dynamics over large *** this paper,an improved logistic model that combines double logistic model and global function was *** this model with SPOT/NDVI data,three key vegetation phenology metrics,the start of growing season (SOS),the end of growing season (EOS) and the length of growing season (LOS),were extracted and mapped in the Changbai Mountains,and the relationship between the key phenology metrics and elevation were *** show that average SOS of forest,cropland and grassland in the Changbai Mountains are on the 119th,145th,and 133rd day of year,*** EOS of forest and grassland are similar,with the average on the 280th and 278th,*** comparison,average EOS of the cropland is relatively *** LOS of forest is mainly from the 160th to 180th,that of the grassland extends from the 140th to the 160th,and that of cropland stretches from the 110th to the *** the latitude increases for the same land cover in the study area,the SOS significantly delays and the EOS becomes *** SOS delays approximately three days as the elevation increases 100 m in the areas with elevation higher than 900 m above sea level (a.s.l.).The EOS is slightly earlier as the elevation increases especially in the areas with elevation below 1200 m *** LOS shortens approximately four days as the elevation increases 100 m in the areas with elevation higher than 900 m *** relationships between vegetation phenology metrics and elevation may be greatly influenced by the land *** by comparing with the field data and previous research results indicates that the improved logistic model is reliable and effective for extracting vegetation phenology metrics.

关键词： Logistic模型物候指标植被动态长白山提取海拔高度生长季节土地覆盖

Multi-Scale Mixed Attention Tea Shoot Instance Segmentation Model

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 261-275页

作者： Dongmei Chen Peipei Cao lijie Yan Huidong Chen Jia Lin Xin Li Lin Yuan Kaihua wu School of Automation Hangzhou Dianzi UniversityHangzhou310018China Tea Research Institute Chinese Academy of Agriculture SciencesHangzhou310018China School of Information Engineering Zhejiang University of Water Resources and Electric PowerHangzhou310018China

Tea leaf picking is a crucial stage in tea production that directly influences the quality and value of the *** tea-picking machines may compromise the quality of the tea ***-quality teas are often handpicked and need more delicate operations in intelligent picking *** with traditional image processing techniques,deep learning models have stronger feature extraction capabilities,and better generalization and are more suitable for practical tea shoot ***,current research mostly focuses on shoot detection and cannot directly accomplish end-to-end shoot segmentation *** propose a tea shoot instance segmentation model based on multi-scale mixed attention(Mask2FusionNet)using a dataset from the tea garden in *** further analyzed the characteristics of the tea shoot dataset,where the proportion of small to medium-sized targets is 89.9%.Our algorithm is compared with several mainstream object segmentation algorithms,and the results demonstrate that our model achieves an accuracy of 82%in recognizing the tea shoots,showing a better performance compared to other *** ablation experiments,we found that ResNet50,PointRend strategy,and the Feature Pyramid Network(FPN)architecture can improve performance by 1.6%,1.4%,and 2.4%,*** experiments demonstrated that our proposed multi-scale and point selection strategy optimizes the feature extraction capability for overlapping small *** results indicate that the proposed Mask2FusionNet model can perform the shoot segmentation in unstructured environments,realizing the individual distinction of tea shoots,and complete extraction of the shoot edge contours with a segmentation accuracy of 82.0%.The research results can provide algorithmic support for the segmentation and intelligent harvesting of premium tea shoots at different scales.

关键词： Tea shoots attention mechanism multi-scale feature extraction instance segmentation deep learning

Characterization of Five Kinds of Wood Vinegar Obtained from Agricultural and Forestry Wastes and Identification of Major Antioxidants in Wood Vinegar

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Chemical Research in Chinese Universities 2019年第1期35卷 12-20页

作者： LI Zhanchao ZHANG Zhiquan wu lijie ZHANG Hanqi WANG Ziming College of Chemistry Jilin UniversityChangchun 130012P.R.China College of Chinese Materia Media Tianjin University of Traditional Chinese Medicine Tianjin 300193P.R.China

Wood vinegar(WV)has a powerful antioxidant activity,but it is unclear which components are responsible for the antioxidant *** the present study,the double-column retention index qualitative method was used for the identification of the major components in five kinds of W7 And the major antioxidants of wood vinegar were accurately identified with the aid of Pearson product-moment correlation coefficients and authentic standard samples. Our results demonstrate that phenolic compounds are mainly responsible for the powerful antioxidant activity. 2,6-Dimethoxyphenol is the most powerful antioxidant in WV.2-Methoxyphenol and 3-methyl-1,2-cyclopentanedioue also have an important influence on the antioxidant activity of *** results suggest that the contents of 2-methoxyphenol,2,6-dimethoxyphenol and 3-methyl-1,2-cyclopentanedione should act as the criteria for evaluating the antioxidant activity of *** work will provide useful information for WV's application in the fields of food and medicine as antioxidants.

关键词： Antioxidant activity 2,6-Dimethoxyphenol 3-Methyl-1,2-cyclopentanedione 2-Methoxyphenol Retention index Wood vinegar

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滹沱河水系形成问题的新探讨

干旱区资源与环境 2022年第12期36卷 64-71页

作者：吴利杰西北大学地质学系大陆动力学国家重点实验室西安710069 中国地质科学院第四纪年代学与水文环境演变重点实验室厦门361009

通过将滹沱河流域的断陷湖盆、峡谷、河流及山前冲洪积扇作为一个统一的自然地理系统,从构造地貌与沉积响应两个方面进行综合分析,对滹沱河上游水系“袭夺”问题及其最终形成年代等问题进行了探讨。研究表明:石岭关风口为中新世-上新世... 详细信息

通过将滹沱河流域的断陷湖盆、峡谷、河流及山前冲洪积扇作为一个统一的自然地理系统,从构造地貌与沉积响应两个方面进行综合分析,对滹沱河上游水系“袭夺”问题及其最终形成年代等问题进行了探讨。研究表明:石岭关风口为中新世-上新世之交(>5.20Ma)一条纵贯山西中部(忻定-太原)地堑谷的古河谷遗迹。约5.20Ma石岭关断块隆起,忻定、太原两个相对独立演化的山间断陷盆地初具雏形。滹沱河彻底贯通太行山流入华北平原,形成一个独立的水系格架的时间厘定为第四纪初期(2.58-2.12Ma),新构造运动应是滹沱河形成的主要驱动力。滹沱河形成后未经石岭关南流进入太原盆地而与汾河水系沟通,其“袭夺”问题的争论可以休止。

关键词：滹沱河忻定盆地滹沱河冲洪积扇河流袭夺新构造运动