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Synthesis and antitumor activity of nitric oxide releasing derivatives of AT1 antagonist

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Chinese Chemical Letters 2009年第3期20卷 302-305页

作者： Yan Chun Zhang Jin Pei Zhou Xiao Ming wu wei hong Pan Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A series of novel nitric oxide-donating derivatives （7a-e, 8a-e） were synthesized by coupling furoxan and nitric oxide with irbesartan analogue and their cytotoxicity against BEL7402 cells in vitro were evaluated by MTT method. It was found that 8c exhibits the most cytotoxic activities with ICso value of 12.5 μmol/L. The hybrids of AT1 antagonist and nitric oxide donor appear to have beneficial effects on antitumor.

关键词： AT1 antagonist Nitric oxide-donating Antitumor Synthesis

Optical Microsphere Nano-Imaging:Progress and Challenges

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Engineering 2024年第5期36卷 102-123页

作者： Guangxing wu Minghui hong Department of Electrical and Computer Engineering National University of SingaporeSingapore 117576Singapore Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

The optical diffraction effect imposes a radical obstacle preventing conventional optical microscopes from achieving an imaging resolution beyond the Abbe diffraction limit and thereby restricting their usage in a multitude of nanoscale *** the past decade,the optical microsphere nanoimaging technique has been demonstrated to be a cost-effective solution for overcoming the diffraction limit and has achieved an imaging resolution of up to about k6k8 in a real-time and label-free manner,making it highly competitive among numerous super-resolution imaging *** this review,we summarize the underlying nano-imaging mechanisms of the microsphere nanoscope and key advancements aimed at imaging performance enhancement:first,to change the working environment or modify the peripheral hardware of a single microsphere nanoscope at the system level;second,to compose the microsphere compound lens;and third,to engineer the geometry or ingredients of *** also analyze challenges yet to be overcome in optical microsphere nano-imaging,followed by an outlook of this technique.

关键词： Microsphere Nano-imaging Virtual imaging Microsphere compound lens Engineered microsphere

Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells

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World Journal of Gastroenterology 2005年第29期11卷 4461-4464页

作者： Kun wu Lin-hong Yuan wei Xia Department of Nutrition and Food Hygiene Public Health College Harbin Medical University Harbin 150001 Heilong jiang Province China

AIM： To explore the growth inhibition and apoptosisinducing effect of apigenin on human gastric carcinoma SGC-7901 cells. METHODS： The effects of apigenin on the growth, clone formation and proliferation of human gastric carcinoma SGC-7901 cells were observed by N-rr, done-forming assay, and morphological observation. Fluorescent staining and flow cytometry analysis were used to detect apoptosis of cells. RESULTS： Apigenin obviously inhibited the growth, clone formation and proliferation of SGC-7901 cells in a dosedependent manner. Inhibition of growth was observed on d 1 at the concentration of 80 μmol/L, while after 4 d, the inhibition rate （IR） was 90%. The growth IRs at the concentration of 20, 40, and 80 μmol/L were 38%, 71%, and 99% respedJvely on the 7^th d. After the cells were treated with apigenin for 48 h, the number of clone-forming in control, 20, 40, and 80 μmol/L groups was 217±16.9, 170±11.1 （P〈0.05）, 98±11.1 （P〈0.05）, and 25±3.5 （P〈0.05） respectively. Typical morphological changes of apoptosis was found by fluorescent staining. The cell nuclei had lost its smooth boundaries, chromatin was condensed, and cell nuclei were broken. Flow cytometry detected typical apoptosis peak. After the cells were treated with apigenin for 48 h, the apoptosis rates were 5.76%, 19.17%, and 29.30% respectively in 20, 40, and 80 μmol/L groups. CONCLUSION： Apigenin shows obvious inhibition on the growth and clone formation of SGC-7901 cells by inducing apoptosis.

关键词： Apigenin Apoptosis Anti-cancer effect Gastric carcinoma

基于Fluent的板管型蒸发式冷凝器的流动与换热研究

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节能技术 2024年第3期42卷 213-218,236页

作者：孙凯刘湘云柯秀芳陈观生刘良德吴宏伟广东工业大学材料与能源学院广东广州510006 广州城建职业学院机电学院广东广州510925 英国赫特福德大学机械工程学院赫特福德郡284000

为了研究板管型蒸发式冷凝器的流动和传热特性,并优化其板片凹陷孔的结构,本研究采用商用软件Fluent对气液流动模型进行数值模拟。通过控制变量、逐层优化的方法,研究了各雷诺数(Re)下板片凹陷孔的不同深度(H)和小直径(D_(1))对板片流... 详细信息

