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Defects in phospholipase C zeta cause polyspermy and low fertilization after conventional IVF:not just ICSI failure

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Asian Journal of Andrology 2024年第2期26卷 175-182页

作者： Jian-Fang Che Hui-Xia wu Si-Cong zeng Yue-ren wu Jing Dai De-hua Cheng Fei Gong Guang-Xiu lu Ge Lin Can Dai School of Medicine Hunan Normal UniversityChangsha 410013China Reproductive and Genetic Hospital of CITIC-Xiangya Changsha 410008China Clinical Research Center for Reproduction and Genetics in Hunan Province Changsha 410078China National Engineering and Research Center of Human Stem Cell Changsha 410205China

Phospholipase C zeta(PLC)is a key sperm-borne oocyte-activating factor that triggers Ca^(2+)oscillations and the subsequent block to polyspermy following gamete *** in PLCZ1,the gene encoding PLCζ,cause male infertility and intracytoplasmic sperm injection(ICSI)fertilization failure;and PLCζ expression and localization patterns are significantly correlated with ICSI fertilization rate(FR).However,in conventional in vitro fertilization(cIVF),whether and how sperm PLCζ affects fertilization remain ***,we identified one previously reported and two novel PLCZ1 mutations associated with polyspermy in vitro that are characterized by excessive sperm-zona binding and a delay in pronuclei(PN)*** staining and oocyte activation testing revealed that virtually all spermatozoa from patients lacked functional PLCζ and were thus unable to evoke Ca^(2+) *** with an artificial oocyte activation treatment successfully rescued the polyspermic phenotype and resulted in a live ***,we analyzed PLCζ in an additional 58 males after cIVF treatment in the Reproductive and Genetic Hospital of CiTiC-Xiangya(Changsha,China)between February 2019 and January *** found that the proportion of spermatozoa that expressed PLCζ was positively correlated with both 2PN rate and total *** optimal cutoff value below which males were likely to experience low FR(total FR≤30%)after clVF was 56.7%for the proportion of spermatozoa expressing *** study expands the mutation and the phenotypic spectrum of PLCZ1 and further suggests that PLCζ constitutes a promising biomarker for identifying low FRs cases in cIVF due to sperm-related oocyte activation deficiency and that sperm PLCζ analysis may benefit the widermale population and not onlymen with IcsI failure.

关键词： conventional IVF gene variants PLCζ polyspermy

Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese medicine and Western medicine

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Military Medical Research 2024年第3期11卷 313-322页

作者： Ying-Hui Jin Yan-Ping Wang Ying-Lan Xie Gui-hua Tian Xiao-Yu Zhang Nan-Nan Shi Ke-Hu Yang Xin Sun Yao-Long Chen Da-Rong wu Xin-Feng Guo Long Ge Chen Zhao Cheng lu Yin Jiang Jing Guo Si-Yu Yan Yong-Bo Wang Qiao huang Xiang-Ying ren Ying-Yue Rao Yun-Yun Wang Meng-Qian Yuan Xian-Tao zeng Hong-Cai Shang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China China Center for Evidence Based Traditional Chinese Medicine Beijing 100029China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430074China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China China Center for Evidence-Based Medicine West China Hospital of Sichuan UniversityChengdu 610041China State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Evidence-based Medicine Team Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510120China Nanjing University of Chinese Medicine Nanjing 210023China Jiangsu Province Hospital of Chinese Medicine Nanjing 210029China

Integrated traditional Chinese medicine(TCM)and Western medicine(WM)is a new medical science grounded in the knowledge bases of both TCM and WM,which then forms a unique modern medical system in *** TCM and WM has a long history in China,and has made important achievements in the process of clinical diagnosis and ***,the methodological defects in currently published clinical practice guidelines(CPGs)limit its *** organic integration of TCM and WM is a deeper integration of TCM and *** realize the progression of"integration"to"organic integration",a targeted and standardized guideline development methodology is ***,the purpose of this study is to establish a standardized development procedure for clinical practice guidelines for the organic integration of TCM and WM to promote the systematic integration of TCM and WM research results into clinical practice guidelines in order to achieve optimal results as the whole is greater than the sum of the parts.

