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Level Set interface treatment and its application in Euler method

Science china(Physics,Mechanics & Astronomy) 2010年第2期53卷 227-236页

作者： wu kaiteng1,2,hao li3,wang cheng4.& zhang li1,2 1 numerical simulation sichuan higher school key laboratory,neijiang normal university,neijiang 64.112,china 2 College of Mathematics and Information Science,neijiang normal university,neijiang 64.112,china 3 College of Science,Beijing university of Civil Engineering and Architecture,Beijing 100044,china 4 State key laboratory of Explosion Science and Technology,Beijing Institute of Technology,Beijing 100081,china 1. numerical simulation sichuan higher school key laboratory Neijiang Normal University Neijiang 641112 China2. College of Mathematics and Information Science Neijiang Normal University Neijiang 641112 China3. College of Science Beijing University of Civil Engineering and Architecture Beijing 100044 China4. State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology Beijing 100081 China

Level Set interface treatment method is introduced into Euler method,which is employed for interface treatment method for multi-materials. Combined with the ghost fluid method,the moving interface is tracked. Fifth-order WENO spatial discretization and third-order TVD Runge-Kutta time discretization methods are used. Shock-wave action on bubble,implosion and velocity field Shock effect bubbles; implosion and velocity field are simulated by means of LS-MMIC3D programmed by C++. Nu-merical results show that the Level Set interface treatment method is effective and feasible for multi-material interface treatment in comparison with the WENO method.

关键词： Euler method Level Set method shock-wave action on bubble implosion numerical simulation

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Efficacy and safety of CM310 in moderate-to-severe atopic dermatitis:A multicenter,randomized,double-blind,placebo-controlled phase 2b trial

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Chinese Medical Journal 2024年第2期137卷 200-208页

作者： Yan Zhao Jianzhong zhang Bin Yang Jingyi li Yangfeng Ding liming wu litao zhang Jinyan wang Xiaohong Zhu Furen zhang Xiaohua Tao Yumei li Chunlei zhang linfeng li Jianyun Lu Qingchun Diao Qianjin Lu Xiaoyong Man Fuqiu li Xiujuan Xia hao cheng Yingmin Jia Guoqing Zhao Jinchun Yan Bo Chen Department of Dermatology Peking University People’s HospitalBeijing 100044China Department of Dermatology Dermatology HospitalSouthern Medical UniversityGuangzhouGuangdong 510091China Department of Dermatology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Dermatology Shanghai Skin Disease HospitalInstitute of PsoriasisTongji University School of MedicineShanghai 200443China Department of Dermatology Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Department of Dermatology Ningbo No.2 HospitalNingboZhejiang 315010China Department of Dermatology The Wuxi Second Affiliated Hospital of Nanjing Medical UniversityWuxiJiangsu 214002China Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Veneorology Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250022China Center for Plastic&Reconstructive Surgery Department of DermatologyZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)HangzhouZhejiang 310014China Department of Dermatology Affiliated Hospital of Jiangsu UniversityZhenjiangJiangsu 212001China Department of Dermatology Peking University Third HospitalBeijing 100191China Department of Dermatology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Dermatology The Third Xiangya Hospital of Central South UniversityChangshaHunan 410013China Department of Dermatology Chongqing Traditional Chinese Medicine HospitalChongqing 400011China Hunan key laboratory of Medical Epigenomics Department of DermatologyThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Dermatology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Departme