为了研究板管型蒸发式冷凝器的流动和传热特性,并优化其板片凹陷孔的结构,本研究采用商用软件Fluent对气液流动模型进行数值模拟。通过控制变量、逐层优化的方法,研究了各雷诺数(Re)下板片凹陷孔的不同深度(H)和小直径(D_(1))对板片流动与换热效率的影响。研究发现,在所有Re的条件下,努塞尔数(Nu)随着H的增大而增大,且存在一个最佳值——H=3 mm,当H继续增加时,Nu反而开始下降。在确定H的最佳值后,发现在所有Re的条件下,不同D_(1)对Nu的变化影响也存在一个最佳值D_(1)=6 mm,使得换热效果最好。通过实验验证,最佳尺寸下的数值模拟结果与实验结果吻合较好。虽然Re越大,换热效果越好,但也带来了更高的能耗,因此在最佳结构下需要在能耗和效率之间做出取舍。

关键词：蒸发式冷凝器数值模拟强化换热结构优化气液两相

Application of in-situ characterization techniques in modern aqueous batteries

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Rare Metals 2024年第8期43卷 3553-3575页

作者： Jia-Hao wu hong-wei Cai Zhao-Hui Deng Jean-Jacques Gaumet Yu Bao Wen Luo Department of Physics State Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingSchool of Materials Science and EngineeringWuhan University of TechnologyWuhan430070China Laboratoire de Chimie Et Physique:Approche Multi-Echelles Des Milieux Complexes(LCP-A2MC)Institut Jean BarriolUniversitéde Lorraine57070MetzFrance Department of Medicinal Chemistry Hubei College of Chinese MedicineJingzhou 434020China

The development of high-performance aqueous batteries calls for an in-depth knowledge of their chargedischarge redox and failure mechanism,as well as a systematic understanding of the dynamic evolution of microstructure,phase composition,chemical composition,and local chemical environment of the materials for ***-situ characterization technology is expected to understand and reveal the problems faced by aqueous rechargeable batteries,such as the dissolution of electrode materials,the growth of metal negative electrode dendrites,passivation,corrosion,side reactions and a series of *** on this,typical in-situ characterization techniques and their basic mechanisms are summarized,including in-situ optical visualization,in-situ microscopy techniques(in-situ scanning electron microscopy(SEM),in-situ transmission electron microscopy(TEM)),in-situ X-ray techniques(in-situ X-ray diffraction(XRD),in-situ X-ray photoelectron spectroscopy(XPS),in-situ near-edge structural X-ray absorption spectroscopy(XANES)),and in-situ spectroscopy techniques(in-situ Raman spectroscopy,in-situ Fourier transform infrared(FTIR)).Moreover,some emerging techniques concerning aqueous battery research,especially gas evolution and materials dissolution issues,such as in-situ electrochemical quartz crystal microbalance(EQCM).in-situ fiber-optic sensing,in-situ gas chromatography(GC) are *** last,the applications of advanced in-situ characterizations in future research of aqueous batteries are emphasized and discussed,along with some of the remaining challenges and possible solutions.

关键词： Aqueous battery In-situ characterization Phase transformation Solid electrolyte interphase Zinc dendrite growth

In situ meso-tetra(4-carboxyphenyl)porphyrin ligand substitution in Hf-MOF for enhanced catalytic activity and stability in photoredox reactions

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Rare Metals 2024年第6期43卷 2682-2694页

作者： Jie Hu hong-Xin Lao Xiu-wu Xu wei-Kang Wang Le-Le Wang Qin-Qin Liu School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China College of Chemistry and Materials Engineering Research Center of Carbon NeutralityAnhui Normal UniversityWuhu 241002China Fujian Provincial Key Laboratory of Ecology-Toxicological Effects and Control for Emerging Contaminants Putian UniversityPutian 351100China

Though there are numerous intrinsic merits of metal-organic frameworks(MOFs),low charge separation efficiency has imposed heavy restrictions on their photocatalytic ***,in situ porphyrin ligand substitution,as a strategy for improving the charge separation efficiency and increasing the amounts of active sites,has been designed and realized in a Hf-biphenyl dicarboxylic acid(BPDC)***,a size and geometry matched meso-tetra(4-carboxyphenyl)porphyrin(TCPP)ligand was selected and doped into Hf-BPDC MOF by forming coordinating bonds with Hf centers,forming dualligand Hf-BPDC-TCPP *** resultant Hf-BPDC-TCPP MOF showed significantly improved activity and chemical stability in the photocatalytic H_(2)generation(261μmol·g^(-1)·h^(-1))and tetracycline(TC)degradation reactions(95.8%),which was 48 and 1.47 folds higher than that of the Hf-BPDC *** and electrochemical studies revealed that the introduction of porphyrin ligand could generate a stronger internal electric field for boosting the charge separation and transfer,increase the specific surface area for providing more active sites,and narrow the band gap to enhance the visible light *** in situ ligand substitution method provides a promising approach to build a tunable platform for constructing high-performance MOF photocatalysts.