关键词： Methodology Traditional Chinese medicine Western medicine Organic integration Clinical practice guidelines(CPGs)

具有不确定控制增益严格反馈系统的自适应命令滤波控制

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自动化学报 2024年第5期50卷 1015-1023页

作者：吴锦娃刘勇华苏春翌鲁仁全广东工业大学自动化学院广州510006 粤港智能决策与协同控制联合实验室广州510006 广东省智能决策与协同控制重点实验室广州510006

针对一类具有不确定控制增益的严格反馈系统,提出一种基于命令滤波反推技术的自适应神经网络控制方法.该方法采用神经网络对系统中的未知非线性函数进行逼近,并引入命令滤波反推技术克服“计算膨胀”的问题.与现有的命令滤波反推控制文... 详细信息

针对一类具有不确定控制增益的严格反馈系统,提出一种基于命令滤波反推技术的自适应神经网络控制方法.该方法采用神经网络对系统中的未知非线性函数进行逼近,并引入命令滤波反推技术克服“计算膨胀”的问题.与现有的命令滤波反推控制文献相比,本文通过构造自适应误差补偿系统,同时消除滤波器产生的边界层误差和不确定控制增益对系统性能造成的影响.仿真结果验证了所提控制方法的有效性.

关键词：非线性系统命令滤波反推神经网络控制自适应控制

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： huaNG Hao-yue LIN Yu-ping WEI hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling WEN Jian-xuan wu Li-yan zeng Hui-yan ZHANG Jin-ming lu Qi-yun HE Liu SONG Wei SUN lu luO lu-lu HE Jia-li XIE Wen-wen LIANG Qing-shun huaNG Yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng wu Ming-hui LI An-xiang huaNG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

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竹定向刨花单元加工技术研究

林产工业 2024年第8期61卷 52-58页

作者：沈周杨兴武魏任重芦童陆铜华千年舟新材科技集团股份有限公司浙江杭州310000 杭州海美自动化设备有限公司浙江杭州310000

我国竹材资源丰富,竹材定向刨花板作为一种绿色高强的生态建材,一直未能被大范围推广。这主要由原料加工的产能较低、产品质量不稳定、加工设备不成熟等因素导致。本文分析了竹材定向刨花板产业化的困境,并通过对原料加工技术的探讨提... 详细信息

我国竹材资源丰富,竹材定向刨花板作为一种绿色高强的生态建材,一直未能被大范围推广。这主要由原料加工的产能较低、产品质量不稳定、加工设备不成熟等因素导致。本文分析了竹材定向刨花板产业化的困境,并通过对原料加工技术的探讨提出了竹刨花加工的技术难点,并提供了一种径向弦切定厚技术及设备,可有效解决产品原料加工效率低、产品质量差的问题。此外,对竹定向刨花板现存的制备问题及行业发展等进行了总结与展望。

关键词：竹材定向刨花板竹刨花原料资源径向弦切定厚技术加工技术

Superconductivity in kagome metal ThRu3Si2

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Chinese Physics B 2024年第5期33卷 50-55页

作者：刘艺厉静杨武璋卢佳依曹博雅李华旬柴万力武思祺李佰卓孙云蕾焦文鹤王操许晓峰任之曹光旱 School of Physics Zhejiang University Department of Applied Physics Zhejiang University of Technology School of Science Westlake Institute for Advanced Study Westlake University Department of Physics Shandong University of Technology School of Information and Electrical Engineering Zhejiang University City College Interdisciplinary Center for Quantum Information and State Key Laboratory of Silicon and Advanced Semiconductor MaterialsZhejiang University Collaborative Innovation Centre of Advanced Microstructures Nanjing University

We report the physical properties of ThRu3Si2featured with distorted Ru kagome lattice. The combined experiments of resistivity, magnetization and specific heat reveal bulk superconductivity with Tc= 3.8 K. The specific heat jump and calculated electron–phonon coupling indicate a moderate coupled BCS superconductor. In comparison with LaRu3Si2,the calculated electronic structure in ThRu3Si2shows an electron-doping effect with electron filling lifted from 100 meV below flat bands to 300 meV above it. This explains the lower superconducting transition temperature and weaker electron correlations observed in ThRu3Si2. Our work suggests the Tc and electronic correlations in the kagome superconductor could have an intimate connection with the flat bands.