Background:Atopic dermatitis(AD)affects approximately 10%of adults ***310 is a humanized monoclonal antibody targeting interleukin-4 receptor alpha that blocks interleukin-4 and interleukin-13 *** trial aimed to evaluate the efficacy and safety of CM310 in Chinese adults with moderate-to-severe ***:This multicenter,randomized,double-blind,placebo-controlled,phase 2b trial was conducted in 21 medical institutions in china from February to November *** 120 eligible patients were enrolled and randomized(1:1:1)to receive subcutaneous injections of 300 mg CM310,150 mg CM310,or placebo every 2 weeks for 16 weeks,followed by an 8-week follow-up *** primary endpoint was the proportion of patients achieving≥75%improvement in the Eczema Area and Severity Index(EASI-75)score from baseline at week *** and pharmacodynamics were also ***:At week 16,the proportion of EASI-75 responders from baseline was significantly higher in the CM310 groups(70%[28/40]for high-dose and 65%[26/40]for low-dose)than that in the placebo group(20%[8/40]).The differences in EASI-75 response rate were 50%(high ***,95%CI 31%-69%)and 45%(low ***,95%CI 26%-64%),with both P valuesnumerical Rating Scale,AD-affected body surface area,and Dermatology life Quality Index compared with ***310 treatment reduced levels of thymus and activation-regulated chemokine,total immunoglobulin E,lactate dehydrogenase,and blood *** incidence of treatment-emergent adverse events(TEAEs)was similar among all three groups,with the most common TEAEs reported being upper respiratory tract infection,atopic dermatitis,hyperlipidemia,and *** severe adverse events were deemed to be attributed to ***:CM310 at 150 mg and 300 mg every 2 weeks demonstrated significant efficacy and was well-tol

关键词： CM310 Moderate-to-severe atopic dermatitis Interleukin-4 receptor alpha Adults

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多因素耦合作用下缓冲材料对铀的长期阻滞效应数值模拟

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核化学与放射化学 2022年第4期44卷 474-487页

作者：王哲王玉平李江波张振龙冯喜杨罗莹张家千曾秋平刘艳易发成张灏赵雨王振雨吴亚东西南科技大学核废物与环境安全国防重点学科实验室四川绵阳621010 中国科学技术大学地球与空间科学学院安徽合肥230026 宜宾学院国际应用技术学部四川宜宾644000 中国工程物理研究院材料研究所四川江油621700 四川轻化工大学计算机科学与技术学院四川宜宾644000

近场环境条件下核素在缓冲材料中的迁移扩散受控于温度场、渗流场、膨胀应力场和化学吸附场的耦合作用,其对核素的阻滞特性将影响到核素随地下水向处置库围岩迁移并返回生物圈的能力,开展多因素耦合作用下缓冲材料对铀的长期阻滞效应研... 详细信息

近场环境条件下核素在缓冲材料中的迁移扩散受控于温度场、渗流场、膨胀应力场和化学吸附场的耦合作用,其对核素的阻滞特性将影响到核素随地下水向处置库围岩迁移并返回生物圈的能力,开展多因素耦合作用下缓冲材料对铀的长期阻滞效应研究,对地质处置库的长期安全性评价具有重要的意义。本研究基于混合物理论、连续介质理论、质量守恒、动量守恒、能量守恒及溶质扩散的Fick定律,推导出饱和缓冲材料中核素迁移扩散的热-水-力-化耦合控制方程,并借助于COMSOL Multiphysics软件的直接全耦合求解优势,以自主研制的缓冲材料长期阻滞性能Mock-up实验装置为几何模型,采用内置接口和添加热-水-力-化耦合控制方程中的耦合项作为源项相结合方式,实现了多物理场耦合作用下铀在饱和缓冲材料中迁移扩散行为的直接耦合分析,其长期阻滞特性数值模拟结果表明:初期阶段铀在缓冲材料中迁移扩散较缓慢,迁移距离随时间增幅在1 m左右;中后期阶段,随缓冲材料对铀的吸附容量逐渐趋于饱和后,其迁移距离较初期阶段增加更为明显,迁移距离随时间增幅为3 m左右。多因素耦合下核素在饱和缓冲材料中迁移扩散的热-水-力-化耦合控制方程构建、求解及长期阻滞性能模拟研究的方法,能够为我国高放废物深地质处置库地下实验室开展1∶1工程尺度的工程屏障设计与安全性能评价提供技术参考。

关键词：缓冲材料耦合作用阻滞效应高放废物地质处置铀 COMSOL Multiphysics软件

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