关键词： Ligand substitution Metal organic frameworks Meso-tetra(4-carboxyphenyl)porphyrin Hydrogen evolution reaction Tetracycline degradation

Magnetic field imaging with radio-frequency optically pumped magnetometers [Invited]

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Chinese Optics Letters 2024年第6期22卷 38-45页

作者： Xiyu Liu Junlong Han wei Xiao Teng wu Xiang Peng hong Guo School of Electronics Peking UniversityBeijing 100871China

High-sensitivity radio-frequency optically pumped magnetometers (RF-OPMs), working without cryogenic condition, play a critical role in magnetic field imaging(MFI) at low frequencies(e.g., 100 Hz to 1 MHz). We introduce the principle of operation and recent developments of RF-OPMs and focus on reviewing the MFI applications in magnetic induction tomography, ultralow-field magnetic resonance imaging, and magnetic particle imaging. For the applications of RF-OPMs, ranging from industrial monitoring to medical imaging and security screening, the unshielded and portable RF-OPMs(and RF-OPM array)techniques are still under the further development for detecting and scanning over the target object for accomplishing the final three-dimensional imaging, and thus extremely require the abilities of active compensation of the ambient magnetic field and sensor miniaturization in the future.

关键词： magnetic field imaging radio frequency optically pumped magnetometer

Low Surface Brightness Galaxies Selected by Different Model Fitting

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Research in Astronomy and Astrophysics 2024年第1期24卷 223-236页

作者： Bing-Qing Zhang hong wu wei Du Pin-Song Zhao Min He Feng-Jie Lei Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

We present a study of low surface brightness galaxies(LSBGs) selected by fitting the images for all the galaxies inα.40 SDSS DR7 sample with two kinds of single-component models and two kinds of two-component models(disk+bulge):single exponential,single sersic,exponential+deVaucular(exp+deV),and exponential+sérsic(exp+ser).Under the criteria of the B band disk central surface brightness μ_(0,disk)(B)≥22.5 mag arcsec^(-2) and the axis ratio b/a> 0.3,we selected four none-edge-on LSBG samples from each of the models which contain 1105,1038,207,and 75 galaxies,*** are 756 galaxies in common between LSBGs selected by exponential and sersic models,corresponding to 68.42% of LSBGs selected by the exponential model and 72.83% of LSBGs selected by the sersic model,the rest of the discrepancy is due to the difference in obtaining μ_(0) between the exponential and sersic *** on the fitting,in the range of 0.5≤n≤1.5,the relation of μ_(0) from two models can be written as μ_(0,sérsic)-μ_(0,exp)=-1.34(n-1).The LSBGs selected by disk+bulge models(LSBG_(2)comps) are more massive than LSBGs selected by single-component models(LSBG_1comp),and also show a larger disk *** the bulges in the majority of our LSBG_(2)comps are not prominent,more than 60% of our LSBG_(2)comps will not be selected if we adopt a single-component model *** also identified 31 giant low surface brightness galaxies(gLSBGs) from LSBG_(2)*** are located at the same region in the color-magnitude diagram as other *** we compared different criteria of gLSBGs selection,we find that for gas-rich LSBGs,M_(*)> 10^(10)M_⊙ is the best to distinguish between gLSBGs and normal LSBGs with bulge.

关键词： catalogs galaxies:spiral galaxies:bulges methods:data analysis methods:statistical

Mixed H_(∞)/Passive Exponential Synchronization for Delayed Memristive Neural Networks with Switching Event-Triggered Control

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Journal of Systems Science & Complexity 2024年第1期37卷 294-317页

作者： wu Wenhuang GUO Lulu CHEN hong Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai 200092China Department of Control Science and Engineering Tongji UniversityShanghai 201804China

This paper is devoted to event-triggered synchronization of delayed memristive neural networks with H∞and passivity *** aim is to guarantee the exponential synchronization and mixed H∞and passivity control for memristive neural networks by using event-triggered ***,a switching system is constructed under the event-triggered control ***,by adopting a piece-wise Lyapunov functional,a sufficient condition is established for the exponential synchronization and mixed H_(∞)and passivity ***,an event-triggered controller design scheme is proposed using matrix decoupling ***,the effectiveness of the designed controller is exemplified by a numerical example.

关键词： Event-triggered control exponential synchronization memristive neural networks time delays.