关键词： superconductivity kagome lattice flat band

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong huang Wei-hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-Yuan luan Chang-Jun Ning Bin-Bin Qi Jie ren Zhi-Zhou ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang wu Xuan wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

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长江流域地表水中镉生态风险的区域差异分析

环境科学 2024年第6期45卷 3186-3195页

作者：丁仁廖梓童陆韻巫寅虎陈卓高桦楠徐红卫陆松柳惠二清魏东斌胡洪营清华大学环境学院环境模拟与污染控制国家重点联合实验室国家环境保护环境微生物利用与安全控制重点实验室环境前沿技术北京实验室北京100084 上海勘测设计研究院有限公司上海200093 长江生态环保集团有限公司武汉430014 中国科学院生态环境研究中心北京100085 清华苏州环境创新研究院苏州215163

围绕长江流域地表水中镉(Cd)的水质基准和生态风险的区域差异展开分析.首先,根据我国《淡水水生生物水质基准——镉》推荐的方法,结合长江流域地表水的硬度分布对Cd长期水质基准值进行了校正;在此基础上,考虑长江流域的物种区系特征,进... 详细信息

围绕长江流域地表水中镉(Cd)的水质基准和生态风险的区域差异展开分析.首先,根据我国《淡水水生生物水质基准——镉》推荐的方法,结合长江流域地表水的硬度分布对Cd长期水质基准值进行了校正;在此基础上,考虑长江流域的物种区系特征,进一步修正得到了Cd长期水质风险阈值,并依此阐释了长江流域的Cd长期水质风险阈值分布和风险商分布的区域差异性.结果发现,经硬度校正和物种修正后,长江流域不同城市间Cd长期水质风险阈值的最大值为0.75μg·L^(-1),最小值为0.08μg·L^(-1),二者相差近10倍;不同城市间Cd风险商的最高值为1.12,最低值为0.035,二者相差达32倍.长江流域上中游交界区和洞庭湖水系等重点区域的Cd生态风险高,尚需深入研究.

关键词：长江流域水质基准镉(Cd) 生态风险区域差异物种分布

铅冶炼场地土壤微生物群落结构与硫氧化菌作用

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Journal of Central South University 2024年第4期31卷 1050-1063页

作者：吴川陈虹任陆永平漆彦婷李海峰罗兴华陈玥如娄伟杨卫春李伟展 School of Metallurgy and Environment Central South UniversityChangsha 410083China Department of Science and Environmental Studies The Education University of Hong KongHong Kong 999007China China Railway Seventh Bureau Group Nanjing Engineering Co. Ltd.Nanjing 210012China Hunan Hikee Environmental Technology Co. Ltd.Changsha 410001China

长期的铅冶炼生产活动给周边地区带来了严重的重金属污染。重金属污染土壤的微生物群落结构和组成对其风险评估和污染修复具有重要意义。本文选择某铅冶炼区域的周边环境,研究重金属污染在垂直剖面上对土壤微生物群落结构和组成的影响... 详细信息

长期的铅冶炼生产活动给周边地区带来了严重的重金属污染。重金属污染土壤的微生物群落结构和组成对其风险评估和污染修复具有重要意义。本文选择某铅冶炼区域的周边环境,研究重金属污染在垂直剖面上对土壤微生物群落结构和组成的影响。结果表明,重金属含量随着土壤垂直深度的增加而逐渐降低,中度污染土壤中微生物群落多样性高于低污染土;无论污染程度如何,表层土壤微生物群落多样性均高于底层;相对丰度优势属包括Perlucidibaca、Limnobacter、Delftia、Hydrogenophaga、Thiobacillus、Sulfurifustis、Sphingopyxis,其中硫氧化菌(SOB)丰度较高。XRD结果表明,土壤中存在PbSO_(4),可能是由于SOB的富集对硫的氧化作用。这种硫循环特征可能是铅(Pb)转化为PbSO_(4)的稳定化修复潜力。

关键词：有色冶炼重金属土壤污染硫氧化菌微生物群落